1,359 research outputs found

    Ιδιωτικής χρήσης αυτοκίνητα στης Αθήνα: μια αυτοπαλίνδρομη διανυσματική προσέγγιση (VAR)

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    The natural mortality (M) and purse-seine catchability and selectivity were estimated for Trachurus novaezelandiae, Richardson, 1843 (yellowtail scad)-a small inshore pelagic species harvested off south-eastern Australia. Hazard functions were applied to two decades of data describing catches (mostly stable at a mean +- SE of 315 +- 14 t p.a.) and effort (declining from a maximum of 2289 to 642 boat days between 1999/00 and 2015/16) and inter-dispersed (over nine years) annual estimates of size-at-age (0+ to 18 years) to enable survival analysis. The data were best described by a model with eight parameters, including catchability (estimated at < 0.1 x 10-7 boat day-1), M (0.22 year-1) and variable age-specific selection up to 6 years with a 50% retention among 5-year olds (larger than the estimated age at maturation). The low catchability implied minimal fishing mortality by the purse-seine fleet. Ongoing monitoring and applied gear-based studies are required to validate purse-seine catchability and selectivity, but the data nevertheless imply T. novaezelandiae could incur substantial additional fishing effort and, in doing, so alleviate pressure on other regional small pelagics

    Center-surround filters emerge from optimizing predictivity in a free-viewing task

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    In which way do the local image statistics at the center of gaze differ from those at randomly chosen image locations? In 1999, Reinagel and Zador [1] showed that RMS contrast is significantly increased around fixated locations in natural images. Since then, numerous additional hypotheses have been proposed, based on edge content, entropy, self-information, higher-order statistics, or sophisticated models such as that of Itti and Koch [2]. While these models are rather different in terms of the used image features, they hardly differ in terms of their predictive power. This complicates the question of which bottom-up mechanism actually drives human eye movements. To shed some light on this problem, we analyze the nonlinear receptive fields of an eye movement model which is purely data-driven. It consists of a nonparametric radial basis function network, fitted to human eye movement data. To avoid a bias towards specific image features such as edges or corners, we deliberately chose raw pixel values as the input to our model, not the outputs of some filter bank. The learned model is analyzed by computing its optimal stimuli. It turns our that there are two maximally excitatory stimuli, both of which have center-surround structure, and two maximally inhibitory stimuli which are basically flat. We argue that these can be seen as nonlinear receptive fields of the underlying system. In particular, we show that a small radial basis function network with the optimal stimuli as centers predicts unseen eye movements as precisely as the full model. The fact that center-surround filters emerge from a simple optimality criterion—without any prior assumption that would make them more probable than e.g. edges, corners, or any other configuration of pixels values in a square patch—suggests a special role of these filters in free-viewing of natural images

    Spectroscopy of a fractional Josephson vortex molecule

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    In long Josephson junctions with multiple discontinuities of the Josephson phase, fractional vortex molecules are spontaneously formed. At each discontinuity point a fractional Josephson vortex carrying a magnetic flux Φ<Φ0|\Phi|<\Phi_0, Φ02.07×1015\Phi_0\approx 2.07\times 10^{-15} Wb being the magnetic flux quantum, is pinned. Each vortex has an oscillatory eigenmode with a frequency that depends on Φ/Φ0\Phi/\Phi_0 and lies inside the plasma gap. We experimentally investigate the dependence of the eigenfrequencies of a two-vortex molecule on the distance between the vortices, on their topological charge =2πΦ/Φ0\wp=2\pi\Phi/\Phi_0 and on the bias current γ\gamma applied to the Josephson junction. We find that with decreasing distance between vortices, a splitting of the eigenfrequencies occurs, that corresponds to the emergence of collective oscillatory modes of both vortices. We use a resonant microwave spectroscopy technique and find good agreement between experimental results and theoretical predictions.Comment: submitted to Phys. Rev.

    A goal programming methodology for multiobjective optimization of distributed energy hubs operation

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    This paper addresses the problem of optimal energy flow management in multicarrier energy networks in the presence of interconnected energy hubs. The overall problem is here formalized by a nonlinear constrained multiobjective optimization problem and solved by a goal attainment based methodology. The application of this solution approach allows the analyst to identify the optimal operation state of the distributed energy hubs which ensures an effective and reliable operation of the multicarrier energy network in spite of large variations of load demands and energy prices. Simulation results obtained on the 30 bus IEEE test network are presented and discussed in order to demonstrate the significance and the validity of the proposed method

    R5X4 HIV-1 coreceptor use in primary target cells: implications for coreceptor entry blocking strategies

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    Entry coreceptor use by HIV-1 plays a pivotal role in viral transmission, pathogenesis and disease progression. In many HIV-1 infected individuals, there is an expansion in coreceptor use from CCR5 to include CXCR4, which is associated with accelerated disease progression. While targeting HIV-1 envelope interactions with coreceptor during viral entry is an appealing approach to combat the virus, the methods of determining coreceptor use and the changes in coreceptor use that can occur during disease progression are important factors that may complicate the use of therapies targeting this stage of HIV-1 replication. Indicator cells are typically used to determine coreceptor use by HIV-1 in vitro, but the coreceptors used on these cells can differ from those used on primary cell targets. V3 based genetic sequence algorithms are another method used to predict coreceptor use by HIV-1 strains. However, these algorithms were developed to predict coreceptor use in cell lines and not primary cells and, furthermore, are not highly accurate for some classes of viruses. This article focuses on R5X4 HIV-1, the earliest CXCR4-using variants, reviewing the pattern of coreceptor use on primary CD4+ lymphocytes and macrophages, the relationship between primary cell coreceptor use and the two principal approaches to coreceptor analysis (genetic prediction and indicator cell phenotyping), and the implications of primary cell coreceptor use by these strains for treatment with a new class of small molecule antagonists that inhibit CCR5-mediated entry. These are important questions to consider given the development of new CCR5 blocking therapies and the prognosis associated with CXCR4 use
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