7 research outputs found
A Trimodality Comparison of Volumetric Bone Imaging Technologies. Part I: Short-term Precision and Validity
- Author
- Alexandra Papaioannou
- Andy K.O. Wong
- Angela M.W. Cheung
- Blumenfeld
- Boutroy
- Burghardt
- Calder
- Christopher L. Gordon
- Colin E. Webber
- Falcao
- Falcao
- Fedorov
- Folkesson
- Folkesson
- Gluer
- Guglielmi
- Jonathan D. Adachi
- Karen A. Beattie
- Kazakia
- Kevin K.H. Min
- Kreiger
- Krug
- Laib
- Lala
- Macdonald
- MacIntyre
- MacNeil
- Ouyang
- Parfitt
- Pauchard
- Schneider
- Sheu
- Wehrli
- Zanchetta
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
A Trimodality Comparison of Volumetric Bone Imaging Technologies. Part III: SD, SEE, LSC Association With Fragility Fractures
- Author
- Alexandra Papaioannou
- Andy K.O. Wong
- Angela M.W. Cheung
- Augat
- Boutroy
- Boutry
- Cejka
- Chang
- Christopher L. Gordon
- Clowes
- Colin E. Webber
- Cortet
- Formica
- Gorai
- Grampp
- Hangartner
- Horikoshi
- Jamal
- Jonathan D. Adachi
- Karen A. Beattie
- Kevin K.H. Min
- Kreiger
- Laib
- Laib
- Link
- Liu
- MacIntyre
- Majumdar
- Melton
- Melton
- Parfitt
- Pauchard
- Sheu
- Sornay-Rendu
- Sornay-Rendu
- Symons
- Szulc
- Vico
- Vilayphiou
- Wyrwich
- Zamir Merali
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
A Trimodality Comparison of Volumetric Bone Imaging Technologies. Part II: 1-Yr Change, Long-Term Precision, and Least Significant Change
- Author
- Alexandra Papaioannou
- Andy K.O. Wong
- Angela M.W. Cheung
- Baecker
- Berger
- Bonnick
- Bonnick
- Brown
- Burghardt
- Burghardt
- Burghardt
- Christopher L. Gordon
- Colin E. Webber
- Fedorov
- Folkesson
- Frost
- Gluer
- Gordon
- Hansen
- Jonathan D. Adachi
- Karen A. Beattie
- Kevin K.H. Min
- Khoo
- Kreiger
- Laib
- Leslie
- Macdonald
- Macdonald
- MacIntyre
- MacNeil
- Moyer-Mileur
- Ouyang
- Parfitt
- Pauchard
- Reszka
- Rinaldi
- Russell
- Schafer
- Sode
- Syddall
- Valkema
- Verheij
- Wang
- Zamir Merali
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
High-Dimensional Characterization of the Systemic Immune Landscape Informs on Synergism Between Radiation Therapy and Immune Checkpoint Blockade
- Author
- Alessandra Nardin
- Andrews
- Auslander
- Chee Keong Toh
- Chen
- Cirkel
- Daniel S.W. Tan
- Dennis J.J. Poon
- Dewan
- Eisenhauer
- Enya H.W. Ong
- Eugenia L.L. Yeo
- Evan W. Newell
- Fehlings
- Formenti
- Garon
- Gettinger
- Haitao Wang
- Hellmann
- Hermi Sumatoh
- Joseph T.S. Wee
- Kai Yao
- Kamphorst
- Kar Perng Low
- Kevin L.M. Chua
- Khee Chee Soo
- Luo Huang
- Massard
- Mei-Kim Ang
- Melvin L.K. Chua
- Menon
- Michael Fehlings
- Mittal
- Mohamad Farid
- N. Gopalakrishna Iyer
- Newell
- Pek Lim Chu
- Ravindran Kanesvaran
- Rebecca Dent
- Roselli
- Schietinger
- Seymour
- Shaverdian
- Spranger
- Tony K.H. Lim
- Tumeh
- Wai Yee Woo
- Watson
- Wen-long Nei
- Xin Min Cheng
- Young
- Zaretsky
- Zhong-guo Liang
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Fungal Biodiversity Profiles 1–10
- Author
- Adamčík S.
