A High-Resolution Atlas of Uranium-Neon in the H Band

We present a high-resolution (R ~ 50 000) atlas of a uranium-neon (U/Ne) hollow-cathode spectrum in the H-band (1454 nm to 1638 nm) for the calibration of near-infrared spectrographs. We obtained this U/Ne spectrum simultaneously with a laser-frequency comb spectrum, which we used to provide a first-order calibration to the U/Ne spectrum. We then calibrated the U/Ne spectrum using the recently-published uranium line list of Redman et al. (2011), which is derived from high-resolution Fourier transform spectrometer measurements. These two independent calibrations allowed us to easily identify emission lines in the hollow cathode lamp that do not correspond to known (classified) lines of either uranium or neon, and to compare the achievable precision of each source. Our frequency comb precision was limited by modal noise and detector effects, while the U/Ne precision was limited primarily by the signal-to-noise ratio (S/N) of the observed emission lines and our ability to model blended lines. The standard deviation in the dispersion solution residuals from the S/N-limited U/Ne hollow cathode lamp were 50% larger than the standard deviation of the dispersion solution residuals from the modal-noise-limited laser frequency comb. We advocate the use of U/Ne lamps for precision calibration of near-infrared spectrographs, and this H-band atlas makes these lamps significantly easier to use for wavelength calibration.Comment: 23 pages, 7 figures, submitted and accepted in ApJSS. Online-only material to be published online by ApJS

Realistic atomistic structure of amorphous silicon from machine-learning-driven molecular dynamics

Amorphous silicon (a-Si) is a widely studied noncrystalline material, and yet the subtle details of its atomistic structure are still unclear. Here, we show that accurate structural models of a-Si can be obtained using a machine-learning-based interatomic potential. Our best a-Si network is obtained by simulated cooling from the melt at a rate of 1011 K/s (that is, on the 10 ns time scale), contains less than 2% defects, and agrees with experiments regarding excess energies, diffraction data, and 29Si NMR chemical shifts. We show that this level of quality is impossible to achieve with faster quench simulations. We then generate a 4096-atom system that correctly reproduces the magnitude of the first sharp diffraction peak (FSDP) in the structure factor, achieving the closest agreement with experiments to date. Our study demonstrates the broader impact of machine-learning potentials for elucidating structures and properties of technologically important amorphous materials

The Infrared Spectrum of Uranium Hollow Cathode Lamps from 850 nm to 4000 nm: Wavenumbers and Line Identifications from Fourier Transform Spectra

We provide new measurements of wavenumbers and line identifications of 10 100 UI and UII near-infrared (NIR) emission lines between 2500 cm-1 and 12 000 cm-1 (4000 nm to 850 nm) using archival FTS spectra from the National Solar Observatory (NSO). This line list includes isolated uranium lines in the Y, J, H, K, and L bands (0.9 {\mu}m to 1.1 {\mu}m, 1.2 {\mu}m to 1.35 {\mu}m, 1.5 {\mu}m to 1.65 {\mu}m, 2.0 {\mu}m to 2.4 {\mu}m, and 3.0 {\mu}m to 4.0 {\mu}m, respectively), and provides six times as many calibration lines as thorium in the NIR spectral range. The line lists we provide enable inexpensive, commercially-available uranium hollow-cathode lamps to be used for high-precision wavelength calibration of existing and future high-resolution NIR spectrographs.Comment: 23 pages, 6 Figure

Influence of Metoprolol Dosage Release Formulation on the Pharmacokinetic Drug Interaction With Paroxetine

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97158/1/0091270010365559.pd

Occupant Tenability in Single Family Homes: Part II: Impact of Door Control, Vertical Ventilation and Water Application

