354 research outputs found
Π‘ΠΈΡΡΠ΅ΠΌΠ° Π°Π²ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π³ΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΡΠ΅ΠΏΠ»ΠΎΠ½ΠΎΡΠΈΡΠ΅Π»Ρ ΡΠ΅ΠΏΠ»ΠΎΡΠ΅ΡΠΈ ΠΊΠΎΡΠ΅Π»ΡΠ½ΠΎΠΉ β4 ΠΠΠ Β«ΠΠ°Π·ΠΏΡΠΎΠΌ Π’ΡΠ°Π½ΡΠ³Π°Π· Π’ΠΎΠΌΡΠΊΒ»
ΠΡΠΏΡΡΠΊΠ½Π°Ρ ΠΊΠ²Π°Π»ΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ°Π±ΠΎΡΠ° ΡΠΎΠ΄Π΅ΡΠΆΠΈΡ 112 Ρ., ΡΠΈΡ.12, ΡΠ°Π±Π».29, 19 ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ², ΠΏΡΠΈΠ».6.
ΠΠ±ΡΠ΅ΠΊΡΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΈΡΡΠ΅ΠΌΠ° ΡΠ΅ΠΏΠ»ΠΎΡΠ½Π°Π±ΠΆΠ΅Π½ΠΈΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Π·Π΄Π°Π½ΠΈΠΉ Π£ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΠΈΠ‘Π’ ΠΠΠ ?ΠΠ°Π·ΠΏΡΠΎΠΌ Π’ΡΠ°Π½ΡΠ³Π°Π· Π’ΠΎΠΌΡΠΊ? Π² Π³. Π’ΠΎΠΌΡΠΊΠ΅.
Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° Π‘ΠΠ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΡΠ΅ΠΏΠ»ΠΎΠ½ΠΎΡΠΈΡΠ΅Π»Ρ ΡΠ΅ΠΏΠ»ΠΎΡΠ΅ΡΠΈ Π΄Π»Ρ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ΅ΠΏΠ»ΠΎΡΠ½Π°Π±ΠΆΠ΅Π½ΠΈΡ.
Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΡΠ°Π±ΠΎΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ Π°Π½Π°Π»ΠΈΠ· ΠΎΠ±ΡΠ΅ΠΊΡΠ° ΡΠ΅Π³ΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ, ΡΡΡΡΠΊΡΡΡΠ½ΠΎΠΉ, ΠΈ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡ
Π΅ΠΌΡ Π‘ΠΠ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΡΠ΅ΠΏΠ»ΠΎΠ½ΠΎΡΠΈΡΠ΅Π»Ρ, ΡΠ°ΡΡΠ΅Ρ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² Π½Π°ΡΡΡΠΎΠΉΠΊΠΈ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ°, Π²ΡΠ±ΠΎΡ ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ² Π°Π²ΡΠΎΠΌΠ°ΡΠΈΠ·Π°ΡΠΈΠΈ Π΄Π»Ρ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ΅ΠΊΡΠ°. Π Ρ
ΠΎΠ΄Π΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΡΠΎΠΈΠ·Π²Π΅Π΄Π΅Π½Π° ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠΈΡΡΠ΅ΠΌΡ Π°Π²ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π³ΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΡΠ΅ΠΏΠ»ΠΎΠ½ΠΎΡΠΈΡΠ΅Π»Ρ Π½Π° Π±Π°Π·Π΅ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ² Π°Π²ΡΠΎΠΌΠ°ΡΠΈΠ·Π°ΡΠΈΠΈ.Final qualifying work contains 112 pages., pictures12, 29 tables, 19 sources, applications 6.
The object of research is the system of heat supply of the complex motor and special transport management of buildings LLC "Gazprom Transgaz Tomsk" in Tomsk.
Objective - Development of automatic control system coolant temperature heating system for the heating system.
