A Change-of-Measure Approach to Per- Flow Delay Measurement Combining Passive and Active Methods : Mathematical Formulation for CoMPACT Monitor

One problem with active measurement is that, while it is suitable for measuring time-average network performance, it is difficult to measure per-flow quality of service (QoS), which is defined as the average over packets in the flow. To achieve such per-flow QoS measurement, the authors proposed a new technique, called the change- of- measure-based passive/active monitoring (CoMPACT Monitor), which is based on the change-of-measure framework in probability/measure theory and transforms actively obtained information by using passively monitored data. This technique enables us to concurrently measure one-way delay information about individual users, applications, and organizations in detail in a lightweight manner. This paper presents the mathematical formulation for the CoMPACT Monitor and verifies that it works well under some weak conditions. In addition, we investigate its characteristics regarding several implementation issues through simulation and actual network experiments. The results reveal that our technique provides highly qualified estimates involving only a limited amount of extra traffic from active probes

Development of Flat Tube Heat Exchanger for Heat Pump Air Conditoner

We developed a new type of a heat pump outdoor unit using an aluminum flat tube heat exchanger in order to improve the energy saving capability of an air conditioner. There are several difficulties in keeping a desired drainage performance, frost formation performance, as well as even distribution of refrigerant, when applying the flat tube heat exchanger to heat pump outdoor units. In order to achieve the same drainage performance and the frost formation performance as those of conventional heat exchangers, we have adopted new plate fins with ellipse cutouts. Flat tubes were inserted in the ellipse cutouts, and the slit position on a plate fin was properly adjusted. In order to achieve the even distribution of refrigerant, an aluminum distributor and 3-way pipes were installed to the evaporator. In this report, first we describe features of the flat tube heat exchanger. Next, we present and explain experimental results of the air-side heat transfer coefficient and the air-side pressure drop on the condition of dry, wet, and frost state respectively. Moreover, we present experimental results of the total heat transfer performance, including the refrigerant performance, under the conditions of the condensation and the evaporation. Finally, we explain the heat transfer performance and the effect of the flat tube heat exchanger to a conventional one in the case that the developed heat exchanger was mounted in heat pump outdoor unit

Ziram, a dithiocarbamate fungicide, exhibits pseudo-cytoprotective actions against oxidative stress in rat thymocytes : Possible environmental risks

Ziram, a dithiocarbamate fungicide, protects various vegetables and fruits against infections by fungus. Recently, there have been increasing anxieties about the risks in the use of dithiocarbamate fungicides. Our previous studies showed that Zn2+ was a determinant of Ziram cytotoxicity. In addition, Zn2+ is linked to H2O2 cytotoxicity. Therefore, in this study, we aimed to test the hypothesis that Ziram could augment the cytotoxicity of H2O2 by examining the changes induced by Ziram in some cellular parameters in rat thymic lymphocytes subjected to H2O2-induced oxidative stress using flow-cytometric methods with fluorescent dyes. Ziram significantly attenuated H2O2-induced cell death at sublethal concentrations. However, in the cells under oxidative stress elicited by H2O2, Ziram promoted the changing over from intact cells to living cells with exposed phosphatidylserine (PS) on plasma membranes, whereas it inhibited the transition from PS-exposed living cells to dead cells. Ziram significantly augmented H2O2 actions, including reduction of cellular glutathione levels and elevation of intracellular Zn2+ concentrations. Conversely, it attenuated H2O2-induced depolarization of mitochondrial membrane potential. Ziram at sublethal concentrations seems to exhibit promotive and suppressive actions on the process of cell death caused by H2O2. Ziram increased the number of living cells with exposed PS, a phenomenon characteristic of early stages of apoptosis. Thus, it is concluded that Ziram exhibits pseudo-cytoprotective actions against H2O2- induced oxidative stress

