An Inside Look at Sunspot Oscillations with Higher Azimuthal Wavenumbers

Solar chromospheric observations of sunspot umbrae offer an exceptional view of magneto-hydrodynamic wave phenomena. In recent years, a wealth of wave signatures related to propagating magneto-acoustic modes have been presented, which demonstrate complex spatial and temporal structuring of the wave components. Theoretical modelling has demonstrated how these ubiquitous waves are consistent with an m=0 slow magneto-acoustic mode, which are excited by trapped sub-photospheric acoustic (p-mode) waves. However, the spectrum of umbral waves is broad, suggesting that the observed signatures represent the superposition of numerous frequencies and/or modes. We apply Fourier filtering, in both spatial and temporal domains, to extract chromospheric umbral wave characteristics consistent with an m=1 slow magneto-acoustic mode. This identification has not been described before. Angular frequencies of 0.037 +/- 0.007 rad/s (2.1 +/- 0.4 deg/s), corresponding to a period approximately 170 s for the m=1 mode are uncovered for spatial wavenumbers in the range of 0.45<k<0.90 arcsec^-1 (5000-9000 km). Theoretical dispersion relations are solved, with corresponding eigenfunctions computed, which allows the density perturbations to be investigated and compared with our observations. Such magnetohydrodynamic modelling confirms our interpretation that the identified wave signatures are the first direct observations of an m=1 slow magneto-acoustic mode in the chromospheric umbra of a sunspot

Research Design Formation to Determine Quality Indicators of Potential Api, 2. Quality Risks Arising in the Process of Scaling the Synthesis Procedure

Within the framework of the current pharmaceutical legislation, harmonized as much as possible with the EU and the USA to ensure the import / export of high-quality medicines (within the framework of the ICH and the positions of the global pharmaceutical sector), the transfer of technology for obtaining an active pharmaceutical ingredient requires taking into account many factors. Particular attention should be paid to identifying and eliminating risks that may arise when transferring a compound synthesis procedure to an industrial site. The scaling up of the synthesis procedure is accompanied by risks that can affect the quality of the final product, its safety and effectiveness.The aim. The aim of this work is to summarize information regarding the emergence of risks that may arise when scaling the method of synthesis of active biological substances and quality control methods that allow avoiding the emergence of risks in production, studying stability and further application in medical practice.Materials and methods. To carry out the research, we used the collection and analysis of data presented in modern scientific literature and documents of regulatory bodies and the results of our own experimental studies. With the help of FMEA analysis, the stages of scaling of the synthesis technique are identified, which are the most critical, and appropriate measures are proposed to reduce them. Based on the results of a survey of experts in the field of organic synthesis and pharmaceutical production, an appropriate matrix was drawn up and the priority number of risks was calculated according to three criteria: the severity of the consequences, the likelihood of influencing the stages of scaling up the synthesis method, and the degree of probability of detecting a hazard.Results. The risks arising from changes in the synthesis technology during the transfer of a laboratory procedure to a pilot and/or industrial site (simplification of the synthesis scheme, use of reagents and solvents of a different purity class, replacement of a compound isolation method, etc.) have been identified and can affect the pharmacological action, efficiency, safety and storage conditions of biologically active substances. On the basis of risk analysis, it is proposed to use quality control techniques that allow avoiding these risks in the future in the production of a biologically active compound.Conclusions. The stages of scaling up the methodology for the synthesis of a potential active compound for transfer to clinical and preclinical trials are determined, the reasons for the emergence of risks that must be taken into account in the industrial synthesis of BAS, the development of quality control methods and the preparation of an appropriate “certificate of quality” for a new biologically active compound are considere

Influence of A New Derivative of 4-aminobutanoic Acid on the Level of Neuromediatory Aminoacids, Neuromediators and the State of the Rats' Hypocamp in Conditions of Brain Ischemia

The aim: to investigate the effect of a new derivative of 4-aminobutanoic acid (compounds KGM-5) on the level of neurotransmitters and neurotransmitter amino acids and the structural-functional state of the hippocampus of rats with acute cerebrovascular accident (ACVA). Materials and methods. ACVA was reproduced in rats by occlusion of the left carotid artery under anesthesia (sodium thiopental (35 mg/kg) intraperitoneally (i/p). 5 groups of animals were used: intact control (IC, n=6), untreated animals with ACVA (CP, n=13); animals with ACVA (n=14), which were treated for 5 days with KGM-5 at a dose of 30 mg/kg i/p, animals with ACVA (n=13), who received i/p comparison drug “Picamilon” (17 mg/kg). There was a group of pseudo-operated animals (POA, n=8). Withdrawal of animals from the experiment was performed on day 6 after modeling ACVA by painless euthanasia under anesthesia. Histological examinations of CA1 and CA3 zones of the ventral hippocampus were performed with staining of sections with thionine by the method of Nissl and hematoxylin, eosin. In the rat brain, neurotransmitter amino acids and neurotransmitters were identified. Statistical processing was performed using the W-Shapiro-Wills test to verify the normality of the distribution and the nonparametric Mann-Whitney U-test. The accepted significance level is p&lt;0.05. Results. Under the influence of the compound KGM-5 and “Picamilon” in the CA1 zone of the hippocampus, the number of normochromic neurons increased by 20 % and 16.6 %, respectively, hyperchromic pycnomorphic neurons and shadow cells decreased respectively by 5.8; 2.9 times and 6.3; 3.5 times, the index of alteration of neurons decreased by 6 times and 4.8 times, respectively, the area of ​​the perikaryon of these neurons increased by 39.7 % and 77.8 %, respectively, compared with KP (p&lt;0.05). Both studied agents showed a less pronounced normalizing effect on the CA3 area of the hippocampus. The new compound KGM-5 showed a normalizing effect similar to “Picamilon” on the level of neurotransmitter amino acids and neurotransmitters in the brain of rats with ACVA. Conclusions. Therapeutic administration of KGM-5 increases the survival of ventral hippocampal neurons, reducing the relative proportion of irreversibly altered cells, and helps to restore impaired levels of neurotransmitter amino acids and neurotransmitters in the brain of rats with ACVA. The neuroprotective effect of the new compound KGM-5 corresponds to this comparison drug “Picamilon

