Ru(II)-Catalyzed Site-Selective Hydroxylation of Flavone
and Chromone Derivatives: The Importance of the 5‑Hydroxyl
Motif for the Inhibition of Aurora Kinases
- Publication date
- Publisher
Abstract
An
efficient protocol for Ru(II)-catalyzed direct C–H oxygenation
of a broad range of flavone and chromone substrates was developed.
This convenient and powerful synthetic tool allows for the rapid installation
of the hydroxyl group into the flavone, chromone, and other related
scaffolds and opens the way for analog synthesis of highly potent
Aurora kinase inhibitors. The molecular docking simulations indicate
that the formation of bidentate H-bonding patterns in the hinge regions
between the 5-hydroxyflavonoids and Ala213 was the significant binding
force, which is consistent with experimental and computational findings