STUDY OF THE LEUKOCYTE MIGRATION INHIBITORY FACTOR IN HUMAN GLOMERULONEPHRITIS FROM THE ASPECT OF THE PROGNOSIS

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On the Slow Roll Expansion for Brane Inflation

One possibility for identifying the inflaton in the framework of string theory is that it is a $D$-brane modulus. This option involves a specific, non-canonical form of the kinetic energy -- the Dirac-Born-Infeld action. This note investigates the applicability of the slow roll approximation in inflationary models of this type. To this end the slow roll expansion of Liddle, Parsons and Barrow is derived for the case of the DBI action. The resulting slow roll conditions augment the standard ones valid in the case of canonical kinetic terms. It is also shown that in DBI models inflation does not require that the potential dominate the energy density.Comment: References adde

Brane Bremsstrahlung in DBI Inflation

We consider the effect of trapped branes on the evolution of a test brane whose motion generates DBI inflation along a warped throat. The coupling between the inflationary brane and a trapped brane leads to the radiation of non-thermal particles on the trapped brane. We calculate the Gaussian spectrum of the radiated particles and their backreaction on the DBI motion of the inflationary brane. Radiation occurs for momenta lower than the speed of the test brane when crossing the trapped brane. The slowing down effect is either due to a parametric resonance when the interaction time is small compared to the Hubble time or a tachyonic resonance when the interaction time is large. In both cases the motion of the inflationary brane after the interaction is governed by a chameleonic potential,which tends to slow it down. We find that a single trapped brane can hardly slow down a DBI inflaton whose fluctuations lead to the Cosmic Microwave Background spectrum. A more drastic effect is obtained when the DBI brane encounters a tightly spaced stack of trapped branes.Comment: 20 pages, 1 figur

DBI Inflation using a One-Parameter Family of Throat Geometries

We demonstrate the possibility of examining cosmological signatures in the DBI inflation setup using the BGMPZ solution, a one-parameter family of geometries for the warped throat which interpolate between the Maldacena-Nunez and Klebanov-Strassler solutions. The warp factor is determined numerically and subsequently used to calculate cosmological observables including the scalar and tensor spectral indices, for a sample point in the parameter space. As one moves away from the KS solution for the throat the warp factor is qualitatively different, which leads to a significant change for the observables, but also generically increases the non-Gaussianity of the models. We argue that the different models can potentially be differentiated by current and future experiments.Comment: 17 pages, 10 figures; v2: section 4 expanded, references added; v3: typos fixe

Cosmology of the Tachyon in Brane Inflation

In certain implementations of the brane inflationary paradigm, the exit from inflation occurs when the branes annihilate through tachyon condensation. We investigate various cosmological effects produced by this tachyonic era. We find that only a very small region of the parameter space (corresponding to slow-roll with tiny inflaton mass) allows for the tachyon to contribute some e-folds to inflation. In addition, non-adiabatic density perturbations are generated at the end of inflation. When the brane is moving relativistically this contribution can be of the same order as fluctuations produced 55 e-folds before the end of inflation. The additional contribution is very nearly scale-invariant and enhances the tensor/scalar ratio. Additional non-gaussianities will also be generated, sharpening current constraints on DBI-type models which already predict a significantly non-gaussian signal.Comment: 30 pages, 2 figures; v3, minor revision, JCAP versio

Associations between diffusion MRI microstructure and cerebrospinal fluid markers of Alzheimer's disease pathology and neurodegeneration along the Alzheimer's disease continuum

INTRODUCTION: White matter (WM) degeneration is a critical component of early Alzheimer's disease (AD) pathophysiology. Diffusion-weighted imaging (DWI) models, including diffusion tensor imaging (DTI), neurite orientation dispersion and density imaging (NODDI), and mean apparent propagator MRI (MAP-MRI), have the potential to identify early neurodegenerative WM changes associated with AD. METHODS: We imaged 213 (198 cognitively unimpaired) aging adults with DWI and used tract-based spatial statistics to compare 15 DWI metrics of WM microstructure to 9 cerebrospinal fluid (CSF) markers of AD pathology and neurodegeneration treated as continuous variables. RESULTS: We found widespread WM injury in AD, as indexed by robust associations between DWI metrics and CSF biomarkers. MAP-MRI had more spatially diffuse relationships with Aβ42/40 and pTau, compared with NODDI and DTI. DISCUSSION: Our results suggest that WM degeneration may be more pervasive in AD than is commonly appreciated and that innovative DWI models such as MAP-MRI may provide clinically viable biomarkers of AD-related neurodegeneration in the earliest stages of AD progression

