98 research outputs found
Phase II study of induction chemotherapy with TPF followed by radioimmunotherapy with Cetuximab and intensity-modulated radiotherapy (IMRT) in combination with a carbon ion boost for locally advanced tumours of the oro-, hypopharynx and larynx - TPF-C-HIT
<p>Abstract</p> <p>Background</p> <p>Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensification of treatment schedules through introduction of novel induction and combination chemotherapy regimen and altered fractionation regimen, patient tolerance to higher treatment intensities is limited by accompanying side-effects. Combined radioimmunotherapy with cetuximab as well as modern radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) and carbon ion therapy (C12) are able to limit toxicity while maintaining treatment effects. In order to achieve maximum efficacy with yet acceptable toxicity, this sequential phase II trial combines induction chemotherapy with docetaxel, cisplatin, and 5-FU (TPF) followed by radioimmunotherapy with cetuximab as IMRT plus carbon ion boost. We expect this approach to result in increased cure rates with yet manageable accompanying toxicity.</p> <p>Methods/design</p> <p>The TPF-C-HIT trial is a prospective, mono-centric, open-label, non-randomized phase II trial evaluating efficacy and toxicity of the combined treatment with IMRT/carbon ion boost and weekly cetuximab in 50 patients with histologically proven locally advanced SCCHN following TPF induction chemotherapy. Patients receive 24 GyE carbon ions (8 fractions) and 50 Gy IMRT (2.0 Gy/fraction) in combination with weekly cetuximab throughout radiotherapy. Primary endpoint is locoregional control at 12 months, secondary endpoints are disease-free survival, progression-free survival, overall survival, acute and late radiation effects as well as any adverse events of the treatment as well as quality of life (QoL) analyses.</p> <p>Discussion</p> <p>The primary objective of TPF-C-HIT is to evaluate efficacy and toxicity of cetuximab in combination with combined IMRT/carbon ion therapy following TPF induction in locally advanced SCCHN.</p> <p>Trial Registration</p> <p>Clinical Trial Identifier: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01245985">NCT01245985</a> (clinicaltrials.gov)</p> <p>EudraCT number: 2009 - 016489- 10</p
The promoter of ZmMRP-1, a maize transfer cell-specific transcriptional activator, is induced at solute exchange surfaces and responds to transport demands
Transfer cells have specializations that facilitate the transport of solutes across plant exchange surfaces. ZmMRP-1 is a maize (Zea mays) endosperm transfer cell-specific transcriptional activator that plays a central role in the regulatory pathways controlling transfer cell differentiation and function. The present work investigates the signals controlling the expression of ZmMRP-1 through the production of transgenic lines of maize, Arabidopsis, tobacco and barley containing ZmMRP-1promoter:GUS reporter constructs. The GUS signal predominantly appeared in regions of active transport between source and sink tissues, including nematode-induced feeding structures and at sites of vascular connection between developing organs and the main plant vasculature. In those cases, promoter induction was associated with the initial developmental stages of transport structures. Significantly, transfer cells also differentiated in these regions suggesting that, independent of species, location or morphological features, transfer cells might differentiate in a similar way under the influence of conserved induction signals. In planta and yeast experiments showed that the promoter activity is modulated by carbohydrates, glucose being the most effective inducer
The Effects of Stinking Smut (Bunt) and Seed Treatment upon the Yield of Winter Wheat
The depreciating effects of bunt or stinking smut (Tilletia levis Kuhn and tritici [Bjerk.] Wint.) upon the yield and quality of winter wheat in Nebraska and many other states are well known. The practical control of this disease through seed treatment has also been established and is being extensively practiced by growers. At the time these experiments were initiated in 1923, formaldehyde was the most commonly used disinfectant, while copper carbonate was just gaining recognition following its introduction by Darnell-Smith in 1915. It has been the chief purpose of the investigations herein reported to study the relative merits of various modified treatments with these two disinfectants, and to establish the relationship between the degree of infection and grain yield of a susceptible variety. The comparative effectiveness of several other fungicides and the longevity of spores, as well as the effect of variation in several cultural practices, have also been studied. The application of the results obtained concerning seed treatments should be restricted to regions where the wheat is not subject to infection from spores carried in the soil. So far as is known, this would exclude only the Pacific Northwest
Beitrag zur normalen und pathologischen Anatomie des Schläfenbeins mit besonderer Rücksicht auf das kindliche Schläfenbein
Annual Fodder and Silage Crops for Nebraska
The present shortage in the seed supply of all standard varieties of annual forage crops has created a special demand for information concerning their relative productivity and the possible use of substitute crops. This circular reports the yields secured from such crops at the Experiment Station, in an effort to help farmers reach a decision as to which crops should be grown this year for roughage, and which ones especially should have their seed supply increased for use in future years. Feed value and production costs as well as yields should be taken into consideration by the grower
Mixed Claims Commission, United States-Germany: Administrative Decision No. VIII Dealing with Claims of the Association of American Holders of Foreign Securities, Incorporated, and its Members
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