Improvements in Attitude Determination and Control of the Small Satellite Flying Laptop

Precise attitude control is a key factor of many payloads with high ground resolutions, small fields of view or narrow beams such as an optical data downlink. The small satellite Flying Laptop (FLP), launched in July 2017, was developed by graduate and undergraduate students at the Institute of Space Systems of the University of Stuttgart with support by the space industry and research institutions. The satellite is three-axis stabilized with reaction wheels as main actuators. FLP is equipped with the OSIRIS optical data downlink which was built by the German Aerospace Center (DLR). As this instrument is body mounted on an optical bench, the attitude determination and control system (ACS) is required to point the whole satellite in the direction of the ground station with a high pointing accuracy of 150 arcseconds. At the time of launch the ACS did not reach this precision. This paper describes how the attitude determination and control were improved to achieve the required performance. The improvements can be divided into two parts. The first part includes the enhancement of on-board sensor processing and attitude control. In the second part, in-orbit data were utilized to increase the accuracy of parameters which are used to control the spacecraft. The first part includes the addition of a Kalman filter, an improved position propagation, and the introduction of adaptive gains to the on-board ACS. The FLP simulation test bed was used to verify the changes. The test bed was also used to find adequate initial values for the Kalman filter and to find inaccuracies in the sensor processing. In the second part, the adaptive gains and the Kalman initial values were validated in-orbit after the upload of the new sensor processing. Moreover, the on-board component orientation settings were corrected for the star trackers, the multi-spectral camera system, and the OSIRIS instrument on FLP. As a result, the satellite fulfills the pointing requirement of less than 150 arcsecond deviation from the target attitude for a sufficient period of time during a pass over the target. Successful links with the optical data downlink were demonstrated with the DLR ground station in Oberpfaffenhofen

Update on DLR's OSIRIS program and first results of OSIRISv1 on Flying Laptop

Optical satellite links have gained increasing attention throughout the last years. Especially for the application of optical satellite downlinks. Within the OSIRIS program, DLR's Institute of Communications and Navigation develops optical terminals and systems which are optimized for small satellites. After the successful qualification and launch of two precursor terminals, DLR currently develops OSIRISv3, a 3rd generation OSIRIS terminal with up to 10 Gbps downlink rate, and OSIRIS4Cubesat, a miniaturized version optimized for Cubesat Applications. The University of Stuttgart's Institute of Space Systems develops small satellites, which are used to demonstrate novel technologies in the Space domain. Together, DLR and University of Stuttgart integrated the first OSIRIS generation onboard the Flying Laptop satellite, which was launched in July 2017 and has been successfully operated since. This paper will give an overview about DLR's OSIRIS program. Furthermore, it will show first results of OSIRISv1 on Flying Laptop. Therefore, the Flying Laptop satellite and OSIRISv1 will be explained. Preliminary results from the validation campaign, where optical downlinks have been demonstrated, will be given. © 2019 SPIE. Downloading of the abstract is permitted for personal use only

Genetic Analyses of Heme Oxygenase 1 (HMOX1) in Different Forms of Pancreatitis

Contains fulltext : 107993.pdf (publisher's version ) (Open Access)BACKGROUND: Heme oxygenase 1 (HMOX1) is the rate limiting enzyme in heme degradation and a key regulator of inflammatory processes. In animal models the course of pancreatitis was ameliorated by up-regulation of HMOX1 expression. Additionally, carbon monoxide released during heme breakdown inhibited proliferation of pancreatic stellate cells and might thereby prevent the development of chronic pancreatitis (CP). Transcription of HMOX1 in humans is influenced by a GT-repeat located in the promoter. As such, HMOX1 variants might be of importance in the pathogenesis of pancreatitis. METHODS: The GT-repeat and SNP rs2071746 were investigated with fluorescence labelled primers and by melting curve analysis in 285 patients with acute pancreatitis, 208 patients with alcoholic CP, 207 patients with idiopathic/hereditary CP, 147 patients with alcoholic liver cirrhosis, and in 289 controls, respectively. GT-repeat analysis was extended to a total of 446 alcoholic CP patients. In addition, we performed DNA sequencing in 145 patients with alcoholic CP, 138 patients with idiopathic/hereditary CP, 147 patients with alcoholic liver cirrhosis, and 151 controls. Exon 3 screening was extended to additional patients and controls. RESULTS: S- and L-alleles of the GT-repeat, genotypes and alleles of SNP rs2071746 and non-synonymous variants detected by sequencing were found with similar frequencies in all groups. CONCLUSIONS: Although functional data implicate a potential influence of HMOX1 variants on the pathogenesis of pancreatitis, we did not find any association. As rare non-synonymous HMOX1 variants were found in patients and controls, it is rather unlikely that they will have functional consequences essential for pancreatitis development

