A Case Study on Yonivrana (Vaginal Ulcer)

Vaginal infections are a burning problem in today’s era. Vaginal discharges serve an important housewife function in the female reproductive system. It affects the whole reproductive as well as general health of the women. Ayurvedic texts have descried about various Sthanik Chikitsa for Yonigata Rogas. Despite wide range of treatment modalities in contemporary medicine search for safe option, non-surgical, effective and without any adverse effect is needed. This article describes the case report of 35yrs old woman who was complaining of vaginal discharge, itching at vagina. It was observed that Sthanika Chikitsa along with oral medications has provided significant relief in all symptoms

Combinatorial Theorems about Embedding Trees on the Real Line ∗

We consider the combinatorial problem of embedding a tree metric into the real line with low distortion. For two special families of trees — the family of complete binary trees and the family of subdivided stars — we provide embeddings whose distortion is provably optimal, up to a constant factor. We also prove that the optimal distortion of a linear embedding of a tree can be arbitrarily low or high even when it has bounded degree.

Comparison of melatonin levels in saliva in individuals with healthy periodontium, generalized chronic gingivitis and generalized chronic periodontitis

Introduction: Melatonin, is a hormone secreted by the pineal gland which activates several elements of the immune system that reduce tissue destruction during the inflammatory response, either directly by scavenging free radical, reactive oxygen species and reactive nitrogen species or indirectly by modulating the action of agents such as cytokines and adhesion molecules, which contribute to the advance of cell damage. Aim: The aim of the present study was to compare and evaluate melatonin levels in saliva in individuals with healthy periodontium, generalized chronic gingivitis and generalized chronic periodontitis. Materials and method: A total of 60 patients were examined and assessed and divided into 3 groups; Group 1: 20 individuals with healthy periodontium, Group 2: 20 individuals with generalised chronic gingivitis and Group 3: 20 individuals with generalised chronic periodontitis. Saliva samples were collected from each sample and melatonin levels were assessed using ELISA, a competitive immunoassay using a capture antibody technique. Results: Melatonin levels in saliva was highest in individuals with healthy periodontium when compared to gingivitis and periodontitis group which was highly significant and inversely proportional correlation was observed between periodontal index and melatonin levels which was statically significant

An artifact-minimizing method for total dust sampling and chemical characterization of industrial high-temperature aerosols

<p>Conventional methods for total dust sampling from industrial high-temperature aerosols containing condensable species, e.g., in boilers of municipal solid waste incinerators (MSWI), are always influenced by condensation artifacts. Therefore, we extended the scope of a previously developed probe intended for size-fractionated aerosol sampling with reduced artifacts and employed it for total dust measurements. The dust is collected on quartz fiber filters, which are gravimetrically evaluated and chemically analyzed by energy dispersive X-ray spectroscopy and wet-chemical methods. First measurements in the boiler of an MSWI confirm that the probe is also suitable for artifact-minimized total dust sampling. The data are consistent with results from measurements with the size-fractionating method conducted in parallel. By combining the results of both sampling methods, we reveal the average chemical composition of the submicron particles in the aerosol, which is not accessible by one of the two methods alone.</p> <p>© 2017 American Association for Aerosol Research</p

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

RNA polymerase I (Pol I) transcription of ribosomal RNA genes (rDNA) is tightly regulated downstream of oncogenic pathways, and its dysregulation is a common feature in cancer. We evaluated CX-5461, the first-in-class selective rDNA transcription inhibitor, in a first-in-human, phase I dose-escalation study in advanced hematologic cancers. Administration of CX-5461 intravenously once every 3 weeks to 5 cohorts determined an MTD of 170 mg/m2, with a predictable pharmacokinetic profile. The dose-limiting toxicity was palmar–plantar erythrodysesthesia; photosensitivity was a dose-independent adverse event (AE), manageable by preventive measures. CX-5461 induced rapid on-target inhibition of rDNA transcription, with p53 activation detected in tumor cells from one patient achieving a clinical response. One patient with anaplastic large cell lymphoma attained a prolonged partial response and 5 patients with myeloma and diffuse large B-cell lymphoma achieved stable disease as best response. CX-5461 is safe at doses associated with clinical benefit and dermatologic AEs are manageable.This work was supported by the National Health and Medical Research Council (NHMRC) of Australia Development grant (#1038852), Cancer Council Victoria (CCV) grants-in-aid (#1084545 and #1100892) and the Peter MacCallum Cancer Foundation. Senhwa Biosciences provided financial support with respect to drug supply and pharmacokinetic studies. Researchers were funded by NHMRC Fellowships (to G.A. McArthur, R.B. Pearson, R.D. Hannan) and the Snowdome Foundation fellowship funding (to A. Khot)