262 research outputs found
Antihypertensive activities of royal jelly protein hydrolysate and its fractions in spontaneously hypertensive rats
Angiotensin I-converting enzyme (ACE) inhibitory and hypotensive effects of 7 peptide fractions (Frs) of royal jelly protein hydrolysate (RJPH) were studied in comparison with those of RJPH alone. Fr 4 and Fr 5 were the highest in ACE inhibitory activity and yield, respectively. Molecular weights (MWs) of RJPH and Fr 1-Fr 7 were distributed from 100 to 5,000 and those of Fr 1-Fr 7 increased in order from Fr 1 to Fr 7. RJPH, Fr 3 and Fr 4 at doses of 10, 30 and 100mg/kg i.v. and Fr 5 and Fr 6 at doses of 30 and 100mg/kg i.v. caused transiently significant hypotensive effects in spontaneously hypertensive rats (SHR). Fr 3, Fr 4, Fr 5 and Fr 6 at a dose of 1,000mg/kg also caused significant hypotensive effects 3h, 4-5h, 7-8h and 8h after oral administration in SHR, respectively. RJPH caused a long-lasting hypotensive effect in proportion to the magnitude of the MWs of RJPH fractions. The hypotensive pattern of RJPH was similar to the combined pattern of Fr 3-Fr 6. From these results, it can be concluded that the long-lasting hypotensive effect of oral administration of RJPH is dependent on the MWs of its ACE inhibitory peptides and the time required to digest them.</p
Three-dimensional structure of monoanionic methionine-enkephalin: X-ray structure of tert-butyloxycarbonyl-Tyr-Gly-Gly-(4-bromo)Phe-Met-OH
AbstractThe conformation of tert-butyloxycarbonyl-Tyr-Gly-Gly-(4-bromo)Phe-Met-OH, as a monoanionic derivative of Met-enkephalin, was elucidated by X-ray crystal analysis. The molecule took an extended conformation which was bended at the Phe residue. The implication of the dimer formation caused by 4 intermolecular hydrogen bonds was discussed in the relation with the opiate receptor
Волонтерство как социальный институт
Работа выполнена при поддержке РГНФ в рамках проекта №14-03-00072
Japanese VLBI Network observations of radio-loud narrow-line Seyfert 1 galaxies
We performed phase-reference very long baseline interferometry (VLBI)
observations on five radio-loud narrow-line Seyfert 1 galaxies (NLS1s) at 8.4
GHz with the Japanese VLBI Network (JVN). Each of the five targets (RXS
J08066+7248, RXS J16290+4007, RXS J16333+4718, RXS J16446+2619, and B3
1702+457) in milli-Jansky levels were detected and unresolved in
milli-arcsecond resolutions, i.e., with brightness temperatures higher than
10^7 K. The nonthermal processes of active galactic nuclei (AGN) activity,
rather than starbursts, are predominantly responsible for the radio emissions
from these NLS1s. Out of the nine known radio-loud NLS1s, including the ones
chosen for this study, we found that the four most radio-loud objects
exclusively have inverted spectra. This suggests a possibility that these NLS1s
are radio-loud due to Doppler beaming, which can apparently enhance both the
radio power and the spectral frequency.Comment: 8 pages, 2 figures, accepted for publication in PAS
VLBI Detections of Parsec-Scale Nonthermal Jets in Radio-Loud Broad Absorption Line Quasars
We conducted radio detection observations at 8.4 GHz for 22 radio-loud broad
absorption line (BAL) quasars, selected from the Sloan Digital Sky Survey
(SDSS) Third Data Release, by a very-long-baseline interferometry (VLBI)
technique. The VLBI instrument we used was developed by the Optically ConnecTed
Array for VLBI Exploration project (OCTAVE), which is operated as a subarray of
the Japanese VLBI Network (JVN). We aimed at selecting BAL quasars with
nonthermal jets suitable for measuring their orientation angles and ages by
subsequent detailed VLBI imaging studies to evaluate two controversial issues
of whether BAL quasars are viewed nearly edge-on, and of whether BAL quasars
are in a short-lived evolutionary phase of quasar population. We detected 20
out of 22 sources using the OCTAVE baselines, implying brightness temperatures
greater than 10^5 K, which presumably come from nonthermal jets. Hence, BAL
outflows and nonthermal jets can be generated simultaneously in these central
engines. We also found four inverted-spectrum sources, which are interpreted as
Doppler-beamed, pole-on-viewed relativistic jet sources or young radio sources:
single edge-on geometry cannot describe all BAL quasars. We discuss the
implications of the OCTAVE observations for investigations for the orientation
and evolutionary stage of BAL quasars.Comment: 10 pages, no figure, 3 tables, accepted for publication in PAS
Risk Score to Predict 1-Year Mortality after Haemodialysis Initiation in Patients with Stage 5 Chronic Kidney Disease under Predialysis Nephrology Care
Background
Few risk scores are available for predicting mortality in chronic kidney disease (CKD) patients undergoing predialysis nephrology care. Here, we developed a risk score using predialysis nephrology practice data to predict 1-year mortality following the initiation of
haemodialysis (HD) for CKD patients.
