Analysis of Yield Attributing Characters of Different Genotypes of Wheat in Rupandehi, Nepal

Field experiment was conducted at National Wheat Research Program, Bhairahawa, Rupandehi with the objective to identify high yielding superior wheat genotypes for Rupandehi district of Nepalduring 2014. Experiment was laid out in one factorial Randomized completely block design with ten wheat genotypes including both released and promising; Annapurna 1, Annapurna 3, Pasang Lahmu, Bijaya, BL 3623, Bhirkuti, NL 297, BL 4316, BL 3978 and BL 4347with three replications. The results showed that the grain yield of BL 3978 was found higher (4.03 t ha-1) than other genotypes followed by BL 4347 (3.93t ha-1). BL 3978 have also higher number of effective tillers m-2 and test weight. Among release varieties, NL 297 show higher yield (4 t ha-1) followed by Bhirkuti (3.43 t ha-1)and Bijaya (3.37 t ha-1). From this experiment it can be concluded that BL 3978 was found promising among all genotypes however should be tested at on-farms before promoted for general cultivation in Rupandehi district of Nepal

Bi-Allelic Mutations in Zebrafish pank2 Gene Lead to Testicular Atrophy and Perturbed Behavior without Signs of Neurodegeneration

Coenzyme A (CoA) is an essential cofactor in all living organisms, being involved in a large number of chemical reactions. Sequence variations in pantothenate kinase 2 (PANK2), the first enzyme of CoA biosynthesis, are found in patients affected by Pantothenate Kinase Associated Neurodegeneration (PKAN), one of the most common forms of neurodegeneration, with brain iron accumulation. Knowledge about the biochemical and molecular features of this disorder has increased a lot in recent years. Nonetheless, the main culprit of the pathology is not well defined, and no treatment option is available yet. In order to contribute to the understanding of this disease and facilitate the search for therapies, we explored the potential of the zebrafish animal model and generated lines carrying biallelic mutations in the pank2 gene. The phenotypic characterization of pank2-mutant embryos revealed anomalies in the development of venous vascular structures and germ cells. Adult fish showed testicular atrophy and altered behavioral response in an anxiety test but no evident signs of neurodegeneration. The study suggests that selected cell and tissue types show a higher vulnerability to pank2 deficiency in zebrafish. Deciphering the biological basis of this phenomenon could provide relevant clues for better understanding and treating PKAN

Creation of the CMB spectrum: precise analytic solutions for the blackbody photosphere

The blackbody spectrum of CMB was created in the blackbody photosphere at redshifts z>2x10^6. At these early times, the Universe was dense and hot enough that complete thermal equilibrium between baryonic matter (electrons and ions) and photons could be established. Any perturbation away from the blackbody spectrum was suppressed exponentially. New physics, for example annihilation and decay of dark matter, can add energy and photons to CMB at redshifts z>10^5 and result in a Bose-Einstein spectrum with a non-zero chemical potential ($\mu$). Precise evolution of the CMB spectrum around the critical redshift of z~2x10^6 is required in order to calculate the $\mu$-type spectral distortion and constrain the underlying new physics. Although numerical calculation of important processes involved (double Compton process, comptonization and bremsstrahlung) is not difficult, analytic solutions are much faster and easier to calculate and provide valuable physical insights. We provide precise (better than 1%) analytic solutions for the decay of $\mu$, created at an earlier epoch, including all three processes, double Compton, Compton scattering on thermal electrons and bremsstrahlung in the limit of small distortions. This is a significant improvement over the existing solutions with accuracy ~10% or worse. We also give a census of important sources of energy injection into CMB in standard cosmology. In particular, calculations of distortions from electron-positron annihilation and primordial nucleosynthesis illustrate in a dramatic way the strength of the equilibrium restoring processes in the early Universe. Finally, we point out the triple degeneracy in standard cosmology, i.e., the $\mu$ and $y$ distortions from adiabatic cooling of baryons and electrons, Silk damping and annihilation of thermally produced WIMP dark matter are of similar order of magnitude (~ 10^{-8}-10^{-10})

Consistency, comprehensiveness, and compatibility of pathway databases

<p>Abstract</p> <p>Background</p> <p>It is necessary to analyze microarray experiments together with biological information to make better biological inferences. We investigate the adequacy of current biological databases to address this need.</p> <p>Description</p> <p>Our results show a low level of consistency, comprehensiveness and compatibility among three popular pathway databases (KEGG, Ingenuity and Wikipathways). The level of consistency for genes in similar pathways across databases ranges from 0% to 88%. The corresponding level of consistency for interacting genes pairs is 0%-61%. These three original sources can be assumed to be reliable in the sense that the interacting gene pairs reported in them are correct because they are curated. However, the lack of concordance between these databases suggests each source has missed out many genes and interacting gene pairs.</p> <p>Conclusions</p> <p>Researchers will hence find it challenging to obtain consistent pathway information out of these diverse data sources. It is therefore critical to enable them to access these sources via a consistent, comprehensive and unified pathway API. We accumulated sufficient data to create such an aggregated resource with the convenience of an API to access its information. This unified resource can be accessed at <url>http://www.pathwayapi.com</url>.</p

