The Effect of Eight Weeks Elected Aerobic Exercise on the Levels of (AST, ALT) Enzymes of Men Patients with Have Fat Liver

AbstractThe purpose of present study is the effect of eight weeks elected aerobic exercise on the levels of (AST, ALT) enzymes of men patients with have fat liver, age's 20 to 45 in shooshtar city. that providing of lack of control it will have the garlic of large virulent to destroy liver fiber and cell destruction as usually hard and rough liver fiber and it density is aspired in stenography. Also the measure of cholesterol and triglyceride with liver enzymes increase in these patients. in this study the numbers of 24 patients of referred to sonography clinics of shooshtar town with the distinction of fat liver disease selected by randomly and divided to two groups of control and experimental. Measurement of (AST, ALT) diseases in two groups as pre-test were done. After eight week aerobic exercise the analysis and resolution of data were done by computer and with use of SPSS soft ware and statistical methods of deduction (t-test) and descriptive. The results of comparison between two groups showed that eight weeks aerobic exercise with a≤0.05 it cause to be the decrease of measure of (AST,ALT) of liver cells of experimental group

THE LINK BETWEEN ALLERGIC RHINITIS AND RHEUMATIC DISORDERS: FROM AVICENNA'S VIEW TO RECENT FINDINGS

Allergic rhinitis (AR) is one of the most prevalent allergic disorder across the globe which has significant socioeconomic costs. In addition to direct and indirect costs, the disease also has hidden direct costs related to comorbid conditions. AR can result in several complications such as pharyngitis, sinusitis, asthma, otitis media, eczema and lymphoid hypertrophy. Although associations between AR and other airway disorders have been investigated for years, less attention has been focused on the association of this disease with non-respiratory disorders. Cosidering the fact that AR is rarely found in isolation and reprts of traditional Persian medical literatures on the relationship between rhinitis and joint disorders, this study aimed to investigate the link between AR and rheumatic disorders. In this regard, Avicenna’s Canon of Medicine which was a well known medical textbook until 17th century was reviewed. Modern medical databases were searched as well. The results of this study showed that as mentioned in the teachings of Avicenna, allergic rhinitis may have association with some rheumatic disorders such as rheumatoid arthritis, low back pain and gout. Findings that support this hypothesis include the wide range of symptoms and complications of allergic rhinitis, emphasizing the association by prominent medical scholars of the past like Rhazes and Avicenna, studies found an association between AR or chronic rhnosinusitis with rheumatic diseases and common cytokines and inflammatory biomarkers that serve similar roles in both allergic rhinitis and rheumatic diseases like IL-4, IL-6, IL-8, IL-17 and TNF-alpha. It is suggested that studies be conducted with the main aim of investigating the relationship between these diseases and evaluating underlying mechanisms. The result of such research can be helpful in finding new treatment modalities in both groups. Keywords: allergic rhinitis; rheumatic disorder; comorbidity, traditional medicine; Persian medicine; Avicenn

Hypofractionated Radiation Versus Conventional Fractionated Radiation: A Network Analysis

Hypofractionated Versus Conventional Fractionated Radiation: A Network Analysis Introduction: Conventional fractionated (CF) and hypofractionated (HF) are two radiotherapy methods against cancer which are applied in medicine. Understanding efficacy and molecular mechanism of two methods implies more investigations. In the present study proteomic findings about the mentioned methods relative to the controls are analyzed via network analysis.  Methods: The significant differentially expressed proteins (DEPs) of prostate cancer (PCa) cell line DU145 in response to CF and HF radiation therapy versus controls were extract from literature. The protein-protein interaction (PPI) networks were constructed via STRING database via cytoscape software. The Networks were analyzed by “NetworkAnalyzer” to determine hub DEPs. Results: Number of 126 and 63 significant DEPs were identified for treated DU145 with CF and HF radiation respectively. The PPI networks were constructed by the queried DEPs plus 100 first neighbors. ALB, CD44, THBS1, EPCAM, F2, KRT19, and MCAM were highlighted as common hubs. VTM, OCLN, HSPB1, FLNA, AHSG, and SERPINC1 were appeared as discriminator hub between the studied cells. Conclusion: The 70% of hubs were common between CF and HF conditions and induce radio-resistance activity in the survived cells. Six central proteins were introduced that discriminate function of the two group of irradiated cells. Based on these finding it seems that DU145-CF cells are more radio-resistant relative to the DU145-UF cells

Investigation of Chronic Low-Dose Ionizing Radiation Effect on Gene Expression Profile of Human HUVECs Cells

