Comparison of postoperative pulmonary function and air leakage between pleural closure vs. mesh-cover for intersegmental plane in segmentectomy

<p>Abstract</p> <p>Background</p> <p>To prevent postoperative air leakage after lung segmentectomy, we used two methods for the intersegmental plane: closing it by suturing the pleural edge (pleural closure), or opening it with coverage using polyglycolic acid mesh and fibrin glue (mesh-cover). The preserved forced expiratory volume in one second (FEV₁) of each lobe and the postoperative air leakage were compared between the two groups.</p> <p>Methods</p> <p>For 61 patients who underwent pleural closure and 36 patients who underwent mesh-cover, FEV₁of the lobe before and after segmentectomy was measured using lung-perfusion single-photon-emission computed tomography and CT (SPECT/CT). The groups' results were compared, revealing differences of the preserved FEV₁of the lobe for several segmentectomy procedures and postoperative duration of chest tube drainage.</p> <p>Results</p> <p>Although left upper division segmentectomy showed higher preserved FEV₁of the lobe in the mesh-cover group than in the pleural closure one (<it>p </it>= 0.06), the other segmentectomy procedures showed no differences between the groups. The durations of postoperative chest drainage in the two groups (2.0 ± 2.5 vs. 2.3 ± 2.2 days) were not different.</p> <p>Conclusions</p> <p>Mesh-cover preserved the pulmonary function of remaining segments better than the pleural closure method in left upper division segmentectomy, although no superiority was found in the other segmentectomy procedures. However, the data include no results obtained using a stapler, which cuts the segment without recognizing even the intersegmental plane and the intersegmental vein. Mesh-cover prevented postoperative air leakage as well as the pleural closure method did.</p

Combined subsegmentectomy: postoperative pulmonary function compared to multiple segmental resection

<p>Abstract</p> <p>Background</p> <p>For small peripheral c-T1N0M0 non-small cell lung cancers involving multiple segments, we have conducted a resection of subsegments belonging to different segments, i.e. combined subsegmentectomy (CSS), to avoid resection of multiple segments or lobectomy. Tumor size, location of tumor, and forced expiratory volume in 1 second (FEV₁) of each preserved lobe were compared among the CSS, resection of single segment, and that of multiple segments.</p> <p>Methods</p> <p>FEV₁of each preserved lobe were examined in 17 patients who underwent CSS, 56 who underwent resection of single segment, and 41 who underwent resection of multiple segments, by measuring pulmonary function and lung-perfusion single-photon-emission computed tomography and computed tomography before and after surgery.</p> <p>Results</p> <p>Tumor size in the CSS was significantly smaller than that in the resection of multiple segments (1.4 ± 0.5 vs. 2.0 ± 0.8 cm, p = 0.002). Tumors in the CSS were located in the right upper lobe more frequently than those in the resection of multiple segments (53% vs. 5%, p < 0.001). Postoperative of FEV₁of each lobe after the CSS was higher than that after the resection of multiple segments (0.3 ± 0.2 vs. 0.2 ± 0.2 l, p = 0.07). Mean FEV₁of each preserved lobe per subsegment after CSS was significantly higher than that after resection of multiple segments (0.05 ± 0.03 vs. 0.03 ± 0.02 l, p = 0.02). There was no significant difference of these factors between the CSS and resection of single segment.</p> <p>Conclusions</p> <p>The CSS is effective for preserving pulmonary function of each lobe, especially for small sized lung cancer involving multiple segments in the right upper lobe, which has fewer segments than other lobes.</p

APPLICABILITY OF MINIATURE C(T) SPECIMEN TO EVALUATION OF FRACTURE TOUGHNESS FOR REACTOR PRESSURE VESSEL STEEL

ABSTRACT Irradiation embrittlement of Japanese reactor pressure vessels (RPV) is usually monitored by conducting tests on irradiated RPV material according to surveillance test program. Although fracture toughness specimens are contained in Japanese PWR surveillance capsule, the number of specimens is limited due to capacity of capsule. In order to evaluate lower bound of fracture toughness considering its scatter with higher reliability, it is expected to obtain additional fracture toughness data using remaining broken specimens of irradiated materials. One of solutions to this problem is specimen reconstitution technique. However, it is difficult to make numbers of specimens by reconstitution because of need for specific equipments and time-consuming machining operations. As an alternative method, fracture toughness test using miniature C(T) specimens with dimension of 4×10×10mm, which can be taken from broken halves of Charpy specimen, is proposed and the studies to verify the reliability and robustness of evaluation method have been conducted in the Japanese round robin program since 2010. In this study, fracture toughness tests were performed on Japanese SA 533 Gr.B Cl.1 steel using miniature C(T) specimens and the effect of specimen size on reference temperature T 0 was studied by the Master Curve approach. In addition, the issues related to application to irradiated materials were discussed

