Efektivitas Kinerja Ombudsman dalam Menangani Pengaduan Pelayanan (Kasus Maladministrasi di Kota Pekanbaru)

Ombudsman has a very important role in makingthe good public service because as a supervisory institution of public service provider which is according to Constitution Number 37 of 2008.Therefore the Ombudsman should emphasize on the effectiveness in overseeing public service provider. Included in implement the programs such as implementing socialization activity like introduction of the Ombudsman institution, investigation activities, monitoring and supervision of public service providers based on the issues of maladministration report. As this study aims to determine how the effectiveness and barriers of Riau Province Representative Ombudsman of the Indonesia Republic in supervision of public service provider.This research is a descriptive study that using qualitative approach as a tool of analysis. This research is conducted in the city of Pekanbaru with key informant interviews as an object of information that aims to achieve the goal to have the information. in this study. Data used in this study are primary data and secondary data obtained through direct observation and interviews with key informants.Riau Province Representative Ombudsman in dealing with complaints of maladministration had not been effective,especially in the prevention and settlement report, caused its there barriers such lack of human resources, the limited budget, the lack of facilities to support the performance of the Ombudsman of Riau Province Representative. This has an impact on the number of reports of unresolved by the ombudsman as well as the persistence of maladministration undertaken by public service provider in Pekanbaru so it is very detrimental to the public and sides related. Therefore, needs additional human resources, increasing in the funding, the addition of support facilities and needssocialization evenly related to the Riau Representative Ombudsman of the Indonesia Republi

Comparative investigation of derivatives of (E)-N-((E)-3-phenylallylidene)aniline: Synthesis, structural characterization, biological evaluation, density functional theory analysis, and in silico molecular docking

Bacterial resistance to antibiotics poses a significant global challenge for the public sector. Globally, researchers are actively investigating solutions to tackle the issue of bacterial resistance to antibiotics, with Schiff bases standing out as promising contenders in the fight against antimicrobial resistance. This study focused on synthesizing a series of Schiff bases (CA1-CA10) by reacting cinnamaldehyde with various aniline derivatives. Various analytical techniques, such as NMR, FTIR, UV–Vis, elemental analysis, and mass spectrometry, were employed to elucidate the structures of the synthesized compounds. Furthermore, crystal structure of CA8 was obtained using single crystal X-ray spectroscopy. The compounds were subjected to in vitro testing to assess their antibacterial and antifungal properties against eleven bacterial strains and four fungal strains. The results revealed diverse activity levels against the pathogens at varying concentrations, with notable potency observed in compounds CA3, CA4, CA9, and CA10, as indicated by their minimum inhibitory concentrations (MIC) values. The observed activity of the compounds seemed to be influenced by the specific substituents attached to their molecular structure. By conducting computational and molecular docking studies, the electronic properties of the compounds were investigated, further substantiating their potential as effective antimicrobial agents

Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation

Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in Alzheimer’s Disease (AD), though mechanisms underlying this dysfunction remain elusive. Here, primary microglia from adult AD (5xFAD) mice were utilized to demonstrate that 5xFAD microglia fail to degrade Aβ and express low levels of autophagy cargo receptor NBR1. In 5xFAD mouse brains, we show for the first time that AD microglia express elevated levels of microRNA cluster Mirc1/Mir17-92a, which is known to downregulate autophagy proteins. By in situ hybridization in post-mortem AD human tissue sections, we observed that the Mirc1/Mir17-92a cluster member miR-17 is also elevated in human AD microglia, specifically in the vicinity of Aβ deposits, compared to non-disease controls. We show that NBR1 expression is negatively correlated with expression of miR-17 in human AD microglia via immunohistopathologic staining in human AD brain tissue sections. We demonstrate in healthy microglia that autophagy cargo receptor NBR1 is required for Aβ degradation. Inhibiting elevated miR-17 in 5xFAD mouse microglia improves Aβ degradation, autophagy, and NBR1 puncta formation in vitro and improves NBR1 expression in vivo. These findings offer a mechanism behind dysfunctional autophagy in AD microglia which may be useful for therapeutic interventions aiming to improve autophagy function in AD