Abstract: A Critical Examination Exploring the Differences between Geotourism and Ecotourism

Geotourism differentiates itself from ecotourism by focusing on the working landscape of the region. Geotourism is not bounded by a protected or pristine area, but ties sustainability to all aspects of the region where people interact with the environment. This paper suggests that geotourism will emerge as a new way to view sustainable tourism even though the tourism literature is inundated with a variety of sustainable tourism definitions and niche segments like ecotourism. Geotourism is presented as a measurable and concrete concept. The forthcoming Geotourism Survey Instrument is a result of this study

Validating Hemoglobin Saturation and Dissolved Oxygen in Tumors using the OxyLab Probe and Photoacoustic Imaging

The goal of this experiment is to validate the relationship between hemoglobin saturation (SaO2) and partial pressure of dissolved oxygen (pO2) in breast tumors in mice using photoacoustic computed tomographic (PCT) imaging and OxyLite probe, respectively. In its simplest form, the relationship is described by the dissociation curve, or Hill’s equation, for hemoglobin, and is modeled as a sigmoidal curve that is a function of two parameters – the Hill coefficient, n, and the net association constant of HbO2, K (or pO2 at 50% SaO2). First, a calibration study to validate Hill’s equation in blood was performed by creating a closed circuit phantom to test the SaO2 (co-oximeter) and pO2 (Oxylite probe) relationship (K=23.2mmHg and n=2.26). Next, non-invasive localized measurements of SaO2 in MDA-MD-231 and MCF7 breast tumors using PCT spectroscopic methods were compared to pO2 levels, where pO2 levels were measured in 1mm increments across the central axis of the tumor. The fitted results for MCF7 and MDA-MD-231 were K=17.2mmHg and 20.7mmHg, and n=1.76and 1.63, respectively. The results are consistent with sigmoidal form of Hill’s equation. The lower value of K is indicative of the acidic microenvironment associated with tumors. Ongoing work to correct for photon transport and image artifacts are anticipated to enhance the quality of the results. In conclusion, the results from this study demonstrate photoacoustic can be used to measure tumor oxygenation, and its potential use in investigating the effectiveness of anti-angiogenesis therapy

Training Underrepresented High School Students as a Strategy to Increase Diversity in the Biomedical Research and Health Professions Workforce

This manuscript introduces the abstracts from the University of California, Los Angeles Coordinating Center

Slim Epistemology with a Thick Skin

The distinction between ‘thick’ and ‘thin’ value concepts, and its importance to ethical theory, has been an active topic in recent meta-ethics. This paper defends three claims regarding the parallel issue about thick and thin epistemic concepts. (1) Analogy with ethics offers no straightforward way to establish a good, clear distinction between thick and thin epistemic concepts. (2) Assuming there is such a distinction, there are no semantic grounds for assigning thick epistemic concepts priority over the thin. (3) Nor does the structure of substantive epistemological theory establish that thick epistemic concepts enjoy systematic theoretical priority over the thin. In sum, a good case has yet to be made for any radical theoretical turn to thicker epistemology

vivo antibacterial efficacy of ultrasound after hand and rotary instrumentation in human mandibular molars

Abstract The purpose of this prospective, randomized, singleblind study was to compare the in vivo antibacterial efficacy of a hand/rotary technique versus a hand/ rotary/ultrasound technique in mesial root canals of necrotic mandibular molars. The hand/rotary group consisted of 16 mesial roots prepared with a hand/ rotary technique. The hand/rotary/ultrasound group consisted of 15 mesial roots prepared similarly, followed by 1 minute of ultrasonic irrigation per canal with an ultrasonic needle in a MiniEndo unit and 15 mL/canal of 6.0% sodium hypochlorite. Canals were sampled before and after instrumentation and after 1 minute of ultrasonic irrigation. Samples were incubated anaerobically on reduced blood agar for 7 days at 37°C, and colony-forming units (CFUs) were counted. The addition of 1 minute of ultrasonic irrigation resulted in significant (p ϭ .0006) reduction in CFU count and positive cultures (p ϭ .0047). Logistic regression analysis indicated the addition of ultrasonic irrigation was 7 times more likely to yield a negative culture. (J Endo

Multimodal cardiovascular magnetic resonance quantifies regional variation in vascular structure and function in patients with coronary artery disease: Relationships with coronary disease severity

<p>Abstract</p> <p>Background</p> <p>Cardiovascular magnetic resonance (CMR) of the vessel wall is highly reproducible and can evaluate both changes in plaque burden and composition. It can also measure aortic compliance and endothelial function in a single integrated examination. Previous studies have focused on patients with pre-identified carotid atheroma. We define these vascular parameters in patients presenting with coronary artery disease and test their relations to its extent and severity.</p> <p>Methods and Results</p> <p>100 patients with CAD [single-vessel (16%); two-vessel (39%); and three-vessel (42%) non-obstructed coronary arteries (3%)] were studied. CAD severity and extent was expressed as modified Gensini score (mean modified score 12.38 ± 5.3). A majority of carotid plaque was located in the carotid bulb (CB). Atherosclerosis in this most diseased segment correlated modestly with the severity and extent of CAD, as expressed by the modified Gensini score (R = 0.251, P < 0.05). Using the AHA plaque classification, atheroma class also associated with CAD severity (rho = 0.26, P < 0.05). The distal descending aorta contained the greatest plaque, which correlated with the degree of CAD (R = 0.222; P < 0.05), but with no correlation with the proximal descending aorta, which was relatively spared (R = 0.106; P = n. s.). Aortic distensibility varied along its length with the ascending aorta the least distensible segment. Brachial artery FMD was inversely correlated with modified Gensini score (R = -0.278; P < 0.05). In multivariate analysis, distal descending aorta atheroma burden, distensibility of the ascending aorta, carotid atheroma class and FMD were independent predictors of modified Gensini score.</p> <p>Conclusions</p> <p>Multimodal vascular CMR shows regional abnormalities of vascular structure and function that correlate modestly with the degree and extent of CAD.</p

Advancing the Transition to a High Performance Rural Health System

There are growing concerns about the current and future state of rural health. Despite decades of policy efforts to stabilize rural health systems through a range of policies and loan and grant programs, accelerating rural hospital closures combined with rapid changes in private and public payment strategies have created widespread concern that these solutions are inadequate for addressing current rural health challenges. The rural health system of today is the product of legacy policies and programs that often do not “fit” current local needs. Misaligned incentives undermine high-value and efficient care delivery. While there are limitations related to scalability in rural health system development, rural communities do have enormous potential to achieve the objectives of a high performance rural health system. This brief (and a companion paper at http://www.rupri.org/areas-of-work/health-policy/) discusses strategies and options for creating a pathway to a transformed, high performing rural health system

Pursuing High Performance in Rural Health Care

Rural Futures Lab Foundation Papers are intended to present current thinking on the economic drivers and opportunities that will shape the future of rural America. They provide the foundation upon which it will be possible to answer the question that drives the Lab’s work—What has to happen today in order to achieve positive rural outcomes tomorrow