354 research outputs found

    БистСма автоматичСского рСгулирования Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹ тСплоноситСля тСплосСти ΠΊΠΎΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ β„–4 ООО Β«Π“Π°Π·ΠΏΡ€ΠΎΠΌ Врансгаз Вомск»

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    Выпускная квалификационная Ρ€Π°Π±ΠΎΡ‚Π° содСрТит 112 с., рис.12, Ρ‚Π°Π±Π».29, 19 источников, ΠΏΡ€ΠΈΠ».6. ΠžΠ±ΡŠΠ΅ΠΊΡ‚ΠΎΠΌ исслСдования являСтся систСма тСплоснабТСния комплСкса Π·Π΄Π°Π½ΠΈΠΉ УправлСния АиБВ ООО ?Π“Π°Π·ΠΏΡ€ΠΎΠΌ Врансгаз Вомск? Π² Π³. ВомскС. ЦСль Ρ€Π°Π±ΠΎΡ‚Ρ‹ – Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° БАР Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹ тСплоноситСля тСплосСти для систСмы тСплоснабТСния. Π’ процСссС выполнСния Ρ€Π°Π±ΠΎΡ‚Ρ‹ проводился Π°Π½Π°Π»ΠΈΠ· ΠΎΠ±ΡŠΠ΅ΠΊΡ‚Π° рСгулирования, Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ, структурной, ΠΈ ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏΠΈΠ°Π»ΡŒΠ½ΠΎΠΉ элСктричСской схСмы БАР Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹ тСплоноситСля, расчСт ΠΎΠΏΡ‚ΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹Ρ… ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΎΠ² настройки рСгулятора, Π²Ρ‹Π±ΠΎΡ€ тСхничСских срСдств Π°Π²Ρ‚ΠΎΠΌΠ°Ρ‚ΠΈΠ·Π°Ρ†ΠΈΠΈ для Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡŠΠ΅ΠΊΡ‚Π°. Π’ Ρ…ΠΎΠ΄Π΅ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½Ρ‹Ρ… исслСдований ΠΏΡ€ΠΎΠΈΠ·Π²Π΅Π΄Π΅Π½Π° Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° систСмы автоматичСского рСгулирования Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹ тСплоноситСля Π½Π° Π±Π°Π·Π΅ соврСмСнных тСхничСских срСдств Π°Π²Ρ‚ΠΎΠΌΠ°Ρ‚ΠΈΠ·Π°Ρ†ΠΈΠΈ.Final qualifying work contains 112 pages., pictures12, 29 tables, 19 sources, applications 6. The object of research is the system of heat supply of the complex motor and special transport management of buildings LLC "Gazprom Transgaz Tomsk" in Tomsk. Objective - Development of automatic control system coolant temperature heating system for the heating system. In carrying out the work, an analysis of the object of regulation, the development of functional, structural, and electrical schematic diagram of the system of automatic control of the flow temperature, the calculation of the optimal controller settings, the choice of means of automation of the object

    ΠŸΡ€ΠΎΠ΅ΠΊΡ‚ установки каталитичСского прСвращСния синтСз-Π³Π°Π·Π° Π² ΠΌΠ΅Ρ‚Π°Π½ΠΎΠ»