- Adamčík S.
- Adamčík S.
- Alexandre R. Machado
- André W. C. Rosado
- Arx J.A.Von.
- Bart Buyck
- Bas C.
- Beardslee H.C.
- Bessette A.E.
- Boidin J.
- Boidin J.
- Buyck B.
- Buyck B.
- Chunying Deng
- Cotter H. V. T.
- Danilo B. Pinho
- Dong-Qin Dai
- Dyutiparna Chakraborty
- Eriksson J.
- Eriksson J.
- Ewald Langer
- Fang Liu
- Gao Q.
- Gerhold N.
- H. Van T. Cotter
- Hall T.A.
- Harkness H.W.
- Hjortstam K.
- Hughes S.J.
- Hyde K.D.
- Ichinoe M.
- Indu B. Prasher
- Jiao Qin
- K.P. Deepna Latha
- Kanad Das
- Kevin D. Hyde
- Kirk P.M.
- Knudsen H.
- Kobayasi Y.
- Kreisel H.
- Kreisel H.
- Lakhanpal T.N.
- Larsson K.H.
- Lei Cai
- Lendner A.
- Li T.H.
- Li-Wei Zhou
- Liu B.
- Liu J.K.
- LV Shu-Xia
- LV Wei
- Masoomeh Ghobad-Nejhad
- Massee G.
- Naumov N.A.
- Nylander J.
- Nylander J.A.A.
- Nylander J.A.A.
- Olinto L. Pereira
- Peyronel B.
- Qin Wang
- Rajnish K. Verma
- Ribaldi M.S.
- Shi-Liang Liu
- Sierra A. M.
- Singer R.
- Slavomir Adamčík
- Smith A.H.
- Swofford D.L.
- Tingting Liu
- Verma B.
- Wen-Min Qin
- Whitton S.R.
- Wu S.H.
- Wu S.H.
- Wu S.H.
- Xiao-Dan Yu
- Xiong H.X.
- Xu-Hui Chen
- Yu-Cheng Dai
- Zhu-Liang Yang
- Publication venue
- 'BioOne'
- Publication date
- Field of study
Rare and low-frequency coding variants alter human adult height
- Author
- Abecasis G.R. (Gonçalo)
- Aben K.K.H. (Katja)
- Adair L.S. (Linda)
- Alam D.S. (Dewan S.)
- Albrecht E. (Eva)
- Allin K.H. (Kristine H)
- Allison M.A. (Matthew)
- Amouyel P. (Philippe)
- Angelantonio E. (Emanuele) di
- Appel E.V. (Emil V.)
- Arveiler D. (Dominique)
- Asselbergs F.W. (Folkert)
- Auer P. (Paul)
- Bakker P.I.W. (Paul) de
- Balkau B. (Beverley)
- Banas B. (Bernhard)
- Bang L.E. (Lia E.)
- Benn M. (Marianne)
- Bergmann S. (Sven)
- Bielak L.F. (Lawrence F.)
- Blüher M. (Matthias)
- Boehnke M. (Michael)
- Boeing H. (Heiner)
- Boerwinkle E.A. (Eric)
- Bonnycastle L.L. (Lori)
- Borecki I.B. (Ingrid)
- Bork-Jensen J. (Jette)
- Borst G.J. (Gert) de
- Bots M.L. (Michiel)
- Bottinger E.P. (Erwin)
- Bowden D.W. (Donald)
- Brandslund I. (Ivan)
- Breen G. (Gerome)
- Brilliant M.H. (Murray H.)
- Broer L. (Linda)
- Burt A.D. (Alastair)
- Butterworth A.S. (Adam)
- Böger C.A. (Carsten)
- Carey D.J. (David J.)
- Caulfield M. (Mark)
- Chambers J.C. (John)
- Chasman D.I. (Daniel)
- Chen Y.-D.I. (Yii-Der Ida)
- Chowdhury R. (Rajiv)
- Christensen C. (Cramer)
- Chu A.Y. (Audrey)
- Cocca M. (Massimiliano)
- Collins F.S. (Francis)
- Cook J.P. (James P.)
- Corley J. (Janie)
- Cox A.J. (Amanda J.)
