Early Spectral Evolution of the Rapidly Expanding Type Ia SN 2006X

We present optical spectroscopic and photometric observations of Type Ia supernova (SN) 2006X from --10 to +91 days after the $B$-band maximum. This SN exhibits one of the highest expansion velocity ever published for SNe Ia. At premaximum phases, the spectra show strong and broad features of intermediate-mass elements such as Si, S, Ca, and Mg, while the O{\sc i}$\lambda$7773 line is weak. The extremely high velocities of Si{\sc ii} and S{\sc ii} lines and the weak O{\sc i} line suggest that an intense nucleosynthesis might take place in the outer layers, favoring a delayed detonation model. Interestingly, Si{\sc ii}$\lambda$5972 feature is quite shallow, resulting in an unusually low depth ratio of Si{\sc ii}$\lambda$5972 to $\lambda$6355, $\cal R$(Si{\sc ii}). The low $\cal R$(Si{\sc ii}) is usually interpreted as a high photospheric temperature. However, the weak Si{\sc iii}$\lambda$4560 line suggests a low temperature, in contradiction to the low $\cal R$(Si{\sc ii}). This could imply that the Si{\sc ii}$\lambda$5972 line might be contaminated by underlying emission. We propose that $\cal R$(Si{\sc ii}) may not be a good temperature indicator for rapidly expanding SNe Ia at premaximum phases.Comment: 20 pages, 7 figures, (Received 2008 August 17; Accepted 2009 April 13

Involvement of Lgl and Mahjong/VprBP in Cell Competition

Mahjong is a novel Lethal giant larvae-binding protein that plays a vital role in cell competition in both flies and mammals

A new static visual field test algorithm: the Ambient Interactive ZEST (AIZE)

Abstract Visual field (VF) test is one of the most vital tests in the diagnosis of glaucoma and to monitor the disease worsening. In the past couple of decades, the standard automated perimetry (SAP) test takes a major role in VF test for glaucoma patients. The SAP has been demanded to finish a test in short time without sacrificing accuracy. In this study, we developed and evaluated the performance of a new perimetric algorithm (ambient interactive zippy estimation by sequential testing (ZEST): AIZE) by computer simulation. AIZE is a modification of the ZEST procedure that utilizes the spatial information (weighted likelihood: WL) of neighboring test locations, which varies from the distance to the tested location, to estimate a visual threshold. Ten glaucomatous and 10 normal empirical visual field (VF) test results were simulated with five error conditions [(3% false positives (FP), 3% false negatives (FN)), (9% FP, 9% FN), (15% FP, 15% FN), (3% FP, 15% FN), (15% FP, 3% FN)]. The total number of test presentations and the root mean square error (RMSE) of the estimated visual sensitivities were compared among AIZE, the non-weighted test (WL = 0) and the fixed-weighted test (WL = 0.33). In both glaucomatous (G) and normal (N) VFs, the fixed-weighted test had the lowest number of test presentations (median G 256, N 139), followed by the AIZE (G 285, N 174) and the non-weighted test (G 303, N 195). The RMSE of the fixed-weighted test was lower (median 1.7 dB) than that of the AIZE (1.9 dB) and the non-weighted test (1.9 dB) for normal VFs, whereas the AIZE had a lower RMSE (3.2 dB) than the fixed-weighted test (4.5 dB) and the non-weighted test (4.0 dB) for glaucomatous VFs. Simulation results showed that AIZE had fewer test presentations than the non-weighted test strategy without affecting the accuracy for glaucomatous VFs. The AIZE is a useful time saving test algorithm in clinical settings

Visual Field Testing with Head-Mounted Perimeter 'imo'.

We developed a new portable head-mounted perimeter, "imo", which performs visual field (VF) testing under flexible conditions without a dark room. Besides the monocular eye test, imo can present a test target randomly to either eye without occlusion (a binocular random single eye test). The performance of imo was evaluated.Using full HD transmissive LCD and high intensity LED backlights, imo can display a test target under the same test conditions as the Humphrey Field Analyzer (HFA). The monocular and binocular random single eye tests by imo and the HFA test were performed on 40 eyes of 20 subjects with glaucoma. VF sensitivity results by the monocular and binocular random single eye tests were compared, and these test results were further compared to those by the HFA. The subjects were asked whether they noticed which eye was being tested during the test.The mean sensitivity (MS) obtained with the HFA highly correlated with the MS by the imo monocular test (R: r = 0.96, L: r = 0.94, P < 0.001) and the binocular random single eye test (R: r = 0.97, L: r = 0.98, P < 0.001). The MS values by the monocular and binocular random single eye tests also highly correlated (R: r = 0.96, L: r = 0.95, P < 0.001). No subject could detect which eye was being tested during the examination.The perimeter imo can obtain VF sensitivity highly compatible to that by the standard automated perimeter. The binocular random single eye test provides a non-occlusion test condition without the examinee being aware of the tested eye