486 research outputs found
Exploring the impact of hand movement delays and hand appearance on myoelectric prosthesis embodiment using immersive virtual reality
Prosthesis embodiment, the feeling of a prosthesis being part of the user, is reported by some prosthesis users. Myoelectric prostheses are electrically powered which produce a delay with fixed and variable components. The latter introduces uncertainty over hand behaviour, likely influencing embodiment. Embodiment may also be influenced by hand appearance. An Immersive Virtual Reality experimental study is currently in preparation. It involves anatomically-intact participants to systematically measure the impact of movement delays and appearance on embodiment of a virtual prosthesis. This includes a head-mounted display and motion tracking of a myoelectric prosthesis, with various virtual appearances and hand-movement delays
The reality of myoelectric prostheses : understanding what makes these devices difficult for some users to control
Users of myoelectric prostheses can often find them difficult to control. This can lead to passive-use of the device or total rejection, which can have detrimental effects on the contralateral limb due to overuse.
Current clinically available prostheses are ‘open loop’ systems, and although considerable effort has been focused on developing biofeedback to “close the loop”, there is evidence from laboratory-based studies that other factors, notably improving predictability of response, may be as, if not more, important. Interestingly, despite a large volume of research aimed at improving myoelectric prostheses, it is not currently known which aspect of clinically available systems has the greatest impact on overall functionality and everyday usage. A protocol has therefore been designed to assess EMG skill of the user and predictability of the prosthesis response as significant parts of the control chain, and to relate these to functionality and everyday usage. Here we present the protocol and results from early pilot work.
A set of experiments has been developed. Firstly to characterize user skill in generating the required level of EMG signal, as well as the speed with which users are able to make the decision to activate the appropriate muscles. Secondly, to measure unpredictability introduced at the skin-electrode interface, in order to understand the effects of the socket mounted electrode fit under different loads on the variability of time taken for the prosthetic hand to respond. To evaluate prosthesis user functionality, four different outcome measures are assessed. Using a simple upper limb functional task prosthesis users are assessed for (1) success of task completion, (2)task duration, (3) quality of movement, and (4) gaze behavior. To evaluate everyday usage away from the clinic, the symmetricity of their real-world arm use is assessed using activity monitoring.
These methods will later be used to assess a prosthesis user cohort, to establish the relative contribution of each control factor to the individual measures of functionality and everyday usage (using multiple regression models). The results will support future researchers, designers and clinicians in concentrating their efforts on the area which will have the greatest impact on improving prosthesis use
Upper limb activity of twenty myoelectric prosthesis users and twenty healthy anatomically intact adults
The upper limb activity of twenty unilateral upper limb myoelectric prosthesis users and twenty anatomically intact adults were recorded over a 7-day period using two wrist worn accelerometers (Actigraph, LLC). This dataset reflects the real-world activities of the participants during their normal day-to-day routines. Participants included students, working adults, and retirees recruited from across the United Kingdom. This is the first published dataset of its kind and offers a potential wealth of knowledge into a poorly understood cohort. The raw unprocessed data files and the activity count data exported from the Actilife software are provided. We also provide a non-wear algorithm developed for the removal of prosthesis non-wear periods and resulting activity count data corresponding to prothesis wear periods. Finally, we have included the transposed activity diaries provided by the participants. Analysis to date has primarily involved assessment of the symmetry of upper limb activity, however, there is potential to undertake additional analysis such as understanding the differences in the way a prosthesis is used compared to an anatomical arm
Upper- and lower-limb amputees show reduced levels of eeriness for images of prosthetic hands
The uncanny phenomenon describes the feeling of unease associated with seeing an image which is close to appearing human. Prosthetic hands in particular are well-known to induce this effect. Little is known, however, about this phenomenon from the viewpoint of prosthesis users. We studied perceptions of eeriness and human-likeness for images of different types of mechanical, cosmetic,
and anatomical hands in upper-limb prosthesis users (n=9), lower-limb prosthesis users (n=10), prosthetists (n=16), control participants with no prosthetic training (n=20), and control participants who were trained to use a myoelectric prosthetic hand simulator (n=23). Both the upper- and lowerlimb prosthesis user groups showed a reduced uncanny phenomenon (i.e., significantly lower levels of eeriness) for cosmetic prosthetic hands compared to the other groups, with no concomitant reduction in how these stimuli were rated in terms of human-likeness. However, a similar effect was found neither for prosthetists with prolonged visual experience of prosthetic hands, nor for the group with short-term training with the simulator. These findings in the prosthesis users therefore seem likely to be related to limb absence or prolonged experience with prostheses
