Indigenous Mexicans’ Experiences with Discrimination, Prejudice, and Inequality in Mexico and the United States: A Quantitative Approach

Since the arrival of the Spanish over five centuries ago, Indigenous people in Mexico have been marginalized and relegated to the bottom of a social hierarchy rooted in the coloniality of power. Now two centuries post-independence, while there are increased government-led efforts to better address the needs of Indigenous communities and remedy the problems they experience, ranging from poverty to discrimination to limited educational and occupational opportunities, Indigenous communities still face many barriers to upward mobility, including significant structural and interpersonal discrimination. The objective of this dissertation is to understand the unequal treatment of Indigenous Mexicans on both sides of the US &ndash; Mexico border and the demographic factors that influence perceptions of racial difference by non-Indigenous people and perceptions of discrimination by Indigenous people. To achieve this goal, I use three nationally representative data sources with Indigenous representation &ndash; two in Mexico and one in the US &ndash; and a variety of multivariable statistical techniques. This research uses datasets from Vanderbilt University&rsquo;s Latin American Public Opinion Project (LAPOP), the Project on Ethnicity and Race in Latin America (PERLA), and the US Labor Department&rsquo;s National Agricultural Workers Survey (NAWS). Results show mestizaje and multiculturalism appear to coexist in Mexico, potentially in a mutually constitutive manner, highlighted by a greater appreciation of multiculturalism and recognition of the needs of marginalized racial and ethnic populations, while some stereotypical beliefs and discriminatory attitudes persist. Despite the endurance of these attitudes, large majorities of people, including Indigenous Mexicans, say they have not been targeted by skin color, linguistic, economic, and gender discrimination, although economic discrimination is most common. These results are likely not a reflection of there being little discrimination in Mexico, but instead that people may not have the vocabulary to describe the discrimination they experience. While dominant racial ideologies continue to be brought to the US by Mexican immigrants, results show inequality in health care and health outcomes are not dictated by racial and ethnic identity, but by gender, legal status, poverty status, and geographic location. Together, these findings contribute an improved understanding of the nuance and heterogeneity of the experiences of Indigenous Mexicans.</p

The Fe XXII I(11.92 A)/I(11.77 A) Density Diagnostic Applied to the Chandra High Energy Transmission Grating Spectrum of EX Hydrae

Using the Livermore X-ray Spectral Synthesizer, which calculates spectral models of highly charged ions based primarily on HULLAC atomic data, we investigate the temperature, density, and photoexcitation dependence of the I(11.92 A)/I(11.77 A) line ratio of Fe XXII. We find that this line ratio has a critical density n_c \approx 5x10^13 cm^-3, is approximately 0.3 at low densities and 1.5 at high densities, and is very insensitive to temperature and photoexcitation, so is a useful density diagnostic for sources like magnetic cataclysmic variables in which the plasma densities are high and the efficacy of the He-like ion density diagnostic is compromised by the presence of a bright ultraviolet continuum. Applying this diagnostic to the Chandra High Energy Transmission Grating spectrum of the intermediate polar EX Hya, we find that the electron density of its T_e \approx 12 MK plasma is n_e = 1.0^{+2.0}_{-0.5} x 10^14 cm^-3, orders of magnitude greater than that typically observed in the Sun or other late-type stars.Comment: 11 pages including 3 encapsulated postscript figures; LaTeX format, uses aastex.cls; accepted on 2003 April 3 for publication in The Astrophysical Journa

Faecal and urine metabolites, but not gut microbiota, may predict response to low FODMAP diet in irritable bowel syndrome

BackgroundThe low FODMAP diet (LFD) leads to clinical response in 50%-80% of patients with irritable bowel syndrome (IBS). It is unclear why only some patients respond.AimsTo determine if differences in baseline faecal microbiota or faecal and urine metabolite profiles may separate clinical responders to the diet from non-responders allowing predictive algorithms to be proposed.MethodsWe recruited adults fulfilling Rome III criteria for IBS to a blinded randomised controlled trial. Patients were randomised to sham diet with a placebo supplement (control) or LFD supplemented with either placebo (LFD) or 1.8 g/d B-galactooligosaccharide (LFD/B-GOS), for 4 weeks. Clinical response was defined as adequate symptom relief at 4 weeks after the intervention (global symptom question). Differences between responders and non-responders in faecal microbiota (FISH, 16S rRNA sequencing) and faecal (gas-liquid chromatography, gas-chromatography mass-spectrometry) and urine (1 H NMR) metabolites were analysed.ResultsAt 4 weeks, clinical response differed across the 3groups with adequate symptom relief of 30% (7/23) in controls, 50% (11/22) in the LFD group and 67% (16/24) in the LFD/B-GOS group (p = 0.048). In the control and the LFD/B-GOS groups, microbiota and metabolites did not separate responders from non-responders. In the LFD group, higher baseline faecal propionate (sensitivity 91%, specificity 89%) and cyclohexanecarboxylic acid esters (sensitivity 80%, specificity 78%), and urine metabolite profile (Q2 0.296 vs. randomised -0.175) predicted clinical response.ConclusionsBaseline faecal and urine metabolites may predict response to the LFD

