A systematic review and qualitative meta-synthesis of first-hand conceptualisations of nonsuicidal self-injury (NSSI)

Nonsuicidal self-injury (NSSI) is a growing phenomenon that correlates with significantly negative outcomes including psychopathology, hospitalisation and suicide; however, there exists little consensus on how to best understand it. This lack of conceptual consensus risks inconsistent clinical practice in a population that often reports poor experiences of professional support, therefore an understanding of how individuals conceptualise their own NSSI without attempting to fit it into existing causal and functionalist models is needed. This review sought to examine and synthesise first-hand conceptualisations of NSSI in existing qualitative literature using interpretive phenomenological synthesis. A systematic database search of qualitative literature was conducted, including interviews with individuals with experience of NSSI across all ages and settings, published in English from 1950 to 2022. Twenty-three studies were included in the final meta-synthesis. Three superordinate themes were generated via the synthesis: (1) NSSI is embedded in the social world; (2) NSSI is symbolic and communicative; and (3) NSSI represents taking back agency. This synthesis, comprised of both reported data and the themes identified by the researchers in the papers, highlighted that NSSI is a diverse behaviour that is inextricably linked with sociocultural context and that, paradoxically, it can be simultaneously communicative and private. This research urges an introspective examination of how clinicians and researchers in the field conceptualise NSSI and how this juxtaposes with how individuals who engage in the behaviour conceptualise it

Regional-scale input of dispersed and discrete volcanic ash to the Izu-Bonin and Mariana subduction zones

We have geochemically and statistically characterized bulk marine sediment and ash layers at Ocean Drilling Program Site 1149 (Izu-Bonin Arc) and Deep Sea Drilling Project Site 52 (Mariana Arc), and have quantified that multiple dispersed ash sources collectively comprise ~30-35% of the hemipelagic sediment mass entering the Izu-Bonin-Mariana subduction system. Multivariate statistical analyses indicate that the bulk sediment at Site 1149 is a mixture of Chinese Loess, a second compositionally distinct eolian source, a dispersed mafic ash, and a dispersed felsic ash. We interpret the source of these ashes as respectively being basalt from the Izu-Bonin Front Arc (IBFA) and rhyolite from the Honshu Arc. Sr-, Nd-, and Pb isotopic analyses of the bulk sediment are consistent with the chemical/statistical-based interpretations. Comparison of the mass accumulation rate of the dispersed ash component to discrete ash layer parameters (thickness, sedimentation rate, and number of layers) suggests that eruption frequency, rather than eruption size, drives the dispersed ash record. At Site 52, the geochemistry and statistical modeling indicates that Chinese Loess, IBFA, dispersed BNN (boninite from Izu-Bonin), and a dispersed felsic ash of unknown origin are the sources. At Site 1149 the ash layers and the dispersed ash are compositionally coupled, whereas at Site 52 they are decoupled in that there are no boninite layers, yet boninite is dispersed within the sediment. Changes in the volcanic and eolian inputs through time indicate strong arc- and climate-related controls

Prevalence of HPV Infection in Racial-Ethnic Subgroups of Head and Neck Cancer Patients

The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3,129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P<0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16/18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P<0.0001). There was no statistically significant difference in HPV16/18 prevalence in non-oropharyngeal cancer by race (P=0.682). With regard to the pattern of HPV16/18 status and p16 expression, White patients had the highest proportion of HPV16/18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0% and 22.6%, respectively) [P <0.0001]. Our findings suggest that the pattern of HPV16/18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities

Prevalence of HPV infection in racial–ethnic subgroups of head and neck cancer patients

The landscape of human papillomavirus (HPV) infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N=798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P<0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16,18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P<0.0001). There was no statistically significant difference in HPV16,18 prevalence in non-oropharyngeal cancer by race (P=0.682). With regard to the pattern of HPV16,18 status and p16 expression, White patients had the highest proportion of HPV16,18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0 and 22.6%, respectively) [P<0.0001]. Our findings suggest that the pattern of HPV16,18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities

Marine and terrestrial environmental changes in NW Europe preceding carbon release at the Paleocene-Eocene transition