- Cuellar-Partida G. (Gabriel)
- Danesh J. (John)
- Davies G. (Gail)
- De Denus S. (Simon)
- De Groot M.C.H. (Mark C.H.)
- Deary I.J. (Ian)
- Dedoussis G.V. (George)
- Deloukas P. (Panos)
- Demerath E.W. (Ellen)
- Dennis J. (Joe)
- Drenos F. (Fotios)
- Du M. (Mengmeng)
- Duijn C.M. (Cornelia) van
- Dunning A.M. (Alison M.)
- Easton D.F. (Douglas)
- Ebeling T. (Tapani)
- Edwards T.L. (Todd L.)
- Ellinor P.T. (Patrick)
- Elliott P. (Paul)
- Esko T. (Tõnu)
- Evangelou E. (Evangelos)
- Farmaki A.-E. (Aliki-Eleni)
- Faul J.D. (Jessica D.)
- Feitosa M.F. (Mary Furlan)
- Feng S. (Shuang)
- Ferrannini E. (Ele)
- Ferrario M.M. (Marco M.)
- Ferrieres J. (Jean)
- Fine R.S. (Rebecca S.)
- Florez J.C. (Jose)
- Ford I.
- Fornage M. (Myriam)
- Franks P.W. (Paul)
- Frayling T.M. (Timothy)
- Frikke-Schmidt R. (Ruth)
- Galbany J.C. (Jordi Corominas)
- Galesloot T.E. (Tessel)
- Gan W. (Wei)
- Gandin I. (Ilaria)
- Gasparini P. (Paolo)
- Giedraitis V. (Vilmantas)
- Giri A. (Ayush)
- Girotto S.
- Gordon S.D. (Scott D.)
- Gordon-Larsen P. (Penny)
- Gorski M. (Mathias)
- Graff M.J. (Maud J.L.)
- Grarup N. (Niels)
- Grove M.L. (Megan)
- Gudnason V. (Vilmundur)
- Guo X. (Xiuqing)
- Gustafsson S. (Stefan)
- Hansen T. (T.)
- Harris K.M. (Kathleen Mullan)
- Harris T.B. (Tamara)
- Hart't L.M. (Leen M.)
- Hattersley A.T. (Andrew)
- Hayward C. (Caroline)
- He L. (Liang)
- Heard-Costa N.L. (Nancy)
- Heid I.M. (Iris)
- Heikkilä K. (Kauko)
- Helgeland Ø. (Øyvind)
- Hernesniemi J. (Jussi)
- Hewit A.W. (Alex)
- Highland H. (Heather)
- Hirschhorn J.N. (Joel)
- Hocking L.J. (Lynne)
- Hollander A.I. (Anneke)
- Hollensted M. (Mette)
- Holmen O.L. (Oddgeir)
- Hovingh G.K. (Kees)
- Howson J.M.M. (Joanna M.M.)
- Hoyng C.B. (Carel)
- Huang P.L. (Paul L.)
- Hveem K. (Kristian)
- Ikram M.K. (Kamran)
- Ingelsson E. (Erik)
- Jackson A.U. (Anne)
- Jansson J.-H. (Jan-Håkan)
- Jarvik G.P. (Gail)
- Jensen G.B. (Gorm B.)
- Jhun M.A. (Min A.)
- Jia Y. (Yucheng)
- Jiang X. (Xuejuan)
- Johansson S. (Stefan)
- Jorgensen T. (Torben)
- Jousilahti P. (Pekka)
- Jukema J.W. (Jan Wouter)
- Justice A.E. (Anne)
- Jørgensen M.E. (Marit E.)
- Kahali B. (Bratati)
- Kahn R. (René)
- Kamstrup P.R. (Pia R.)
- Kanoni S. (Stavroula)
- Kao W.H.L. (Wen)
- Kaprio J. (Jaakko)
- Karaderi T. (Tugce)
- Karaleftheri M. (Maria)
- Kardia S.L.R. (Sharon L.R.)
- Karpe F. (Fredrik)
- Kathiresan S. (Sekar)
- Kee F. (Frank)
- Keeman J.N.
