284 research outputs found
Enabling Grant-Free URLLC for AoI Minimization in RAN-Coordinated 5G Health Monitoring System
Age of information (AoI) is used to evaluate the performance of 5G health monitoring systems because stale data can be fatal for patients with serious illness. Recently, grant-free ultra-reliable and low latency communications (URLLC) have shown greater potential of minimizing AoI than conventional grant-based approaches; however, existing grant-free schedulers cannot provide guaranteed performance in 5G health monitoring systems because they involve two fundamental problems in time and frequency domains, namely the joint scheduling problem and physical resource block (PRB) allocation. In this study, we investigate two resource allocation problems for the first time, aiming to enable grant-free URLLC to minimize AoI in 5G health monitoring systems. Specifically, we propose two adaptive solutions based on an open radio access network-coordinated wireless system: 1) a joint scheduling algorithm and 2) an adaptive PRB allocation algorithm. To verify the effectiveness of the proposed solutions, we built a simulation environment similar to a real health monitoring system and captured the performance variations under realistic deployment scenarios
Growth Characteristics and Productivity of a New Cold‐Tolerant Italian Ryegrass (\u3cem\u3eLolium multiflorum\u3c/em\u3e L.) Variety Kowinearly in Northern Part of South Korea
Field Performance of Transgenic Tall Fescue (\u3ci\u3eFestuca arundinacea\u3c/i\u3e Schreb.) with Enhanced Tolerance to Environmental Stress
Monoclinic and Correlated Metal Phase in VO_2 as Evidence of the Mott Transition: Coherent Phonon Analysis
In femtosecond pump-probe measurements, the appearance of coherent phonon
oscillations at 4.5 THz and 6.0 THz indicating the rutile metal phase of VO_2
does not occur simultaneously with the first-order metal-insulator transition
(MIT) near 68^oC. The monoclinic and correlated metal(MCM) phase between the
MIT and the structural phase transition (SPT) is generated by a photo-assisted
hole excitation which is evidence of the Mott transition. The SPT between the
MCM phase and the rutile metal phase occurs due to subsequent Joule heating.
The MCM phase can be regarded as an intermediate non-equilibrium state.Comment: 4 pages, 2 figure
Expression of RsMYB1 in chrysanthemum regulates key anthocyanin biosynthetic genes
Background: Several MYB genes belonging to R2R3 MYB transcription
factors have been used in several plant species to enhance anthocyanin
production, and have shown various expression or regulation patterns.
This study focused on the effect of ectopic expression of an RsMYB1
isolated from radish ( Raphanus sativa ) on chrysanthemum cv.
\u2018Shinma\u2019. Results: The RT-PCR results confirmed that
RsMYB1 regulated the expression of three key biosynthetic genes (CmF3H,
CmDFR, and CmANS) that are responsible for anthocyanin production in
transgenic chrysanthemum, but were not detected in the non-transgenic
line. In all transgenic plants, higher expression levels of key
biosynthetic genes were observed in flowers than in leaves. However,
the presence of RsMYB1 in chrysanthemum did not affect any
morphological characteristics, such as plant height, leaf shape or
size, and number of flowers. Furthermore, no anthocyanin accumulation
was visually observed in the leaves and floral tissue of any of the
transgenic lines, which was further confirmed by anthocyanin content
estimation. Conclusion: To our knowledge, this is the first time the
role of an MYB transcription factor in anthocyanin production has been
investigated in chrysanthemum
Diagnosis of Pure Ulnar Sensory Neuropathy Around the Hypothenar Area Using Orthodromic Inching Sensory Nerve Conduction Study: A Case Report
Ulnar neuropathy at the wrist is an uncommon disease and pure ulnar sensory neuropathy at the wrist is even rarer. It is difficult to diagnose pure ulnar sensory neuropathy at the wrist by conventional methods. We report a case of pure ulnar sensory neuropathy at the hypothenar area. The lesion was localized between 3 cm and 5 cm distal to pisiform using orthodromic inching test of ulnar sensory nerve to stimulate at three points around the hypothenar area. Ultrasonographic examination confirmed compression of superficial sensory branch of the ulnar nerve. Further, surgical exploration reconfirmed compression of the ulnar nerve. This case report demonstrates the utility of orthodromic ulnar sensory inching test
Spectrum of movement disorders in GNAO1 encephalopathy: in-depth phenotyping and case-by-case analysis
Background
GNAO1 encephalopathy is a rare neurodevelopmental disorder characterized by distinct movement presentations and early onset epileptic encephalopathy. Here, we report the in-depth phenotyping of genetically confirmed patients with GNAO1 encephalopathy, focusing on movement presentations.
Results
Six patients who participated in Korean Undiagnosed Disease Program were diagnosed to have pathogenic or likely pathogenic variants in GNAO1 using whole exome sequencing. All medical records and personal video clips were analyzed with a literature review. Three of the 6 patients were male. Median follow-up duration was 41 months (range 7–78 months) and age at last examination was 7.4 years (range 3.3–16.9 years). Initial complaints were hypotonia or developmental delay in 5 and right-hand clumsiness in 1 patient, which were noticed at median age of 3 months (range 0–75 months). All patients showed global developmental delay and 4 had severely retarded development. Five patients (5/6, 83.3%) had many different movement symptoms with various onset and progression. The symptoms included stereotyped hands movement, non-epileptic myoclonus, dyskinesia, dystonia and choreoathetosis. Whole exome sequencing identified 6 different variants in GNAO1. Three were novel de novo variants and atypical presentation was noted in a patient. One variant turned out to be inherited from patients mother who had mosaic variant. Distinct and characteristics movement phenotypes in patients with variant p.Glu246Lys and p.Arg209His were elucidated by in-depth phenotyping and literature review.
Conclusions
We reported 6 patients with GNAO1 encephalopathy showing an extremely diverse clinical spectrum on video. Some characteristic movement features identified by careful inspection may also provide important diagnostic insight and practice guidelines.This study was supported by a research program funded by the Korea Centers for Disease Control and Prevention (Grant No. 2018-ER6901-02)
A case of Rubinstein-Taybi Syndrome with a CREB-binding protein gene mutation
Rubinstein-Taybi syndrome (RTS) is a congenital disorder characterized by typical facial features, broad thumbs and toes, with mental retardation. Additionally, tumors, keloids and various congenital anomalies including congenital heart defects have been reported in RTS patients. In about 50% of the patients, mutations in the CREB binding protein (CREBBP) have been found, which are understood to be associated with cell growth and proliferation. Here, we describe a typical RTS patient with Arnold-Chiari malformation. A mutation in the CREBBP gene, c.4944_4945insC, was identified by mutational analysis
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