Comprehensive Performance Analysis of Neurodegenerative disease Incidence in the Females of 60-96 year Age Group

Neurodegenerative diseases such as Alzheimer's disease and dementia are gradually becoming more prevalent chronic diseases, characterized by the decline in cognitive and behavioral symptoms. Machine learning is revolu-tionising almost all domains of our life, including the clinical system. The application of machine learning has the potential to enormously augment the reach of neurodegenerative care thus building it more proficient. Throughout the globe, there is a massive burden of Alzheimer's and demen-tia cases; which denotes an exclusive set of difficulties. This provides us with an exceptional opportunity in terms of the impending convenience of data. Harnessing this data using machine learning tools and techniques, can put scientists and physicians in the lead research position in this area. The ob-jective of this study was to develop an efficient prognostic ML model with high-performance metrics to better identify female candidate subjects at risk of having Alzheimer's disease and dementia. The study was based on two diverse datasets. The results have been discussed employing seven perfor-mance evaluation measures i.e. accuracy, precision, recall, F-measure, Re-ceiver Operating Characteristic (ROC) area, Kappa statistic, and Root Mean Squared Error (RMSE). Also, a comprehensive performance analysis has been carried out later in the study

A STUDY CONDUCTED FOR THE DETECTION OF HEPATITIS B VIRUS SEROPREVALANCE AND ASSOCIATED RISK FACTORS IN A TEACHING HOSPITAL MYSURU KARNATAKA.

Objectives and Aim:We performed a study on Seroprevelance of HBVandassociated risk factors among the patients attending a tertiary care hospital in India. Background:Globally,Hepatitis B is one of the most common infectious diseases. It is ranked by the WHO as one of the top ten killers. The virus is responsible for approximately 1.5 million deaths worldwide in each year, two thirds of which are attributable to primary Hepatocellular carcinoma following HBV infection. About 360 million people are estimated to be chronically infected with HBV. Method --284 samples were positive for HBsAg by ELISA. Results-The seroprevalence of Hepatitis B infection in our study was 6%, associated with blood transfusion as the major risk factor

An Exploratory Study to Find the Early Trend and Pattern Recognition of COVID-19 Infection in India: A Severity Model-Based Prediction

Background: Recent Coronavirus Disease 2019 (COVID-19) pandemic has inflicted the whole world critically. Although India has been listed amongst the top ten highly affected countries to date, one cannot rule out COVID-19 associated complications in the near future. Aim & Objective: We aim to build the COVID-19 severity model employing logistic function which determines the inflection point and help in the prediction of the future number of confirmed cases. Methods and Material: An empirical study was performed on the COVID-19 patient status in India. We performed the study commencing from 30 January 2020 to 12 July 2020 for the analysis. Exploratory data analysis (EDA) tools and techniques were applied to establish a correlation amongst the various features. The acute stage of the disease was mapped in order to build a robust model. We collected five different datasets to execute the study. Results: We found that men were more prone to get infected with the coronavirus disease as compared to women. On 165-days based analysis, we found a trending pattern of confirmed, recovered, deceased and active cases of COVID-19 in India. The as-developed growth model provided an inflection point of 72.0 days. It also predicted the number of confirmed cases as 17,80,000.0 in the future i.e. after 12th July. A growth rate of 32.0 percent was obtained. We achieved statistically significant correlations amongst growth rate and predicted COVID-19 confirmed cases. Conclusions: This study demonstrated the effective application of EDA and analytical modeling in building a mathematical severity model for COVID-19 in India

Impact of Medical Advancement: Prostheses

This chapter shall provide a brief introduction to the prostheses and their development in the current advance technological era. The prosthesis design, control, and architecture completely changed with the change in the amputation level. The transradial amputee stump design, electronics, battery, and circuit placement change significantly with the change of the residual arm of the amputee. This leads to designing the prostheses with the focus of the amputation level and ease of customization. Recent development in the 3D printing and open source prosthetic design leads the user to choose, modify, and print the prostheses with the required sets of functionalities. In this chapter, a brief introduction of the prostheses has been given, starting with the types of prostheses according to the level of amputation and functionality. Then, the state-of-the-art prostheses available commercially and under research will be introduced. Afterward, the 3D printed prostheses are discussed. This chapter will end with the comparison of the medical advancement over the average life of people in general and comparison of the same for countries with low and high per capita income

When less-virulent becomes virulent!! An atypical presentation of Streptococcus Viridians.

