Circular business model innovation in incumbents: a tool for tactical experimentation

This paper addresses the following question using a design science approach: How to design and integrate a tactical decision-making artifact that facilitates the circular business model experimentation process with the customer in the B2B context of an incumbent company?The paper contributes to the literature in two ways. Firstly, it presents one solution for integrating impact assessments in the decision-making processes of CBM experimentation, addressing the lack of impact assessments in business model research. Secondly, the paper builds upon the micro-foundations of dynamic capabilities (Santa-Maria, Vermeulen & Baumgartner, 2022) and operational management actions needed for experimentation capability (Bocken & Konietzko, 2022b) to make the experimentation discourse more tactical

Effect of intracanal time of triple antibiotic paste on its removal from simulated immature roots using passive ultrasonic irrigation and XP-endo Finisher

Background. The aim of this study was to evaluate the effectiveness of different irrigation techniques in the removal of triple antibiotic paste (TAP), which was applied for 7, 21 or 90 days, from simulated root canals of immature teeth. Methods. The root canal spaces of 190 maxillary canine teeth were filled with TAP and randomly divided into a control and 3 experimental groups according to the intracanal medicament period (7, 21 or 90 days). Syringe irrigation (SI), passive ultrasonic irrigation (PUI) and XP-endo Finisher (XP) were used for the removal of TAP (n=20). The amount of remaining medicament was calculated under a stereomicroscope using a 4-grade scoring system. Kruskal-Wallis H and Wilcoxon signedrank tests were used for statistical analyses (P0.05), whereas the efficacy of SI and XP was significantly affected (P0.05); however, at 90-day interval, PUI removed significantly greater amount of TAP than XP did (P<0.05). Conclusion. The time of the TAP in the root canal negatively affected the removal efficacy of the SI and XP-Endo Finisher; however, it did not affect the efficacy of the PUI

Efficacy of novel thermomechanically treated reciprocating systems for gutta-percha removal from root canals obturated with warm vertical compaction

Background. The present study aimed to test the efficacy of novel reciprocating systems in terms of gutta-percha removal from root canals obturated with warm vertical compaction technique. Methods. Ninety straight-rooted maxillary incisors were enlarged with hand files up to a #50/02 apical size and obturated using warm vertical compaction technique. The specimens were divided into four groups according to the system used for removal of obturating material: Reciproc Blue, Reciproc, WaveOne Gold and hand instrumentation. The residual filling materials and time required for root canal removal were calculated. Statistical analyses were performed using one-way ANOVA and Tukey tests at 5% significance threshold. Results. There were no significant differences among Reciproc, Reciproc Blue and WaveOne Gold (P>0.05). The hand instrumentation group exhibited significantly more resisual root canal filling material (P<0.05). The time required for root canal filling removal was significantly shorter in the Reciproc group followed by WaveOne Gold, Reciproc Blue and hand instrumentation groups (P<0.05). Conclusion. Efficacy of Reciproc Blue, WaveOne Gold and Reciproc instruments for root canal filling removal were similar and superior to hand instrumentation

Circular Economy in Industrial Design Research:A Review

In the past decades, industrial design practice and research have focused extensively on how to optimize production and consumption, as a way to prevent negative environmental impacts, such as resource depletion, pollution, and excessive waste. Recently, the “circular economy” concept is increasingly used to achieve environmental benefits and economic growth simultaneously. Industrial design can contribute to a circular economy by fostering systems changes to achieve durability, optimal reuse, refurbishment, remanufacturing, and recycling of products and materials. Indeed, researchers have examined both the theoretical and practical aspects of how design knowledge can support the transition to a circular economy. However, this body of knowledge has not been systematically analyzed yet. To address this critical gap, this paper poses the following question: How has industrial design research so far contributed to advancing the circular economy knowledge? Accordingly, we survey relevant design literature focusing on the circular economy, through a review of contributions published in 42 scientific journals. Based on our results, we discuss how industrial design practices can potentially contribute to a circular economy across four thematic areas: (1) design for circular production processes, (2) design for circular consumption, (3) design to support policy towards the circular economy, and (4) design education for the circular economy.Marketing and Consumer Researc

Protein substitutions as new-generation pharmanutrition approach to managing phenylketonuria

Phenylketonuria (PKU), an autosomal recessive inherited metabolic disorder, is caused by a mutation in the phenylalanine hydroxylase (PAH) gene on the 12th chromosome. Defective PAH activity ultimately leads to increased phenylalanine (Phe) blood concentrations (hyperphenylalaninemia) that harm the brain. The primary purpose of PKU treatment is to maintain the blood Phe level to prevent certain undesired effects. Hence, lifelong medical nutrition therapy is recommended for these patients. The usefulness of natural protein sources may be limited, as they are based on individual Phe tolerance, and a patient’s daily protein requirements are supported by Phe-free amino acid mixtures. A few PKU treatment centers recently started using supplemental casein glycomacropeptide, pegvaliase, or large neutral amino acids, and some patients are treated by responding to tetrahydrobiopterin, which works as a pharmaceutical chaperone (prescribed as sapropterin dihydrochloride). This review discusses the efficacy and safety considerations of basic medical nutrition approaches and newgeneration protein substitutes that are used to treat PKU

Beslenme ve sporun adolesan sporcularda büyüme durumuna etkisi

Bu araştırma adolesan dönemde büyüme kriterlerinden boy ve kilo persentil değerleriyle spor aktivitesi ve beslenme durumunun bağlantısını incelemek amacıyla yapılmıştır. Araştırmaya 43 kadın, 50 erkek olmak üzere 93 adölesan sporcu katılmıştır. Araştırma verileri kişisel bilgi formu ve boy kilo ölçümü yapılarak elde edilmiştir. Araştırma sonucunda elde edilen verilerin istatistiksel analizlerinde frekans, yüzde ve Ki-kare Fisher Kesinlik Testi kullanılmıştır. İstatistiksel analizlerde anlamlılık düzeyi olarak (p<0,05) değeri kabul edilmiştir. Elde edilen bulgulardan katılımcıların kendi belirledikleri bir beslenme programını uygulama durumları ile boy persetil ve kilo percentil durumları arasında istatistiksel olarak bağlantılı olduğu tespit edilmiştir (p<0,05). Haftalık antrenman sıklığı, günlük öğün sayısı ve günlük öğün atlama durumlarının ise boy ve kilo persentil durumlarıyla istatistiksel olarak bağlantılı bulunmamıştır (p<0,05). Sonuç olarak herhangi bir uzman tavsiyesine dayanmayan, bilinçsiz uygulanan diyetlerin adolesan dönemde, çocukların boy ve kilo percentil durumunu dolayısıyla büyüme ve gelişim düzeylerini olumsuz etkileyebileceği şeklinde yorumlanabilir

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P &lt; 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely