Formation of consumer loyalty in the field of digital ecosystem products

The article is devoted to studying the importance of increasing customer loyalty for successful business development in the digital era. The author identifies brand equity, customer trust and satisfaction as key factors influencing the level of customer loyalty. The article identifies the complexities of the modern market and the need to use digital tools to form and maintain consumer loyalty.The study aims to identify methods for building customer loyalty, including analyzing the importance of various factors, market segmentation and the use of digital technologies. The results of the study will be useful for companies aimed at strengthening their base of loyal customers.It is worth not only satisfying the needs of customers, but also building emotional connections with them, taking into account their individual preferences. The author draws attention to the importance of service quality, brand reputation, pricing and personalization in creating and maintaining customer loyalty.The study also highlights the importance of moving from product loyalty to brand loyalty to increase customer retention and ensure sustainable business growth. Particular attention is paid to the emotional connection with clients and the importance of quality of service in establishing long–term relationships

Petrography and Geochemistry of Metasedimentary Rocks from the Taku Schist in Kelantan, North-East Peninsular Malaysia.

The Taku Schist, which is located in the north-east Peninsular Malaysia, is characterized by its North-South oriented elongated body. It forms part of the Indonesian orogenic build-up that was generated via the convergence of the Sibumasu continental unit and Sukhothai Arc. Subsequent petrography analyses of the metasedimentary rocks sourced from the Taku Schist revealed that their formation was attributable to the metamorphism of greenschist into amphibolite facies, which could be observed near the Triassic and Cretaceous intrusions of the Kemahang Granite. The evolutionary process of the rocks could be linked with the interactions occurring between contact and regional metamorphisms. The resulting chemical classification upon their assessment disclosed that the metasedimentary rocks of Taku Schist were made up of greywacke and shale, grouped into the quartzose sedimentary provenance, and belonged to the Continental Island Arc (CIA). This information is required for the tectonic setting discrimination purpose. It is a reflection of the episodic contractions underwent by the Taku Schist, wherein they would lead to the Sibumasu sedimentary cover along with both an accretionary wedge and the genetically-correlated Bentong-Raub melange to different greenschist. Otherwise associated with amphibolite facies, the conditions and depths of the facies were determined according to their position in relation to the upper plate of the Sukhothai Arc

Immunopathogenesis of inflammatory bowel diseases

The aim of review. To present analysis of data on immunopathogenesis of inflammatory bowel diseases.Key points. At genetically sensitive animals inflammatory bowel diseases (IBD) develop at various effects on innate and adaptive systems of immune defense (knock-out and transgenic mice), causing changes of expression of significant immunologic factors with distortion of pro- and anti-inflammatory cells and molecules ratio at their contact to microbiota structures. The physiological state of intestine is characterized by balanced interaction of effector (Th1, Th2, Th17) and regulatory (Treg) cells determining presence of immune tolerance to resident microflora antigens. Innate immunity changes revealed in last years, related to mutations of genes of bacterial structures receptors (NOD2, toll-like receptors, autophagy), cause disorder of endocellular signal processes and pathological activation of cells of adaptive immunodefense of intestinal mucosa and conforming profile of cytokines with development of chronic inflammation which will be mediated: at Crohn's disease – by Th1-and Th17-cells, cytokines IL-12, interferon-γ etc., at ulcerative colitis – by Th2-and NKT-cells, cytokines IL-4 and IL-3 in combination to incompetence of suppressor function of regulatory Т-cells and their cytokines TGF-β (transforming growth factor) and IL-10.Conclusion. Investigations of experimental enterocolites and human IBD confirm immunologic hypothesis of pathogenesis: relation of their development to defects of innate and adaptive immune system

Finite Element Analysis of Ti-6Al-4V Lattice Cubic Scaffolds for Mandibular Bone Implant Applications

This study evaluates the compressive strength of a cubic lattice scaffold made from Titanium alloy (Ti-6Al-4V) for mandibular bone implants. Scaffold designs with pore sizes ranging from 800 µm to 1000 µm were analyzed using finite element analysis under compressive forces of up to 800 N. Pore sizes of 800 µm and 850 µm achieved a safety factor greater than 1.4, indicating their suitability for both dynamic and static loading. Planned production with bound metal deposition, maintaining a density below 35%, emphasizes material efficiency and cost-effectiveness. Results indicate that 800 µm and 850 µm pore sizes offer optimal strength and safety, suggesting effective mandibular implant integration. Further research on cyclic load testing and osseointegration is recommended

