The Photo Degradation of 2,3-dimethyl phenol in Drinking Water using Nano TiO2, ZnS and SnO2 Particles

The work presented in this paper is concernd with the preliminary study of semiconductors photochemical degradation of 2,3-dimethyl phenol by using powder and nanoparticles of TiO2,ZnS and SnO2. Degradation of 2,3-dimethyl phenol was carried out by using UV light at wave length of 267nm in the presence of oxygen.The absorpitivity of 2,3-dimethyl phenol decay was measured in the presence of UV light with capacity of 250 watt .The rate of degradation is increased with the weight of photocatalyst and reached  maximum value at 0.1gm (TiO2), 0.5gm (ZnO) and 1gm (SnO2).In this paper,the effects of various operating parameters of the photolytic degradation of 2,3-dimethyl phenol are presented. It was found that, different parameters, such as type of photocatalyst composition, initial substrate concentration, and amount of catalyst can play an important role on photocatalytic degradation of 2,3-dimethyl phenol. It was also found that the type and particle size of nano TiO2, SnO2 and ZnS play an important factor for accelerating the photo degradation. The activity of nano particle was found in the order: TiO2> ZnS> SnO2. The results of photodegradation are represented by Lagmuir-Hinshelwood relationship and indicate that the results are Pseudo first order. The particle size of TiO2, SnO2 and ZnS was estimated using XRD technique.  Keywords : Photodegradation, Drinking water, Nanoparticle

Exploring Exchange Interactions in Two-Qubit System

We studied the effect of magnetic field and interdot distance on the exchange interaction in two systems of double qubits, one made of Si and the other made of GaAs. We found that the effect is the same for both systems, but the exchange value for Si qubits is smaller due to the larger effective mass of electrons. This study provides insights into the exchange interaction, which is essential for the development of quantum computers

Computer Simulation of PMSM Motor with Five Phase Inverter Control using Signal Processing Techniques

The signal processing techniques and computer simulation play an important role in the fault diagnosis and tolerance of all types of machines in the first step of design. Permanent magnet synchronous motor (PMSM) and five phase inverter with sine wave pulse width modulation (SPWM) strategy is developed. The PMSM speed is controlled by vector control. In this work, a fault tolerant control (FTC) system in the PMSM using wavelet switching is introduced. The feature extraction property of wavelet analysis used the error as obtained by the wavelet de-noised signal as input to the mechanism unit to decide the healthy system. The diagnosis algorithm, which depends on both wavelet and vector control to generate PWM as current based manage any parameter variation. An open-end phase PMSM has a larger range of speed regulation than normal PMSM. Simulation results confirm the validity and effectiveness of the switching strategy

An Application of Using Support Vector Machine Based on Classification Technique for Predicting Medical Data Sets

© 2019, Springer Nature Switzerland AG. This paper illustrates the utilise of various kind of machine learning approaches based on support vector machines for classifying Sickle Cell Disease data set. It has demonstrated that support vector machines generate an essential enhancement when applied for the pre-processing of clinical time-series data set. In this aspect, the objective of this study is to present discoveries for a number of classes of approaches for therapeutically associated problems in the purpose of acquiring high accuracy and performance. The primary case in this study includes classifying the dosage necessary for each patient individually. We applied a number of support vector machines to examine sickle cell data set based on the performance evaluation metrics. The result collected from a number of models have indicated that, support vector Classifier demonstrated inferior outcomes in comparison to Radial Basis Support Vector Classifier. For our Sickle cell data sets, it was found that the Parzen Kernel Support Vector Classifier produced the highest levels of performance and accuracy during training procedure accuracy 0.89733, AUC 0.94267. Where the testing set process, accuracy 0.81778, the area under the curve with 0.86556

OnabotulinumtoxinA in the treatment of overactive bladder: a cost-effectiveness analysis versus best supportive care in England and Wales