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    Π’ Π΄Π°Π½Π½ΠΎΠΌ Π΄ΠΈΠΏΠ»ΠΎΠΌΠ½ΠΎΠΌ ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π΅ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Π° установка каталитичСского прСвращСния синтСз-Π³Π°Π·Π° Π² ΠΌΠ΅Ρ‚Π°Π½ΠΎΠ». ΠŸΡ€ΠΈ Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½ΠΈΠΈ Π΄Π°Π½Π½ΠΎΠΉ Ρ€Π°Π±ΠΎΡ‚Ρ‹ ΠΎΡΠ½ΠΎΠ²Ρ‹Π²Π°ΡŽΡΡŒ Π½Π° производство ΠΌΠ΅Ρ‚Π°Π½ΠΎΠ»Π° ΠΈΠ· ΠΏΡ€ΠΈΡ€ΠΎΠ΄Π½ΠΎΠ³ΠΎ Π³Π°Π·Π°. ΠœΠΎΡ‰Π½ΠΎΡΡ‚ΡŒ ΠΏΡ€ΠΎΠ΅ΠΊΡ‚ΠΈΡ€ΡƒΠ΅ΠΌΠΎΠΉ установки 815000 Ρ‚/Π³ΠΎΠ΄, с Π²Ρ‹Ρ…ΠΎΠ΄ΠΎΠΌ основного вСщСства 99,95 % Π² ΠΌΠ΅Ρ‚Π°Π½ΠΎΠ»Π΅-Ρ€Π΅ΠΊΡ‚ΠΈΡ„ΠΈΠΊΠ°Ρ‚Π΅. Π˜Π·Π»ΠΎΠΆΠ΅Π½Ρ‹ тСорСтичСскиС основы получСния ΠΌΠ΅Ρ‚Π°Π½ΠΎΠ»Π°. ΠŸΡ€ΠΈΠ²Π΅Π΄Π΅Π½Ρ‹ расчСты ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΈ Ρ‚Π΅ΠΏΠ»ΠΎΠ²ΠΎΠ³ΠΎ балансов. Π’Ρ‹ΠΏΠΎΠ»Π½Π΅Π½Ρ‹ мСханичСскиС ΠΈ тСхнологичСскиС расчСты, Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Π° схСма ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½ΠΎ-ΠΈΠ·ΠΌΠ΅Ρ€ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… ΠΏΡ€ΠΈΠ±ΠΎΡ€ΠΎΠ² ΠΈ Π°Π²Ρ‚ΠΎΠΌΠ°Ρ‚ΠΈΠ·Π°Ρ†ΠΈΠΈ. Π Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½ Ρ€Π°Π·Π΄Π΅Π»Ρ‹: «Ѐинансовый ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ‚, Ρ€Π΅ΡΡƒΡ€ΡΠΎΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΈ рСсурсосбСрСТСниС» ΠΈ Β«Π‘ΠΎΡ†ΠΈΠ°Π»ΡŒΠ½Π°Ρ ΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²Π΅Π½Π½ΠΎΡΡ‚ΡŒΒ».The methanol synthesis reactor, catalyst, synthesis gas, column, plate, raw methanol, temperature, pressure. In this thesis project developed a catalytic conversion of synthesis gas to methanol. When performing this work are based on the production of methanol from natural gas. The projected capacity of the installation 815000 tons/year, with the release of the basic substance 99.95 % of the methanol-rectified. The theoretical basis for the production of methanol. The calculations of material and heat balance. Performed mechanical and process calculations, developed a scheme of instrumentation and automation. Developed sections: Financial management, resource efficiency and resource conservation" and "Social responsibility"

    Manidipine regulates the transcription of cytokine genes.

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    Management der PrimΓ€ren CiliΓ€ren Dyskinesie

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    Die PrimΓ€re CiliΓ€re Dyskinesie (PCD, MIM 242650) ist eine seltene hereditΓ€re Multisystemerkrankung mit klinisch heterogenem PhΓ€notyp. Leitsymptom ist eine chronische Sekretretention der oberen und unteren Atemwege, welche durch die Dysfunktion motiler respiratorischer Zilien entsteht. In der Folge kommt es zur Ausbildung von Bronchiektasen, hΓ€ufig zu einer Infektion durch Pseudomonas aeruginosa sowie einer abnehmenden Lungenfunktion bis hin zum Lungenversagen. Bislang gibt es kaum evidenzbasierte Therapieempfehlungen, da randomisierte Langzeitstudien zur Behandlung der PCD fehlten. In diesem Jahr wurden die Daten einer ersten placebokontrollierten Medikamentenstudie bei PCD verΓΆffentlicht. AnlΓ€sslich dieses Meilensteins im Management der PCD wurde der vorliegende Übersichtsartikel als Konsens von Patientenvertretern sowie Klinikern, die langjΓ€hrige Erfahrung in der Behandlung der PCD haben, verfasst. Diese Arbeit bietet eine Zusammenfassung aktuell eingesetzter Behandlungsverfahren, die ΓΌberwiegend auf persΓΆnlichen Erfahrungen und Expertenmeinungen beruhen oder von anderen Atemwegserkrankungen wie der Cystischen Fibrose (CF), COPD oder Bronchiektasen-Erkrankung abgeleitet werden. Da es derzeit keine kurative Therapie fΓΌr PCD gibt, stehen symptomatische Maßnahmen wie die regelmÀßige Reinigung der Atemwege und die Behandlung von rezidivierenden Atemwegsinfektionen im Fokus. Nicht respiratorische Manifestationen werden organspezifisch behandelt. Um neben der ersten Medikamentenstudie mehr evidenzbasiertes Wissen zu generieren, werden weitere Projekte etabliert, u.β€Ša. ein internationales PCD-Register. HierΓΌber wird Patienten der Zugang zu klinischen und wissenschaftlichen Studien erleichtert und die Vernetzung behandelnder Zentren gefΓΆrdert. Des Weiteren kΓΆnnen Erkenntnisse ΓΌber eine Genotyp-spezifische Erkrankungsschwere erlangt werden, um folglich die therapeutische Versorgung der Patienten zu verbessern und somit zu individualisieren. = Primary Ciliary Dyskinesia (PCD, MIM 242650) is a rare, hereditary multiorgan disease characterized by malfunction of motile cilia. Hallmark symptom is a chronic airway infection due to mucostasis leading to irreversible lung damage that may progress to respiratory failure. There is no cure for this genetic disease and evidence-based treatment is limited. Until recently, there were no randomized controlled trials performed in PCD, but this year, data of the first placebo-controlled trial on pharmacotherapy in PCD were published. This cornerstone in the management of PCD was decisive for reviewing currently used treatment strategies. This article is a consensus of patient representatives and clinicians, which are highly experienced in care of PCD-patients and provides an overview of the management of PCD. Treatments are mainly based on expert opinions, personal experiences, or are deduced from other lung diseases, notably cystic fibrosis (CF), COPD or bronchiectasis. Most strategies focus on routine airway clearance and treatment of recurrent respiratory tract infections. Non-respiratory symptoms are treated organ specific. To generate further evidence-based knowledge, other projects are under way, e. g. the International PCD-Registry. Participating in patient registries facilitates access to clinical and research studies and strengthens networks between centers. In addition, knowledge of genotype-specific course of the disease will offer the opportunity to further improve and individualize patient care