A review of clinical decision-making: Models and current research

Aims and objectives: The aim of this paper was to review the current literature with respect to clinical decision-making models and the educational application of models to clinical practice. This was achieved by exploring the function and related research of the three available models of clinical decision making: information processing model, the intuitive-humanist model and the clinical decision making model. Background: Clinical decision-making is a unique process that involves the interplay between knowledge of pre-existing pathological conditions, explicit patient information, nursing care and experiential learning. Historically, two models of clinical decision making are recognised from the literature; the information processing model and the intuitive-humanist model. The usefulness and application of both models has been examined in relation the provision of nursing care and care related outcomes. More recently a third model of clinical decision making has been proposed. This new multidimensional model contains elements of the information processing model but also examines patient specific elements that are necessary for cue and pattern recognition. Design: Literature review Methods: Evaluation of the literature generated from MEDLINE, CINAHL, OVID, PUBMED and EBESCO systems and the Internet from 1980 – November 2005

Non-Gaussianities from Perturbing Recombination

We approximately compute the bispectrum induced on the CMB temperature by fluctuations in the standard recombination epoch. Of all the second order sources that can induce non-Gaussianity during recombination, we concentrate on those proportional to the perturbation in the free electron density, which is about a factor of 5 larger than the other first order perturbations. This term induces some non-Gaussianity by delaying the time of recombination and by changing the photon diffusion scale. We find that the signal is not scale invariant, peaked on squeezed triangles with the smaller multipole around the scale of the first acoustic peak, and that its size corresponds to an effective f_NL ~ -3.5, which could be marginally detected by Planck if both temperature and polarization are measured.Comment: 37 pages, 13 figures. v2: Corrected algebraic mistake, numerical results marginally affected; added reference

Tension Dynamics and Linear Viscoelastic Behavior of a Single Semiflexible Polymer Chain

We study the dynamical response of a single semiflexible polymer chain based on the theory developed by Hallatschek et al. for the wormlike-chain model. The linear viscoelastic response under oscillatory forces acting at the two chain ends is derived analytically as a function of the oscillation frequency . We shall show that the real part of the complex compliance in the low frequency limit is consistent with the static result of Marko and Siggia whereas the imaginary part exhibits the power-law dependence +1/2. On the other hand, these compliances decrease as the power law -7/8 for the high frequency limit. These are different from those of the Rouse dynamics. A scaling argument is developed to understand these novel results.Comment: 23 pages, 6 figure

Cosmic 21-cm Fluctuations as a Probe of Fundamental Physics

Fluctuations in high-redshift cosmic 21-cm radiation provide a new window for observing unconventional effects of high-energy physics in the primordial spectrum of density perturbations. In scenarios for which the initial state prior to inflation is modified at short distances, or for which deviations from scale invariance arise during the course of inflation, the cosmic 21-cm power spectrum can in principle provide more precise measurements of exotic effects on fundamentally different scales than corresponding observations of cosmic microwave background anisotropies.Comment: 8 pages, 2 figure

Hunting for Primordial Non-Gaussianity in the Cosmic Microwave Background

Since the first limit on the (local) primordial non-Gaussianity parameter, fNL, was obtained from COBE data in 2002, observations of the CMB have been playing a central role in constraining the amplitudes of various forms of non-Gaussianity in primordial fluctuations. The current 68% limit from the 7-year WMAP data is fNL=32+/-21, and the Planck satellite is expected to reduce the uncertainty by a factor of four in a few years from now. If fNL>>1 is found by Planck with high statistical significance, all single-field models of inflation would be ruled out. Moreover, if the Planck satellite finds fNL=30, then it would be able to test a broad class of multi-field models using the four-point function (trispectrum) test of tauNL>=(6fNL/5)^2. In this article, we review the methods (optimal estimator), results (WMAP 7-year), and challenges (secondary anisotropy, second-order effect, and foreground) of measuring primordial non-Gaussianity from the CMB data, present a science case for the trispectrum, and conclude with future prospects.Comment: 33 pages, 4 figures. Invited review, accepted for publication in the CQG special issue on nonlinear cosmological perturbations. (v2) References added. More clarifications are added to the second-order effect and the multi-field consistency relation, tauNL>=(6fNL/5)^2