A Common Variant of PNPLA3 (p.I148M) Is Not Associated with Alcoholic Chronic Pancreatitis

Contains fulltext : 110441.pdf (publisher's version ) (Open Access)BACKGROUND: Chronic pancreatitis (CP) is an inflammatory disease that in some patients leads to exocrine and endocrine dysfunction. In industrialized countries the most common aetiology is chronic alcohol abuse. Descriptions of associated genetic alterations in alcoholic CP are rare. However, a common PNPLA3 variant (p.I148M) is associated with the development of alcoholic liver cirrhosis (ALC). Since, alcoholic CP and ALC share the same aetiology PNPLA3 variant (p.I148M) possibly influences the development of alcoholic CP. METHODS: Using melting curve analysis we genotyped the variant in 1510 patients with pancreatitis or liver disease (961 German and Dutch alcoholic CP patients, 414 German patients with idiopathic or hereditary CP, and 135 patients with ALC). In addition, we included in total 2781 healthy controls in the study. RESULTS: The previously published overrepresentation of GG-genotype was replicated in our cohort of ALC (p-value <0.0001, OR 2.3, 95% CI 1.6-3.3). Distributions of genotype and allele frequencies of the p.I148M variant were comparable in patients with alcoholic CP, idiopathic and hereditary CP and in healthy controls. CONCLUSIONS: The absence of an association of PNPLA3 p.I148M with alcoholic CP seems not to point to a common pathway in the development of alcoholic CP and alcoholic liver cirrhosis

(Ré)concilier les inconciliables Regards croisés sur la réparation des AT-MP

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TUNABLE SEPARATION AND DNA MANIPULATION IN METAL COATED PILLAR ARRAYS

Implementing electrically connected metal-coated posts in a Deterministic Lateral Displacement (DLD) device and applying electric fields, we use electrokinetics to achieve tunable particle separations and to trap and manipulate DNA. The strength of DLD stems from its typically binary behavior. Particles move in one out of two trajectories based on their effective size. For particles that are close to the threshold size, a minute external force is sufficient to nudge the particles from one trajectory to another. Dielectrophoresis (DEP) provides such a force and also gives specificity based on the dielectric properties of the particles

OSIRISv1 on Flying Laptop: Measurement Results and Outlook

Optical satellite links have gained increasing attention throughout the last years. Especially for the application of optical satellite downlinks, DLR's Institute of Communications and Navigation is developing a number of experimental payloads for various satellites. Within the OSIRIS program, DLR develops optical terminals and systems which are optimized for small satellites. This paper will show measurements conducted with DLR's OSIRISv1-payload hosted on University of Stuttgart's Flying Laptop satellite. Furthermore, a summary of the OSIRIS program's current status will be given as well

The separation of nano-sized particles in micro-scaled post arrays

The precise separation of nanoscale particles has proven challenging due to diffusion and the need to use nanoscale devices. We show the separation of particles in the 100 nm size range in Deterministic Lateral Displacement (DLD) devices with feature sizes in the 10 µm size range. We achieve this using Dielectrophoretic (DEP) forces, generated between the metal coated posts that act as active electrodes. This opens up for the separation of submicron particles based not only on size but also on electric and dielectric properties