“Well, I’m thinking about horse poverty”: Teaching and Learning about Social Justice and the Arts with Elementary School Students

This paper analyzes a social justice arts program that I developed and taught to third, fourth, and fifth grade students at one school in the Poughkeepsie, NY area. I begin this project by considering my own experiences in art class as an elementary school student, and analyzing the strengths and weaknesses of my school’s art curriculum. Next, I take a multidisciplinary approach to evaluate the current literature on social justice arts education. In this section, I define the characteristics of a high-quality social justice arts program and analyze commonly-available arts education resources for teachers. I continue with an outline of the development of my particular curriculum, as well as my methods for selecting schools and evaluating my program. Finally, I analyze the impact of this project on both myself and my students. I ultimately argue that social justice education of any form takes time, strong relationships, communication, and support from multiple actors

Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling.

Protein phosphatase 2A (PP2A), the major serine/threonine phosphatase in eukaryotic cells, is a heterotrimeric protein composed of structural, catalytic, and targeting subunits. PP2A assembly is governed by a variety of mechanisms, one of which is carboxyl-terminal methylation of the catalytic subunit by the leucine carboxyl methyltransferase LCMT1. PP2A is nearly stoichiometrically methylated in the cytosol, and although some PP2A targeting subunits bind independently of methylation, this modification is required for the binding of others. To examine the role of this methylation reaction in mammalian tissues, we generated a mouse harboring a gene-trap cassette within intron 1 of Lcmt1. Due to splicing around the insertion, Lcmt1 transcript and LCMT1 protein levels were reduced but not eliminated. LCMT1 activity and methylation of PP2A were reduced in a coordinate fashion, suggesting that LCMT1 is the only PP2A methyltransferase. These mice exhibited an insulin-resistance phenotype, indicating a role for this methyltransferase in signaling in insulin-sensitive tissues. Tissues from these animals will be vital for the in vivo identification of methylation-sensitive substrates of PP2A and how they respond to differing physiological conditions

Home Literacy Environment as a Predictor for Letter Identification Skills for Preschool-Aged Children

Research clearly states that quality home literacy environments and overall literacy development are related; however, there is limited research exploring the effect on home literacy environments as a predictor for letter identification scores for preschool-aged children. Understanding this relationship will help care givers and early educators create quality literacy environments for young children. The purpose of this study was to examine if the home literacy environment for preschool-aged children is a predictor for letter identification scores. The current research examined parent/care giver responses to the Get Ready to Read Home Literacy Environment checklist and students’ scores on the curriculum-based measure for letter identification. This investigation examined parent/care giver responses to the Get Ready to Read Home Literacy Environment checklist and student scores on the curriculum-based letter identification measure. The participants included 83 preschool-aged children in an urban Southern Arizona school district. The students attended an inclusive school district preschool program; therefore, both students with and without disabilities were included in the sample. The findings of the study suggested a significant relationship between home literacy environment and letter identification scores for preschool-aged children

Accountability, Cost-Effectiveness, and Program Performance: Progress Since 1998

The authors summarize the progress made in the past decade toward making homeless assistance programs more accountable to funders, consumers, and the public. They observe that research on the costs of homelessness and cost offsets associated with intervention programs has been limited to people who are homeless with severe mental illness. But this research has raised awareness of the value of this approach, such that dozens of new studies in this area are underway, mostly focused on chronic homelessness. Less progress has been made in using cost and performance data to systematically assess interventions for families, youth, and transitionally homeless adults. The authors present case studies of promising practices from the State of Arizona and Columbus, Ohio, demonstrating innovative uses of client and program data to measure performance and improve program management toward state policy goals, such as increased housing placement rates, reduced lengths of homelessness, and improved housing stability

Football Game Program 3 1965

Football Game Program 3 196

Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury

Abstract Introduction Ligament and meniscal damage can cause joint disease. Arthritic joints contain increased amounts of epidermal growth factor receptor (EGFR) protein, and polymorphisms in EGFR are associated with arthritis risk. The role of endogenous EGFR regulation during joint disease due to ligament and meniscal trauma is unknown. Mitogen-inducible gene 6 (MIG-6) can reduce EGFR phosphorylation and downstream signaling. We examined the effect of EGFR modulation by MIG-6 on joint disease development after ligament and meniscus injury. Methods Knee ligament transection and meniscus removal were performed surgically on mice homozygous for a global inactivating mutation in MIG-6 (Mig-6 −/− ) and in wild-type (WT) animals. Results Two weeks after surgery, Mig-6 −/− mice had bone erosion as well as greater fibrous tissue area and serum RANKL concentration than WT mice. Four weeks after surgery, Mig-6 −/− mice had less cartilage and increased cell proliferation relative to contralateral control and WT knees. Increased apoptotic cells and growth outside the articulating region occurred in Mig-6 −/− mice. Tibia trabecular bone mineral density (BMD) and the number of trabeculae were lower in surgically treated knees relative to the respective control knees for both groups. BMD, as well as trabecular thickness and number, were lower in surgically treated knees from Mig-6 −/− mice relative to WT surgically treated knees. Phosphorylated EGFR staining in surgically treated knees decreased for WT mice and increased for Mig-6 −/− mice. Fewer inflammatory cells were present in the knees of WT mice. Conclusion Mig-6 −/− mice have rapid and increased joint damage after ligament and meniscal trauma. Mig-6 modification could lessen degenerative disease development after this type of injury.http://deepblue.lib.umich.edu/bitstream/2027.42/109507/1/13075_2013_Article_4169.pd

