Problems of World Air Transportation Market Globalization

The principles of civil aviation safety and efficiency in conditions of air transportation market globalization are considered. The paper paid special attention to the civil aviation threats and risks in the context of globalization processes. The paper deals with problems of changes of multilateral and bilateral regulations philosophy, the liberalization of airlines designation, national ownership and control provisions, the development of airline alliances, code-sharing agreements and franchising, the development of low-cost carriers operations, the outsourcing of ground handling, aircraft repair and maintenance, the globalization and commercialization of airports and air navigation service providers, the significant growth of air cargo and logistics transportations

Post-Summit Results, Delegates’ Summit: Best Practice and Definitions – Algorithm and Algorithm Signification

Post-Summit Results, Delegates' Summit, September 11, 2023, The (12+1)th Symposium on Advanced Computation and Information in Natural and Applied Sciences (SACINAS), The 21th International Conference of Numerical Analysis and Applied Mathematics (ICNAAM), September 11-17, 2023, Heraklion, Crete, Greec

Використання віртуального середовища Proteus для підготовки майбутніх ІТ-фахівців

Based on literature review it was established that the use of augmented reality as an innovative technology of student training occurs in following directions: 3D image rendering; recognition and marking of real objects; interaction of a virtual object with a person in real time. The main advantages of using AR and VR in the educational process are highlighted: clarity, ability to simulate processes and phenomena, integration of educational disciplines, building an open education system, increasing motivation for learning, etc. It has been found that in the field of physical process modelling the Proteus Physics Laboratory is a popular example of augmented reality. Using the Proteus environment allows to visualize the functioning of the functional nodes of the computing system at the micro level. This is especially important for programming systems with limited resources, such as microcontrollers in the process of training future IT professionals. Experiment took place at Borys Grinchenko Kyiv University and Sumy State Pedagogical University named after A. S. Makarenko with students majoring in Computer Science (field of knowledge is Secondary Education (Informatics)). It was found that computer modelling has a positive effect on mastering the basics of microelectronics. The ways of further scientific researches for grounding, development and experimental verification of forms, methods and augmented reality, and can be used in the professional training of future IT specialists are outlined in the article.На основі огляду літератури було встановлено, що використання доповненої реальності як інноваційної технології навчання студентів відбувається у таких напрямках: 3D-рендерінг зображень; розпізнавання та маркування реальних об'єктів; взаємодія віртуального об’єкта з людиною в режимі реального часу. Висвітлено основні переваги використання АР та ВР у навчальному процесі: чіткість, вміння моделювати процеси та явища, інтеграція навчальних дисциплін, побудова відкритої системи освіти, підвищення мотивації до навчання тощо. Виявлено, що в цій галузі фізичного моделювання процесів лабораторія фізики протея є популярним прикладом доповненої реальності. Використання середовища Proteus дозволяє візуалізувати функціонування функціональних вузлів обчислювальної системи на мікрорівні. Це особливо важливо для систем програмування з обмеженими ресурсами, наприклад мікроконтролерів у процесі підготовки майбутніх ІТ-фахівців. Експеримент відбувся у Київському університеті імені Бориса Грінченка та Сумському державному педагогічному університеті імені А. С. Макаренка зі студентами спеціальності "Інформатика" (сфера знань - середня освіта (інформатика)). Було встановлено, що комп'ютерне моделювання позитивно впливає на оволодіння основами мікроелектроніки. У статті окреслено шляхи подальших наукових досліджень щодо обґрунтування, розробки та експериментальної перевірки форм, методів та доповненої реальності, які можуть бути використані у професійній підготовці майбутніх ІТ-фахівців

Технологія конструкційних матеріалів

У навчальному посібнику наведена стисла інформація про основні технологічні процеси одержання матеріалів і виробництво заготовок. Розглянуто технології металургійного одержання матеріалів, заготовок литтям, обробкою тиском. Подано короткі відомості про технологічні процеси з’єднання зварюванням, паянням. Проаналізовано технології неметалевих та композиційних конструкційних матеріалі

Оцінка ризику ураження шкіри кліщами роду Демодекс серед студентів з вугровою хворобою