In carrying out the work, an analysis of the object of regulation, the development of functional, structural, and electrical schematic diagram of the system of automatic control of the flow temperature, the calculation of the optimal controller settings, the choice of means of automation of the object
ΠΡΠΎΠ΅ΠΊΡ ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ΅Π²ΡΠ°ΡΠ΅Π½ΠΈΡ ΡΠΈΠ½ΡΠ΅Π·-Π³Π°Π·Π° Π² ΠΌΠ΅ΡΠ°Π½ΠΎΠ»
Π Π΄Π°Π½Π½ΠΎΠΌ Π΄ΠΈΠΏΠ»ΠΎΠΌΠ½ΠΎΠΌ ΠΏΡΠΎΠ΅ΠΊΡΠ΅ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠ° ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ΅Π²ΡΠ°ΡΠ΅Π½ΠΈΡ ΡΠΈΠ½ΡΠ΅Π·-Π³Π°Π·Π° Π² ΠΌΠ΅ΡΠ°Π½ΠΎΠ». ΠΡΠΈ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠΈ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΠΎΡΠ½ΠΎΠ²ΡΠ²Π°ΡΡΡ Π½Π° ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²ΠΎ ΠΌΠ΅ΡΠ°Π½ΠΎΠ»Π° ΠΈΠ· ΠΏΡΠΈΡΠΎΠ΄Π½ΠΎΠ³ΠΎ Π³Π°Π·Π°. ΠΠΎΡΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ΅ΠΊΡΠΈΡΡΠ΅ΠΌΠΎΠΉ ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ 815000 Ρ/Π³ΠΎΠ΄, Ρ Π²ΡΡ
ΠΎΠ΄ΠΎΠΌ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠ³ΠΎ Π²Π΅ΡΠ΅ΡΡΠ²Π° 99,95 % Π² ΠΌΠ΅ΡΠ°Π½ΠΎΠ»Π΅-ΡΠ΅ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠ΅. ΠΠ·Π»ΠΎΠΆΠ΅Π½Ρ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠ½ΠΎΠ²Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΡΠ°Π½ΠΎΠ»Π°. ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ°ΡΡΠ΅ΡΡ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΡΠ΅ΠΏΠ»ΠΎΠ²ΠΎΠ³ΠΎ Π±Π°Π»Π°Π½ΡΠΎΠ². ΠΡΠΏΠΎΠ»Π½Π΅Π½Ρ ΠΌΠ΅Ρ
Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ°ΡΡΠ΅ΡΡ, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° ΡΡ
Π΅ΠΌΠ° ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎ-ΠΈΠ·ΠΌΠ΅ΡΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΠΈΠ±ΠΎΡΠΎΠ² ΠΈ Π°Π²ΡΠΎΠΌΠ°ΡΠΈΠ·Π°ΡΠΈΠΈ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΡΠ°Π·Π΄Π΅Π»Ρ: Β«Π€ΠΈΠ½Π°Π½ΡΠΎΠ²ΡΠΉ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ, ΡΠ΅ΡΡΡΡΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ ΡΠ΅ΡΡΡΡΠΎΡΠ±Π΅ΡΠ΅ΠΆΠ΅Π½ΠΈΠ΅Β» ΠΈ Β«Π‘ΠΎΡΠΈΠ°Π»ΡΠ½Π°Ρ ΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎΡΡΡΒ».The methanol synthesis reactor, catalyst, synthesis gas, column, plate, raw methanol, temperature, pressure. In this thesis project developed a catalytic conversion of synthesis gas to methanol. When performing this work are based on the production of methanol from natural gas. The projected capacity of the installation 815000 tons/year, with the release of the basic substance 99.95 % of the methanol-rectified. The theoretical basis for the production of methanol. The calculations of material and heat balance. Performed mechanical and process calculations, developed a scheme of instrumentation and automation. Developed sections: Financial management, resource efficiency and resource conservation" and "Social responsibility"
Management der PrimΓ€ren CiliΓ€ren Dyskinesie
Die PrimΓ€re CiliΓ€re Dyskinesie (PCD, MIM 242650) ist eine seltene hereditΓ€re Multisystemerkrankung mit klinisch heterogenem PhΓ€notyp. Leitsymptom ist eine chronische Sekretretention der oberen und unteren Atemwege, welche durch die Dysfunktion motiler respiratorischer Zilien entsteht. In der Folge kommt es zur Ausbildung von Bronchiektasen, hΓ€ufig zu einer Infektion durch Pseudomonas aeruginosa sowie einer abnehmenden Lungenfunktion bis hin zum Lungenversagen.