Environmental changes associated with the Paleocene–Eocene thermal maximum (PETM, ∼56 Ma) have not yet been documented in detail from the North Sea Basin. Located within proximity to the North Atlantic igneous province (NAIP), the Kilda Basin, and the northern rain belt (paleolatitude 54 °N) during the PETM, this is a critical region for testing proposed triggers of atmospheric carbon release that may have caused the global negative carbon isotope excursion (CIE) in marine and terrestrial environments. The CIE onset is identified from organic matter δ13C in exceptional detail within a highly expanded sedimentary sequence. Pollen and spore assemblages analysed in the same samples for the first time allow a reconstruction of possible changes to vegetation on the surrounding landmass. Multiproxy palynological, geochemical, and sedimentologic records demonstrate enhanced halocline stratification and terrigenous deposition well before (103 yrs) the CIE, interpreted as due to either tectonic uplift possibly from a nearby magmatic intrusion, or increased precipitation and fluvial runoff possibly from an enhanced hydrologic cycle. Stratification and terrigenous deposition increased further at the onset and within the earliest CIE which, coupled with evidence for sea level rise, may be interpreted as resulting from an increase in precipitation over NW Europe consistent with an enhanced hydrologic cycle in response to global warming during the PETM. Palynological evidence indicates a flora dominated by pollen from coastal swamp conifers before the CIE was abruptly replaced with a more diverse assemblage of generalist species including pollen similar to modern alder, fern, and fungal spores. This may have resulted from flooding of coastal areas due to relative sea level rise, and/or ecologic changes forced by climate. A shift towards more diverse angiosperm and pteridophyte vegetation within the early CIE, including pollen similar to modern hickory, documents a long term change to regional vegetation

Improving certainty in marine ecosystems: A biophysical modelling approach in the remote, data-limited Gulf of Carpentaria

Remote, data-limited marine environments are poorly understood, making conservation and resource management major challenges in the rapidly changing environment. High field data collection costs results in sparse data, which limits the traditional scientific approach to understand the functioning of these remote ecosystems. The Gulf of Carpentaria is a vast, remote and data-limited region in northern Australia that is vulnerable to rapid changes due to climate change and externally derived marine debris, but extremely difficult and costly to access. This study aimed to test a method of improving certainty in ecological and physical processes in the Gulf of Carpentaria by maximising the use of alternative biophysical data from local Indigenous-owned and managed land and sea country, to elucidate the ecosystem functioning. We investigated the role of currents and wind in previously published Green turtle (Chelonia mydas) post-nesting satellite tracking migration data, and found they had no influence on the turtles’ migration path. We also found that turtles did not use compass bearing alone to make their migration, rather they seemingly used coastal cues to ’leap-frog’ along the coastline until they reached their foraging grounds. Next, we identified the spatio-temporal distribution of floating marine plastics using Indigenous-lead citizen science coastal marine debris surveys, and found that previous studies have underestimated marine debris presence in the region. Finally, biophysical modelling suggests that large migrations (>200 km in 28–35 days) of tagged male Giant mud crabs (Scylla serrata) against prevailing winds, currents and tides were possible by using selective tidal stream transport and directional swimming. These case-studies demonstrate the effectiveness of explorative biophysical modelling supported by alternative field data, and improve certainty in ecological processes with significance in culture, conservation and commercial values in the region

The genomic history of the Bronze Age Southern Levant

We report genome-wide DNA data for 73 individuals from five archaeological sites across the Bronze and Iron Ages Southern Levant. These individuals, who share the “Canaanite” material culture, can be modeled as descending from two sources: (1) earlier local Neolithic populations and (2) populations related to the Chalcolithic Zagros or the Bronze Age Caucasus. The non-local contribution increased over time, as evinced by three outliers who can be modeled as descendants of recent migrants. We show evidence that different “Canaanite” groups genetically resemble each other more than other populations. We find that Levant-related modern populations typically have substantial ancestry coming from populations related to the Chalcolithic Zagros and the Bronze Age Southern Levant. These groups also harbor ancestry from sources we cannot fully model with the available data, highlighting the critical role of post-Bronze-Age migrations into the region over the past 3,000 years