- Kiemeney L.A.L.M. (Bart)
- Kitajima H. (Hidetoshi)
- Kjaer T.R. (Troels R.)
- Kluivers K.B. (Kirsten B.)
- Kocher T.
- Komulainen P. (Pirjo)
- Kontto J. (Jukka)
- Kooner J.S. (Jaspal S.)
- Kooperberg C. (Charles)
- Kovacs P. (Peter)
- Kriebel J. (Jennifer)
- Kuivaniemi H. (Helena)
- Kutalik Z. (Zoltán)
- Kuusisto J. (Johanna)
- Kähönen M. (Mika)
- Küry S. (Sébastien)
- La Bianca M. (Martina)
- Laakso M. (Markku)
- Lakka T.A. (Timo)
- Lamparter D. (David)
- Lange E.M. (Ethan)
- Lange L.A. (Leslie)
- Langefeld C.D. (Carl)
- Langenberg C. (Claudia)
- Larson E.B. (Eric B.)
- Lee I.-T. (I-Te)
- Lehtimäki T. (Terho)
- Lettre G. (Guillaume)
- Lewis C.E. (Cora E.)
- Li H. (Huaixing)
- Li J. (Jin)
- Li-Gao R. (Ruifang)
- Lin H. (Honghuang)
- Lin L.-A. (Li-An)
- Lin X. (Xu)
- Lindgren C.M. (Cecilia M.)
- Lindström J. (Jaana)
- Linneberg A. (Allan)
- Liu D. (Dajiang)
- Liu Y. (Yeheng)
- Liu Y. (YongMei)
- Lo K.S.
- Locke A. (Adam)
- Loohuis L.M.O. (Loes M. Olde)
- Loos R.J.F. (Ruth)
- Lophatananon A. (Artitaya)
- Lu Y. (Yingchang)
- Luan J. (Jian'An)
- Lubitz S.A. (Steven)
- Lyytikäinen L.-P. (Leo-Pekka)
- Mackey D.A. (David A.)
- Madden P.A. (Pamela)
- Mahajan A. (Anubha)
- Manning A.K. (Alisa)
- Marenne G. (Gaëlle)
- Marouli E. (Eirini)
- Marten J. (Jonathan)
- Martin N.G. (Nicholas)
- Masca N.G.D. (Nicholas G.D.)
- Mazul A.L. (Angela L.)
- McCarthy M.I. (Mark I.)
- Medina-Gomez C. (Carolina)
- Meidtner K. (Karina)
- Metspalu A. (Andres)
- Mitchell P. (Paul)
- Mohlke K.L. (Karen)
- Mook-Kanamori D.O. (Dennis)
- Morgan A. (Anna)
- Morris A.D. (Andrew D.)
- Morris A.P. (Andrew)
- Mudgal P. (Poorva)
- Munroe P. (Patricia)
- Mutsert R. (Reneé) de
- Männistö S. (Satu)
- Müller-Nurasyid M. (Martina)
- Nalls M.A. (Michael)
- Nauck M. (Matthias)
- Nelson C.P. (Christopher P.)
- Neville M.J. (Matthew)
- Ng M.C.Y. (Maggie C.Y.)
- Nielsen S.F. (Sune)
- Nikus K. (Kjell)
- Njolstad P. (Pal)
- Nordestgaard B.G. (Børge)
- North K.E. (Kari)
- Ntalla I. (Ioanna)
- O'Connel J.R. (Jeffrey R.)
- Oksa H. (Heikki)
- Ophoff R.A. (Roel)
- Owen K.R. (Katharine R.)
- Oxvig C. (Claus)
- Packard C.J. (Chris J.)
- Padmanabhan S. (Sandosh)
- Palmer C.N.A. (Colin)
- Pasterkamp G. (Gerard)
- Patel A.P. (Aniruddh)
- Pattie A. (Alison)
- Pedersen O. (Oluf)
- Peissig P.L. (Peggy L.)
- Peloso G.M. (Gina)
- Pennell C.E. (Craig)
- Perola M. (Markus)
- Perry J.A. (James A.)
- Perry J.R.B. (John R.B.)
