60 research outputs found
The Grizzly, December 3, 1982
Graterford Prisoners Counseled • Phi Psi Sponsors Santa • Chem Society Rated Outstanding • Renowned Professor Dies • Steinbright Scholarships Offered • News Briefs: Sigma Pi Sigma Inducts New Members; Operation Native Talent; New Evening School Class; Winterfest II Schedules Events; Going for Baroque • Commuters Don\u27t Get No Respect! • Letters to the Editor • Is Tuition Increase Justified? • Recent Thefts and Attacks Prompt Security Questions • Cheating at Ursinus? • A Last Squeeze Before Departing • The Missionary: A Blessing • Roving Reporter: How Do You Feel About the New Security System in the Quad? • Challenge Yourself at Outward Bound • The Perfect Man • UC Faculty Not Burnt Out • Sports Profile: Mullahy and Bazow, Football Captains • Women\u27s Basketball Tops Aggies in Opener: Jankauskas Scoring and Rebounding Was Key • UC Making a Contribution to Olympic Efforthttps://digitalcommons.ursinus.edu/grizzlynews/1090/thumbnail.jp
The Grizzly, November 13, 1981
Suspicious Visitor Causes Alarm • Whistle Blowing: The Problem of Ethics in Business • Two Students Caught In Breaking and Entering • Pledging Discussion • Student Teachers Putting in Their Hours • Powlette Speaks on Values • USGA Notes • Students Attend Orchestra Concert in Philadelphia • Ursinus Represented at PCCA Choir Festival • Winterfest Brings Culture Shock to UC • Study Abroad Series: Gidget Goes to Rome • UC Attempts \u27World\u27s Largest Sandcastle\u27 • Davis Selected All-American • Dickinson vs Bears in ECAC Championship • Student Plays for Peru in Pan Am Games • Swimmers Enthusiastic About New Season • Fencing Foils F&M • Bears End Disappointing Season With Loss • Grapplers Anxious To Begin • U.C. Harriers MAC Champs... Againhttps://digitalcommons.ursinus.edu/grizzlynews/1067/thumbnail.jp
The Grizzly, September 18, 1981
Thomas P. Glassmoyer Elected Board President • APO Retains Highest GPA Last Spring • Chemistry, Economics, History and English Departments Receive New Faculty • Forum Programs Now \u27til Christmas • Editorial: Just Like the Good Old Days? • Message From the President: Play an Active Part • Evening in Photography Offered • Evening School Expands Computer Program • New Staff Appointments • Dr. Schultze Represents UC in Conference • UC Buying Up Main Street: New Off-Campus Housing • Anarchy in America: Let\u27s Kill All the Lawyers • Decatur Follows Shakespeare to Germany • Electric Factory Does it Again • IFC Getting it All Together • USGA Notes • Six New Faculty • Improving Relationships and Self-Image Workshop • Lacrosse Club Announces Fall Season • Gridders Kick Off \u2781 Season With Victory • Field Hockey Looking Good • Cross Country Team Off to Fast Starthttps://digitalcommons.ursinus.edu/grizzlynews/1060/thumbnail.jp
A Phase I Double Blind, Placebo-Controlled, Randomized Study of a Multigenic HIV-1 Adenovirus Subtype 35 Vector Vaccine in Healthy Uninfected Adults
<div><h3>Background</h3><p>We conducted a phase I, randomized, double-blind, placebo-controlled trial to assess the safety and immunogenicity of escalating doses of two recombinant replication defective adenovirus serotype 35 (Ad35) vectors containing gag, reverse transcriptase, integrase and nef (Ad35-GRIN) and env (Ad35-ENV), both derived from HIV-1 subtype A isolates. The trial enrolled 56 healthy HIV-uninfected adults.</p> <h3>Methods</h3><p>Ad35-GRIN/ENV (Ad35-GRIN and Ad35-ENV mixed in the same vial in equal proportions) or Ad35-GRIN was administered intramuscularly at 0 and 6 months. Participants were randomized to receive either vaccine or placebo (10/4 per group, respectively) within one of four dosage groups: Ad35-GRIN/ENV 2×10<sup>9</sup> (A), 2×10<sup>10</sup> (B), 2×10<sup>11</sup> (C), or Ad35-GRIN 1×10<sup>10</sup> (D) viral particles.</p> <h3>Results</h3><p>No vaccine-related serious adverse event was reported. Reactogenicity events reported were dose-dependent, mostly mild or moderate, some severe in Group C volunteers, all transient and resolving spontaneously. IFN-γ ELISPOT responses to any vaccine antigen were detected in 50, 56, 70 and 90% after the first vaccination, and in 75, 100, 88 and 86% of Groups A–D vaccine recipients after the second vaccination, respectively. The median spot forming cells (SFC) per 10<sup>6</sup> PBMC to any antigen was 78–139 across Groups A–C and 158–174 in Group D, after each of the vaccinations with a maximum of 2991 SFC. Four to five HIV proteins were commonly recognized across all the groups and over multiple timepoints. CD4+ and CD8+ T-cell responses were polyfunctional. Env antibodies were detected in all Group A–C vaccinees and Gag antibodies in most vaccinees after the second immunization. Ad35 neutralizing titers remained low after the second vaccination.</p> <h3>Conclusion/Significance</h3><p>Ad35-GRIN/ENV reactogenicity was dose-related. HIV-specific cellular and humoral responses were seen in the majority of volunteers immunized with Ad35-GRIN/ENV or Ad35-GRIN and increased after the second vaccination. T-cell responses were broad and polyfunctional.</p> <h3>Trial Registration</h3><p>ClinicalTrials.gov <a href="http://clinicaltrials.gov/ct2/results?term=NCT00851383">NCT00851383</a></p> </div
