1,166 research outputs found
Focused laser Doppler velocimeter
A system for remotely measuring velocities present in discrete volumes of air is described. A CO2 laser beam is focused by a telescope at such a volume, a focal volume, and within the focusable range, near field, of the telescope. The back scatter, or reflected light, principally from the focal volume, passes back through the telescope and is frequency compared with the original frequency of the laser, and the difference frequency or frequencies represent particle velocities in that focal volume
Comparison of surface and column measurements of aerosol scattering properties over the western North Atlantic Ocean at Bermuda
Light scattering by size-resolved aerosols in near-surface air at Tudor
Hill, Bermuda, was measured between January and June 2009. Vertical
distributions of aerosol backscattering and column-averaged aerosol optical
properties were characterized in parallel with a micro-pulse lidar (MPL) and
an automated sun–sky radiometer. Comparisons were made between extensive
aerosol parameters in the column, such as the lidar-retrieved extinction at
400 m and the aerosol optical depth (AOD), and scattering was measured with a
surface nephelometer. Comparisons were also made for intensive parameters
such as the Ångström exponent and calculations using
AERONET(Aerosol Robotic Network)-derived
aerosol physical parameters (size distribution, index of refraction) and Mie
theory, and the ratio of submicron scattering to total scattering for size-segregated
nephelometer measurements. In these comparisons the <i>r</i><sup>2</sup> was
generally around 0.50. Data were also evaluated based on back trajectories.
The correlation between surface scattering and lidar extinction was highest
for flows when the surface scattering was dominated by smaller particles and
the flow had a longer footprint over land then over the ocean. The
correlation of AOD with surface scatter was similar for all flow regimes.
There was also no clear dependence of the atmospheric lapse rate, as
determined from a nearby radiosonde station, on flow regime. The
Ångström exponent for most flow regimes was 0.9–1.0, but for the
case of air originating from North America, but with significant time over
the ocean, the Ångström exponent was 0.57 ± 0.18. The submicron
fraction of aerosol near the surface (<i>R</i><sub>sub-surf</sub>) was significantly
greater for the flows from land (0.66 ± 0.11) than for the flows which
spent more time over the ocean (0.40 ± 0.05). When comparing
<i>R</i><sub>sub-surf</sub> and the column-integrated submicron scattering fraction,
<i>R</i><sub>sub-col</sub>, the correlation was similar, <i>r</i><sup>2</sup> = 0.50, but
<i>R</i><sub>sub-surf</sub> was generally less than <i>R</i><sub>sub-col</sub>, indicating more large
particles contributing to light scattering at the surface, contrary to
conditions over continents and for polluted continental transport over the
ocean. In general, though, the marginal correlations indicate that the column
optical properties are weakly correlated with the surface optical
measurements. Thus, if it is desired to associate aerosol chemical/physical
properties with their optical properties, it is best to use optical and
chemical/physical measurements with both collected at the surface or both
collected in the column
The Spitzer Space Telescope Mission
The Spitzer Space Telescope, NASA's Great Observatory for infrared astronomy,
was launched 2003 August 25 and is returning excellent scientific data from its
Earth-trailing solar orbit. Spitzer combines the intrinsic sensitivity
achievable with a cryogenic telescope in space with the great imaging and
spectroscopic power of modern detector arrays to provide the user community
with huge gains in capability for exploration of the cosmos in the infrared.