- Pers T.H. (Tune)
- Person A.D. (Anthony)
- Pirie A. (Ailith)
- Polasek O. (Ozren)
- Posthuma D. (Danielle)
- Raitakari O.T. (Olli T.)
- Rasheed A. (Asif)
- Rauramaa R. (Rainer)
- Reilly D.F. (Dermot F.)
- Reiner A. (Alexander)
- Renström F. (Frida)
- Ridker P.M. (Paul)
- Rioux J.D. (John)
- Rivadeneira Ramirez F. (Fernando)
- Rivas M.A. (Manuel)
- Robertson N.R. (Neil)
- Robino A. (Antonietta)
- Rolandsson O. (Olov)
- Rotter J.I. (Jerome I.)
- Rudan I. (Igor)
- Ruth K.S. (Katherine S.)
- Rüeger S. (Sina)
- Saleheen D. (Danish)
- Salomaa V. (Veikko)
- Samani N.J. (Nilesh)
- Sandow K. (Kevin)
- Sapkota Y. (Yadav)
- Sattar N. (Naveed)
- Schmidt M.K. (Marjanka)
- Schoor N.M. (Natasja) van
- Schreiner P.J. (Pamela)
- Schulze M.B. (Matthias B)
- Schurmann C. (Claudia)
- Scott R.A. (Robert)
- Segura-Lepe M.P. (Marcelo P.)
- Setten J. (Jessica) van
- Shah S.H. (Svati)
- Sim X. (Xueling)
- Sivapalaratnam S. (Suthesh)
- Small K.S. (Kerrin)
- Smith A.V. (Albert Vernon)
- Smith J.A. (Jennifer A)
- Southam L. (Lorraine)
- Spector T.D. (Timothy)
- Speliotes E.K. (Elizabeth K.)
- Starr J.M. (John)
- Steinthorsdottir V. (Valgerdur)
- Stirrups K. (Kathy)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Surendran P. (Praveen)
- Tansey K.E. (Katherine E.)
- Tardif J.-C. (Jean-Claude)
- Taylor K.D. (Kent)
- Teumer A. (Alexander)
- Thompson D. (Deborah)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Thuesen B.H. (Betina H.)
- Tromp G. (Gerard)
- Trompet S. (Stella)
- Tsafantakis E. (Emmanouil)
- Tuomilehto J. (Jaakko)
- Turcot V. (Valérie)
- Tybjaerg-Hansen A. (Anne)
- Tyrer J.P. (Jonathan)
- Tönjes A. (Anke)
- Uher R.
- Uitterlinden A.G. (André)
- Ulivi S. (Sheila)
- Van Der Laan S.W. (Sander W.)
- Van Der Leij A.R. (Andries R.)
- Varbo A. (Anette)
- Varga T.V. (Tibor V.)
- Varma R. (Rohit)
- Vedantam S. (Sailaja)
- Velez Edwards D.R. (Digna R.)
- Vermeulen S.H.H.M. (Sita)
- Vestergaard H. (Henrik)
- Vitart V. (Veronique)
- Vogt T.F. (Thomas F.)
- Vozzi D. (Diego)
- Walker M. (Mark)
- Wang C.A. (Carol A.)
- Wang F. (Feijie)
- Wang S. (Shuai)
- Wang Y. (Yiqin)
- Wareham N.J. (Nicholas J.)
- Warren H. (Helen)
- Wessel J. (Jennifer)
- Willems S.M. (Sara)
- Willer C.J. (Cristen)
- Wilson J.F. (James)
- Winkler T.W. (Thomas W.)
- Witte D.R. (Deniel)
- Wood A.R. (Andrew)
- Woods M.O. (Michael)
- Wu Y. (Ying)
- Yaghootkar H. (Hanieh)
- Yao J. (Jiefen)
- Yao P. (Pang)
- Yerges-Armstrong L.M. (Laura)
- Young K.L. (Kristin L.)