This paper describes experimental investigations of fire service ventilation and suppression practices in full-scale residential structures, including a one-story, 112 m2, 3 bedroom, 1 bathroom house with 8 total rooms and a two-story 297 m2, 4 bedroom, 2.5 bathroom house with 12 total rooms. The two-story house featured a modern open floor plan, two-story great room and open foyer. Seventeen experiments were conducted varying fire location, ventilation locations, the size of ventilation openings and suppression techniques. The experimental series was designed to examine the impact of several different tactics on tenability: door control, vertical ventilation size, and exterior suppression. The results of these experiments examine potential occupant and firefighter tenability and provide knowledge the fire service can use to examine their vertical ventilation and exterior suppression standard operating procedures and training content. It was observed that door control performed better at controlling the thermal exposure to occupants than did fully opening the door. Additionally, the impact of increased vertical ventilation area was minimal, and only slightly reduced the thermal exposure to occupants in a few non-fire rooms. In the two-story structure, the non-fire rooms on the second floor consistently had larger thermal fractional effective rate (FER) values (approximately 2.59 the thermal risk to oocupants) than did the non-fire rooms on the first floor. Water application was also shown to reduce the thermal risk to occupants 60 s after water application 1/3rd the original values on second floor rooms of the two-story structure and by at least 1/5th of the original values on the first floor rooms of both structures. Data also showed that the impact of front door ventilation on the toxic gases exposure was minimal, as the toxic gases FER actually increased after front door ventilation for several experiments. However, after vertical ventilation there was a 30% reduction in the toxic gases exposure rate in two of the one-story structure experiments.Funding was provided by the Department of Homeland Security (Grant No. EMW-2010-FP-00661).Ope

Occupant Tenability in Single Family Homes: Part I—Impact of Structure Type, Fire Location and Interior Doors Prior to Fire Department Arrival

This paper describes an experimental investigation of the impact of structure geometry, fire location, and closed interior doors on occupant tenability in typical single family house geometries using common fuels from twenty-first century fires. Two houses were constructed inside a large fire facility; a one-story, 112 m2, 3-bedroom, 1-bathroom house with 8 total rooms, and a two-story 297 m2, 4-bedroom, 2.5-bathroom house with 12 total rooms. Seventeen experiments were conducted with varying fire locations. In all scenarios, two bedrooms had doors remaining open while the door remained closed in a third bedroom immediately adjacent to the open door bedrooms. Temperature and gas measurement at the approximate location of a crawling or crouching trapped occupant (0.9 m from the floor) were utilized with the ISO 13571 fractional effective dose (FED) methodology to characterize occupant tenability up to the point of firefighter intervention. The FED values for the fire room were higher for heat exposure than for toxic gases, while target rooms reached highest FED due to CO/CO2 exposure. The closed interior door decreased FED significantly, with the worst case scenario resulting in a 2% probability of receiving an incapacitating dose compared to the worst case scenario for an open bedroom of 93% probability of receiving an incapacitating dose. In fact, in 7 of the 17 experiments, the closed interior door resulted in a less than 0.1% chance of an occupant receiving an incapacitating dose prior to firefighter ‘intervention.’Funding was provided by U.S. Department of Homeland Security (Grant No. EMW-2010-FP-00661).Ope

Contamination of firefighter personal protective equipment and skin and the effectiveness of decontamination procedures

Firefighters’ skin may be exposed to chemicals via permeation/penetration of combustion byproducts through or around personal protective equipment (PPE) or from the cross-transfer of contaminants on PPE to the skin. Additionally, volatile contaminants can evaporate from PPE following a response and be inhaled by firefighters. Using polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs) as respective markers for non-volatile and volatile substances, we investigated the contamination of firefighters’ turnout gear and skin following controlled residential fire responses. Participants were grouped into three crews of twelve firefighters. Each crew was deployed to a fire scenario (one per day, four total) and then paired up to complete six fireground job assignments.Wipe sampling of the exterior of the turnout gear was conducted pre- and post-fire.Wipe samples were also collected from a subset of the gear after field decontamination. VOCs off-gassing from gear were also measured pre-fire, post-fire, and post-decon. Wipe sampling of the firefighters’ hands and neck was conducted pre- and post-fire. Additional wipes were collected after cleaning neck skin. PAH levels on turnout gear increased after each response and were greatest for gear worn by firefighters assigned to fire attack and to search and rescue activities. Field decontamination using dish soap, water, and scrubbing was able to reduce PAH contamination on turnout jackets by a median of 85%. Off-gassing VOC levels increased post-fire and then decreased 17–36 min later regardless of whether field decontamination was performed. Median post-fire PAH levels on the neck were near or below the limit of detection (<24 micrograms per square meter [μg/m2]) for all positions. For firefighters assigned to attack, search, and outside ventilation, the 75th percentile values on the neck were 152, 71.7, and 39.3 μg/m2, respectively. Firefighters assigned to attack and search had higher post-fire median hand contamination (135 and 226 μg/m2, respectively) than other positions (<10.5 μg/m2). Cleansing wipes were able to reduce PAH contamination on neck skin by a median of 54%.This study was funded through a U.S. Department of Homeland Security, Assistance to Firefighters Grant (EMW-2013- FP-00766). This project was also made possible through a partnership with the CDC Foundation.Ope

