Unified Superfluid Dark Sector

We present a novel theory of a unified dark sector, where late-time cosmic acceleration emerges from the dark matter superfluid framework. The system is described by a superfluid mixture consisting of two distinguishable states with a small energy gap, such as the ground state and an excited state of dark matter. Given their contact in the superfluid, interaction between those states can happen, converting one state into the other. This long range interaction within the superfluid couples the two superfluid phonon species through a cosine potential motivated by Josephson/Rabi interactions. As a consequence of this potential, a new dynamics of late-time accelerated expansion emerges in this system, without the need of dark energy, coming from a universe containing only this two-state DM superfluid. Because the superfluid species are non-relativistic, their sound speeds remain suitably small throughout the evolution. We calculate the expansion history and growth of linear perturbations, and compare the results to $\Lambda$CDM cosmology. For the fiducial parameters studied here, the predicted expansion and growth function are close to those of $\Lambda$CDM, but the difference in the predicted growth rate is significant at late times. The present theory nicely complements the recent proposal of dark matter superfluidity to explain the empirical success of MOdified Newtonian Dynamics (MOND) on galactic scales, thus offering a unified framework for dark matter, dark energy, and MOND phenomenology.Comment: 27 pages, 4 figures. v2: Version accepted in JCA

Trans-Planckian Physics and the Spectrum of Fluctuations in a Bouncing Universe

In this paper, we calculate the spectrum of scalar field fluctuations in a bouncing, asymptotically flat Universe, and investigate the dependence of the result on changes in the physics on length scales shorter than the Planck length which are introduced via modifications of the dispersion relation. In this model, there are no ambiguities concerning the choice of the initial vacuum state. We study an example in which the final spectrum of fluctuations depends sensitively on the modifications of the dispersion relation without needing to invoke complex frequencies. Changes in the amplitude and in the spectral index are possible, in addition to modulations of the spectrum. This strengthens the conclusions of previous work in which the spectrum of cosmological perturbations in expanding inflationary cosmologies was studied, and it was found that, for dispersion relations for which the evolution is not adiabatic, the spectrum changes from the standard prediction of scale-invariance.Comment: 10 pages, 6 figures, RevTeX4. Analytical determination of the spectrum, corrected some typos, conclusions unchange

On the Generation of a Scale-Invariant Spectrum of Adiabatic Fluctuations in Cosmological Models with a Contracting Phase

In Pre-Big-Bang and in Ekpyrotic Cosmology, perturbations on cosmological scales today are generated from quantum vacuum fluctuations during a phase when the Universe is contracting (viewed in the Einstein frame). The backgrounds studied to date do not yield a scale invariant spectrum of adiabatic fluctuations. Here, we present a new contracting background model (neither of Pre-Big-Bang nor of the Ekpyrotic form) involving a single scalar field coupled to gravity in which a scale-invariant spectrum of curvature fluctuations and gravitational waves results. The equation of state of this scalar field corresponds to cold matter. We demonstrate that if this contracting phase can be matched via a nonsingular bounce to an expanding Friedmann cosmology, the scale-invariance of the curvature fluctuations is maintained. We also find new background solutions for Pre-Big-Bang and for Ekpyrotic cosmology, which involve two scalar fields with exponential potentials with background values which are evolving in time. We comment on the difficulty of obtaining a scale-invariant spectrum of adiabatic fluctuations with background solutions which have been studied in the past.Comment: 8 pages, revised version without the section on perturbations, matching the version published on Phys. Rev. D. For cosmological perturbations in the two field model see astro-ph/021127

A World-Volume Perspective on the Recombination of Intersecting Branes

We study brane recombination for supersymmetric configurations of intersecting branes in terms of the world-volume field theory. This field theory contains an impurity, corresponding to the degrees of freedom localized at the intersection. The Higgs branch, on which the impurity fields condense, consists of vacua for which the intersection is deformed into a smooth calibrated manifold. We show this explicitly using a superspace formalism for which the calibration equations arise naturally from F- and D-flatness.Comment: References adde

Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis

With enhanced concerns of terrorist attacks, dual exposure to radiation and thermal combined injury (RCI) has become a real threat with devastating immunosuppression. NLRP12, a member of the NOD-like receptor family, is expressed in myeloid and bone marrow cells and has been implicated as a checkpoint regulator of inflammatory cytokines as well as an inflammasome activator. We show that NLRP12 has a profound impact on hematopoietic recovery during RCI by serving as a checkpoint of TNF signaling and preventing hematopoietic apoptosis. Using a mouse model of RCI, increased NLRP12 expression was detected in target tissues. Nlrp12−/− mice exhibited significantly greater mortality, inability to fight bacterial infection, heightened levels of pro-inflammatory cytokines, overt granulocyte/monocyte progenitor cell apoptosis and failure to reconstitute peripheral myeloid populations. Anti-TNF antibody administration improved peripheral immune recovery. These data suggest that NLRP12 is essential for survival after RCI by regulating myelopoiesis and immune reconstitution

Bouncing Braneworlds Go Crunch!

Recently, interesting braneworld cosmologies in the Randall-Sundrum scenario have been constructed using a bulk spacetime which corresponds to a charged AdS black hole. In particular, these solutions appear to `bounce', making a smooth transition from a contracting to an expanding phase. By considering the spacetime geometry more carefully, we demonstrate that generically in these solutions the brane will encounter a singularity in the transition region.Comment: 17 pages, 4 figures, ref adde

Studying complex interventions : reflections from the FEMHealth project on evaluating fee exemption policies in West Africa and Morocco

Peer reviewedPublisher PD

Isotropization in Brane Gas Cosmology

Brane Gas Cosmology (BGC) is an approach to unifying string theory and cosmology in which matter is described by a gas of strings and branes in a dilaton gravity background. The Universe is assumed to start out with all spatial dimensions compact and small. It has previously been shown that in this context, in the approximation of neglecting inhomogeneities and anisotropies, there is a dynamical mechanism which allows only three spatial dimensions to become large. However, previous studies do not lead to any conclusions concerning the isotropy or anisotropy of these three large spatial dimensions. Here, we generalize the equations of BGC to the anisotropic case, and find that isotropization is a natural consequence of the dynamics.Comment: 11 pages, 4 eps figures, references adde

The Surgical Infection Society revised guidelines on the management of intra-abdominal infection

Background: Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and 2010. At the time the most recent guideline was released, the plan was to update the guideline every five years to ensure the timeliness and appropriateness of the recommendations. Methods: Based on the previous guidelines, the task force outlined a number of topics related to the treatment of patients with IAI and then developed key questions on these various topics. All questions were approached using general and specific literature searches, focusing on articles and other information published since 2008. These publications and additional materials published before 2008 were reviewed by the task force as a whole or by individual subgroups as to relevance to individual questions. Recommendations were developed by a process of iterative consensus, with all task force members voting to accept or reject each recommendation. Grading was based on the GRADE (Grades of Recommendation Assessment, Development, and Evaluation) system; the quality of the evidence was graded as high, moderate, or weak, and the strength of the recommendation was graded as strong or weak. Review of the document was performed by members of the SIS who were not on the task force. After responses were made to all critiques, the document was approved as an official guideline of the SIS by the Executive Council. Results: This guideline summarizes the current recommendations developed by the task force on the treatment of patients who have IAI. Evidence-based recommendations have been made regarding risk assessment in individual patients; source control; the timing, selection, and duration of antimicrobial therapy; and suggested approaches to patients who fail initial therapy. Additional recommendations related to the treatment of pediatric patients with IAI have been included. Summary: The current recommendations of the SIS regarding the treatment of patients with IAI are provided in this guideline