Ustekinumab as Induction and Maintenance Therapy for Crohn’s Disease

BACKGROUND Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin-12 and inter-leukin-23, was evaluated as an intravenous induction therapy in two populations with moderately to severely active Crohn’s disease. Ustekinumab was also evaluated as subcutaneous maintenance therapy. METHODS We randomly assigned patients to receive a single intravenous dose of ustekinumab (either 130 mg or approximately 6 mg per kilogram of body weight) or placebo in two induction trials. The UNITI-1 trial included 741 patients who met the criteria for primary or secondary nonresponse to tumor necrosis factor (TNF) antagonists or had unacceptable side effects. The UNITI-2 trial included 628 patients in whom conventional therapy failed or unacceptable side effects occurred. Patients who completed these induction trials then participated in IM-UNITI, in which the 397 patients who had a response to ustekinumab were randomly assigned to receive subcutaneous maintenance injections of 90 mg of ustekinumab (either every 8 weeks or every 12 weeks) or placebo. The primary end point for the induction trials was a clinical response at week 6 (defined as a decrease from baseline in the Crohn’s Disease Activity Index [CDAI] score of ≥100 points or a CDAI score <150). The primary end point for the maintenance trial was remission at week 44 (CDAI score <150). RESULTS The rates of response at week 6 among patients receiving intravenous ustekinumab at a dose of either 130 mg or approximately 6 mg per kilogram were significantly higher than the rates among patients receiving placebo (in UNITI-1, 34.3%, 33.7%, and 21.5%, respectively, with P≤0.003 for both comparisons with placebo; in UNITI-2, 51.7%, 55.5%, and 28.7%, respectively, with P<0.001 for both doses). In the groups receiving maintenance doses of ustekinumab every 8 weeks or every 12 weeks, 53.1% and 48.8%, respectively, were in remission at week 44, as compared with 35.9% of those receiving placebo (P = 0.005 and P = 0.04, respectively). Within each trial, adverse-event rates were similar among treatment groups. CONCLUSIONS Among patients with moderately to severely active Crohn’s disease, those receiving intravenous ustekinumab had a significantly higher rate of response than did those receiving placebo. Subcutaneous ustekinumab maintained remission in patients who had a clinical response to induction therapy. (Funded by Janssen Research and Development; ClinicalTrials.gov numbers, NCT01369329, NCT01369342, and NCT01369355.

Multi-detector computer tomography as effective method for Crohn's disease diagnostics

Aim of investigation. Improvement of diagnostics and efficacy of radiological methods of investigation by technique computer-tomography (CT) enterography at inflammatory bowel diseases.Material and methods. Original investigation was based on the data of comprehensive clinical and instrumental investigation of 111 patients with suspected Crohn's disease (CD). The set of tests included colonoscopy, abdominal US, CT-enterography, X-ray investigation of small intestine. Signs of CD were obtained by CT-enterography in 62 patients (55,9%), in all of these cases it was possible to establish localization of process, to estimate its spread and reveal complications.Results. Data of roentgenological and CT investigation comparative analysis were similar. Thus, CT-enterography technique of can be regarded either as alternative to X-ray investigation of the small intestine at CD diagnostics or important addition to diagnostic algorithm for this group of patients

Analisa Hasil Sambungan Las ( Pipa STKM 13B Dan Plat SPH 440) Dengan Pengujian Tarik dan Photomacro

ABSTRACTGMAW (Gas Metal Arc Welding) is a fast, versatile welding technique that can be used in various positions, but it often results porosity in welded joints.This research aims to analysis of the welded joints of STKM13B pipe and SPD 440 plate using tensile and micro testing, using welding a current of 18 and varying voltages of 110, 130, and 150. The results is the shape of the welded joint of the plate and pipe is perfectly connected, the tensile test results showed that the ultimate strength values for specimen 1, 2, 3 (A110/V18, A130/V18, A150/V18) were (18,959, 27,886, 40,005 N) respectively. The highest ultimate strength values were obtained from the specimens (A150/V18) while the lowest ultimate strength value was obtained from specimen (A110/V18). The use of welding current strongly correlates with ultimate strength value and photomacro results, with higher currents resulting in higher density levels, minimizing porosity, and increasing ultimate strength. Keywords: GMAW Welding, Tensile Test, Macro Optical Test.

Draft interdisciplinary guidelines for diagnosis, methods for estimation of the degree of activity, for evaluation of therapeutic efficacy, and for use of biological agents in patients with concomitant immunoinflammatory diseases (psoriasis, psoriatic arthritis, Crohn's disease)

Due to that one patient may be at high risk for developing several immunoinflammatory diseases (psoriasis, psoriatic arthritis (PsA), and Crohn's disease (CD)), their early diagnosis and adequate therapy are extremely relevant. The Interdisciplinary Working Group that includes experts in rheumatology, gastroenterology and dermatology has developed draft guidelines for early diagnosis, methods for activity assessments and for indications for the use of biological agents in patients with concomitant immunoinflammatory diseases (psoriasis, PsA, and CD). In accordance with the decision adopted by the Council of Experts and with the results of a discussion with experts from different regions of the Russian Federation, further steps will be undertaken to validate the guidelines

Genome analysis of E. coli isolated from Crohn's disease patients

© 2017 The Author(s). Background: Escherichia coli (E. coli) has been increasingly implicated in the pathogenesis of Crohn's disease (CD). The phylogeny of E. coli isolated from Crohn's disease patients (CDEC) was controversial, and while genotyping results suggested heterogeneity, the sequenced strains of E. coli from CD patients were closely related. Results: We performed the shotgun genome sequencing of 28 E. coli isolates from ten CD patients and compared genomes from these isolates with already published genomes of CD strains and other pathogenic and non-pathogenic strains. CDEC was shown to belong to A, B1, B2 and D phylogenetic groups. The plasmid and several operons from the reference CD-associated E. coli strain LF82 were demonstrated to be more often present in CDEC genomes belonging to different phylogenetic groups than in genomes of commensal strains. The operons include carbon-source induced invasion GimA island, prophage I, iron uptake operons I and II, capsular assembly pathogenetic island IV and propanediol and galactitol utilization operons. Conclusions: Our findings suggest that CDEC are phylogenetically diverse. However, some strains isolated from independent sources possess highly similar chromosome or plasmids. Though no CD-specific genes or functional domains were present in all CD-associated strains, some genes and operons are more often found in the genomes of CDEC than in commensal E. coli. They are principally linked to gut colonization and utilization of propanediol and other sugar alcohols