Фактором ризику, що сприяють підвищенню вірогідності виникнення ураження кліщами роду Demodex, може виступати наявність вугрових вугрів або інші хронічні дерматози. Застосування теорії шансів є доцільним для обчислення ризиків виникнення кліщового ураження серед пацієнтів з вугровоюхворобою.Матеріали та методи. У дослідження було включено132 студенти медичного інституту, що були розділені на дві групи: 1 група –56 студентів, які не мали елементів прищів, 2 група –76 студентів із легкою формою вугрової хвороби. Визначення наявності кліщів роду Demodex, із застосуваннямепітеліальногоскотч-тесту, проводили двічі: на моменті включення у дослідження та через 12 місяців. Для оцінки впливу вугрової хвороби на появу кліщів роду Demodexбуловикористано методтеоріїшансів.Результати. При проведенні другого скотч-тесту через 12 місяців встановленонаявність кліщів роду Demodex у 3,57% студентів 1-ї групи та 21,05% студентів 2-ї групи. Значення ймовірності (P) серед студентів 1-ї групи було P1= 0, 037; студентів 2-ї гру-пи P2= 0,266. Показник коефіцієнта шансу (O) у 1-й групі студен-тів склав O1= 0,04, у 2-й групі O2= 0,21. Значення коефіцієнта відношення шансів (OR) у групах (випадок/контроль) дорівнюва-ло7,20. Довірчий інтервал складав (95% CI) –(1,582, 32,765): нижня межа довірчого інтервалу (2.019, + ∞); верхня межа довірчого інтервалу (-∞, 25680). Значення тесту значущості р = 0,00533. Висновок.Вугрова хвороба є одним із обтяжуючих факторів, що збільшує ризик виникнення кліщів DemodexThe study of comorbid pathologies that influence the severity of the disease and impair the effectiveness of treatment is carried out to optimize the treatment of the main disease.Materials and methods.The total of 132 medical students wasdivided into two groups: the 1st group:56 students who didn`t haveacne elements, the 2nd group:76 students with mild acne vulgaris.At the baseline and after 12 months epithelial tape-test wasperformed to defineDemodex mitespresence. The theory of chanceswas usedto assessthe impact of acne on the occurrence of Demodexmites. Results. The presence of Demodex mites was observed in 3.57% of students in the 1stgroup and in 21.05% of students in the 2ndgroup on repeatedtape-test. The probability value (P) among students of the 1stgroup wasP1= 0.037; among students of the 2ndgroup–P2= 0.266. The odds (O) indicator in the 1stgroup of students without acne elements was O1= 0.04, in the 2nd group diagnosed withacne –O2= 0.21. The odds ratio (OR) value in the case/control groups was 7.20. Confidence intervals (95% CI) –(1.582, 32.765): the lower limit of the confidence interval (2.019, + ∞); the upper limit of the confidence interval (-∞, 25680). Significance test p-value was 0.00533. Conclusion. Acne vulgaris is one of aggravating factor that increases the risk of Demodex mites

The Influence of Parents’ Mutual Support on the Socialization of Children with Special Needs in Rehabilitation Centres: Neuropsychological Aspects

The article presents theoretical and methodological aspects of social support for families with adolescents with musculoskeletal disorders (MSDs) in rehabilitation centres. In particular, it describes the process and results from the implementation of the author’s work with mutual support groups of parents of adolescents with MSDs. The article aims to determine and quasi-experimentally verify the methods of rehabilitation of individuals with MSDs and prove their effectiveness in rehabilitation centres with the involvement of parents. During the implementation of the programme, social work with families in centres for social rehabilitation of children with MSDs consists of the following main areas: family therapy, family psychoprophylaxis, providing social assistance to families, mediation in resolving family conflicts, family counselling, social and pedagogical work with families.  The content and forms of social and pedagogical work with the family are determined by a group of the following factors: a family type, problems in the family; areas of professional training of the specialist providing services to the family. The quasi-experimental group (EG) consists of 40 leavers from the Vinnytsia Centre for Social Rehabilitation of Children with Special Needs “Promin”, who are diagnosed with cerebral palsy, and six leavers with mild mental disorders. The control group (CG) consists of 40 individuals diagnosed with cerebral palsy and seven individuals with mild mental disorders. The age requirement for EG is 14-19 years old. The formative experiment also involves 27 parents of children with MSDs. The measures taken during the experiment have contributed to developing the skills of conscious psychological separation from constant parental care, taking responsibility for their lives, setting real-life goals and destroying the position of helplessness in individuals with MSDs. The article shows that a set of causes and factors affecting families’ well-being positively or negatively determines the interpersonal relationships and the traditions of family education. The international relevance of the article lies in the effective combination of social support for families with adolescents with MSDs in rehabilitation centres and parents’ involvement. The author’s methodology forms the basis for the new aspects of synergistic family and institutional rehabilitation and support.</p

Biological properties of domestic strain vRub-Ant of rubella virus

Introduction. Rubella is a mild infectious disease affecting mainly children and is caused by the rubella virus, part of the Matonoviridae family, genus Rubivirus. Rubella causes congenital rubella syndrome (CRS) and is the main cause of developmental abnormalities, especially blindness and deafness. There is no specific treatment for rubella and CRS. In order to avoid possible complications from rubella infection, a live attenuated rubella vaccine based on the foreign strain of Wistar RA 27/3 rubella virus is used. However, the actual, more effective and preferred vaccine strain the rubella virus for the Russian Federation is considered to be a viral strain of rubella circulating on its territory. The aim of the study was to study the biological properties of the developed domestic cold-adapted strain vRub-Ant circulating in the territory of the Russian Federation. Materials and methods. Following cell cultures were used in the study human embryo lung diploid cell strain LECH-3, transferable cell line from embryonic kidney cells of green monkeys Vero CCL-81 and Vero ECC, human mesenchymal stem cells, human peripheral blood mononuclear cells (PBMC). Cell cultures were grown on a DMEM/F12 nutrient medium with the addition of 5% fetal bovine serum. Swabs from the pharynx and nasal passages from a child with rubella were used as clinical virus-containing material. Monoclonal anti-idiotypic antibodies m(anti-ID)Ab were used to assess the expression level of alpha/beta and gamma interferon receptors (/ and IFN-R)Ab, imitating the biological effects of alpha/beta and gamma interferons (/ and IFN) of humans. The cultural, virological, immunochemical and serological research methods were applied in the study. Results. Attenuation of the vRub-Ant clinical isolate of rubella virus was carried out for 20 consecutive passages on LECH-3 diploid cells at a reduced temperature of 30C. The main biological markers of attenuation were determined to be ts and ca phenotypes. The avirulence of the attenuated viral strain (att-phenotype) was assessed by the level of expression of / and IFN-R. A lower level of / and IFN-R expression was found on the membranes of human PBMC induced by the vaccine strain vRub-Ant in comparison with the parent wild variant of the rubella virus. This trait,the att phenotype, is characteristic of attenuated viral strains. It has been shown that the vaccine strain vRub-Ant has lost neurotropism and was unable to bind to the membrane receptors of the brain (MRB) of guinea pig embryos, unlike its parent rubella virus strain. The high immunogenicity of the domestic cold-adapted strain vRub-Ant was confirmed by high titers of neutralizing rubella antibodies observed in guinea pigs immunized subcutaneously with one vaccination dose of the virus. Conclusion. A domestic attenuated vaccine strain vRub-Ant of the rubella virus that has the main biological markers of attenuation (ts-ca and att phenotypes) has been developed. The vaccine strain vRub-Ant induces a high levels of neutralizing antibodies in guinea pigs following the immunization with a single vaccination dose of the vaccine. The viral strain vRub-Ant has lost its tropism to the MRB of guinea pig embryos, unlike its parent variant

Virus-inhibitory activity of the antigen complex of opportunistic pathogenic bacteria against SARS-CoV-2

Introduction. The antigen complex of opportunistic pathogenic bacteria (ACOPB) has a protective effect against avian influenza viruses, herpes virus type 2, and other viruses that cause acute respiratory viral infections. In the context of the COVID-19 pandemic, an important task is to find out whether ACOPB has a protective effect against SARS-CoV-2. The purpose of the study was to evaluate in vitro the ACOPB virus-inhibitory activity against the Dubrovka laboratory strain of SARS-CoV-2. Materials and methods. The study was performed using Vero cell line CCL-81, human peripheral blood mononuclear cells (PBMCs), mouse monoclonal anti-idiotypic antibodies structurally mimicking biological effects of human interferons (IFNs), the Dubrovka laboratory strain of SARS-CoV-2. The infectivity of the virus was assessed by two methods: by virus titration using cell cultures and the limiting dilution method when the results are assessed by a cytopathic effect; the second method was a plaque assay. The in vitro virus inhibition test was performed using the cell culture susceptible to SARS-CoV-2; the mixture containing a specific dose of the virus and a two-fold dilution of ACOPB was transferred to the cell culture after the ACOPB medication had interacted with the virus at 4C for 2 hours. The ACOPB virus-inhibitory activity against SARS-CoV-2 was assessed by the functional activity of / and IFN receptors (RIFN) in human PBMCs induced in vitro by ACOPB and the ACOPB mixture with the specific dose of SARS-CoV-2. The RIFN expression level was measured by the indirect membrane immunofluorescence test. Results. Hemagglutination assay using chicken, mouse, guinea pig, and human red blood cells was performed for detection of the SARS-CoV-2 inhibitory protein. The lysate of Vero CCL-81 cells infected with SARS-CoV-2 Dubrovka demonstrated the highest hemagglutination activity with guinea pig red blood cells and low titers of hemagglutination in the virus-containing fluid. The virus inhibition test in the Vero CCL-81 cell culture demonstrated that ACOPB inhibited 10 doses of SARS-CoV-2 Dubrovka with the titer 1 : 32, providing 100% protection of the cell culture for 8 days (the monitoring period). ACOPB induced / and RIFN expression on membranes of human PBMCs in in vitro cultures and decreased RIFN / and expression after its interaction with SARS-CoV-2 Dubrovka. Conclusion. The experimental studies including the virus inhibition test in the cell culture susceptible to SARS-CoV-2 Dubrovka and the indirect membrane immunofluorescence assay using monoclonal anti-idiotypic antibodies mimicking IFN-like properties demonstrated that ACOPB had both an immunomodulatory and a virus-inhibitory effect

Технологія конструкційних матеріалів

У навчальному посібнику наведена стисла інформація про основні технологічні процеси одержання матеріалів і виробництво заготовок. Розглянуто технології металургійного одержання матеріалів, заготовок литтям, обробкою тиском. Подано короткі відомості про технологічні процеси з’єднання зварюванням, паянням. Проаналізовано технології неметалевих та композиційних конструкційних матеріалі