Introduction: Understanding molecular mechanism of chronic low-dose ionizing radiation (LDIR) effects on human body is subject of many researches. Several aspects of cell function such as cell proliferation, apoptosis, inflammation, and tumorigenesis are affected by LDIR. Detection of the main biological process that is targeted by LIDR via network analysis is the main aim of this study.   Methods: GSE66720 including gene expression profiles of human umbilical vein endothelial cells (HUVECs) included irradiated and control cells is downloaded from gene expression omnibus (GEO). The significant differentially Expressed genes (DEGs) are determined and analyzed via protein-protein interaction (PPI) network analysis to find the central individuals. The main cell function which was related to the central nodes was introduced. Results: Among 64 queried DEGs 48 genes were recognized by STRING database. Five hub nodes including; C-X-C motif chemokine ligand 8 (CXCL8), intercellular adhesion molecule 1 (ICAM1), Melanoma growth-stimulatory activity/growth-regulated protein α (CXCL1), vascular cell adhesion molecule 1 (VCAM-1), and nerve growth factor (NGF) were introduced as hub nodes. Conclusion: Findings indicates that inflammation is the main initial target of LDIR in cellular level which is associated with alteration in the other essential functions of the irradiated cells

Effects of different dosages of caffeine administration on wrestling performance during a simulated tournament

The aim of the present study was to investigate the effects of different forms of caffeine administration on physical performance during a simulated wrestling tournament. In a double-blind and randomized experiment, twelve male freestyle wrestlers competed in a simulated wrestling tournament (5 wrestling matches consisting of 2×3-min wrestling rounds) following the ingestion of: a placebo, a high-dose of caffeine (10 mg/kg), a moderate-dose caffeine (4 mg/kg), a repeated-dose caffeine (2 mg/kg before each match to a total of 10 mg/kg) or a selective caffeine administration based on performance decrement previously measured (6.16±1.58 mg/kg). The Pittsburgh Wrestling Performance Test (PWPT) was measured before each match to assess physical performance. In comparison to the placebo, the high dose of caffeine only reduced PWPT time before the first match (56.8±2.0 vs. 52.9±1.8 s; p < 0.05). The moderate dose of caffeine did not affect PWPT performance during the tournament. Both, the repeated dose and the selective administration of caffeine reduced PWPT time with respect to the placebo in the third (66.7±1.8 vs. ~63.1±1.4 s; p < 0.05) and fourth matches (72.3±2.4 vs. ~65.9±1.3 s; p < 0.05). However, only the selective dose of caffeine reduced PWPT time before the fifth match (62.7±3.0 vs. 56.3±2.0; p < 0.05). The dosage and administration of caffeine affect the ergogenic effects obtained following the ingestion of this substance. An individualized protocol to provide caffeine when physical performance is expected to be reduced might improve wrestling performance during the latter stages of a tournament

Investigation of Crucial Affected Proteins in Rat Liver in the Presence of Scrophularia

Background and objectives: Radix Scropholaria is dried root Scrophularia ningpoensis Hemsl. which is used uses as a drug against several diseases. In the present study, the crucial affected proteins of rat liver in the presence of radix Scrophularia have been investigated. Methods: The differentially expressed proteins (DEPs) were downloaded from literature. The significant DEPs plus 100 added first neighbors were determined and included in “protein query” of STRING database via Cytoscape software. The network was analyzed and the central nodes among the queried DEPs were identified. The 10 first neighbors of the central DEPs were determined. Results: RT1-CE12, Gfer, Serpina3c, Rab13, Rbm14, Ighg Psmb8, COX2, Olr796, Mga, Ugt1a6, Ugt2b, Ebpl, Ugt2b, Igf2r, and Amacr as significant DEPs were analyzed via protein-protein interaction (PPI) network analysis, Ugt1a1 and Ugt2b the two up-regulated proteins were highlighted as the crucial proteins in response to the radix Scrophularia. Conclusion: Two members of UDP glucuronosyltransferase family; Ugt1a1 and Ugt2b, were pointed as the critical liver enzyme which are dysregulated under effect of radix Scrophulariae. Due to crucial role of Ugt1a1 in the liver function, it is suggested that consumption of Scrophularia ningpoensis Hemsl. as a traditional medicine required more investigation

Low-Level Laser Therapy Effects on Rat Blood Hemostasis Via Significant Alteration in Fibrinogen and Plasminogen Expression Level: Low Level Laser Therapy Effects on Rat Blood Hemostasis

Introduction: There are many documents about the significant role of low-level laser therapy (LLLT) in different processes such as regenerator medicine and bone formation. The aim of this study is to assess the role of LLLT in blood hemostasis in rats via bioinformatic investigation.Methods: The differentially expressed plasma proteins of treated rats via LLLT from the literature and the added 50 first neighbors were investigated via network analysis to find the critical dysregulated proteins and biological processes by using Cytoscape software, the STRING database, and ClueGO.Results: A scale-free network including 55 nodes was constructed from queried and added first neighbor proteins. Fibrinogen gamma, fibrinogen alpha, and plasminogen were highlighted as the central genes of the analyzed network. Fibrinolysis was determined as the main group of biological processes that were affected by LLLT.Conclusion: Findings indicate that LLLT affects blood hemostasis which is an important point inapproving the therapeutic application of LLLT and also preventing its possible complication. DOI: 10.34172/jlms.2021.5