4,564 research outputs found

    Matanuska Valley Memoir

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    We acknowledge indebtedness to the historians and developers of Alaskana who preceded us and provided much of the information we have compiled into our account of the birth of a community. Many "old timers" from the Valley provided valuable insight into situations they had experienced. Mr. Roland Snodgrass, Mrs, June Murphy and Miss Dolores Pommier assisted in compilation and preparation of background data. Mr. James Hurley made available to us the ARRC unpublished files for compilation of certain data. Various public officials aided us in many ways as we worked· our way through recorded . history. Several old photos were contributed by Mr. Walter Teeland of Wasilla and Mr. Don L. Irwin of Palmer. Several persons in public and private life who know Alaskan conditions have reviewed the manuscript and suggested improvements, Special acknowledgement is due Don L. Irwin, Director of the Alaska Agricultural Experiment Station, His vision and foresight were largely responsible for the undertaking, His encouragement and advice bolstered our lagging spirits before the long task was completed. He has read each chapter critically and has assisted particularly with interpretation of materials since 1935,The Matanuska Valley was created through action of ice, water and wind. When the last glaciers retreated up the Susitna, the Knik and the Matanuska valleys, vegetation began cove ring the scars, Over several centuries a dense growth of trees and brush screened the land from Knik Arm to the mountain slopes of the Talkeetna range . Here and there a lake broke the uniform forest mantle. A salt marsh at the mouth of the Matanuska River kept the rank undergrowth from reaching tide water, A few low spots near the Little Susitna and other swampy areas supported a thick cover of moss or grass. The Valley, which really isn't a valley at all but a reworked foreland, rises from the Matanuska River in a series of benches ranging in width from a few hundred feet to more than a mile. Some areas are flat, others are rolling. Soil depth varies from eight feet in thickness for the region bordering the Matanuska River to a few inches in sections west of Wasilla. The soil mantle, of windblown loessial materials, is of relatively new geologic development, The Valley is bounded by the Chugach Mountains on the east, the Talkeetnas on the north, the Susitna Valley on the west and Knik Arm on the south. Winters are long but usually not unduly severe; summers cool and relatively moist, To this country came trappers, prospectors and traders in closing years of the nineteenth century. Hordes of insects, difficult trails, sparse population and great distance s from supply points discouraged many potential residents, Those who stayed were interested primarily in the Willow Creek gold field or the Matanuska coal deposits. Another generation, an uneasy international situation and social crises within the United States were required before the Matanuska Valley and the rest of Upper Cook Inlet were ripe for use. This history of the Valley is designed to trace the many human elements affecting the ebb and flow of agricultural development here. It brings into focus many problems that must be solved before new areas in Alaska can be settled satisfactorily

    Abiotic Factors Influencing the Breeding, Movement, and Foraging of the Eastern Spadefoot (Scaphiopus holbrookii) in West Virginia

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    Haphazard searches and telemetry methods were used to track movements and habitat use of two recently discovered and only known populations of Scaphiopus holbrookii in West Virginia. It was the purpose of this study to determine the home range and habitat use of S. holbrookii. Toads were found to forage a mean distance of 13.5 in. (34.5 cm) from their burrows. Habitat consisted of open areas with soil textures of sandy loam, loamy sand, or sand. Radio- transmitters were surgically implanted in two specimens from one breeding site to provide data about habitat use and emergence. Data loggers were installed at each of the two sites. Abiotic factors were recorded to help determine conditions required for breeding and foraging of S. holbrookii. Toads emerged at a minimum relative humidity of 73%, and a mean air temperature of 63.9 °F (17.7 °C). Toads were found at a minimum soil temperature of 59 °F (15 °C). Rain was not a factor in toad emergence. Toads did not breed at either site in 2002

    Preclinical Alzheimer Disease - The Challenges Ahead

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    There is growing recognition that the pathophysiological process of Alzheimer disease (AD) begins many years prior to clinically obvious symptoms, and the concept of a presymptomatic or preclinical stage of AD is becoming more widely accepted. Advances in biomarker studies have enabled detection of AD pathology in vivo in clinically normal older individuals. The predictive value of these biomarkers at the individual patient level, however, remains to be elucidated. The ultimate goal of identifying individuals in the preclinical stages of AD is to facilitate early intervention to delay and perhaps even prevent emergence of the clinical syndrome. A number of challenges remain to be overcome before this concept can be validated and translated into clinical practice

