Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol

The objective of the work was to develop, optimize and evaluate self-microemulsifying drug delivery system (SMEDDS) of carvedilol (CDL), a poorly water-soluble drug. SMEDDS was developed to increase the solubility, dissolution rate and ultimately, oral bioavailability of CDL. The solubility of CDL was determined in various oils, surfactants and cosolvents. Pseudoternary phase diagrams were used to identify the region of microemulsification. The SMEDDS were characterized by morphological observation, droplet size and zeta-potential, cloud point, % transmission study and emulsification time. The optimized formulation was composed of Capmul MCM C8 (18 %), Tween 80 (65.6 %), and polyethylene glycol 400 (14.4 %). The SMEDDS formulation showed complete release in 20 min as compared with the plain drug, which showed a limited dissolution rate.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Design and Development of Garlic Peeling Machine by Human Powered Flywheel Motor Concept for Rural Dwellers Development

This invention is a new proposed model of peeling the garlic skins with mechanical functionality. Working with the simple and basic mechanism, this is utilising to peel the skin of garlic cloves. This device consists of components like flywheel, process unitand peeler. It reduces the time consumption and protects the hand fingers from the welfare issues like irritation in fingers and nail breakings