On Power Law Inflation in DBI Models

Inflationary models in string theory which identify the inflaton with an open string modulus lead to effective field theories with non-canonical kinetic terms: Dirac-Born-Infeld scalar field theories. In the case of a $D$-brane moving in an AdS throat with a quadratic scalar field potential DBI kinetic terms allow a novel realization of power law inflation. This note adresses the question of whether this behaviour is special to this particular choice of throat geometry and potential. The answer is that for any throat geometry one can explicitly find a potential which leads to power law inflation. This generalizes the well known fact that an exponential potential gives power law inflation in the case of canonical kinetic terms.Comment: References and comments adde

Non-gaussianity from the bispectrum in general multiple field inflation

We study the non-gaussianity from the bispectrum in multi-field inflation models with a general kinetic term. The models include the multi-field K-inflation and the multi-field Dirac-Born-Infeld (DBI) inflation as special cases. We find that, in general, the sound speeds for the adiabatic and entropy perturbations are different and they can be smaller than 1. Then the non-gaussianity can be enhanced. The multi-field DBI-inflation is shown to be a special case where both sound speeds are the same due to a special form of the kinetic term. We derive the exact second and third order actions including metric perturbations. In the small sound speed limit and at leading order in the slow-roll expansion, we derive the three point function for the curvature perturbation which depends on both adiabatic and entropy perturbations. The contribution from the entropy perturbations has a different momentum dependence if the sound speed for the entropy perturbations is different from the adiabatic one, which provides a possibility to distinguish the multi-field models from single field models. On the other hand, in the multi-field DBI case, the contribution from the entropy perturbations has the same momentum dependence as the pure adiabatic contributions and it only changes the amplitude of the three point function. This could help to ease the constraints on the DBI-inflation models.Comment: 16 pages, no figur

Constraints on Brane Inflation and Cosmic Strings

By considering simple, but representative, models of brane inflation from a single brane-antibrane pair in the slow roll regime, we provide constraints on the parameters of the theory imposed by measurements of the CMB anisotropies by WMAP including a cosmic string component. We find that inclusion of the string component is critical in constraining parameters. In the most general model studied, which includes an inflaton mass term, as well as the brane-antibrane attraction, values n_s < 1.02 are compatible with the data at 95 % confidence level. We are also able to constrain the volume of internal manifold (modulo factors dependent on the warp factor) and the value of the inflaton field to be less than 0.66M_P at horizon exit. We also investigate models with a mass term. These observational considerations suggest that such models have r < 2*10^-5, which can only be circumvented in the fast roll regime, or by increasing the number of antibranes. Such a value of r would not be detectable in CMB polarization experiment likely in the near future, but the B-mode signal from the cosmic strings could be detectable. We present forecasts of what a similar analysis using PLANCK data would yield and find that it should be possible to rule out G\mu > 6.5*10^-8 using just the TT, TE and EE power spectra.Comment: 11 pages, 3 figures, revtex4, typos corrected, references adde

Combined local and equilateral non-Gaussianities from multifield DBI inflation

We study multifield aspects of Dirac-Born-Infeld (DBI) inflation. More specifically, we consider an inflationary phase driven by the radial motion of a D-brane in a conical throat and determine how the D-brane fluctuations in the angular directions can be converted into curvature perturbations when the tachyonic instability arises at the end of inflation. The simultaneous presence of multiple fields and non-standard kinetic terms gives both local and equilateral shapes for non-Gaussianities in the bispectrum. We also study the trispectrum, pointing out that it acquires a particular momentum dependent component whose amplitude is given by $f_{NL}^{loc} f_{NL}^{eq}$. We show that this relation is valid in every multifield DBI model, in particular for any brane trajectory, and thus constitutes an interesting observational signature of such scenarios.Comment: 38 pages, 11 figures. Typos corrected; references added. This version matches the one in press by JCA