16 research outputs found
Archives of the Local Lore Department of the Perm Territory Library
ΠΠ°Π½ ΠΎΠ±Π·ΠΎΡ Π°ΡΡ
ΠΈΠ²Π½ΡΡ
ΡΠΎΠ½Π΄ΠΎΠ² ΠΎΡΠ΄Π΅Π»Π° ΠΊΡΠ°Π΅Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΠ΅ΡΠΌΡΠΊΠΎΠΉ ΠΊΡΠ°Π΅Π²ΠΎΠΉ Π±ΠΈΠ±Π»ΠΈΠΎΡΠ΅ΠΊΠΈ, ΡΡΠ΅Π΄ΠΈ ΠΊΠΎΡΠΎΡΡΡ
ΠΊΠΎΠ»Π»Π΅ΠΊΡΠΈΡ Π΄Π΅Π» ΡΠ΅Π°ΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π΄Π΅ΡΡΠ΅Π»Ρ Π‘. Π. ΠΡΠ³ΠΈΠ»Π΅Π²Π°, Π»ΠΈΡΠ½ΡΠ΅ ΡΠΎΠ½Π΄Ρ ΠΏΠ΅ΡΠΌΡΠΊΠΈΡ
ΠΊΡΠ°Π΅Π²Π΅Π΄ΠΎΠ² ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ Π. Π. Π Π΅ΡΡΠΎΠ²Π°, Π‘. Π. Π’ΠΎΡΠΎΠΏΠΎΠ²Π°, Π. Π. Π‘ΡΠ΅ΠΏΠ°Π½ΠΎΠ²Π°, Π‘. Π€. ΠΠΈΠΊΠΎΠ»Π°Π΅Π²Π°.There is given a review of the archives of the Local Lore Department of the Perm Territory Library, which include a collection of documents belonging to Sergey Diaghilev, private collections of local lore experts and researches from Perm β I.A. Reutov, S.A. Toporov, M.N. Stepanov, S.F. Nikolaev
Means of expression of incentive modality in Tatar and English languages
The relevance of the investigated problem is caused by the need to improve the functional approach to understanding the nature of the content incentive modality. The aim of the study is to identify the means of expression incentive modality in the Tatar and Russian languages, their similarities and differences. The leading approach to the study of the problems is selected descriptive-comparative method with its components - observation, comparison and generalization. The findings suggest that, in both languages there are corresponding counterparts, causing typological commonality; the most frequent way of expressing incentive modality in the English language are modal verbs and modal words, in Tatar - modal words as part of a complex predicate, the use of which depends on the context. Article Submissions may be useful in lecture courses on linguistics, in special courses on the problems of modality, as well as in the practice of teaching the Tatar and English languages.Keywords: language, translation, bilingual, incentive modality, means of expression, typological intention
The technology of creation of the standard base for socio-economic dimensions
Β© Medwell Journals, 2016.Practice education standards for assessing and comparing (comparing/contrasting) heterogeneous properties of controlled processes of socio-economic spheres. Design technique and technology to create a reference framework for processes in socio-economic sphere and on this basis to apply for measuring operations scientific methods of metrology. In this researchers methods of imitating and semantic modeling in a complex with methods of the economical and statistical analysis are used. Possibility of creation of the expert system reproducing technical and operational properties of natural market metrology, formation of general estimated function and a comparable measure of productivity for a set of diverse and multidirectional indicators is discussed. The model of creation of reference base for private indicators providing an integrated rating assessment of a condition of various organizational structures and processes is developed. The conclusion is that in terms of multidirectional indicators the most viable scheme of management of organizational systems is the formation of the reference base, the formation of normative-evaluative, the synthesis of multidimensional processes to one-dimensionality of a single criterion