    Π Π΅ΠΆΠΈΠΌ Ρ€Π°Π±ΠΎΡ‚Ρ‹ элСктрооборудования Π½Π° Ρ‚Π΅ΠΏΠ»ΠΎΠ²ΠΎΠΉ станции ΠΌΠΎΡ‰Π½ΠΎΡΡ‚ΡŒΡŽ 520 ΠœΠ’Ρ‚

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    Π’ Π΄Π°Π½Π½ΠΎΠΉ выпускной ΠΊΠ²Π°Π»ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ Ρ€Π°Π±ΠΎΡ‚Π΅ Π±Ρ‹Π»Π° спроСктирована элСктричСская Ρ‡Π°ΡΡ‚ΡŒ кондСнсационной элСктричСской станции. Π‘Ρ‹Π»ΠΈ рассчитаны Ρ€Π΅ΠΆΠΈΠΌΡ‹ Π΅Π΅ Ρ€Π°Π±ΠΎΡ‚Ρ‹ ΠΈ Π² ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΠ΅ "мустанг Π±Ρ‹Π» смодСлирован самозапуск Π΄Π²ΠΈΠ³Π°Ρ‚Π΅Π»Π΅ΠΉ собствСнных Π½ΡƒΠΆΠ΄.In this final qualification work, the electrical part of the condensation power plant was designed. Its modes of operation were calculated and the self-launching of self-propelled engines was modeled in the Mustang program

    ΠŸΡ€ΠΎΠ΅ΠΊΡ‚ ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ Ρ€Π΅ΠΌΠΎΠ½Ρ‚Π½ΠΎΠΉ мастСрской Π² условиях ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ "БандайскоС ΠΊΠΎΠ»Π»Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΠ΅ ΡΠ΅Π»ΡŒΡ…ΠΎΠ·ΠΏΡ€Π΅Π΄ΠΏΡ€ΠΈΡΡ‚ΠΈΠ΅" ΠΏ. ВяТин, ΠšΠ΅ΠΌΠ΅Ρ€ΠΎΠ²ΡΠΊΠΎΠΉ области

