Integrating tuberculosis/HIV treatment: an evaluation of the tuberculosis outcomes of patients co-infected with tuberculosis and HIV in the Breede Valley subdistrict

Background: The Infectious Disease Clinic of Worcester Hospital introduced an integrated tuberculosis/human immunodeficiency virus (HIV) service in July 2009 to provide comprehensive management to patients who were co-infected with tuberculosis and HIV.Method: In a retrospective cohort study that was carried out from 1 July 2009 to 31 March 2010, the tuberculosis outcomes of co-infected patients attending the Infectious Disease Clinic for antiretroviral (ARV) treatment and receiving their tuberculosis medication at the Infectious Disease Clinic, were compared with those of patients receiving ARV treatment at the Infectious Disease Clinic and tuberculosis treatment at their local clinic.Results: Seventy-four per cent of patients completed their treatment and 26% were cured, with no defaults or deaths, in the tubercuolosis/HIV integrated cohort. Thirty-eight per cent completed their treatment, 45% were cured, 9% died and another 9% defaulted in the cohort receiving their tuberculosis treatment at a local clinic. This indicates that there was a significantly better tuberculosis outcome in the tuberculosis/HIV cohort (p-value < 0.05).Conclusion: The significantly better tuberculosis outcome that resulted when tuberculosis and HIV services were integrated led to services being integrated in the Breede Valley subdistrict.Keywords: tuberculosis/HIV treatment integration, human immunodeficiency virus, tuberculosis, outcome

Person-centred community-based interprofessional care: a strategic opportunity for service-learning to reform health professions education

Please help populate SUNScholar with the full text of SU research output. Also - should you need this item urgently, please send us the details and we will try to get hold of the full text as quick possible. E-mail to [email protected]. Thank you.Geneeskunde en GesondheidswetenskappeSentrum vir Gesondheidsberoepe Onderwy

Globalizing beauty: Attitudes toward beauty pageants among Nepali women

A series of focus groups and semi-structured interviews were conducted exploring the beliefs of urban Nepali women about the introduction of beauty pageants to Nepal. This qualitative study examined how the competing pressures of modernization and traditionality impinge on Nepali women who are attempting to both resist patriarchal restrictions and preserve long-established cultural values. The large majority of participants expressed ambivalence toward beauty contests in Nepal. They expressed the belief that beauty pageants can help to empower Nepali women, facilitate progress in Nepal, and present Nepal positively on a global stage. Moreover, participants called for the perceived benefits of pageant participation to be extended to rural, impoverished, and lower caste Nepali women. At the same time, participants expressed reservations about Nepali women being objectified by their participation in these contests, deplored their commercial aspects, and felt that beauty pageants could contribute to the development of body image disturbance. Their ambivalence may reflect their conflicting positioning as middle-class citizens and as women in a developing consumer economy that retains strong patriarchal norms. Their complex and conflicting responses help to elucidate the process of gendered social change in a developing country during a time of rapid societal transition. © 2008 SAGE

Žingsniai į sėkmę

Gali būti, kad turite gerą darbą, esate perspektyvus darbuotojas, jums sekasi, nieko netrūksta ir užtikrintai kopiate karjeros laiptais. Gali būti ir atvirkščiai – kasdien stebitės kolegų sėkme (nors jie, atrodo, turi tokį pat išsilavinimą kaip ir jūs, dirba tą patį darbą) ar pavydžiai komentuojate televizijos laidų herojų laimėjimus profesiniame ir asmeniniame gyvenime. Kiekvienas sėkmės siekia (ir pasiekia) skirtingai, tačiau yra tam tikrų dėsningumų. Siūlome susipažinti su pagrindiniais iš jų. Ir visai nesvarbu, kuriai darbuotojų kategorijai priklausote, nes vieni galbūt ko nors išmoks, kiti – tiesiog prisimins.[...]Vytauto Didžiojo universiteta

Towards development of aptamers that specifically bind to lactate dehydrogenase of Plasmodium falciparum through epitopic targeting

Abstract Background Early detection is crucial for the effective treatment of malaria, particularly in those cases infected with Plasmodium falciparum. There is a need for diagnostic devices with the capacity to distinguish P. falciparum from other strains of malaria. Here, aptamers generated against targeted species-specific epitopes of P. falciparum lactate dehydrogenase (rPfLDH) are described. Results Two classes of aptamers bearing high binding affinity and specificity for recombinant P. falciparum lactate dehydrogenase (rPfLDH) and P. falciparum-specific lactate dehydrogenase epitopic oligopeptide (LDHp) were separately generated. Structurally-relevant moieties with particular consensus sequences (GGTAG and GGCG) were found in aptamers reported here and previously published, confirming their importance in recognition of the target, while novel moieties particular to this work (ATTAT and poly-A stretches) were identified. Aptamers with diagnostically-supportive functions were synthesized, prime examples of which are the aptamers designated as LDHp 1, LDHp 11 and rLDH 4 and rLDH 15 in work presented herein. Of the sampled aptamers raised against the recombinant protein, rLDH 4 showed the highest binding to the target rPfLDH in the ELONA assay, with both rLDH 4 and rLDH 15 indicating an ability to discriminate between rPfLDH and rPvLDH. LDHp 11 was generated against a peptide selected as a unique P. falciparum LDH peptide. The aptamer, LDHp 11, like antibodies against the same peptide, only detected rPfLDH and discriminated between rPfLDH and rPvLDH. This was supported by affinity binding experiments where only aptamers generated against a unique species-specific epitope showed an ability to preferentially bind to rPfLDH relative to rPvLDH rather than those generated against the whole recombinant protein. In addition, rLDH 4 and LDHp 11 demonstrated in situ binding to P. falciparum cells during confocal microscopy. Conclusions The utilization and application of LDHp 11, an aptamer generated against a unique species-specific epitope of P. falciparum LDH indicated the ability to discriminate between recombinant P. falciparum and Plasmodium vivax LDH. This aptamer holds promise as a biorecognition element in malaria diagnostic devices for the detection, and differentiation, of P. falciparum and P. vivax malaria infections. This study paves the way to explore aptamer generation against targeted species-specific epitopes of other Plasmodium species