Resources for developing the research publication competencies of Russian researchers
Introduction. In the last decades, due to the increased number of international research collaborations, the role of auxiliary institutions which contribute to the development of research publication competencies has increased. Competencies are required for writing, preparing, publishing, and promoting scientific articles. The formation of such competencies is carried out at different levels of higher education as part of the current Federal State Educational Standard (FSES), including prorammes of additional professional education, as well as initiatives of auxiliary university departments and non-university organisations. Aim. This article aims to analyse the resources available for the development of research publication competencies in Russia in terms of the opportunities offered by different participants of the educational process. Methodology and research methods. The study compared and analysed open access regulatory documentation, reviewed and systematised data from the websites of auxiliary university departments and non-university organisations, and used data from in-depth interviews. Results. The article describes the prerequisites for the formation of research publication competencies in higher education in Russia. An overview of effective practices to develop such competencies is given, taking into account the national context and available higher education programmes. The article provides an overview of the functionality of auxiliary university departments and non-university organisations, whose activities support publication activity. The role of academic writing teachers, consultants, translators, editors, and reviewers in the development of the competencies of the authors of scientific publications is determined. The importance of the closer interaction of all participants in the publication process is substantiated: authors, translators, and editors of texts; and teachers of scientific writing courses with editors and reviewers of scientific journals. Scientific novelty. The scientific novelty of this article refers to a detailed description of the resources for the development of research publication competencies and their compliance with the requirements of the Federal State Educational Standard, which have not been investigated in such correlation before. Practical significance. The results can be used to develop a set of measures to systematise approaches to developing research publication competencies.ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. Π ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π΄Π΅ΡΡΡΠΈΠ»Π΅ΡΠΈΡ Π² ΡΠ²ΡΠ·ΠΈ Ρ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΎΠ±ΡΠ΅ΠΌΠ° ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΡΡ
Π½Π°ΡΡΠ½ΡΡ
ΠΊΠΎΠ»Π»Π°Π±ΠΎΡΠ°ΡΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π΅Ρ ΡΠΎΠ»Ρ Π²ΡΠΏΠΎΠΌΠΎΠ³Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΡΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π½Π°ΡΡΠ½ΠΎ-ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ. ΠΠ°ΡΡΠ½ΠΎ-ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ ΡΠΎΠ±ΠΎΠΉ ΡΠΎΠ²ΠΎΠΊΡΠΏΠ½ΠΎΡΡΡ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ, Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡΡ
Π΄Π»Ρ Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΡ, ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ, ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ ΠΈ ΠΏΡΠΎΠ΄Π²ΠΈΠΆΠ΅Π½ΠΈΡ Π½Π°ΡΡΠ½ΠΎΠΉ ΡΡΠ°ΡΡΠΈ. Π€ΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ, ΡΠ²ΡΠ·Π°Π½Π½ΡΡ
Ρ Π½Π°ΡΡΠ½ΠΎ-ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ ΠΈ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ ΡΠΎΡΡΠΈΠΉΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ, ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π° ΡΠ°Π·Π½ΡΡ
ΡΡΡΠΏΠ΅Π½ΡΡ
Π²ΡΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π² ΡΠ°ΠΌΠΊΠ°Ρ
Π΄Π΅ΠΉΡΡΠ²ΡΡΡΠ΅Π³ΠΎ Π€Π΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠ° (Π€ΠΠΠ‘). ΠΡΠΎΡ ΠΏΡΠΎΡΠ΅ΡΡ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ°Π΅ΡΡΡ Π² ΡΠ°ΠΌΠΊΠ°Ρ
ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ
ΠΈΠ½ΠΈΡΠΈΠ°ΡΠΈΠ² Π²ΡΠΏΠΎΠΌΠΎΠ³Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΡΠΊΠΈΡ
ΠΏΠΎΠ΄ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΠΉ ΠΈ Π²Π½Π΅ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΡΠΊΠΈΡ
ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΉ. Π¦Π΅Π»Ρ Π΄Π°Π½Π½ΠΎΠΉ ΡΡΠ°ΡΡΠΈ β ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΠΈΠΌΠ΅ΡΡΠΈΠ΅ΡΡ ΡΠ΅ΡΡΡΡΡ ΠΏΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π½Π°ΡΡΠ½ΠΎ-ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ Π² Π ΠΎΡΡΠΈΠΈ Ρ ΡΠΎΡΠΊΠΈ Π·ΡΠ΅Π½ΠΈΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠ΅ΠΉ, ΠΏΡΠ΅Π΄Π»Π°Π³Π°Π΅ΠΌΡΡ
ΡΠ°Π·Π½ΡΠΌΠΈ Π°ΠΊΡΠΎΡΠ°ΠΌΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ. ΠΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡ, ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈΡΡ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ-ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· Π½ΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΠΎΠΉ Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠΈ ΠΎΡΠΊΡΡΡΠΎΠ³ΠΎ Π΄ΠΎΡΡΡΠΏΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠ±Π·ΠΎΡ ΠΈ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·Π°ΡΠΈΡ Π΄Π°Π½Π½ΡΡ
Ρ ΠΎΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΡ
ΡΠ°ΠΉΡΠΎΠ² Π²ΡΠΏΠΎΠΌΠΎΠ³Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΡΠΊΠΈΡ
ΠΏΠΎΠ΄ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΠΉ ΠΈ Π²Π½Π΅ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΡΠΊΠΈΡ
ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΉ, ΠΌΠ΅ΡΠΎΠ΄ Π³Π»ΡΠ±ΠΈΠ½Π½ΡΡ
ΠΈΠ½ΡΠ΅ΡΠ²ΡΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π ΡΡΠ°ΡΡΠ΅ ΠΎΠΏΠΈΡΠ°Π½Ρ ΠΏΡΠ΅Π΄ΠΏΠΎΡΡΠ»ΠΊΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π°ΡΡΠ½ΠΎ-ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ Π²ΡΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π² Π ΠΎΡΡΠΈΠΈ. ΠΡΠΈΠ²ΠΎΠ΄ΠΈΡΡΡ ΠΎΠ±Π·ΠΎΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΏΡΠ°ΠΊΡΠΈΠΊ, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΡ
Π½Π° ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π½Π°ΡΡΠ½ΠΎ-ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ, Ρ ΡΡΠ΅ΡΠΎΠΌ Π½Π°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΠ΅ΠΊΡΡΠ° ΠΈ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌ Π²ΡΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ. Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΠΎΠ±Π·ΠΎΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»Π° Π²ΡΠΏΠΎΠΌΠΎΠ³Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΠΎΠ΄ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΠΉ Π²ΡΠ·ΠΎΠ² ΠΈ Π²Π½Π΅ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΡΠΊΠΈΡ
ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΉ, Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΊΠΎΡΠΎΡΡΡ
Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π° Π½Π° ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΡ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° ΡΠΎΠ»Ρ ΠΏΡΠ΅ΠΏΠΎΠ΄Π°Π²Π°ΡΠ΅Π»Π΅ΠΉ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΈΡΡΠΌΠ°, ΠΊΠΎΠ½ΡΡΠ»ΡΡΠ°Π½ΡΠΎΠ², ΠΏΠ΅ΡΠ΅Π²ΠΎΠ΄ΡΠΈΠΊΠΎΠ², ΡΠ΅Π΄Π°ΠΊΡΠΎΡΠΎΠ² ΠΈ ΡΠ΅ΡΠ΅Π½Π·Π΅Π½ΡΠΎΠ² Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ Π°Π²ΡΠΎΡΠΎΠ² Π½Π°ΡΡΠ½ΡΡ
ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ. ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½Π° Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ Π±ΠΎΠ»Π΅Π΅ ΡΠ΅ΡΠ½ΠΎΠ³ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π²ΡΠ΅Ρ
ΡΡΠ°ΡΡΠ½ΠΈΠΊΠΎΠ² ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°: Π°Π²ΡΠΎΡΠΎΠ², ΠΏΠ΅ΡΠ΅Π²ΠΎΠ΄ΡΠΈΠΊΠΎΠ² ΠΈ ΡΠ΅Π΄Π°ΠΊΡΠΎΡΠΎΠ² Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΠΊΡΡΠ°, ΠΏΡΠ΅ΠΏΠΎΠ΄Π°Π²Π°ΡΠ΅Π»Π΅ΠΉ ΠΊΡΡΡΠΎΠ² Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΠΈΡΡΠΌΠ° Ρ ΡΠ΅Π΄Π°ΠΊΡΠΎΡΠ°ΠΌΠΈ ΠΈ ΡΠ΅ΡΠ΅Π½Π·Π΅Π½ΡΠ°ΠΌΠΈ Π½Π°ΡΡΠ½ΡΡ
ΠΆΡΡΠ½Π°Π»ΠΎΠ². ΠΠ°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π° Π΄Π°Π½Π½ΠΎΠΉ ΡΡΠ°ΡΡΠΈ ΡΠΎΡΡΠΎΠΈΡ Π² Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠΈ ΡΠ΅ΡΡΡΡΠΎΠ² ΡΠ°Π·Π²ΠΈΡΠΈΡ Π½Π°ΡΡΠ½ΠΎ-ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ ΠΈ ΠΈΡ
ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΡ ΡΡΠ΅Π±ΠΎΠ²Π°Π½ΠΈΡΠΌ Π€Π΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠ°, ΠΊΠΎΡΠΎΡΡΠ΅ Π² ΡΠ°ΠΊΠΎΠΌ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΠΏΡΠ΅ΠΆΠ΄Π΅ Π½Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈΡΡ. ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄Π»Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΠΉ ΠΏΠΎ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π°ΡΡΠ½ΠΎ-ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠΈΠΉ.ΠΠ²ΡΠΎΡΡ Π²ΡΡΠ°ΠΆΠ°ΡΡ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ½ΠΎΡΡΡ Π·Π° ΠΊΠΎΠ½ΡΡΠ»ΡΡΠ°ΡΠΈΠΈ ΠΈ ΠΏΡΠ΅Π΄ΠΎΡΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄Π°Π½Π½ΡΡ
Π’. Π. ΠΠΎΡΠΊΡΡΠΎΠ²ΠΎΠΉ (ΠΠΠ Π), Π. Π. Π‘Π°ΠΌΠΎΠΉΠ»Π΅Π½ΠΊΠΎ (Π‘ΡΠΠΠ£), Π. Π¨ΡΠ°ΠΉΠ±Π΅Ρ ΠΈ Π. ΠΠΌΠ΅Π»ΡΡΠ½ΠΎΠ²ΠΎΠΉ (ΠΠ°ΠΏΠ°Π΄Π½ΠΎ-Π‘ΠΈΠ±ΠΈΡΡΠΊΠΈΠΉ ΠΌΠ΅ΠΆΡΠ΅Π³ΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΉ ΠΠΠ¦), Π. Π. ΠΠΎΠ³ΡΡΠ»Π°Π²ΡΠΊΠΎΠΉ (ΠΠ€ΠΈΠ Π£ΡΠ Π ΠΠ), Π. Π. ΠΡΡΠ°Π΄Π½ΠΎΠ²ΠΎΠΉ (ΠΡΠ΅Π·ΠΈΠ΄ΠΈΡΠΌ Π£ΡΠ Π ΠΠ), Π‘. Π. ΠΡΠ»ΡΠ½ΠΈΠΊΠΎΠ²Ρ (ΠΠΊΠΎ-ΠΠ΅ΠΊΡΠΎΡ). ΠΠ²ΡΠΎΡΡ Π²ΡΡΠ°ΠΆΠ°ΡΡ ΠΏΡΠΈΠ·Π½Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΡ Π°Π½ΠΎΠ½ΠΈΠΌΠ½ΡΠΌ ΡΠ΅ΡΠ΅Π½Π·Π΅Π½ΡΠ°ΠΌ, ΠΊΠΎΡΠΎΡΡΠ΅ Π²ΡΡΠΊΠ°Π·Π°Π»ΠΈ ΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ Π΄ΠΎΡΠ°Π±ΠΎΡΠΊΠ΅ ΡΡΠ°ΡΡΠΈ.The authors express their gratitude to T. A. Loskutova (RASSEP), I. V. Samoilenko (StSAU), I. Schreiber and N. Emelianova (West Siberian Interregional Scientific Centre), E. L. Boguslavskaya (Institute for Philosophy and Law UB RAS), I. V. Otradnova (Presidium UB RAS), S. V. Mylnikov (Eco-Vector) for their consultations and providing statistical data. The authors are grateful to the anonymous reviewers, who provided valuable suggestions for improving the article
Single cell derived mRNA signals across human kidney tumors.
Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular origin of 1300 childhood and adult kidney tumors. Using single cell mRNA reference maps of normal tissues, we quantify reference "cellular signals" in each tumor. Quantifying global differentiation, we find that childhood tumors exhibit fetal cellular signals, replacing the presumption of "fetalness" with a quantitative measure of immaturity. By contrast, in adult cancers our assessment refutes the suggestion of dedifferentiation towards a fetal state in most cases. We find an intimate connection between developmental mesenchymal populations and childhood renal tumors. We demonstrate the diagnostic potential of our approach with a case study of a cryptic renal tumor. Our findings provide a cellular definition of human renal tumors through an approach that is broadly applicable to human cancer
The technology of creation of the standard base for socio-economic dimensions
Β© Medwell Journals, 2016.Practice education standards for assessing and comparing (comparing/contrasting) heterogeneous properties of controlled processes of socio-economic spheres. Design technique and technology to create a reference framework for processes in socio-economic sphere and on this basis to apply for measuring operations scientific methods of metrology. In this researchers methods of imitating and semantic modeling in a complex with methods of the economical and statistical analysis are used. Possibility of creation of the expert system reproducing technical and operational properties of natural market metrology, formation of general estimated function and a comparable measure of productivity for a set of diverse and multidirectional indicators is discussed. The model of creation of reference base for private indicators providing an integrated rating assessment of a condition of various organizational structures and processes is developed. The conclusion is that in terms of multidirectional indicators the most viable scheme of management of organizational systems is the formation of the reference base, the formation of normative-evaluative, the synthesis of multidimensional processes to one-dimensionality of a single criterion
The technology of creation of the standard base for socio-economic dimensions
Β© Medwell Journals, 2016.Practice education standards for assessing and comparing (comparing/contrasting) heterogeneous properties of controlled processes of socio-economic spheres. Design technique and technology to create a reference framework for processes in socio-economic sphere and on this basis to apply for measuring operations scientific methods of metrology. In this researchers methods of imitating and semantic modeling in a complex with methods of the economical and statistical analysis are used. Possibility of creation of the expert system reproducing technical and operational properties of natural market metrology, formation of general estimated function and a comparable measure of productivity for a set of diverse and multidirectional indicators is discussed. The model of creation of reference base for private indicators providing an integrated rating assessment of a condition of various organizational structures and processes is developed. The conclusion is that in terms of multidirectional indicators the most viable scheme of management of organizational systems is the formation of the reference base, the formation of normative-evaluative, the synthesis of multidimensional processes to one-dimensionality of a single criterion
The technology of creation of the standard base for socio-economic dimensions
Β© Medwell Journals, 2016.Practice education standards for assessing and comparing (comparing/contrasting) heterogeneous properties of controlled processes of socio-economic spheres. Design technique and technology to create a reference framework for processes in socio-economic sphere and on this basis to apply for measuring operations scientific methods of metrology. In this researchers methods of imitating and semantic modeling in a complex with methods of the economical and statistical analysis are used. Possibility of creation of the expert system reproducing technical and operational properties of natural market metrology, formation of general estimated function and a comparable measure of productivity for a set of diverse and multidirectional indicators is discussed. The model of creation of reference base for private indicators providing an integrated rating assessment of a condition of various organizational structures and processes is developed. The conclusion is that in terms of multidirectional indicators the most viable scheme of management of organizational systems is the formation of the reference base, the formation of normative-evaluative, the synthesis of multidimensional processes to one-dimensionality of a single criterion
Precise identification of cancer cells from allelic imbalances in single cell transcriptomes.
A fundamental step of tumour single cell mRNA analysis is separating cancer and non-cancer cells. We show that the common approach to separation, using shifts in average expression, can lead to erroneous biological conclusions. By contrast, allelic imbalances representing copy number changes directly detect the cancer genotype and accurately separate cancer from non-cancer cells. Our findings provide a definitive approach to identifying cancer cells from single cell mRNA sequencing data