468 research outputs found
Energy radiation of moving cracks
The energy radiated by moving cracks in a discrete background is analyzed.
The energy flow through a given surface is expressed in terms of a generalized
Poynting vector. The velocity of the crack is determined by the radiation by
the crack tip. The radiation becomes more isotropic as the crack velocity
approaches the instability threshold.Comment: 7 pages, embedded figure
Correlation between muonic levels and nuclear structure in muonic atoms
A method that deals with the nucleons and the muon unitedly is employed to
investigate the muonic lead, with which the correlation between the muon and
nucleus can be studied distinctly. A "kink" appears in the muonic isotope shift
at a neutron magic number where the nuclear shell structure plays a key role.
This behavior may have very important implications for the experimentally
probing the shell structure of the nuclei far away from the -stable
line. We investigate the variations of the nuclear structure due to the
interaction with the muon in the muonic atom and find that the nuclear
structure remains basically unaltered. Therefore, the muon is a clean and
reliable probe for studying the nuclear structure. In addition, a correction
that the muon-induced slight change in the proton density distribution in turn
shifts the muonic levels is investigated. This correction to muonic level is as
important as the Lamb shift and high order vacuum polarization correction, but
is larger than anomalous magnetic moment and electron shielding correction.Comment: 2 figure
Universality in Bacterial Colonies
The emergent spatial patterns generated by growing bacterial colonies have
been the focus of intense study in physics during the last twenty years. Both
experimental and theoretical investigations have made possible a clear
qualitative picture of the different structures that such colonies can exhibit,
depending on the medium on which they are growing. However, there are
relatively few quantitative descriptions of these patterns. In this paper, we
use a mechanistically detailed simulation framework to measure the scaling
exponents associated with the advancing fronts of bacterial colonies on hard
agar substrata, aiming to discern the universality class to which the system
belongs. We show that the universal behavior exhibited by the colonies can be
much richer than previously reported, and we propose the possibility of up to
four different sub-phases within the medium-to-high nutrient concentration
regime. We hypothesize that the quenched disorder that characterizes one of
these sub-phases is an emergent property of the growth and division of bacteria
competing for limited space and nutrients.Comment: 12 pages, 5 figure
Acting on incidental findings in research imaging
No abstract available
Induction of broad multifunctional CD8+ and CD4+ T cells by hepatitis B virus antigen-based synthetic long peptides ex vivo
Introduction: Therapeutic vaccination based on synthetic long peptides (SLP®) containing both CD4+ and CD8+ T cell epitopes is a promising treatment strategy for chronic hepatitis B infection (cHBV). Methods: We designed SLPs for three HBV proteins, HBcAg and the non-secreted proteins polymerase and X, and investigated their ability to induce T cell responses ex vivo. A set of 17 SLPs was constructed based on viral protein conservation, functionality, predicted and validated binders for prevalent human leukocyte antigen (HLA) supertypes, validated HLA I epitopes, and chemical producibility. Results: All 17 SLPs were capable of inducing interferon gamma (IFNɣ) production in samples from four or more donors that had resolved an HBV infection in the past (resolver). Further analysis of the best performing SLPs demonstrated activation of both CD8+ and CD4+ multi-functional T cells in one or more resolver and patient sample(s). When investigating which SLP could activate HBV-specific T cells, the responses could be traced back to different peptides for each patient or resolver. Discussion: This indicates that a large population of subjects with different HLA types can be covered by selecting a suitable mix of SLPs for therapeutic vaccine design. In conclusion, we designed a set of SLPs capable of inducing multifunctional CD8+ and CD4+ T cells ex vivo that create important components for a novel therapeutic vaccine to cure cHBV.</p
A mean-field kinetic lattice gas model of electrochemical cells
We develop Electrochemical Mean-Field Kinetic Equations (EMFKE) to simulate
electrochemical cells. We start from a microscopic lattice-gas model with
charged particles, and build mean-field kinetic equations following the lines
of earlier work for neutral particles. We include the Poisson equation to
account for the influence of the electric field on ion migration, and
oxido-reduction processes on the electrode surfaces to allow for growth and
dissolution. We confirm the viability of our approach by simulating (i) the
electrochemical equilibrium at flat electrodes, which displays the correct
charged double-layer, (ii) the growth kinetics of one-dimensional
electrochemical cells during growth and dissolution, and (iii) electrochemical
dendrites in two dimensions.Comment: 14 pages twocolumn, 17 figure
Prevalence and correlates of respiratory and non-respiratory panic attacks in the general population
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