When Less Virulent Becomes Virulent!! An Atypical Presentation Of Streptococcus Viridians Samreen Kahn, MBBS Providence Portland Medical Center – Portland, OR Additional Authors: Stavan Patel MS, MD Introduction: There are several cardiac and non-cardiac causes and risk factors for the development of infective endocarditis (IE) in young healthy adults. Some risk factors include prior IE, history of valvular or congenital heart disease, IV drug use, indwelling intravenous lines, immunosuppression, or a recent dental or surgical procedure. Most two common sites of IE are mitral and aortic valve. We present a case of a 45-year-old man with no-known risk factors, who presented with respiratory distress and was found to have streptococcal viridians (SV) endocarditis. Case Presentation: A healthy 45-year-old male presented with a four-day history of acute dyspnea and new-onset of fevers and chills for 24 hours before arrival. He denied any chest pain, dizziness, palpitations, LOC, weakness, increasing LE edema, or palpations. Patient denied any recent travels, prolonged non-ambulatory state, recent sick contacts, IV drug abuse, high risk sexual activities, no-known personal cardiac history, no recent dental manipulation. While in ED, he reported new onset of chest heaviness, and a non-productive cough. Vitals: T 37.2 C, BP 125/9, P 122, RR 26. EKG showed sinus tachycardia with non- specific ST&T wave abnormalities/No prior ECG where available to compare. Troponin 64 ng/L. ABG pH 7.230, PCO2 27.4 mmHg, PO2 82.1 mmHg. A-a gradient calculated to be greater than 200. CXR showed pulmonary vascular congestion. CTPA for PE was deferred as patient could not remain supine during examination secondary to worsening respiratory status. Patient was moved to medical ICU, with rapid worsening of respiratory status requiring intubation. Urgent bronchoscopy revealed diffuse alveolar hemorrhage consistent with severe acute respiratory distress syndrome (ARDS) with multifocal pneumonia. On initial presentation IE was not excepted and patient was treated for viral and bacterial causes of ARDS. Echocardiogram showed aortic valve insufficiency with questionable vegetation with leaflet disruption. Subsequently blood cultures showed gram-positive cocci. Given the combination of aortic insufficiency (AI) and gram-positive cocci IE speculated which was soon followed by aortic valve replacement with intraoperative finding of aortic intra-annular abscess. Clinical course was complicated with cardiogenic shock and multi-organ failure. Blood cultures subsequently grew SV. Case Discussion: Despite advances in medical, surgical and critical care interventions, IE remains a life-threatening illness. SV is not uncommon but are routinely seen in those with underlying heart disease and dental manipulation. SV is responsible for 40-60% of IE in normal valves [3, 4] and patients (young males and over 45 years of age) usually with mitral valves. It is commonly associated with heart failure and lesion such as peri-annular abscesses, fistulas, or pseudo-aneurysms with risk of mortality at 15% [1, 2]. Diagnosis may be difficult given no risk factors, non-specific symptoms but does not exclude this pathogen as a cause.https://digitalcommons.psjhealth.org/ppmc_internal/1013/thumbnail.jp

Impact of Corporate Governance Exerted by Board of Directors on Performance of Commercial Banks of Pakistan (Study Carried out on Prominent Commercial Banks of Rawalpindi)

The corporate governance mechanisms in Pakistan are in most instances thought to be less important to achieve good organizational performance. By enduring the good corporate governance exerted by BODs, organizations may increase the circumstances where management can convince the employees particularly and shareholders generally to obtain long term organizational gains. We used five point likert scale questionnaire to measure the corporate governance in banking sector of Rawalpindi, Pakistan. This empirical study suggests that the corporate governance by board of directors has widespread role in organizational performance. The results suggest that independence and accountability have significant effect on organizational performance. However, effect of independence is higher than accountability. Moreover, our study shows that transparency do not effect on organizational success significantly. Keywords: corporate governance, transparency, independence, accountability, board of directors and organizational performance