Bislang gibt es kaum evidenzbasierte Therapieempfehlungen, da randomisierte Langzeitstudien zur Behandlung der PCD fehlten. In diesem Jahr wurden die Daten einer ersten placebokontrollierten Medikamentenstudie bei PCD verΓΆffentlicht. AnlΓ€sslich dieses Meilensteins im Management der PCD wurde der vorliegende Γbersichtsartikel als Konsens von Patientenvertretern sowie Klinikern, die langjΓ€hrige Erfahrung in der Behandlung der PCD haben, verfasst. Diese Arbeit bietet eine Zusammenfassung aktuell eingesetzter Behandlungsverfahren, die ΓΌberwiegend auf persΓΆnlichen Erfahrungen und Expertenmeinungen beruhen oder von anderen Atemwegserkrankungen wie der Cystischen Fibrose (CF), COPD oder Bronchiektasen-Erkrankung abgeleitet werden. Da es derzeit keine kurative Therapie fΓΌr PCD gibt, stehen symptomatische MaΓnahmen wie die regelmΓ€Γige Reinigung der Atemwege und die Behandlung von rezidivierenden Atemwegsinfektionen im Fokus. Nicht respiratorische Manifestationen werden organspezifisch behandelt. Um neben der ersten Medikamentenstudie mehr evidenzbasiertes Wissen zu generieren, werden weitere Projekte etabliert, u.βa. ein internationales PCD-Register. HierΓΌber wird Patienten der Zugang zu klinischen und wissenschaftlichen Studien erleichtert und die Vernetzung behandelnder Zentren gefΓΆrdert. Des Weiteren kΓΆnnen Erkenntnisse ΓΌber eine Genotyp-spezifische Erkrankungsschwere erlangt werden, um folglich die therapeutische Versorgung der Patienten zu verbessern und somit zu individualisieren.
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Primary Ciliary Dyskinesia (PCD, MIM 242650) is a rare, hereditary multiorgan disease characterized by malfunction of motile cilia. Hallmark symptom is a chronic airway infection due to mucostasis leading to irreversible lung damage that may progress to respiratory failure. There is no cure for this genetic disease and evidence-based treatment is limited. Until recently, there were no randomized controlled trials performed in PCD, but this year, data of the first placebo-controlled trial on pharmacotherapy in PCD were published. This cornerstone in the management of PCD was decisive for reviewing currently used treatment strategies. This article is a consensus of patient representatives and clinicians, which are highly experienced in care of PCD-patients and provides an overview of the management of PCD. Treatments are mainly based on expert opinions, personal experiences, or are deduced from other lung diseases, notably cystic fibrosis (CF), COPD or bronchiectasis. Most strategies focus on routine airway clearance and treatment of recurrent respiratory tract infections. Non-respiratory symptoms are treated organ specific. To generate further evidence-based knowledge, other projects are under way, e. g. the International PCD-Registry. Participating in patient registries facilitates access to clinical and research studies and strengthens networks between centers. In addition, knowledge of genotype-specific course of the disease will offer the opportunity to further improve and individualize patient care