Improving the Process of Hydrothermal Treatment and Dehulling of Different Triticale Grain Fractions in the Production of Groats

The influence of hydrothermal treatment (grain moistening) and dehulling duration on the yield and quality of groats from different fractions of triticale grain was studied. Comparative analysis of groats yield and its culinary quality at different grain moisture, depending on its fractions, was performed. The degree of the influence of the studied factors on the yield and quality of triticale groats was determined. The influence of dehulling duration, the size of a triticale caryopsis and grain moisture content is reliable. These factors significantly influenced the groats yield and quality. In addition, the influence of the duration of grain dehulling was the highest. The highest groats yield was obtained at the dehulling duration of 20 s, the lowest – at dehulling for 180 s.The social survey was conducted and the main priorities for buyers of cereal products were established. It was proved that while choosing food, consumers pay the most attention to culinary characteristics of the finished product.It was established that it is optimal to dehull triticale grain for 100 s. The application of such parameters of treatment makes it possible to obtain the yield of whole groats of 88.8 % with the culinary quality of 6.7 points. The groats quality meets the requirements of DSTU 76992015 "Wheat Groats. Technical specifications".Based on the research, it was established that the separation of the triticale grain into fractions that differ in their geometric properties, in particular, thickness, is effective. The peculiarities of groats yield, depending on the triticale grain fraction, were determined. Application of hydrothermal treatment of triticale grain (moistening up to 14.0 %) makes it possible to increase the groats yield up to 88.7 %. The treatment of the fractions with grain thickness less than 2.4 mm ensures the groats yield up to 87.8 %. The groats yield during dehulling the grain, which has a thickness of more than 2.4 mm, is from 88.8 to 89.1 %.To produce the groats from triticale grain, it is advisable to use the grains that have a thickness of 2.8 mm or more. The optimum duration of dehulling is 100 s. To increase the overall culinary assessment by 1 point, it is recommended to increase the duration of dehulling a large grain up to 140 s. This method differs from the classical one by the fact that it uses a large grain fraction with the lower moisture content.The developed recommendations can be used by grain processing enterprises during processing triticale with the view to intensifying the production

Effect of Electromagnetic Irradiation of Emmer Wheat Grain on the Yield of Flattened Wholegrain Cereal

The effect of water-heat treatment and time of electromagnetic irradiation on the yield and quality of flattened wholegrain cereal from emmer wheat is investigated. A comparative analysis of cereal yield and cooking time at different moisture contents and time of electromagnetic irradiation of grain before flattening is carried out. The degree of influence of the investigated factors on the total yield of flattened wholegrain cereal and high-grade flattened cereal is determined.The effect of electromagnetic irradiation on the yield of high-grade flattened cereal is significant. Moistening does not affect the overall cereal yield. The highest total yield of cereal was obtained after grain irradiation for 20–80 s, and the lowest – after 180 s. The highest yield of high-grade flattened cereal was obtained with an irradiation time of 80–100 s, while the lowest – 20 s.Moistening of emmer wheat grain by 1.0 % allows increasing the yield of high-grade flattened cereal from 89.6 to 92.3 %. In this case, the optimal irradiation time is reduced from 100 to 80 s.It is found that emmer wheat grain cereal is of high culinary quality. The cooking time of high-grade cereal is reduced as a result of moistening and electromagnetic irradiation of grain. With short-term electromagnetic irradiation of grain (20 s), the cooking time of high-grade cereal is 19.1 minutes, and after long-term (180 s) it decreased to 15.9 minutes.The use of optimal processing parameters (moistening by 1.0 %, irradiation for 80–100 s) provides the 91.7–92.3 % yield of high-grade wholegrain flattened cereal with a culinary score of 7.3 points. The cereal quality meets the requirements of DSTU 76992015. The difference from the classical method is the use of unhulled emmer wheat grain. The developed recommendations can be used by enterprises to intensify productio