The observatory systems are largely performing as expected and the projected
cryogenic lifetime is in excess of 5 years. This paper summarizes the on-orbit
scientific, technical and operational performance of Spitzer. Subsequent papers
in this special issue describe the Spitzer instruments in detail and highlight
many of the exciting scientific results obtained during the first six months of
the Spitzer mission.Comment: Accepted for publication in the Astrophyscial Journal Supplement
Spitzer Special Issue, 22 pages, 3 figures. Higher resolution versions of the
figures are available at http://ssc.spitzer.caltech.edu/pubs/journal2004.htm
ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs
This report, issued by the ACVIM Specialty of Cardiology consensus panel, revises guidelines for the diagnosis and treatment of myxomatous mitral valve disease (MMVD, also known as endocardiosis and degenerative or chronic valvular heart disease) in dogs, originally published in 2009. Updates were made to diagnostic, as well as medical, surgical, and dietary treatment recommendations. The strength of these recommendations was based on both the quantity and quality of available evidence supporting diagnostic and therapeutic decisions. Management of MMVD before the onset of clinical signs of heart failure has changed substantially compared with the 2009 guidelines, and new strategies to diagnose and treat advanced heart failure and pulmonary hypertension are reviewed
Flow climatology for physicochemical properties of dichotomous aerosol over the western North Atlantic Ocean at Bermuda
Dichotomous aerosols (nominal super- and sub-μm-diameter size
fractions) in sectored on-shore flow were sampled daily from July 2006
through June 2009, at the Tudor Hill Atmospheric Observatory (THAO) on the
western coast of Bermuda (32.27° N, 64.87° W) and
analyzed for major chemical and physical properties. FLEXPART retroplumes
were calculated for each sampling period and aerosol properties were
stratified accordingly based on transport from different regions. Transport
from the northeastern United States (NEUS) was associated with significantly
higher (factors of 2 to 3 based on median values) concentrations of bulk
particulate non-sea-salt (nss) SO42-,
NO3-, and NH4+
and associated scattering and absorption at 530 nm, relative to transport
from Africa (AFR) and the oceanic background. These differences were driven
primarily by higher values associated with the sub-μm size fraction
under NEUS flow. We estimate that 75(±3)% of the NEUS nss
SO42- was anthropogenic in origin, while only 25(±9)% of the
AFR nss SO42- was anthropogenic. Integrating over all transport
patterns, the contribution of anthropogenic sulfate has dropped 14.6% from
the early 1990s. Bulk scattering was highly correlated with bulk nss
SO42- in all flow regimes but the corresponding regression slopes
varied significantly reflecting differential contributions to total
scattering by associated aerosol components. Absorption by super-μm
aerosol in transport from the NEUS versus AFR was similar although the
super-μm aerosol size fraction accounted for a relatively greater
contribution to total absorption in AFR flow. Significantly greater
absorption Ångström exponents (AAEs) for AFR flow reflects the
wavelength dependence of absorption by mineral aerosols; lower AAEs for NEUS
flow is consistent with the dominance of absorption by combustion-derived
aerosols. Higher AOD associated with transport from both the NEUS and AFR
relative to oceanic background flow results in a top of atmosphere direct
radiative forcing on the order of −1.6 to −2.5 W m−2,
respectively, showing these aerosols drive cooling. The dominance of
transport from the NEUS on an annual basis coupled with the corresponding
decreases in anthropogenic nss SO42- aerosols since the early 1990s
implies that emission reductions in the US account for a decline in
atmospheric cooling over the western North Atlantic Ocean during this period
Formaldehyde, glyoxal, and methylglyoxal in air and cloudwater at a rural mountain site in central Virginia
As part of the Shenandoah Cloud and Photochemistry Experiment (SCAPE), we measured formaldehyde (HCHO), glyoxal (CHOCHO), and methylglyoxal (CH3C(O)CHO) concentrations in air and cloudwater at Pinnacles (elevation 1037 m) in Shenandoah National Park during September 1990. Mean gas‐phase concentrations of HCHO and CHOCHO were 980 and 44 pptv, respectively. The concentration of CH3C(O)CHO rarely exceeded the detection limit of 50 pptv. Mean cloudwater concentrations of HCHO and CHOCHO were 9 and 2 μM, respectively; the mean CH3C(O)CHO concentration was below its detection limit of 0.3 μM. The maximum carbonyl concentrations were observed during stagnation events with high O3, peroxides, and CO. Outside of these events the carbonyls did not correlate significantly with O3, CO, or NOy. Carbonyl concentrations and concentration ratios were consistent with a major source for the carbonyls from isoprene oxidation. Oxidation of CH4 supplies a significant background of HCHO. The carbonyl concentrations were indistinguishable in two size fractions of cloudwater having a cut at d=18 μm. Gas‐ and aqueous‐phase concentrations of HCHO from samples collected during a nighttime cloud event agree with thermodynamic equilibria within a factor of 2. Samples collected during a daytime cloud event show HCHO supersaturation by up to a factor of 4. Positive artifacts in the cloudwater samples due to hydrolysis of hydroxymethylhydroperoxide (HOCH2OOH) could perhaps account for this discrepancy
Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study
Background: Changes in clinical variables associated with the administration of pimobendan to dogs with preclinical myxomatous mitral valve disease (MMVD) and cardiomegaly have not been described.
Objectives: To investigate the effect of pimobendan on clinical variables and the relationship between a change in heart size and the time to congestive heart failure (CHF) or cardiac-related death (CRD) in dogs with MMVD and cardiomegaly. To determine whether pimobendan-treated dogs differ from dogs receiving placebo at onset of CHF.
Animals: Three hundred and fifty-four dogs with MMVD and cardiomegaly.
Materials and Methods: Prospective, blinded study with dogs randomized (ratio 1:1) to pimobendan (0.4-0.6 mg/kg/d) or placebo. Clinical, laboratory, and heart-size variables in both groups were measured and compared at different time points (day 35 and onset of CHF) and over the study duration. Relationships between short-term changes in echocardiographic variables and time to CHF or CRD were explored.