Π Π΅ΠΆΠΈΠΌ ΡΠ°Π±ΠΎΡΡ ΡΠ»Π΅ΠΊΡΡΠΎΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΡ Π½Π° ΡΠ΅ΠΏΠ»ΠΎΠ²ΠΎΠΉ ΡΡΠ°Π½ΡΠΈΠΈ ΠΌΠΎΡΠ½ΠΎΡΡΡΡ 520 ΠΠΡ
Π Π΄Π°Π½Π½ΠΎΠΉ Π²ΡΠΏΡΡΠΊΠ½ΠΎΠΉ ΠΊΠ²Π°Π»ΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ Π±ΡΠ»Π° ΡΠΏΡΠΎΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½Π° ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ°ΡΡΡ ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠ°Π½ΡΠΈΠΈ. ΠΡΠ»ΠΈ ΡΠ°ΡΡΡΠΈΡΠ°Π½Ρ ΡΠ΅ΠΆΠΈΠΌΡ Π΅Π΅ ΡΠ°Π±ΠΎΡΡ ΠΈ Π² ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ΅ "ΠΌΡΡΡΠ°Π½Π³ Π±ΡΠ» ΡΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ ΡΠ°ΠΌΠΎΠ·Π°ΠΏΡΡΠΊ Π΄Π²ΠΈΠ³Π°ΡΠ΅Π»Π΅ΠΉ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΡ
Π½ΡΠΆΠ΄.In this final qualification work, the electrical part of the condensation power plant was designed. Its modes of operation were calculated and the self-launching of self-propelled engines was modeled in the Mustang program
ΠΡΠΎΠ΅ΠΊΡ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ ΡΠ΅ΠΌΠΎΠ½ΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΠ΅ΡΡΠΊΠΎΠΉ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ "Π‘Π°Π½Π΄Π°ΠΉΡΠΊΠΎΠ΅ ΠΊΠΎΠ»Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΡΠ΅Π»ΡΡ ΠΎΠ·ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΠ΅" ΠΏ. Π’ΡΠΆΠΈΠ½, ΠΠ΅ΠΌΠ΅ΡΠΎΠ²ΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ
ΠΠ½ΠΎΡΠ°ΡΠΈΡ
Π ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΠΈ ΡΡΠΏΠ΅ΡΠ½ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Ρ
ΠΎΠ·ΡΠΉΡΡΠ², Π²Π°ΠΆΠ½Π°Ρ ΡΠΎΠ»Ρ ΠΏΡΠΈΠ½Π°Π΄Π»Π΅ΠΆΠΈΡ ΠΈΡ
ΡΠ΅ΠΌΠΎΠ½ΡΠ½ΠΎΠΉ ΡΠ»ΡΠΆΠ±Π΅. Π‘Π΅Π»ΡΡΠΊΠΎΠ΅ Ρ
ΠΎΠ·ΡΠΉΡΡΠ²ΠΎ ΡΡΡΠ°Π½Ρ ΡΠ°ΡΠΏΠΎΠ»Π°Π³Π°Π΅Ρ ΡΠ°Π·Π²ΠΈΡΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠΎΠΉ ΡΠ΅ΠΌΠΎΠ½ΡΠ½ΠΎ-ΠΎΠ±ΡΠ»ΡΠΆΠΈΠ²Π°ΡΡΠΈΡ
ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΠΉ ΠΈ ΠΌΠ°ΡΡΠ΅ΡΡΠΊΠΈΡ
Ρ
ΠΎΠ·ΡΠΉΡΡΠ², ΠΏΡΠ½ΠΊΡΠΎΠ² ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±ΡΠ»ΡΠΆΠΈΠ²Π°Π½ΠΈΡ ΠΌΠ°ΡΠΈΠ½. ΠΠ΄Π½Π°ΠΊΠΎ ΠΏΠ΅ΡΠ΅Π΄ ΡΠ΅Π»ΡΡΠΊΠΈΠΌ Ρ
ΠΎΠ·ΡΠΉΡΡΠ²ΠΎΠΌ ΡΡΠΎΡΡ ΡΠ΅ΡΡΠ΅Π·Π½ΡΠ΅ Π·Π°Π΄Π°ΡΠΈ ΠΏΠΎ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΡ ΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠ½ΠΎΠΉ ΡΠ»ΡΠΆΠ±Ρ Π½Π° ΡΠ΅Π»Π΅. Π‘ΡΡΠ°Π½Π° Π΅ΡΡ Π½Π΅ΡΠ΅Ρ Π±ΠΎΠ»ΡΡΠΈΠ΅ ΠΏΠΎΡΠ΅ΡΠΈ ΠΈΠ·-Π·Π° Π²ΡΡ
ΠΎΠ΄Π° ΠΌΠ°ΡΠΈΠ½ ΠΈΠ· ΡΡΡΠΎΡ, ΠΈΡ
Π½Π΅Π²ΡΡΠΎΠΊΠΎΠ³ΠΎ ΡΠ΅ΡΡΡΡΠ°, Π½Π΅Π²ΡΡΠΎΠΊΠΎΠ³ΠΎ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΡΠ΅ΠΌΠΎΠ½ΡΠ° ΠΈ ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±ΡΠ»ΡΠΆΠΈΠ²Π°Π½ΠΈΡ.