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    Анотация Π’ обСспСчСнии ΡƒΡΠΏΠ΅ΡˆΠ½ΠΎΠΉ Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ хозяйств, ваТная Ρ€ΠΎΠ»ΡŒ ΠΏΡ€ΠΈΠ½Π°Π΄Π»Π΅ΠΆΠΈΡ‚ ΠΈΡ… Ρ€Π΅ΠΌΠΎΠ½Ρ‚Π½ΠΎΠΉ слуТбС. БСльскоС хозяйство страны располагаСт Ρ€Π°Π·Π²ΠΈΡ‚ΠΎΠΉ систСмой Ρ€Π΅ΠΌΠΎΠ½Ρ‚Π½ΠΎ-ΠΎΠ±ΡΠ»ΡƒΠΆΠΈΠ²Π°ΡŽΡ‰ΠΈΡ… прСдприятий ΠΈ мастСрских хозяйств, ΠΏΡƒΠ½ΠΊΡ‚ΠΎΠ² тСхничСского обслуТивания машин. Однако ΠΏΠ΅Ρ€Π΅Π΄ сСльским хозяйством стоят ΡΠ΅Ρ€ΡŒΠ΅Π·Π½Ρ‹Π΅ Π·Π°Π΄Π°Ρ‡ΠΈ ΠΏΠΎ ΡΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½ΡΡ‚Π²ΠΎΠ²Π°Π½ΠΈΡŽ ΠΈΠ½ΠΆΠ΅Π½Π΅Ρ€Π½ΠΎΠΉ слуТбы Π½Π° сСлС. Π‘Ρ‚Ρ€Π°Π½Π° Π΅Ρ‰Ρ‘ нСсСт большиС ΠΏΠΎΡ‚Π΅Ρ€ΠΈ ΠΈΠ·-Π·Π° Π²Ρ‹Ρ…ΠΎΠ΄Π° машин ΠΈΠ· строя, ΠΈΡ… нСвысокого рСсурса, нСвысокого качСства Ρ€Π΅ΠΌΠΎΠ½Ρ‚Π° ΠΈ тСхничСского обслуТивания. БущСствСнным ΠΎΠ±ΡΡ‚ΠΎΡΡ‚Π΅Π»ΡŒΡΡ‚Π²ΠΎΠΌ, Π΄Π΅ΠΉΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠΌ Π² ΠΏΠΎΠ»ΡŒΠ·Ρƒ развития собствСнных Ρ€Π΅ΠΌΠΎΠ½Ρ‚Π½Ρ‹Ρ… мастСрских хозяйств, являСтся Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ выполнСния ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Π½ΠΎΠ³ΠΎ объСма Ρ€Π΅ΠΌΠΎΠ½Ρ‚Π½Ρ‹Ρ… Ρ€Π°Π±ΠΎΡ‚ Π² осСннС-Π·ΠΈΠΌΠ½ΠΈΠΉ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ силами Ρ€Π°Π±ΠΎΡ‚Π½ΠΈΠΊΠΎΠ² хозяйств, Π½Π΅ занятых ΡΠ΅Π»ΡŒΡΠΊΠΎΡ…ΠΎΠ·ΡΠΉΡΡ‚Π²Π΅Π½Π½Ρ‹ΠΌΠΈ Ρ€Π°Π±ΠΎΡ‚Π°ΠΌΠΈ. Π­Ρ‚ΠΎ ΠΏΠΎΠ²Ρ‹ΡˆΠ°Π΅Ρ‚ Π·Π°Π½ΡΡ‚ΠΎΡΡ‚ΡŒ Π² хозяйствСAnnotation In ensuring the success of the economy, an important role belongs to their repair service. The country's agriculture has developed a system repair and service enterprises and workshops farms, settlements maintenance of machinery. However, before agriculture faces serious challenges in improving the engineering service in rural areas. The country still suffers great losses because of the failure of the machines, their low resources, poor quality of repair and maintenance. An important fact, acting in favor of the development of their own repair shops farms, is the ability to perform a certain amount of repair work in the autumn-winter period the forces of farm workers are not engaged in agricultural work. This increases employment in the sector of workers and contributes to the stabilization frames

    Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

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    Sphingosine-1-phosphate (S1P) participates in inflammation;however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through endothelial S1P receptor 3 (S1P(3)) and G alpha(q), PLC beta and Ca2+. Intraarterial S1P administration increases leukocyte rolling, while S1P(3) deficiency or inhibition dramatically reduces it. Mast cells involved in triggering rolling also release S1P that mobilizes P-selectin through S1P(3). Histamine and epinephrine require S1P(3) for full-scale effect accomplishing it by stimulating sphingosine kinase 1 (Sphk1). In a counter-regulatory manner, S1P1 inhibits cAMP-stimulated Sphk1 and blocks rolling as observed in endothelial-specific S1P(1)(-/-) mice. In agreement with a dominant pro-rolling effect of S1P(3),FTY720 inhibits rolling in control and S1P(1)(-/-) but not in S1P(3)(-/-) mice. Our findings identify S1P as a direct and indirect contributor to leukocyte rolling and characterize the receptors mediating its action

    A Jungly Feeling: the Atmospheric Design of Zoos

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    This is the author accepted manuscript. The final version is available from Palgrave Macmillan via the DOI in this recordThis chapter examines the importance of atmosphere in understanding our experiences of zoos. It focuses in particular on the role played by sound in the production of atmospheres in the zoo context. Zoos often work hard to generate atmospheres which are appropriate to their purpose as sites for entertainment, education and conservation, and the encouragement of environmentally responsible behaviour. Drawing on first-hand experiences and observations of zoo visiting, the chapter considers some of the different types of atmosphere that zoos create, pointing to some of the ways in which atmospheres may allude or resist the attempts made to direct or construct them. The chapter also suggests that the non-human animals kept in zoos are likely to have their own atmospheric experiences of zoo space, which are perhaps very different in character from those of visitors and staff. We argue that zoos are atmospherically heterogeneous and complex and face continual challenges as they try to design and maintain atmospheres in line with institutional aims and visitor expectations. A key atmospheric challenge for zoos is to reconcile visitors’ desire to observe and experience forms of natural and ecological otherness with the realities of managing and displaying closely controlled animal populations
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