Results: At day 35, heart size had reduced in the pimobendan group:median change in (Delta) LVIDDN -0.06 (IQR:-0.15 to + 0.02), P < 0.0001, and LA:Ao -0.08 (IQR:-0.23 to + 0.03), P < 0.0001. Reduction in heart size was associated with increased time to CHF or CRD. Hazard ratio for a 0.1 increase in Delta LVIDDN was 1.26, P = 0.0003. Hazard ratio for a 0.1 increase in Delta LA:Ao was 1.14, P = 0.0002. At onset of CHF, groups were similar.
Conclusions and Clinical Importance: Pimobendan treatment reduces heart size. Reduced heart size is associated with improved outcome. At the onset of CHF, dogs treated with pimobendan were indistinguishable from those receiving placebo
Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study - A Randomized Clinical Trial
Background: Pimobendan is effective in treatment of dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD). Its effect on dogs before the onset of CHF is unknown. Hypothesis/Objectives: Administration of pimobendan (0.4-0.6 mg/kg/d in divided doses) to dogs with increased heart size secondary to preclinical MMVD, not receiving other cardiovascular medications, will delay the onset of signs of CHF, cardiac-related death, or euthanasia. Animals: 360 client-owned dogs with MMVD with left atrial-to-aortic ratio >= 1.6, normalized left ventricular internal diameter in diastole >= 1.7, and vertebral heart sum >10.5. Methods: Prospective, randomized, placebo-controlled, blinded, multicenter clinical trial. Primary outcome variable was time to a composite of the onset of CHF, cardiac-related death, or euthanasia. Results: Median time to primary endpoint was 1228 days (95% CI: 856-NA) in the pimobendan group and 766 days (95% CI: 667-875) in the placebo group (P = .0038). Hazard ratio for the pimobendan group was 0.64 (95% CI: 0.47-0.87) compared with the placebo group. The benefit persisted after adjustment for other variables. Adverse events were not different between treatment groups. Dogs in the pimobendan group lived longer (median survival time was 1059 days (95% CI: 952-NA) in the pimobendan group and 902 days (95% CI: 747-1061) in the placebo group) (P = .012). Conclusions and Clinical Importance: Administration of pimobendan to dogs with MMVD and echocardiographic and radiographic evidence of cardiomegaly results in prolongation of preclinical period and is safe and well tolerated. Prolongation of preclinical period by approximately 15 months represents substantial clinical benefit
On Orbit Performance of the MIPS Instrument
The Multiband Imaging Photometer for Spitzer (MIPS) provides long wavelength capability for the mission, in imaging bands at 24, 70, and 160 microns and measurements of spectral energy distributions between 52 and 100 microns at a spectral resolution of about 7%. By using true detector arrays in each band, it provides both critical sampling of the Spitzer point spread function and relatively large imaging fields of view, allowing for substantial advances in sensitivity, angular resolution, and efficiency of areal coverage compared with previous space far-infrared capabilities. The Si:As BIB 24 micron array has excellent photometric properties, and measurements with rms relative errors of 1% or better can be obtained. The two longer wavelength arrays use Ge:Ga detectors with poor photometric stability. However, the use of 1.) a scan mirror to modulate the signals rapidly on these arrays, 2.) a system of on-board stimulators used for a relative calibration approximately every two minutes, and 3.) specialized reduction software result in good photometry with these arrays also, with rms relative errors of less than 10%
Spitzer observations of a 24 micron shadow: Bok Globule CB190
We present Spitzer observations of the dark globule CB190 (L771). We observe
a roughly circular 24 micron shadow with a 70 arcsec radius. The extinction
profile of this shadow matches the profile derived from 2MASS photometry at the
outer edges of the globule and reaches a maximum of ~32 visual magnitudes at
the center. The corresponding mass of CB190 is ~10 Msun. Our 12CO and 13CO J =
2-1 data over a 10 arcmin X 10 arcmin region centered on the shadow show a
temperature ~10 K. The thermal continuum indicates a similar temperature for
the dust. The molecular data also show evidence of freezeout onto dust grains.
We estimate a distance to CB190 of 400 pc using the spectroscopic parallax of a
star associated with the globule. Bonnor-Ebert fits to the density profile, in
conjunction with this distance, yield xi_max = 7.2, indicating that CB190 may
be unstable. The high temperature (56 K) of the best fit Bonnor-Ebert model is
in contradiction with the CO and thermal continuum data, leading to the
conclusion that the thermal pressure is not enough to prevent free-fall
collapse. We also find that the turbulence in the cloud is inadequate to
support it. However, the cloud may be supported by the magnetic field, if this
field is at the average level for dark globules. Since the magnetic field will
eventually leak out through ambipolar diffusion, it is likely that CB190 is
collapsing or in a late pre-collapse stage.Comment: 16 pages, 13 figures, accepted for publication in Ap
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