Prostate Stereotactic Ablative Radiation Therapy Using Volumetric Modulated Arc Therapy to Dominant Intraprostatic Lesions

PurposeTo investigate boosting dominant intraprostatic lesions (DILs) in the context of stereotactic ablative radiation therapy (SABR) and to examine the impact on tumor control probability (TCP) and normal tissue complication probability (NTCP).Methods and MaterialsTen prostate datasets were selected. DILs were defined using T2-weighted, dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging. Four plans were produced for each dataset: (1) no boost to DILs; (2) boost to DILs, no seminal vesicles in prescription; (3) boost to DILs, proximal seminal vesicles (proxSV) prescribed intermediate dose; and (4) boost to DILs, proxSV prescribed higher dose. The prostate planning target volume (PTV) prescription was 42.7 Gy in 7 fractions. DILs were initially prescribed 115% of the PTVProstate prescription, and PTVDIL prescriptions were increased in 5% increments until organ-at-risk constraints were reached. TCP and NTCP calculations used the LQ-Poisson Marsden, and Lyman-Kutcher-Burman models respectively.ResultsWhen treating the prostate alone, the median PTVDIL prescription was 125% (range: 110%-140%) of the PTVProstate prescription. Median PTVDIL D50% was 55.1 Gy (range: 49.6-62.6 Gy). The same PTVDIL prescriptions and similar PTVDIL median doses were possible when including the proxSV within the prescription. TCP depended on prostate α/β ratio and was highest with an α/β ratio = 1.5 Gy, where the additional TCP benefit of DIL boosting was least. Rectal NTCP increased with DIL boosting and was considered unacceptably high in 5 cases, which, when replanned with an emphasis on reducing maximum dose to 0.5 cm3 of rectum (Dmax0.5cc), as well as meeting existing constraints, resulted in considerable rectal NTCP reductions.ConclusionsBoosting DILs in the context of SABR is technically feasible but should be approached with caution. If this therapy is adopted, strict rectal constraints are required including Dmax0.5cc. If the α/β ratio of prostate cancer is 1.5 Gy or less, then high TCP and low NTCP can be achieved by prescribing SABR to the whole prostate, without the need for DIL boosting

Toward an assessment of the global inventory of present-day mercury releases to freshwater environments

Aquatic ecosystems are an essential component of the biogeochemical cycle of mercury (Hg), as inorganic Hg can be converted to toxic methylmercury (MeHg) in these environments and reemissions of elemental Hg rival anthropogenic Hg releases on a global scale. Quantification of effluent Hg releases to aquatic systems globally has focused on discharges to the global oceans, rather than contributions to freshwater systems that affect local exposures and risks associated with MeHg. Here we produce a first-estimate of sector-specific, spatially resolved global aquatic Hg discharges to freshwater systems. We compare our release estimates to atmospheric sources that have been quantified elsewhere. By analyzing available quantitative and qualitative information, we estimate that present-day global Hg releases to freshwater environments (rivers and lakes) associated with anthropogenic activities have a lower bound of ~1000 Mg· a−1. Artisanal and small-scale gold mining (ASGM) represents the single largest source, followed by disposal of mercury-containing products and domestic waste water, metal production, and releases from industrial installations such as chlor-alkali plants and oil refineries. In addition to these direct anthropogenic inputs, diffuse inputs from land management activities and remobilization of Hg previously accumulated in terrestrial ecosystems are likely comparable in magnitude. Aquatic discharges of Hg are greatly understudied and further constraining associated data gaps is crucial for reducing the uncertainties in the global biogeochemical Hg budget

Prospects for ACT: simulations, power spectrum, and non-Gaussian analysis

A new generation of instruments will reveal the microwave sky at high resolution. We focus on one of these, the Atacama Cosmology Telescope, which probes scales 1000<l<10000, where both primary and secondary anisotropies are important. Including lensing, thermal and kinetic Sunyaev-Zeldovich (SZ) effects, and extragalactic point sources, we simulate the telescope's observations of the CMB in three channels, then extract the power spectra of these components in a multifrequency analysis. We present results for various cases, differing in assumed knowledge of the contaminating point sources. We find that both radio and infrared point sources are important, but can be effectively eliminated from the power spectrum given three (or more) channels and a good understanding of their frequency dependence. However, improper treatment of the scatter in the point source frequency dependence relation may introduce a large systematic bias. Even if all thermal SZ and point source effects are eliminated, the kinetic SZ effect remains and corrupts measurements of the primordial slope and amplitude on small scales. We discuss the non-Gaussianity of the one-point probability distribution function as a way to constrain the kinetic SZ effect, and we develop a method for distinguishing this effect from the CMB in a window where they overlap. This method provides an independent constraint on the variance of the CMB in that window and is complementary to the power spectrum analysis.Comment: 22 pages, 11 figures. Submitted to New Astronomy. High resolution figures provided at http://www.princeton.edu/~khuffenb/pubs/prospects-act.htm