7 research outputs found

    Autonomous models solvable through the full interval method

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    The most general exclusion single species one dimensional reaction-diffusion models with nearest-neighbor interactions which are both autonomous and can be solved exactly through full interval method are introduced. Using a generating function method, the general solution for, FnF_n, the probability that nn consecutive sites be full, is obtained. Some other correlation functions of number operators at nonadjacent sites are also explicitly obtained. It is shown that for a special choice of initial conditions some correlation functions of number operators called full intervals remain uncorrelated

    Analysis and design of defected ground structure for EMC improvement in mixed-signal transceiver modules

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    In this research, the return path discontinuity (RPD), located under the power amplifier (PA) substrate, of X-band transceiver module (Base), mounted on a four-layer printed circuit board (PCB), is investigated to improve the signal integrity by reducing the difference in the reference potential. This study is performed by initially employing the wirebond method, through the assessment of both numbers and sizes of bondwires by advanced design system (ADS). Six bondwires of 25 µm are added, producing an improvement of 6.82 dB for the reflection coefficient and 1.19 dB for the isolation and insertion loss. For further improvement, spiral shape defected ground structure (DGS) is implemented in the inner ground layer (layer 2) without using bond wires. The DGS simulation results illustrate an improvement of 3 dB for S11 and 0.6 dB for S12. To improve the electromagnetic compatibility (EMC), the authors propose combination and integration of both wirebond and DGS methods, called wirebond–DGS method, which results in an improvement of 11.86 dB for S11, 1.34 dB for S12 and S21, and 12.03 dB for S22. Finally, the wirebond–DGS RF module was fabricated and the measurement results exhibit an improvement of 8.07 dB for S11 and 9.39 dB for S22 in comparison with the fabricated Base module. In addition, 0.53 dB improvement for both S12 and S21 is also achieved

    A Clinical and Molecular Genetic Study of 50 Families with Autosomal Recessive Parkinsonism Revealed Known and Novel Gene Mutations

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    In this study, the role of known Parkinson�s disease (PD) genes was examined in families with autosomal recessive (AR) parkinsonism to assist with the differential diagnosis of PD. Some families without mutations in known genes were also subject to whole genome sequencing with the objective to identify novel parkinsonism-related genes. Families were selected from 4000 clinical files of patients with PD or parkinsonism. AR inheritance pattern, consanguinity, and a minimum of two affected individuals per family were used as inclusion criteria. For disease gene/mutation identification, multiplex ligation-dependent probe amplification, quantitative PCR, linkage, and Sanger and whole genome sequencing assays were carried out. A total of 116 patients (50 families) were examined. Fifty-four patients (46.55; 22 families) were found to carry pathogenic mutations in known genes while a novel gene, not previously associated with parkinsonism, was found mutated in a single family (2 patients). Pathogenic mutations, including missense, nonsense, frameshift, and exon rearrangements, were found in Parkin, PINK1, DJ-1, SYNJ1, and VAC14 genes. In conclusion, variable phenotypic expressivity was seen across all families. © 2017, Springer Science+Business Media New York

    ALDH as a Stem Cell Marker in Solid Tumors

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