    Demonstration and characterisation of a non-inverting all-optical read/write regenerative memory

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    An all-optical regenerative memory device using a single loop mirror and a semiconductor optical amplifier is experimentally demonstrated. This configuration has potential for a low power all-optical stable memory device with non-inverting characteristics where packets are stored by continuously injecting the regenerated data back into the loop

    α\alpha-Scale Decoupling of the Mechanical Relaxation and Diverging Shear Wave Propagation Lengthscale in Triphenylphosphite

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    We have performed depolarized Impulsive Stimulated Scattering experiments to observe shear acoustic phonons in supercooled triphenylphosphite (TPP) from \sim10 - 500 MHz. These measurements, in tandem with previously performed longitudinal and shear measurements, permit further analyses of the relaxation dynamics of TPP within the framework of the mode coupling theory (MCT). Our results provide evidence of α\alpha coupling between the shear and longitudinal degrees of freedom up to a decoupling temperature TcT_c = 231 K. A lower bound length scale of shear wave propagation in liquids verified the exponent predicted by theory in the vicinity of the decoupling temperature

    Neuroanatomical Structure of the Spinner Dolphin (Stenella longirostris orientalis) Brain From Magnetic Resonance Images

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    High-resolution magnetic resonance (MR) images of the brain of an adult spinner dolphin (Stenella longirostris orientalis) were acquired in the coronal plane at 55 antero-posterior levels. From these scans a computergenerated set of resectioned virtual images in the two remaining orthogonal planes was constructed with the use of the VoxelView and VoxelMath (Vital Images, Inc.) programs. Neuroanatomical structures were labeled in all three planes, providing the first labeled anatomical description of the spinner dolphin brain

    Counter Directed Energy Warfare (CDEW)

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    NPS NRP Executive SummaryCounter Directed Energy Warfare (CDEW)Office of Naval Research (ONR)This research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.

    Thermal and Pressure Characterization of a Wind Tunnel Force Balance Using the Single Vector System

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    Wind tunnel research at NASA Langley Research Center s 31-inch Mach 10 hypersonic facility utilized a 5-component force balance, which provided a pressurized flow-thru capability to the test article. The goal of the research was to determine the interaction effects between the free-stream flow and the exit flow from the reaction control system on the Mars Science Laboratory aeroshell during planetary entry. In the wind tunnel, the balance was exposed to aerodynamic forces and moments, steady-state and transient thermal gradients, and various internal balance cavity pressures. Historically, these effects on force measurement accuracy have not been fully characterized due to limitations in the calibration apparatus. A statistically designed experiment was developed to adequately characterize the behavior of the balance over the expected wind tunnel operating ranges (forces/moments, temperatures, and pressures). The experimental design was based on a Taylor-series expansion in the seven factors for the mathematical models. Model inversion was required to calculate the aerodynamic forces and moments as a function of the strain-gage readings. Details regarding transducer on-board compensation techniques, experimental design development, mathematical modeling, and wind tunnel data reduction are included in this paper

    Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover.

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    Desmosomes are prominent adhesive junctions present between many epithelial cells as well as cardiomyocytes. The mechanisms controlling desmosome assembly and remodeling in epithelial and cardiac tissue are poorly understood. We recently identified protein palmitoylation as a mechanism regulating desmosome dynamics. In this study, we have focused on the palmitoylation of the desmosomal cadherin desmoglein-2 (Dsg2) and characterized the role that palmitoylation of Dsg2 plays in its localization and stability in cultured cells. We identified two cysteine residues in the juxtamembrane (intracellular anchor) domain of Dsg2 that, when mutated, eliminate its palmitoylation. These cysteine residues are conserved in all four desmoglein family members. Although mutant Dsg2 localizes to endogenous desmosomes, there is a significant delay in its incorporation into junctions, and the mutant is also present in a cytoplasmic pool. Triton X-100 solubility assays demonstrate that mutant Dsg2 is more soluble than wild-type protein. Interestingly, trafficking of the mutant Dsg2 to the cell surface was delayed, and a pool of the non-palmitoylated Dsg2 co-localized with lysosomal markers. Taken together, these data suggest that palmitoylation of Dsg2 regulates protein transport to the plasma membrane. Modulation of the palmitoylation status of desmosomal cadherins can affect desmosome dynamics
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