The cost-effectiveness of onabotulinumtoxinA (BOTOX®) 100 U + best supportive care (BSC) was compared with BSC alone in the management of idiopathic overactive bladder in adult patients who are not adequately managed with anticholinergics. BSC included incontinence pads and, for a proportion of patients, anticholinergics and/or occasional clean intermittent catheterisation. A five-state Markov model was used to estimate total costs and outcomes over a 10-year period. The cohort was based on data from two placebo-controlled trials and a long-term extension study of onabotulinumtoxinA. After discontinuation of initial treatment, a proportion of patients progressed to downstream sacral nerve stimulation (SNS). Cost and resource use was estimated from a National Health Service perspective in England and Wales using relevant reference sources for 2012 or 2013. Results showed that onabotulinumtoxinA was associated with lower costs and greater health benefits than BSC in the base case, with probabilistic sensitivity analysis indicating an 89 % probability that the incremental cost-effectiveness ratio would fall below £20,000. OnabotulinumtoxinA remained dominant over BSC in all but two scenarios tested; it was also economically dominant when compared directly with SNS therapy. In conclusion, onabotulinumtoxinA appears to be a cost-effective treatment for overactive bladder compared with BSC alone

Ranking ligand affinity for the DNA minor groove by experiment and simulation

The structural and thermodynamic basis for the strength and selectivity of the interactions of minor-groove binders (MGBs) with DNA is not fully understood. In 2003 we reported the first example of a thiazole containing MGB that bound in a phase shifted pattern that spanned 6 base-pairs rather than the usual 4 (for tricyclic distamycin-like compounds). Since then, using DNA footprinting, nuclear magnetic resonance spectroscopy, isothermal titration calorimetry and molecular dynamics, we have established that the flanking bases around the central 4 being read by the ligand have subtle effects on recognition. We have investigated the effect of these flanking sequences on binding and the reasons for the differences and established a computational method to rank ligand affinity against varying DNA sequences

Sect and House in Syria: History, Architecture, and Bayt Amongst the Druze in Jaramana

This paper explores the connections between the architecture and materiality of houses and the social idiom of bayt (house, family). The ethnographic exploration is located in the Druze village of Jaramana, on the outskirts of the Syrian capital Damascus. It traces the histories, genealogies, and politics of two families, bayt Abud-Haddad and bayt Ouward, through their houses. By exploring the two families and the architecture of their houses, this paper provides a detailed ethnographic account of historical change in modern Syria, internal diversity, and stratification within the intimate social fabric of the Druze neighbourhood at a time of war, and contributes a relational approach to the anthropological understanding of houses

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp. has been identified as a candidate target and it has been shown previously that substituted pyrrolo[2,3-d]pyrimidines are inhibitors of PTR1 from T. brucei (J. Med. Chem. 2010, 53, 221-229). In this study, 61 new pyrrolo[2,3-d]pyrimidines have been prepared, designed with input from new crystal structures of 23 of these compounds complexed with PTR1, and evaluated in screens for enzyme inhibitory activity against PTR1 and in vitro antitrypanosomal activity. 8 compounds were sufficiently active in both screens to take forward to in vivo evaluation. Thus although evidence for trypanocidal activity in a stage I disease model in mice was obtained, the compounds were too toxic to mice for further development

African heritage sites threatened as sea-level rise accelerates

The African coast contains heritage sites of ‘Outstanding Universal Value’ that face increasing risk from anthropogenic climate change. Here, we generated a database of 213 natural and 71 cultural African heritage sites to assess exposure to coastal flooding and erosion under moderate (RCP 4.5) and high (RCP 8.5) greenhouse gas emission scenarios. Currently, 56 sites (20%) are at risk from a 1-in-100-year coastal extreme event, including the iconic ruins of Tipasa (Algeria) and the North Sinai Archaeological Sites Zone (Egypt). By 2050, the number of exposed sites is projected to more than triple, reaching almost 200 sites under high emissions. Emissions mitigation from RCP 8.5 to RCP 4.5 reduces the number of very highly exposed sites by 25%. These findings highlight the urgent need for increased climate change adaptation for heritage sites in Africa, including governance and management approaches, site-specific vulnerability assessments, exposure monitoring, and protection strategies