Π‘ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌ ΠΎΠ±ΡΡΠΎΡΡΠ΅Π»ΡΡΡΠ²ΠΎΠΌ, Π΄Π΅ΠΉΡΡΠ²ΡΡΡΠΈΠΌ Π² ΠΏΠΎΠ»ΡΠ·Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠ΅ΠΌΠΎΠ½ΡΠ½ΡΡ
ΠΌΠ°ΡΡΠ΅ΡΡΠΊΠΈΡ
Ρ
ΠΎΠ·ΡΠΉΡΡΠ², ΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ΅ΠΌΠ° ΡΠ΅ΠΌΠΎΠ½ΡΠ½ΡΡ
ΡΠ°Π±ΠΎΡ Π² ΠΎΡΠ΅Π½Π½Π΅-Π·ΠΈΠΌΠ½ΠΈΠΉ ΠΏΠ΅ΡΠΈΠΎΠ΄ ΡΠΈΠ»Π°ΠΌΠΈ ΡΠ°Π±ΠΎΡΠ½ΠΈΠΊΠΎΠ² Ρ
ΠΎΠ·ΡΠΉΡΡΠ², Π½Π΅ Π·Π°Π½ΡΡΡΡ
ΡΠ΅Π»ΡΡΠΊΠΎΡ
ΠΎΠ·ΡΠΉΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ ΡΠ°Π±ΠΎΡΠ°ΠΌΠΈ. ΠΡΠΎ ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ Π·Π°Π½ΡΡΠΎΡΡΡ Π² Ρ
ΠΎΠ·ΡΠΉΡΡΠ²Π΅Annotation
In ensuring the success of the economy, an important role belongs to their repair service. The country's agriculture has developed a system repair and service enterprises and workshops farms, settlements maintenance of machinery. However, before agriculture faces serious challenges in improving the engineering service in rural areas. The country still suffers great losses because of the failure of the machines, their low resources, poor quality of repair and maintenance.
An important fact, acting in favor of the development of their own repair shops farms, is the ability to perform a certain amount of repair work in the autumn-winter period the forces of farm workers are not engaged in agricultural work. This increases employment in the sector of workers and contributes to the stabilization frames
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
Sphingosine-1-phosphate (S1P) participates in inflammation;however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through endothelial S1P receptor 3 (S1P(3)) and G alpha(q), PLC beta and Ca2+. Intraarterial S1P administration increases leukocyte rolling, while S1P(3) deficiency or inhibition dramatically reduces it. Mast cells involved in triggering rolling also release S1P that mobilizes P-selectin through S1P(3). Histamine and epinephrine require S1P(3) for full-scale effect accomplishing it by stimulating sphingosine kinase 1 (Sphk1). In a counter-regulatory manner, S1P1 inhibits cAMP-stimulated Sphk1 and blocks rolling as observed in endothelial-specific S1P(1)(-/-) mice. In agreement with a dominant pro-rolling effect of S1P(3),FTY720 inhibits rolling in control and S1P(1)(-/-) but not in S1P(3)(-/-) mice. Our findings identify S1P as a direct and indirect contributor to leukocyte rolling and characterize the receptors mediating its action
A Jungly Feeling: the Atmospheric Design of Zoos
This is the author accepted manuscript. The final version is available from Palgrave Macmillan via the DOI in this recordThis chapter examines the importance of atmosphere in understanding our experiences of zoos. It focuses in particular on the role played by sound in the production of atmospheres in the zoo context. Zoos often work hard to generate atmospheres which are appropriate to their purpose as sites for entertainment, education and conservation, and the encouragement of environmentally responsible behaviour. Drawing on first-hand experiences and observations of zoo visiting, the chapter considers some of the different types of atmosphere that zoos create, pointing to some of the ways in which atmospheres may allude or resist the attempts made to direct or construct them. The chapter also suggests that the non-human animals kept in zoos are likely to have their own atmospheric experiences of zoo space, which are perhaps very different in character from those of visitors and staff. We argue that zoos are atmospherically heterogeneous and complex and face continual challenges as they try to design and maintain atmospheres in line with institutional aims and visitor expectations. A key atmospheric challenge for zoos is to reconcile visitorsβ desire to observe and experience forms of natural and ecological otherness with the realities of managing and displaying closely controlled animal populations
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