Exposure to a firefighting overhaul environment without respiratory protection increases immune dysregulation and lung disease risk

Firefighting activities appear to increase the risk of acute and chronic lung disease, including malignancy. While self-contained breathing apparatuses (SCBA) mitigate exposures to inhalable asphyxiates and carcinogens, firefighters frequently remove SCBA during overhaul when the firegrounds appear clear of visible smoke. Using a mouse model of overhaul without airway protection, the impact of fireground environment exposure on lung gene expression was assessed to identify transcripts potentially critical to firefighter-related chronic pulmonary illnesses. Lung tissue was collected 2 hrs post-overhaul and evaluated via whole genome transcriptomics by RNA-seq. Although gas metering showed that the fireground overhaul levels of carbon monoxide (CO), carbon dioxide (CO2), hydrogen cyanine (HCN), hydrogen sulfide (H2S) and oxygen (O2) were within NIOSH ceiling recommendations, 3852 lung genes were differentially expressed when mice exposed to overhaul were compared to mice on the fireground but outside the overhaul environment. Importantly, overhaul exposure was associated with an up/down-regulation of 86 genes with a fold change of 1.5 or greater (p<0.5) including the immunomodulatory-linked genes S100a8 and Tnfsf9 (downregulation) and the cancer-linked genes, Capn11 and Rorc (upregulation). Taken together these findings indicate that, without respiratory protection, exposure to the fireground overhaul environment is associated with transcriptional changes impacting proteins potentially related to inflammation-associated lung disease and cancer.This work was supported by the Department of Homeland Security Fire Prevention and Safety Grant #EMW-2013-FP-00766 to G.H. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ope

The Latest Mars Climate Database (MCD v5.1)

For many years, several teams around the world have developed GCMs (General Circulation Model or Global Climate Model) to simulate the environment on Mars. The GCM developed at the Laboratoire de Météorologie Dynamique in collaboration with several teams in Europe (LATMOS, France, University of Oxford, The Open University, the Instituto de Astrofisica de Andalucia), and with the support of ESA and CNES is currently used for many applications. Its outputs have also regularly been compiled to build a Mars Climate Database, a freely available tool useful for the scientific and engineering communities. The Mars Climate Database (MCD) has over the years been distributed to more than 150 teams around the world. Following the recent improvements in the GCM, a new series of reference simulations have been run and compiled into a new version (version5.1) of the Mars Climate Database, released in the first half of 2014. To summarize, MCD v5.1 provides: - Climatologies over a series of dust scenarios: standard year, cold (ie: low dust), warm (ie: dusty atmosphere) and dust storm, all topped by various cases of Extreme UV solar inputs (low, mean or maximum). These scenarios differ from those of previous versions of the MCD (version 4.x) as they have been derived from home-made, instrument-derived (TES, THEMIS, MCS, MERs), dust climatology of the last 8 Martian years. - Mean values and statistics of main meteorological variables (atmospheric temperature, density, pressure and winds), as well as surface pressure and temperature, CO2 ice cover, thermal and solar radiative fluxes, dust column opacity and mixing ratio, [H20] vapor and ice columns, concentrations of many species: [CO], [O2], [O], [N2], [H2], [O3], ... - A high resolution mode which combines high resolution (32 pixel/degree) MOLA topography records and Viking Lander 1 pressure records with raw lower resolution GCM results to yield, within the restriction of the procedure, high resolution values of atmospheric variables. - The possibility to reconstruct realistic conditions by combining the provided climatology with additional large scale and small scale perturbations schemes. At EGU, we will report on the latest improvements in the Mars Climate Database, with comparisons with available measurements from orbit (e.g.: TES, MCS) or landers (Viking, Phoenix, MSL)