- Young R. (Robin)
- Zeggini E. (Eleftheria)
- Zhan X. (Xiaowei)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Zhao W. (Wei)
- Zheng H. (He)
- Zhou W. (Wei)
- Zwart J-A. (John-Anker)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 09/02/2017
- Field of study
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
- Author
- Abecasis G. (Goncalo)
- Abecasis G.R. (Gonçalo)
- Abecasis G.R. (Gonçalo)
- Aben K.K.H. (Katja)
- Absher D. (Devin)
- Absher D. (Devin)
- Aherrahrou Z. (Zouhair)
- Ahlqvist E. (Emma)
- Ahmadi K.R. (Kourosh)
- Ahmed N. (Nabeel)
- Alavere H. (Helene)
- Alibrandi M.T.S. (Maria)
- Allayee H. (Hooman)
- Allen H.L.
- Almgren P. (Peter)
- Altshuler D. (David)
- Amin N. (Najaf)
- Anand S.S. (Sonia)
- Andersen K.K. (Karl)
- Ardissino D. (Diego)
- Ardlie K.G. (Kristin)
- Armitage J. (Jane)
- Arnold A.M. (Alice)
- Aspelund T. (Thor)
- Assimes T.L. (Themistocles)
- Assmann G. (Gerd)
- Aulchenko Y.S. (Yurii)
- Azhar M. (Muhammad)
- Balkau B. (Beverley)
- Ball S.G. (Stephen G.)
- Barbalic M. (maja)
- Barker A.M. (Adam)
- Barlassina C. (Christina)
- Barlera S. (Simona)
- Barnes D. (Daniel)
- Barnes T.A. (Timothy)
- Barrett A. (Angela)
- Barroso I.E. (Inês)
- Bataille V. (Veronique)
- Becker D.M. (Diane)
- Becker L.C. (Lewis)
- Beckmann J.S. (Jacques)
- Beckmann J.S. (Jacques)
- Beilby J.P. (John)
- Bell J.T. (Jordana)
- Ben-Shlomo Y.
- Ben-Shlomo Y. (Yoav)
- Bennett A.J. (Amanda)
- Berger K. (Klaus)
- Bergman R.N. (Richard N.)
- Bergmann S.M. (Sven)
- Berndt S.I. (Sonja)
- Biebermann H. (Heike)
- Bis J.C. (Joshua)
- Blagieva R. (Roza)
- Blakemore A.I.F. (Alexandra)
- Blankenberg S. (Stefan)
- Boehm B.O. (Bernhard)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boeing H. (Heiner)
- Boeing H. (Heiner)
- Boekholdt S.M. (Matthijs)
- Boerwinkle E.A. (Eric)
- Boes T. (Tanja)
- Bonnycastle L.L. (Lori)
- Boomsma D.I. (Dorret)
- Borecki I.B. (Ingrid)
- Bornstein S.R. (Stefan R.)
- Bornstein S.R. (Stefan)
- Boström K.B. (Kristina Bengtsson)
- Bouatia-Naji N. (Nabila)
- Bowman L.
- Braund P.S. (Peter)
- Bravenboer B. (Bert)
- Buchanan T.A. (Thomas)
- Bumpstead S. (Suzannah)
- Burnett M.S.
- Burtt N.P. (Noël)
- Busonero F.
- Buysschaert I. (Ian)
- Cambien F. (François)
- Campbell H. (Harry)
- Cappuccio F.P. (Francesco P.)
- Cappuccio F.P. (Francesco)
- Carlquist J.F. (John)
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- Hagen K. (Knut)
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- Peters M.J. (Marjolein)
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- Peto R. (R.)
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- Pichler I. (Irene)
- Pietilainen K.H. (Kirsi Hannele)
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- Quyyumi A.A. (Arshed)
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- Raitakari O. (Olli)
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- Schipf S. (Sabine)
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- Scott J. (James)
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- Seedorf U. (Udo)
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- Sehmi J.S. (Joban)
- Sekowska M. (Magdalena)
- Sennblad B. (Bengt)
- Serrano-Ríos M. (Manuel)
- Shah N. (Nisha)
- Shi J. (Jianxin)
- Shi J. (Jianxin)
- Shields B.M. (Beverley)
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- Shrader P. (Peter)
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- Sivapalaratnam S. (Suthesh)
- Sladek R. (Rob)
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- Smit J.H. (Jan)
- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith T.B. (Tamara B.)