A Real Time Optical Biosensor Assay for Amoxicillin and Other β-Lactams in Water Samples

Antibiotic contamination of drinking water and sewage is a matter of environmental and public health concern. Traditionally, ELISA or HPLC methods have been used to detect and measure antibiotic contamination. By applying an optical biosensing method, biolayer inteferometry (BLI), we have developed a kinetic competition binding assay capable of quantitating less than 1ppm (~33 μM) amoxicillin. Similar to surface plasmon resonance, BLI senses changes that occur upon binding of one molecule to another near a surface to measure association and dissociation. Immobilized amoxicillin was used to screen for binding against an analyte solution of anti-amoxicillin equilibrated with amoxicillin-containing water samples, yielding binding that fit a one-state model. Maximal binding correlated highly with amoxicillin concentration. Simplified analysis of samples from water and sewage treatment plants in Georgia allowed quantitation without kinetic modeling. The assay is sensitive, cost-effective, fast and readily adaptable to a variety of samples and other small molecules

Using Mycofiltration Treatment for Stormwater Management

Federal and State environmental regulations require transportation construction and retrofit projects to manage stormwater and improve water quality. MassDOT has legal, financial, and ecological obligations to mitigate pollution from stormwater runoff entering water bodies. Existing green and gray infrastructure in place across the Commonwealth is not always able to address non-point-source stormwater pollution. Mycofiltration is a promising stormwater management technology that utilizes mycelium, or fungal webs, as biological filters to mitigate water contaminants passing through woodchips, straw, or soil. This low-cost and low-tech solution could be added to MassDOT\u2019s typical Stormwater Control Measures (SCMs) to mitigate stormwater containing nitrogen, phosphorus, and biological pollutants (e.g., E. coli). This project analyzed existing literature and case studies on mycofiltration, documented interviews with subject matter experts, and identified MassDOT SCMs most suited for mycofiltration. Conceptual details for mycofiltration SCMs are provided, as are lists of potential local fungal inoculant vendors and academic research partners for future studies. The research indicates that there is currently not enough scientific peer-reviewed literature to support deploying mycofiltration as an addition to MassDOT stormwater SCMs. However, with further testing and verification, there may be benefits of including fungi as SCMs in the future

Generating hypotheses about care needs of high utilizers: lessons from patient interviews.

Informed by a largely secondary and quantitative literature, efforts to improve care and outcomes for complex patients with high levels of emergency and hospital-based health care utilization have offered mixed results. This qualitative study identifies psychosocial factors and life experiences described by these patients that may be important to their care needs. Semi-structured interviews were conducted with 19 patients of the Camden Coalition of Healthcare Providers\u27 Care Management Team. Investigators coded transcripts using a priori and inductively-derived codes, then identified 3 key themes: (1) Early-life instability and traumas, including parental loss, unstable or violent relationships, and transiency, informed many participants\u27 health and health care experiences; (2) Many high utilizers described a history of difficult interactions with health care providers during adulthood; (3) Over half of the participants described the importance to their well-being of positive and caring relationships with primary health care providers and the outreach team. Additionally, the transient and vulnerable nature of this complex population posed challenges to follow-up, both for research and care delivery. These themes illuminate potentially important hypotheses to be explored in more generalizable samples using robust and longitudinal methods. Future work should explore the prevalence and impact of adverse childhood experiences among high utilizers, and the different types of relationships they have with providers. Investigators should test new modes of care delivery that attend to patients\u27 trauma histories. This qualitative study was well suited to provide insight into the life stories of these complex, vulnerable patients, informing research questions for further investigation

A Real Time Optical Biosensor Assay for Amoxicillin And Other β-Lactams in Water Samples

Antibiotic contamination of drinking water and sewage is a matter of environmental and public health concern. Traditionally, ELISA or HPLC methods have been used to detect and measure antibiotic contamination. By applying an optical biosensing method, biolayer inteferometry (BLI), we have developed a kinetic competition binding assay capable of quantitating less than lppm (~33 μM) amoxicillin. Similar to surface plasmon resonance, BLI senses changes that occur upon binding of one molecule to another near a surface to measure association and dissociation. Immobilized amoxicillin was used to screen for binding against an analyte solution of anti-amoxicillin equilibrated with amoxicillin-containing water samples, yielding binding that fit a one-state model. Maximal binding correlated highly with amoxicillin concentration. Simplified analysis of samples from water and sewage treatment plants in Georgia allowed quantitation without kinetic modeling. The assay is sensitive, cost-effective, fast and readily adaptable to a variety of samples and other small molecules