A 0.3-V operating, Vth-variation-tolerant SRAM under DVS environment for memory-rich SoC in 90-nm technology era and beyond

元・大学院自然科学研究科　　現・神戸大学大学院自然科学研究科We propose a voltage control scheme for 6T SRAM cells that makes a minimum operation voltage down to 0.3 V under DVS environment. A supply voltage to the memory cells and wordline drivers, bitline voltage, and body bias voltage of load pMOSFETs are controlled according to read and write operations, which secures operation margins even at a low operation voltage. A self-aligned timing control with a dummy wordline and its feedback is also introduced to guarantee stable operation in a wide range of the supply voltage. A measurement result of a 64-kb SRAM in a 90-nm process technology shows that a power reduction of 30 can be achieved at 100 MHz. In a 65-nm 64-Mb SRAM, a 74 power saving is expected at 1/6 of the maximum operating frequency. The performance penalty by the proposed scheme is less than 1, and area overhead is 5.6. Copyright © 2006 The Institute of Electronics, Information and Communication Engineers

Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor

To establish effective therapeutic strategies for eosinophil-related disorders, it is critical to understand the developmental pathway of human eosinophils. In mouse hematopoiesis, eosinophils originate from the eosinophil lineage-committed progenitor (EoP) that has been purified downstream of the granulocyte/macrophage progenitor (GMP). We show that the EoP is also isolatable in human adult bone marrow. The previously defined human common myeloid progenitor (hCMP) population (Manz, M.G., T. Miyamoto, K. Akashi, and I.L. Weissman. 2002. Proc. Natl. Acad. Sci. USA. 99:11872–11877) was composed of the interleukin 5 receptor α chain+ (IL-5Rα+) and IL-5Rα− fractions, and the former was the hEoP. The IL-5Rα+CD34+CD38+IL-3Rα+CD45RA− hEoPs gave rise exclusively to pure eosinophil colonies but never differentiated into basophils or neutrophils. The IL-5Rα− hCMP generated the hEoP together with the hGMP or the human megakaryocyte/erythrocyte progenitor (hMEP), whereas hGMPs or hMEPs never differentiated into eosinophils. Importantly, the number of hEoPs increased up to 20% of the conventional hCMP population in the bone marrow of patients with eosinophilia, suggesting that the hEoP stage is involved in eosinophil differentiation and expansion in vivo. Accordingly, the phenotypic definition of hCMP should be revised to exclude the hEoP; an “IL-5Rα–negative” criterion should be added to define more homogenous hCMP. The newly identified hEoP is a powerful tool in studying pathogenesis of eosinophilia and could be a therapeutic target for a variety of eosinophil-related disorders

SPECT CT ニ ヨル ハイ クイキ セツジョジュツ ゴ ノ ザンゾン ハイ キノウ ノ ケントウ

近年の画像診断の進歩に伴い、早期肺癌が発見される機会が増えてきた。末梢小型肺癌に対しては標準手術とされる肺葉切除術ではなく、肺区域切除術も十分な根治性を有することが報告されている。cT1N0M0非小細胞肺癌に対する標準術式として肺区域切除術が標準とするべく臨床試験が国内外で進行中であるが、そのエンドポイントとして根治性の非劣性、術後肺機能温存の利点を示す必要がある。本研究の目的はこのうち肺区域切除術の肺機能温存における優位性を証明することを目的として行われた

Relationship Between the Structure of ba and Changing Self : Through Analysing the Experience of Camp Leader

研究ノート(Note

Power-Minimum Frequency/Voltage Cooperative Management Method for VLSI Processor in Leakage-Dominant Technology Era(Low Power Methodology, <Special Section>VLSI Design and CAD Algorithms)

大学院自然科学研究科情報システ

A Feed-Forward Dynamic Voltage Control Algorithm for Low Power MPEG4 on Multi-Regulated Voltage CPU(<Special Section>Low-Power System LSI, IP and Related Technologies)

大学院自然科学研究科情報システ