Structural Modeling and DNA Binding Autoinhibition Analysis of Ergp55, a Critical Transcription Factor in Prostate Cancer
BACKGROUND: The Ergp55 protein belongs to Ets family of transcription factor. The Ets proteins are highly conserved in their DNA binding domain and involved in various development processes and regulation of cancer metabolism. To study the structure and DNA binding autoinhibition mechanism of Ergp55 protein, we have produced full length and smaller polypeptides of Ergp55 protein in E. coli and characterized using various biophysical techniques. RESULTS: The Ergp55 polypeptides contain large amount of α-helix and random coil structures as measured by circular dichorism spectroscopy. The full length Ergp55 forms a flexible and elongated molecule as revealed by molecular modeling, dynamics simulation and structural prediction algorithms. The binding analyses of Ergp55 polypeptides with target DNA sequences of E74 and cfos promoters indicate that longer fragments of Ergp55 (beyond the Ets domain) showed the evidence of auto-inhibition. This study also revealed the parts of Ergp55 protein that mediate auto-inhibition. SIGNIFICANCE: The current study will aid in designing the compounds that stabilize the inhibited form of Ergp55 and inhibit its binding to promoter DNA. It will contribute in the development of drugs targeting Ergp55 for the prostate cancer treatment
Safety and Immunogenicity Study of Multiclade HIV-1 Adenoviral Vector Vaccine Alone or as Boost following a Multiclade HIV-1 DNA Vaccine in Africa
We conducted a double-blind, randomized, placebo-controlled Phase I study of a recombinant replication-defective adenovirus type 5 (rAd5) vector expressing HIV-1 Gag and Pol from subtype B and Env from subtypes A, B and C, given alone or as boost following a DNA plasmid vaccine expressing the same HIV-1 proteins plus Nef, in 114 healthy HIV-uninfected African adults.Volunteers were randomized to 4 groups receiving the rAd5 vaccine intramuscularly at dosage levels of 1×10(10) or 1×10(11) particle units (PU) either alone or as boost following 3 injections of the DNA vaccine given at 4 mg/dose intramuscularly by needle-free injection using Biojector® 2000. Safety and immunogenicity were evaluated for 12 months. Both vaccines were well-tolerated. Overall, 62% and 86% of vaccine recipients in the rAd5 alone and DNA prime - rAd5 boost groups, respectively, responded to the HIV-1 proteins by an interferon-gamma (IFN-γ) ELISPOT. The frequency of immune responses was independent of rAd5 dosage levels. The highest frequency of responses after rAd5 alone was detected at 6 weeks; after DNA prime - rAd5 boost, at 6 months (end of study). At baseline, neutralizing antibodies against Ad5 were present in 81% of volunteers; the distribution was similar across the 4 groups. Pre-existing immunity to Ad5 did not appear to have a significant impact on reactogenicity or immune response rates to HIV antigens by IFN-γ ELISPOT. Binding antibodies against Env were detected in up to 100% recipients of DNA prime - rAd5 boost. One volunteer acquired HIV infection after the study ended, two years after receipt of rAd5 alone.The HIV-1 rAd5 vaccine, either alone or as a boost following HIV-1 DNA vaccine, was well-tolerated and immunogenic in African adults. DNA priming increased the frequency and magnitude of cellular and humoral immune responses, but there was no effect of rAd5 dosage on immunogenicity endpoints.ClinicalTrials.gov NCT00124007
Overconfident Investors, Predictable Returns, and Excessive Trading
The last several decades have witnessed a shift away from a fully rational paradigm of financial markets toward one in which investor behavior is influenced by psychological biases. Two principal factors have contributed to this evolution: a body of evidence showing how psychological bias affects the behavior of economic actors; and an accumulation of evidence that is hard to reconcile with fully rational models of security market trading volumes and returns. In particular, asset markets exhibit trading volumes that are high, with individuals and asset managers trading aggressively, even when such trading results in high risk and low net returns. Moreover, asset prices display patterns of predictability that are difficult to reconcile with rational-expectations–based theories of price formation. In this paper, we discuss the role of overconfidence as an explanation for these patterns