Corneal Nociceptors and Tear Deficiency

Chronic tear deficiency enhances the excitability of corneal cold-sensitive nerves that detect ocular dryness, which can lead to discomfort in patients with dry eye disease (DED). However, changes in corneal nerve excitations through the polymodal nociceptor “transient receptor potential vanilloid 1” (TRPV1) and the potential link between this receptor and symptoms of DED remain unclear. In this study, we examined the firing properties of corneal cold-sensitive nerves expressing TRPV1 and possible contributions of chronic tear deficiency to corneal nerve excitability by TRPV1 activation. The bilateral excision of lacrimal glands in guinea pigs decreased the tear volume and increased the frequency of spontaneous eyeblinks 1–4 weeks after surgery. An analysis of the firing properties of the cold-sensitive nerves was performed by single-unit recordings of corneal preparations 4 weeks after surgery in both the sham-operated and gland-excised groups. Perfusion of the TRPV1 agonist, capsaicin (1 μM), transiently increased the firing frequency in approximately 46–48% of the cold-sensitive nerves characterized by low-background activity and high threshold (LB-HT) cold thermoreceptors in both groups. Gland excision significantly decreased the latency of capsaicin-induced firing in cold-sensitive nerves; however, its magnitude was unchanged. Calcium imaging of cultured trigeminal ganglion neurons from both groups showed that intracellular calcium elevation of corneal neurons induced by a low concentration of capsaicin (0.03 μM) was significantly larger in the gland excision group, regardless of responsiveness to cold. An immunohistochemical study of the trigeminal ganglion revealed that gland excision significantly increased the proportion of corneal neurons enclosed by glial fibrillary acidic protein (GFAP)-immunopositive satellite glial cells. Topical application of the TRPV1 antagonist, A784168 (30 μM), on the ocular surface attenuated eye-blink frequency after gland excision. Furthermore, gland excision enhanced blink behavior induced by a low concentration of capsaicin (0.1 μM). These results suggest that chronic tear deficiency sensitizes the TRPV1-mediated response in the corneal LB-HT cold thermoreceptors and cold-insensitive polymodal nociceptors, which may be linked to dry eye discomfort and hyperalgesia resulting from nociceptive stimuli in aqueous-deficient dry eyes

How Many Mutex Bugs Can a Simple Analysis Find in Go Programs?

In open-source software, it is known that there are many concurrency bugs. A previous study in Go revealed that a considerable number of such bugs are simple (for example, 9% of the bugs are the ones that forget to unlock a mutex,) through a manual program investigation. This paper tries to detect such bugs by applying a simple analysis to see how far such a tool can match the manual analysis. We built a simple intraprocedural control flow analysis in Go, and evaluated its performance concerning the open source programs with concurrency bugs reported in the previous study. Consequently, as for quality, the recall is good at 88%, and the precision is poor at 60%; as for analysis time, it can be finished within a practical amount of time (for example, 1 second per 5000 LoC)

Myocardial Impairment Detected by Late Gadolinium Enhancement in Hypertrophic Cardiomyopathy: Comparison with 99mTc-MIBI/Tetrofosmin and 123I-BMIPP SPECT

Purpose: Myocardial fibrosis is considered to be an important factor in myocardial dysfunction and sudden cardiac death in hypertrophic cardiomyopathy (HCM). The purpose of this study was to compare myocardial fibrosis detected by late gadolinium enhancement (LGE) on cardiac MRI with myocardial perfusion and fatty acid metabolism assessed by single photon emission computed tomography in HCM.Materials and Methods: We retrospectively evaluated 20 consecutive HCM patients (female, 7; mean age, 53.4 years) who underwent LGE, technetium-99m methoxyisobutylisonitrile/tetrofosmin (99mTc-MIBI/tetrofosmin), and iodine-123 beta-methyl-iodophenylpentadecanoic acid (123I-BMIPP) imaging. We calculated the myocardium-to-lumen signal ratio (M/L) for LGE in 17 segments based on the American Heart Association statement. Scoring of 99mTc-MIBI/tetrofosmin (PI) and 123I-BMIPP (BM) was performed for each segment using a 5-point scale (0, normal; 4, highly decreased).Results: Nineteen of 20 patients (95%) and 153 of 340 segments (45%) showed LGE. M/Ls were 0.42ｱ・.16, 0.55ｱ・.17, and 0.65ｱ・.24 in PI0/BM0, PI0/BM1-4 and PI1-4/BM1-4, respectively. All M/Ls were significantly higher than that of a normal control (0.34ｱ・.14) (p<0.001).Conclusions: Myocardial fibrosis in HCM can occur despite normal perfusion and fatty acid metabolism, and is more strongly associated with disorders of fatty acid metabolism than with perfusion abnormalities. M/L may be a useful indicator of disease severity