Addressing unpredictability may be the key to improving performance with current clinically prescribed myoelectric prostheses
The efferent control chain for an upper-limb myoelectric prosthesis can be separated into 3 key areas: signal generation, signal acquisition, and device response. Data were collected from twenty trans-radial myoelectric prosthesis users using their own clinically prescribed devices, to establish the relative impact of these potential control factors on user performance (user functionality and everyday prosthesis usage). By identifying the key factor(s), we can guide future developments to ensure clinical impact. Skill in generating muscle signals was assessed via reaction times and signal tracking. To assess the predictability of signal acquisition, we inspected reaction time spread and undesired hand activations. As a measure of device response, we recorded the electromechanical delay between electrode stimulation and the onset of hand movement. Results suggest abstract measures of skill in controlling muscle signals are poorly correlated with performance. Undesired activations of the hand or incorrect responses were correlated with almost all kinematics and gaze measures suggesting unpredictability is a key factor. Significant correlations were also found between several measures of performance and the electromechanical delay; however, unexpectedly, longer electromechanical delays correlated with better performance. Future research should focus on exploring causes of unpredictability, their relative impacts on performance and interventions to address this
Why does my prosthetic hand not always do what it is told?
There are online videos that appear to show electrically powered prosthetic (artificial) hands to be near-perfect replacements for a missing hand. However, for many users, the reality can be quite different. Prosthetic hands do not always respond as expected, which can be frustrating. A prosthetic hand is controlled by muscle signals in the remaining part of the person’s affected arm, using sensors called electrodes. The electrodes are embedded within the socket, which is the part of the prosthetic arm that connects it to the person’s arm. When they activate their muscles, the hand can open, close, or change its grip. If the socket moves, it can pull the electrodes away from the skin. As a result, the muscle activity signaling the person’s intention cannot be properly detected, and the hand will not work very well. In this article, we explain why socket fit may be the most important part of a prosthetic arm
Visuomotor behaviours when using a myoelectric prosthesis
Background
A recent study showed that the gaze patterns of amputee users of myoelectric
prostheses differ markedly from those seen in anatomically intact subjects. Gaze
behaviour is a promising outcome measures for prosthesis designers, as it appears to
reflect the strategies adopted by amputees to compensate for the absence of
proprioceptive feedback and uncertainty/delays in the control system, factors believed
to be central to the difficulty in using prostheses. The primary aim of our study was to
characterise visuomotor behaviours over learning to use a trans-radial myoelectric
prosthesis. Secondly, as there are logistical advantages to using anatomically intact
subjects in prosthesis evaluation studies, we investigated similarities in visuomotor
behaviours between anatomically intact users of a trans-radial prosthesis simulator
and experienced trans-radial myoelectric prosthesis users.
Methods
In part 1 of the study, we investigated visuomotor behaviours during performance of a
functional task (reaching, grasping and manipulating a carton) in a group of seven
anatomically intact subjects over learning to use a trans-radial myoelectric prosthesis
simulator (Dataset 1). Secondly, we compared their patterns of visuomotor behaviour
with those of four experienced trans-radial myoelectric prosthesis users (Dataset 2).
We recorded task movement time, performance on the SHAP test of hand function
and gaze behaviour.
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Results
Dataset 1 showed that while reaching and grasping the object, anatomically intact
subjects using the prosthesis simulator devoted around 90% of their visual attention to
either the hand or the area of the object to be grasped. This pattern of behaviour did
not change with training, and similar patterns were seen in Dataset 2. Anatomically
intact subjects exhibited significant increases in task duration at their first attempts to
use the prosthesis simulator. At the end of training, the values had decreased and were
similar to those seen in Dataset 2.
Conclusions
The study provides the first functional description of the gaze behaviours seen during
use of a myoelectric prosthesis. Gaze behaviours were found to be relatively
insensitive to practice. In addition, encouraging similarities were seen between the
amputee group and the prosthesis simulator group
Evidence for distinct coastal and offshore communities of bottlenose dolphins in the north east Atlantic.
