525 research outputs found
Rotational inhomogeneities from pre-big bang?
The evolution of the rotational inhomogeneities is investigated in the
specific framework of four-dimensional pre-big bang models. While minimal
(dilaton-driven) scenarios do not lead to rotational fluctuations, in the case
of non-minimal (string-driven) models, fluid sources are present in the pre-big
bang phase. The rotational modes of the geometry, coupled to the divergenceless
part of the velocity field, can then be amplified depending upon the value of
the barotropic index of the perfect fluids. In the light of a possible
production of rotational inhomogeneities, solutions describing the coupled
evolution of the dilaton field and of the fluid sources are scrutinized in both
the string and Einstein frames. In semi-realistic scenarios, where the
curvature divergences are regularized by means of a non-local dilaton
potential, the rotational inhomogeneities are amplified during the pre-big bang
phase but they decay later on. Similar analyses can also be performed when a
contraction occurs directly in the string frame metric.Comment: 21 pages, corrected typos, references added; to appear in Class.
Quantum Gra
Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice
There is still an unmet need for xenotransplantation models that efficiently recapitulate normal and malignant human hematopoiesis. Indeed, there are a number of strategies to generate humanized mice and specific protocols, including techniques to optimize the cytokine environment of recipient mice and drug alternatives or complementary to the standard conditioning regimens, that can be significantly modulated. Unfortunately, the high costs related to the use of sophisticated mouse models may limit the application of these models to studies that require an extensive experimental design. Here, using an affordable and convenient method, we demonstrate that the administration of fludarabine (FludaraTM) promotes the extensive and rapid engraftment of human normal hematopoiesis in immunodeficient mice. Quantification of human CD45+ cells in bone marrow revealed approximately a 102-fold increase in mice conditioned with irradiation plus fludarabine. Engrafted cells in the bone marrow included hematopoietic stem cells, as well as myeloid and lymphoid cells. Moreover, this model proved to be sufficient for robust reconstitution of malignant myeloid hematopoiesis, permitting primary acute myeloid leukemia cells to engraft as early as 8 weeks after the transplant. Overall, these results present a novel and affordable model for engraftment of human normal and malignant hematopoiesis in immunodeficient mice
A phase 1 study assessing the feasibility and safety of intraductal pegylated liposomal doxorubicin (PLD) in women awaiting mastectomy
Atomium:Probing the inner wind of evolved O-rich stars with new, highly excited HO and OH lines
Generation of Functional CLL-Specific Cord Blood CTL Using CD40-Ligated CLL APC
PMCID: PMC3526610This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
The VLT/SPHERE view of the ATOMIUM cool evolved star sample. I. Overview:Sample characterization through polarization analysis
Aims. Through the ATOMIUM project, based on an ALMA large program, we aim to
present a consistent view of a sample of 17 nearby cool evolved stars
(Aymptotic Giant Branch and red supergiant stars).
Methods. Here we present VLT/SPHERE-ZIMPOL polarimetric maps obtained in the
visible of 14 out of the 17 ATOMIUM sources. They were obtained
contemporaneously with the ALMA high spatial resolution data. To help interpret
the polarized signal, we produced synthetic maps of light scattering by dust,
through 3D radiative transfer simulations with the RADMC3D code.
Results. The degree of linear polarization (DoLP) observed by ZIMPOL spreads
across several optical filters. We infer that it primarily probes dust located
just outside of the point spread function, and in or near the plane of the sky,
with a total optical depth close to unity in the line of sight, representing
only a fraction of the total circumstellar dust. The maximum DoLP ranges from
0.03-0.38 depending on the source, fractions that can be reproduced by our 3D
pilot models for grains composed of common dust species. The spatial structure
of the DoLP shows a diverse set of shapes. Only for three sources do we note a
correlation between the ALMA CO and SiO lines, which trace the gas density, and
the DoLP, which traces the dust.
Conclusion. The clumpiness of the DoLP and the lack of a consistent
correlation between the gas and the dust location show that, in the inner
circumstellar environment (CSE), dust formation occurs at very specific sites.
This has potential consequences for the derived mass-loss rates and dust-to-gas
ratio in the inner region of the CSE. Except for ~Gru and perhaps GY
Aql, we do not detect interactions between the circumstellar wind and the
hypothesized companions that shape the wind at larger scales. This suggests
that the orbits of any other companions are tilted out of the plane of the sky.Comment: Accepted for publication in Astronomy & Astrophysics. 22 pages, 15
figures, 5 table
The VLT/SPHERE view of the ATOMIUM cool evolved star sample. I. Overview: Sample characterization through polarization analysis
Aims. Through the ATOMIUM project, based on an ALMA large program, we aim to
present a consistent view of a sample of 17 nearby cool evolved stars
(Aymptotic Giant Branch and red supergiant stars).
Methods. Here we present VLT/SPHERE-ZIMPOL polarimetric maps obtained in the
visible of 14 out of the 17 ATOMIUM sources. They were obtained
contemporaneously with the ALMA high spatial resolution data. To help interpret
the polarized signal, we produced synthetic maps of light scattering by dust,
through 3D radiative transfer simulations with the RADMC3D code.
Results. The degree of linear polarization (DoLP) observed by ZIMPOL spreads
across several optical filters. We infer that it primarily probes dust located
just outside of the point spread function, and in or near the plane of the sky,
with a total optical depth close to unity in the line of sight, representing
only a fraction of the total circumstellar dust. The maximum DoLP ranges from
0.03-0.38 depending on the source, fractions that can be reproduced by our 3D
pilot models for grains composed of common dust species. The spatial structure
of the DoLP shows a diverse set of shapes. Only for three sources do we note a
correlation between the ALMA CO and SiO lines, which trace the gas density, and
the DoLP, which traces the dust.
Conclusion. The clumpiness of the DoLP and the lack of a consistent
correlation between the gas and the dust location show that, in the inner
circumstellar environment (CSE), dust formation occurs at very specific sites.
This has potential consequences for the derived mass-loss rates and dust-to-gas
ratio in the inner region of the CSE. Except for ~Gru and perhaps GY
Aql, we do not detect interactions between the circumstellar wind and the
hypothesized companions that shape the wind at larger scales. This suggests
that the orbits of any other companions are tilted out of the plane of the sky.Comment: Accepted for publication in Astronomy & Astrophysics. 22 pages, 15
figures, 5 table
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