Methods
This was a multicenter cohort study involving CKD patients who started HD between April 2006 and March 2011 at 21 institutions with nephrology care services. Patients who had not received predialysis nephrology care at an estimated glomerular filtration rate (eGFR) of approximately 10 mL/min per 1.73 m2 were excluded. Twenty-nine candidate predictors were selected, and the final model for 1-year mortality was developed via multivariate logistic regression and was internally validated by a bootstrapping technique.
Results
A total of 688 patients were enrolled, and 62 (9.0%) patients died within one year of HD initiation. The following variables were retained in the final model: eGFR, serum albumin, calcium, Charlson Comorbidity Index excluding diabetes and renal disease (modified CCI), performance status (PS), and usage of erythropoiesis-stimulating agent (ESA). Their β-coefficients were transformed into integer scores: three points were assigned to modified CCI�3 and PS 3–4; two to calcium>8.5 mg/dL, modified CCI 1–2, and no use of ESA; and one to albumin7 mL/min per 1.73 m2, and PS 1–2. Predicted 1-year mortality risk was 2.5% (score 0–4), 5.5% (score 5–6), 15.2% (score 7–8), and 28.9% (score 9–12). The area under the receiver operating characteristic curve was 0.83 (95% confidence interval, 0.79–0.89).
Conclusions
We developed a simple 6-item risk score predicting 1-year mortality after the initiation of HD that might help nephrologists make a shared decision with patients and families regarding the initiation of HD.This work was supported by grants from the Institute for Health Outcomes & Process Evaluation research
Global Structure of Three Distinct Accretion Flows and Outflows around Black Holes through Two-Dimensional Radiation-Magnetohydrodynamic Simulations
We present the detailed global structure of black hole accretion flows and
outflows through newly performed two-dimensional radiation-magnetohydrodynamic
simulations. By starting from a torus threaded with weak toroidal magnetic
fields and by controlling the central density of the initial torus, rho_0, we
can reproduce three distinct modes of accretion flow. In model A with the
highest central density, an optically and geometrically thick supercritical
accretion disk is created. The radiation force greatly exceeds the gravity
above the disk surface, thereby driving a strong outflow (or jet). Because of
the mild beaming, the apparent (isotropic) photon luminosity is ~22L_E (where
L_E is the Eddington luminosity) in the face-on view. Even higher apparent
luminosity is feasible if we increase the flow density. In model B with a
moderate density, radiative cooling of the accretion flow is so efficient that
a standard-type, cold, and geometrically thin disk is formed at radii greater
than ~7R_S (where R_S is the Schwarzschild radius), while the flow is
radiatively inefficient otherwise. The magnetic-pressure-driven disk wind
appears in this model. In model C the density is too low for the flow to be
radiatively efficient. The flow thus becomes radiatively inefficient accretion
flow, which is geometrically thick and optically thin. The magnetic-pressure
force, in cooperation with the gas-pressure force, drives outflows from the
disk surface, and the flow releases its energy via jets rather than via
radiation. Observational implications are briefly discussed.Comment: 19 pages, 13 figures, accepted for publication in Ap
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