QUANTITATIVE DETERMINATION OF ETORICOXIB AND PARACETAMOL IN PHARMACEUTICAL DOSAGE FORM AND IN-VITRO COMPARISON BY REVERSED-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (RP-HPLC)

The objective of this present work was todevelop and validate analytical method for quantitativedetermination of Paracetamol and Etoricoxib in a tabletformulation and also the comparison of invitro data withreference dosage form. Chromatographic separations of thetwo drugs were analyzed on a Kromasil C18 column (25cmX 4.6mm, 5 m). The mobile phase constituted of Buffer:Acetonitirile with gradient program was delivered at theflow rate 1.0 mL/min. Detection was performed at 220 nm.Separation was completed within 20 min. Calibrationcurves were linear with coefficient correlation between0.99 to 1.0 over a concentration range of 48 to 146 g/mLof Paracetamol and 6 to 19 g/mL for Etoricoxibrespectively. The relative standard deviation (R.S.D) wasfound to be less than 2.0%. Analysis for dissolution studywas also performed by Reversed-Phase High PerformanceLiquid Chromatography (RP-HPLC) method. Differencefactor (f1) were found to be 2.85 and 3.83 and similarityfactor (f2) were found to be 73.514 and 68.961 forParacetamol and Etoricoxib respectively

DEVELOPMENT AND VALIDATION OF A RP-HPLC FOR THE SIMULTANEOUS ESTIMATION OF ATENOLOL AND HYDROCHLOROTHIAZIDE IN PHARMACEUTICAL DOSAGE FORMS

The reverse phase high performance liquid chromatography (RP-HPLC) method of Atenolol and Hydrochlorothiazide is individually available in United State of Pharmacopoeia-27 (USP-27) but no reference is available for combined estimation of Atenolol and Hydrochlorothiazide in tablets formulation. The aim of our present work was to develop a precise and validated RP-HPLC method for the simultaneous determination of Atenolol and Hydrochlorothiazide in tablets formulation. The quantification was carried out by using Zorbax SB-CN (250 x 4.6 mm), 5μm column in isocratic mode with mobile phase, Water: Buffer: Methanol (50:35:15). The flow rate was 1.2 ml/min. The peak purity of Atenolol and Hydrochlorothiazide were 0.999 and 1.000 respectively. Ruggedness and robustness of method were performed and the percentage relative standard deviation (RSD) was found below 2.0%. The percentage recovery was found in the range of 98% to 102% at three different levels. Calibration curves were linear over studies ranges with correlation co-efficient found between the range of 0.99 to 1.00. Sample and standard solution stability study was performed over 21 h at room temperature and found stable. The percentage deviation was below 2.0%

The role of culture and society in the development of plot in tanushree podders escape from harem and gita mehtas a river sutra: a feminist reading

Culture and Society are often the main gist of most novels. These two factors often influence and control the characters, thus helping in the development of the plot. A plot, as defined by Egan (1978), is used to indicate an outline of events and serves as a skeleton in a literary piece. In other words, it is a tool in making sure the main incidents or scenarios are presented in a particular order to establish a clear understanding of what is being written. Culture and society plays the essence in a novel as it constructs these main ideas in engaging the interest of a reader and also extends the intended message of the particular writer. This paper looks into how culture and society helps in developing the plots of the selected novels using the feminist approach. Tanushree Podder’s, Escape from Harem (2013) and Gita Mehta’s A River Sutra (1993) amazingly are both set in India. Podder and Mehta have inserted the perception society had over women and how male supremacy was glorified in many aspects. The essence of feminist approach was very much present in these two novels. According to Tyson (2006), feminism concerns the ways in which literature undermines the economic, political, social and psychological oppression on women. Though the setting of both novels fall in different eras but the theme of female oppression remains the same. The patriarchal society uses culture and religion as a tool to control women and oppress them. Both authors have shown how the women in the 17th century and in the 20th century face the same kind of judgment from the society and men in general

QUANTITATIVE DETERMINATION OF ETORICOXIB AND PARACETAMOL IN PHARMACEUTICAL DOSAGE FORM AND IN-VITRO COMPARISON BY REVERSED-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (RP-HPLC)

The objective of this present work was todevelop and validate analytical method for quantitativedetermination of Paracetamol and Etoricoxib in a tabletformulation and also the comparison of invitro data withreference dosage form. Chromatographic separations of thetwo drugs were analyzed on a Kromasil C18 column (25cmX 4.6mm, 5 m). The mobile phase constituted of Buffer:Acetonitirile with gradient program was delivered at theflow rate 1.0 mL/min. Detection was performed at 220 nm.Separation was completed within 20 min. Calibrationcurves were linear with coefficient correlation between0.99 to 1.0 over a concentration range of 48 to 146 g/mLof Paracetamol and 6 to 19 g/mL for Etoricoxibrespectively. The relative standard deviation (R.S.D) wasfound to be less than 2.0%. Analysis for dissolution studywas also performed by Reversed-Phase High PerformanceLiquid Chromatography (RP-HPLC) method. Differencefactor (f1) were found to be 2.85 and 3.83 and similarityfactor (f2) were found to be 73.514 and 68.961 forParacetamol and Etoricoxib respectively

Experiments with metallic and ceramic porous media

Work in the area of mechano-caloric phenomena was initiated during 1988 with startup in the Summer 1988 period. The ideal system utilizing He-II super-phenomena is modeled readily, within the frame of thermodynamics energetics, using the concept of an ideal superleak. The real system however uses porous media of non-ideal pore-grain ingredients. The early phase of experimental and related modeling studies is outlined for the time period from Summer 1988 to the end of 1988

Transplant coronary heart disease: Challenges and solutions

Cardiac allograft vasculopathy (CAV) remains one of the leading causes of death and graft failure after heart transplantation. A variety of causes, including donor heart characteristics, recipient risk factors, and immune-mediated influences, are associated with developing CAV. In this review, we will focus on the pathophysiology of developing CAV and various methods to screen for this condition. The pathogenesis of CAV likely involves repeated injuries to the endothelium from a variety of factors such as cellular-mediated rejection, and alloimmune factors, including antibody-mediated injury, ischemia-reperfusion injury at time of transplant, cytomegalovirus infections, immunosuppression medications, systemic inflammation, and tra­ditional atherosclerosis risk factors. Patients with significant CAV are often asymptomatic, and therefore early detection by routine screening prior to graft dysfunction is crucial. There are a variety of invasive, noninvasive, and blood tests that have been studied as screening methods, and we will discuss the role of each of these in this review article. Although some treatment regimens have been established for CAV, this is an area where further studies and research are necessary