Bottlenose dolphin stock structure in the northeast Atlantic remains poorly understood. However, fine scale photo-id data have shown that populations can comprise multiple overlapping social communities. These social communities form structural elements of bottlenose dolphin (Tursiops truncatus) [corrected] populations, reflecting specific ecological and behavioural adaptations to local habitats. We investigated the social structure of bottlenose dolphins in the waters of northwest Ireland and present evidence for distinct inshore and offshore social communities. Individuals of the inshore community had a coastal distribution restricted to waters within 3 km from shore. These animals exhibited a cohesive, fission-fusion social organisation, with repeated resightings within the research area, within a larger coastal home range. The offshore community comprised one or more distinct groups, found significantly further offshore (>4 km) than the inshore animals. In addition, dorsal fin scarring patterns differed significantly between inshore and offshore communities with individuals of the offshore community having more distinctly marked dorsal fins. Specifically, almost half of the individuals in the offshore community (48%) had characteristic stereotyped damage to the tip of the dorsal fin, rarely recorded in the inshore community (7%). We propose that this characteristic is likely due to interactions with pelagic fisheries. Social segregation and scarring differences found here indicate that the distinct communities are likely to be spatially and behaviourally segregated. Together with recent genetic evidence of distinct offshore and coastal population structures, this provides evidence for bottlenose dolphin inshore/offshore community differentiation in the northeast Atlantic. We recommend that social communities should be considered as fundamental units for the management and conservation of bottlenose dolphins and their habitat specialisations
Laparoscopic resection of a lymphangiomatous cyst of the colon: a case report
<p>Abstract</p> <p>Introduction</p> <p>Lymphangiomatous cysts are submucosal masses that are rarely found in the gastrointestinal tract and more often in the neck, oral cavity, and skin. These cysts are benign tumors and mostly clinically silent. Symptoms include abdominal pain, diarrhea, and rectal bleeding. Their pathogenesis remains unclear.</p> <p>Case presentation</p> <p>During a routine ultrasound examination of a Caucasian 25-year-old woman, a structure that raised our suspicions of an ovarian cyst was found. MRI showed a 4.5 cm cystic lesion in the cecal region. Laparoscopic exploration revealed unexpected contact with the ascending colon. The cyst, including its base and of portion of the colon, was resected laparoscopically. The histological examination revealed cystic lymphangioma.</p> <p>Conclusion</p> <p>Lymphangiomatous cysts of the colon are very rare lesions. Although their pathology is benign, the recommended treatment is resection, which can be performed with minimal invasiveness.</p
The Effect of Epstein-Barr Virus Latent Membrane Protein 2 Expression on the Kinetics of Early B Cell Infection
Infection of human B cells with wild-type Epstein-Barr virus (EBV) in vitro leads to activation and proliferation that result in efficient production of lymphoblastoid cell lines (LCLs). Latent Membrane Protein 2 (LMP2) is expressed early after infection and previous research has suggested a possible role in this process. Therefore, we generated recombinant EBV with knockouts of either or both protein isoforms, LMP2A and LMP2B (Δ2A, Δ2B, Δ2A/Δ2B) to study the effect of LMP2 in early B cell infection. Infection of B cells with Δ2A and Δ2A/Δ2B viruses led to a marked decrease in activation and proliferation relative to wild-type (wt) viruses, and resulted in higher percentages of apoptotic B cells. Δ2B virus infection showed activation levels comparable to wt, but fewer numbers of proliferating B cells. Early B cell infection with wt, Δ2A and Δ2B viruses did not result in changes in latent gene expression, with the exception of elevated LMP2B transcript in Δ2A virus infection. Infection with Δ2A and Δ2B viruses did not affect viral latency, determined by changes in LMP1/Zebra expression following BCR stimulation. However, BCR stimulation of Δ2A/Δ2B cells resulted in decreased LMP1 expression, which suggests loss of stability in viral latency. Long-term outgrowth assays revealed that LMP2A, but not LMP2B, is critical for efficient long-term growth of B cells in vitro. The lowest levels of activation, proliferation, and LCL formation were observed when both isoforms were deleted. These results suggest that LMP2A appears to be critical for efficient activation, proliferation and survival of EBV-infected B cells at early times after infection, which impacts the efficient long-term growth of B cells in culture. In contrast, LMP2B did not appear to play a significant role in these processes, and long-term growth of infected B cells was not affected by the absence of this protein. © 2013 Wasil et al
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