- Snoep J.D. (Jaapjan)
- Soranzo N. (Nicole)
- Sparsø T. (Thomas)
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- Speliotes E.K. (Elizabeth)
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- Stančcáková A. (Alena)
- Stark K. (Klaus)
- Stein L.D. (Lincoln)
- Steinthorsdottir V. (Valgerdur)
- Stephens J. (Jonathan)
- Stewart A.F. (Alexandre F.)
- Stirrups K. (Kathy)
- Stoll M. (Monika)
- Strachan D.P. (David)
- Strassburger K. (Klaus)
- Strawbridge R.J. (Rona)
- Strawbridge R.J. (Rona)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Sun Q. (Qi)
- Surdulescu G. (Gabriela)
- Swift A.J. (Amy)
- Syvänen A.C.
- Tammesoo M.L.
- Taneera J. (Jalal)
- Tang W. (W.)
- Tardif J.-C. (Jean-Claude)
- Tennstedt S. (Stephanie)
- Teslovich T.M. (Tanya M.)
- Thiering E. (Eelisabeth)
- Thiering E. (Elisabeth)
- Thompson J.R. (John)
- Thomson B. (Brian)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorgeirsson G. (Gudmundur)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Tichet J. (Jean)
- Timpson N.J. (Nicholas)
- Tognoni G.
- Tomaszewski M. (Maciej)
- Travers M.E. (Mary E.)
- Travers M.E. (Mary)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Turrini F. (Fabiola)
- Tyrer J.P. (Jonathan)
- Tönjes A. (Anke)
- Uda M. (Manuela)
- Uitterlinden A.G. (André)
- Valle T.T. (Timo T.)
- Van Dam R.M. (Rob M.)
- van't Hooft F. (Ferdinand)
- Van't Hooft F. (Ferdinand)
- Vatin V. (Vincent)
- Vedantam S. (Sailaja)
- Visscher P.M. (Peter M.)
- Visscher P.M. (Peter)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Voight B.F. (Benjamin)
- Wabitsch M. (Martin)
- Waeber G. (Gérard)
- Waite L. (Lindsay)
- Walker M. (Mark)
- Wallaschofski H. (Henri)
- Walters G.B. (Bragi)
- Wareham N.J. (Nicholas J.)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R. (Ryan)
- Welch R.P. (Ryan)
- Wells G.A. (George)
- Weyant R.J. (Robert)
- Wheeler E. (Eleanor)
- White C.C. (Charles)
- Wichmann H.-E. (H-Erich)
- Wichmann H.E. (Heinz Erich)
- Widen E. (Elisabeth)
- Wiegand S. (Susanna)
- Wijmenga C. (Cisca)
- Wiklund F. (Fredrik)
- Wild P.S. (Philipp)
- Wild S.H. (Sarah)
- Wilk A. (Alicja)
- Willemsen G.A.H.M. (Gonneke)
- Willenborg C. (Christina)
- Willer C.J. (Cristen)
- Wilson J.F. (James F.)
- Wingerden S. (Sophie) van
- Winkler T.W. (Thomas W.)
- Witte D.R. (Daniel R.)
- Witte D.R. (Deniel)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C.M.)
- Wood A.R. (Andrew)
- Workalemahu T. (Tsegaselassie)
- Wright A.F. (Alan)
- Wright B.J. (Benjamin)
- Wu G. (Guanming)
- Xie W. (Weijia)
- Xu J. (Jianfeng)
- Yang J. (Jian)
- Yang J. (Joanna)
- Yang T.-P. (Tsun-Po)
- Ye S. (Shu)
- Zabena C. (Carina)
- Zaidi M.A. (Aghar)
- Zaman K.S. (Khan Shah)
- Zeggini E. (Eleftheria)
- Zeller T. (Tanja)
- Zethelius B. (Björn)
- Zgaga L. (Lina)
- Zhang Q. (Qunyuan)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zitting P. (Paavo)
- Zondervan K.T. (Krina T.)
- Zondervan K.T. (Krina)
- Zwart J-A. (John-Anker)
- Öhrvik J. (John)
- Östenson C.-G. (Claes-Göran)
- Publication venue
- Publication date
- 01/10/2011
- Field of study
OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 × 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis