381 research outputs found
New Exact Solutions of the Brusselator Reaction Diffusion Model Using the Exp-Function Method
Firstly, using a series of transformations, the Brusselator reaction diffusion
model is reduced into a nonlinear reaction diffusion equation, and then through
using Exp-function method, more new exact solutions are found which contain
soliton solutions. The suggested algorithm is quite efficient and is practically
well suited for use in these problems. The results show the reliability and
efficiency of the proposed method
The effect of dietary nucleotide on the haematological and serum biochemical parameters of Persian sturgeon (Acipenser persicus) juveniles
This study was aimed to examine the impact of different levels of dietary nucleotides (Vannagen) on serum biochemical and blood parameters of Persian sturgeon (Acipenser persicus). Fish (42.37± 2.12 g and 23.67± 0.61 cm) were divided into four treatments with different levels of dietary nucleotides (0, 0.25, 0.35 and 0.5 percent of diet). There were three replicates with a density of 12 fish per tank. After 10 weeks of feeding, serum biochemical and blood parameters were measured. Among the measured factors, blood glucose, triglycerides, cholesterol, erythrocyte and heterophil showed significant differences between the groups fed with nucleotides and the control group (P ≤ 0.05). By increasing the nucleotide levels, the mean heterophil and serum glucose showed significant increase and decrease, respectively. The highest and lowest values of cholesterol and triglyceride were found in groups fed with 0.25% and 0.35% nucleotides, respectively. The other measured factors had no significant difference (P≤0.05). Therefore, it could be said that with regard to the limited capacity of cells to synthesize nucleotides, external preparing of nucleotides could result in the production of needed nucleotides and an increase of its production speed, especially during stress. Such preparation can also improve fish physiology and health status
Genetic and epigenetic contribution to astrocytic gliomas pathogenesis
Astrocytic gliomas are the most common and lethal form of intracranial tumors. These tumors are characterized by a significant heterogeneity in terms of cytopathological, transcriptional, and (epi)genomic features. This heterogeneity has made these cancers one of the most challenging types of cancers to study and treat. To uncover these complexities and to have better understanding of the disease initiation and progression, identification, and characterization of underlying cellular and molecular pathways related to (epi)genetics of astrocytic gliomas is crucial. Here, we discuss and summarize molecular and (epi)genetic mechanisms that provide clues as to the pathogenesis of astrocytic gliomas. (Figure presented.). © 2018 International Society for Neurochemistr
Genetic and epigenetic contribution to astrocytic gliomas pathogenesis
Astrocytic gliomas are the most common and lethal form of intracranial tumors. These tumors are characterized by a significant heterogeneity in terms of cytopathological, transcriptional, and (epi)genomic features. This heterogeneity has made these cancers one of the most challenging types of cancers to study and treat. To uncover these complexities and to have better understanding of the disease initiation and progression, identification, and characterization of underlying cellular and molecular pathways related to (epi)genetics of astrocytic gliomas is crucial. Here, we discuss and summarize molecular and (epi)genetic mechanisms that provide clues as to the pathogenesis of astrocytic gliomas. (Figure presented.). © 2018 International Society for Neurochemistr
Genetic and epigenetic contribution to astrocytic gliomas pathogenesis
Astrocytic gliomas are the most common and lethal form of intracranial tumors. These tumors are characterized by a significant heterogeneity in terms of cytopathological, transcriptional, and (epi)genomic features. This heterogeneity has made these cancers one of the most challenging types of cancers to study and treat. To uncover these complexities and to have better understanding of the disease initiation and progression, identification, and characterization of underlying cellular and molecular pathways related to (epi)genetics of astrocytic gliomas is crucial. Here, we discuss and summarize molecular and (epi)genetic mechanisms that provide clues as to the pathogenesis of astrocytic gliomas. (Figure presented.). © 2018 International Society for Neurochemistr
Genetic and epigenetic contribution to astrocytic gliomas pathogenesis
Astrocytic gliomas are the most common and lethal form of intracranial tumors. These tumors are characterized by a significant heterogeneity in terms of cytopathological, transcriptional, and (epi)genomic features. This heterogeneity has made these cancers one of the most challenging types of cancers to study and treat. To uncover these complexities and to have better understanding of the disease initiation and progression, identification, and characterization of underlying cellular and molecular pathways related to (epi)genetics of astrocytic gliomas is crucial. Here, we discuss and summarize molecular and (epi)genetic mechanisms that provide clues as to the pathogenesis of astrocytic gliomas. (Figure presented.). © 2018 International Society for Neurochemistr
Design and evaluation of oral nanoemulsion drug delivery system of mebudipine
A nanoemulsion drug delivery system was developed to increase the oral bioavailability of mebudipine as a calcium channel blocker with very low bioavailability profile. The impact of nano-formulation on the pharmacokinetic parameters of mebudipine in rats was investigated. Nanoemulsion formulations containing ethyl oleate, Tween 80, Span 80, polyethylene glycol 400, ethanol and deionized water were prepared using probe sonicator. The optimum formulation was evaluated for physicochemical properties, such as particle size, morphology and stability. The particle size of optimum formulation was 22.8 ± 4.0 nm. Based on the results of this study, the relative bioavailability of mebudipine nanoemulsion was enhanced by about 2.6-, 2.0- and 1.9-fold, respectively, compared with suspension, ethyl oleate solution and micellar solution. In conclusion, nanoemulsion is an interesting option for the delivery of poorly water soluble molecules, such as mebudipine. © 2015 Informa UK Limited, trading as Taylor & Francis Group
Optimal generation of Fock states in a weakly nonlinear oscillator
We apply optimal control theory to determine the shortest time in which an
energy eigenstate of a weakly anharmonic oscillator can be created under the
practical constraint of linear driving. We show that the optimal pulses are
beatings of mostly the transition frequencies for the transitions up to the
desired state and the next leakage level. The time of a shortest possible pulse
for a given nonlinearity scale with the nonlinearity parameter delta as a power
law of alpha with alpha=-0.73 +/-0.029. This is a qualitative improvement
relative to the value alpha=1 suggested by a simple Landau-Zener argument.Comment: 10 pages, 6 figure
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