Impact of Body Weight on Self-Esteem among Undergraduate Young Adult Students of Doctor of Physiotherapy, Karachi

Objectives: To determine the recurrence of body disappointment, loss of control and self- related wellbeing in interpose the relationship among body weight and impairments in self-esteem among students of Doctor of Physiotherapy (DPT) Material and Methods: The research was among youthful understudies of the two sexes (boys and girls) of Doctor of Physiotherapy in both campuses—removed for blind review---. Concluded an overview through the questionnaire (Rosenberg Self-Esteem Scale according to the sample size of 298 computed through online programming Open Epi. The survey was acknowledged globally and it was standardized questionnaire. The data was assembled by figuring the BMI among body weight understudies of (DPT) and to check the level of self-esteem by Rosenberg Self-Esteem Scale. The survey conducted from January 2019 to February 2019. Results: Normal weight was adjusted to 18.50 till 24.90 – a total of 81 respondents, Overweight was adjusted to 25.00 till 29.90 of 35 respondents, obese category was adjusted to 30.00 or more a total of 17 respondents were adjudged to be in this category as per weigh ranges BMI. After analyzing the Chi-Square tabulation, it was found that the highest self-esteem was found in the normal weight BMI category respondents followed by the overweight category and the lowest self-esteem was found in obese category. As the table shows that girls have more self-esteem as compared to the boys, although the girl’s respondents are more so than boys are. Conclusion: It has been conclude that the proportion of the highest self-esteem were found in the normal weight BMI category respondents followed by the overweight category and the lowest self-esteem was found in obese category. Keywords: Body Mass Index, Stress, Obesity, Body image, Depression and Self-esteem

A Dynamically Consistent Nonstandard Difference Scheme for a Discrete-Time Immunogenic Tumors Model

This manuscript deals with the qualitative study of certain properties of an immunogenic tumors model. Mainly, we obtain a dynamically consistent discrete-time immunogenic tumors model using a nonstandard difference scheme. The existence of fixed points and their stability are discussed. It is shown that a continuous system experiences Hopf bifurcation at one and only one positive fixed point, whereas its discrete-time counterpart experiences Neimark–Sacker bifurcation at one and only one positive fixed point. It is shown that there is no chance of period-doubling bifurcation in our discrete-time system. Additionally, numerical simulations are carried out in support of our theoretical discussion.Spanish Government and European Commission, Grant RTI2018-094336-B-I00 (MCIU/AEI/FEDER, UE); Basque Government, Grant IT1207-19

Impact of Body Weight on Self-Esteem among Undergraduate Young Adult Students of Doctor of Physiotherapy, Karachi

Objectives: To determine the recurrence of body disappointment, loss of control and self- related wellbeing in interpose the relationship among body weight and impairments in self-esteem among students of Doctor of Physiotherapy (DPT) Material and Methods: The research was among youthful understudies of the two sexes (boys and girls) of Doctor of Physiotherapy in both campuses—removed for blind review---. Concluded an overview through the questionnaire (Rosenberg Self-Esteem Scale according to the sample size of 298 computed through online programming Open Epi. The survey was acknowledged globally and it was standardized questionnaire. The data was assembled by figuring the BMI among body weight understudies of (DPT) and to check the level of self-esteem by Rosenberg Self-Esteem Scale. The survey conducted from January 2019 to February 2019. Results: Normal weight was adjusted to 18.50 till 24.90 – a total of 81 respondents, Overweight was adjusted to 25.00 till 29.90 of 35 respondents, obese category was adjusted to 30.00 or more a total of 17 respondents were adjudged to be in this category as per weigh ranges BMI. After analyzing the Chi-Square tabulation, it was found that the highest self-esteem was found in the normal weight BMI category respondents followed by the overweight category and the lowest self-esteem was found in obese category. As the table shows that girls have more self-esteem as compared to the boys, although the girl’s respondents are more so than boys are. Conclusion: It has been conclude that the proportion of the highest self-esteem were found in the normal weight BMI category respondents followed by the overweight category and the lowest self-esteem was found in obese category. Keywords: Body Mass Index, Stress, Obesity, Body image, Depression and Self-esteem