Lents: Alternatives for the Future
This document is the complement to the Issues Analysis. The Issues Analysis looked at the problems and issues which confront the Lents neighborhood. This document proposes actions that can be taken to address the issues identified in the previous analysis. Each section, e.g. Environment, Transportation, etc., has its own goals and subsequent objectives and actions. A goal is a broad statement of what is the desired outcome for the neighborhood. More specific objectives identify what needs to be done to improve things and to remedy the identified problems. The actions are means to achieve an objective. Specific potential implementers are then proposed for each action suggested. Interconnections between different sections exist for many problems and solutions. For example, the light rail alignment is a transportation issue but has ramifications in all aspects of life. Because of the inter-relatedness of the urban system, it was concluded that a unifying vision would be the best vehicle to present the means of addressing the neighborhood\u27s issues. Three distinct visions of potential futures for the neighborhood of Lents are presented below.
The time scale for these visions is long, approximately 50 years. This allows for three distinctly different visions for Lents. The three visions are; Status Quo, Urban Villages and Regional Attractor. The visions act to encompass all the linkages and provide direction towards a unified future state of existence for the neighborhood. An urban system, like any system, needs to have connection and continuity between its various parts for it to function efficiently. The visions are a means of achieving this.
In the Status Quo vision the neighborhood will continue to move through time without major adjustments to its existing state. The actions for change are congruent with the existing state of the neighborhood. Goals and objectives for this vision relate directly to current neighborhood concerns. The suggested actions work towards alleviating current problems and making the neighborhood a better place to live, work and do business. The land use structure and neighborhood function would be not be altered in any significant way.
The Urban Village\u27s fundamental idea is to strive for neighborhood selfsufficiency. The neighborhood is separated into nodes or activity centers. A node or activity center is a relatively small area of diverse and intense activity. The nodes help to define residents\u27 sense of neighborhood. A node might have a public open space, such as a developed park, which would be surrounded by mixed-use development, commercial on the first floor and residential above. The nodes would be linked by pedestrian friendly greenways (streets improved with trees and flora) encouraging walking as the preferred mode of transportation. Density would be increased around the nodes to further encourage pedestrian travel and make businesses economically viable to customers using this mode of travel. Educational facilities would be linked closely to neighborhood needs, and cottage industries would be encouraged.
In the Regional Attractor vision, the neighborhood would serve a specialized function to the whole metropolitan region. The focus would switch from mainly residential concerns to primaily employment generating concerns. Industry and business would be the critical elements in this neighborhood vision. Automobile or transit use would be the major modes of travel to ensure the neighborhood has regional accessibility. The neighborhood would serve as a single component within a regional system.
This document will explore each of these visions in greater depth and present the means to making the vision a reality. While no single vision of Lents will seem preferable to everyone, the hope in presenting these three distinctly different potential futures for the neighborhood, is to reinforce an understanding of the tradeoffs that must be considered when developing a Lents plan. The intent is not to actually see the implementation of one of these visions, but rather to make the choices that must be made between one action and another more explicit. Our sincere hope is that any dialoque this document provokes will be one in which the interests of all Lents residents, present and future, are considered
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