Measuring Affective Processes In Traumatic Brain Injury

Changes to emotional functioning are difficult to measure after traumatic brain injury (TBI). This study examines how TBI impacts emotional functioning using self-report measures of psychological symptoms, affect, and social participation as well as objective measures of affective processes. The first experiment consists of the development of a novel measure of facial affect recognition that is validated in a sample of 78 non-clinical participants. The second experiment is an exploratory study examining group differences between 50 individuals with mild complicated, moderate, or severe TBI and 32 demographically similar controls. Correlations between self-reported psychological symptoms, affect, and social participation and performance on measures of affective processes are reported. Finally, moderation analyses are used to examine if the relationship between self-reported measures and affective processes changes in the presence of TBI. Results indicated that those with TBI showed different patterns of affective processing as compared to controls. Specifically, TBI participants demonstrated a positive bias when interpreting facial expressions and a negative bias when recalling emotion words. Self-reported measures were also associated with overall performance on measures of affective processing. Findings indicated that the effect of valence appears to be domain specific (e.g. faces versus words) and research within one domain (e.g. affective language) may not generalize to other cognitive-affective processes (e.g. facial affect recognition). Further research on affective processing after TBI is warranted with particular attention given to negatively arousing stimuli

Emotional Responses Following Sports-Related Concussion; a pilot study with controls

Mild traumatic brain injury is associated with new onset emotional symptoms (Caroll et al., 2014; Konrad et al., 2011). This study will address a gap in the literature by examining the relationship between mTBI, autonomic arousal, and emotional symptoms in the acute phase of a concussion in athletes. In this pilot study, skin conduction and heart rate changes in response to emotional stimuli were measured in 25 undergraduate controls. Results indicate that emotional valence of facial expressions did not elicit the expected differential physiological responses as suggested by previous research, but habituation to an acoustic startle over repeated exposures was observed. Changes to the protocol for future research with concussed athletes are discussed

Responding to Secondary Traumatic Stress: A Pilot Study of Torture Treatment Programs in the United States

Providers who care for torture survivors may be at risk for secondary traumatic stress, yet there has been little documentation of the effects of repeated exposure to traumatic issues on their emotional health or exploration of the support systems and resources available to address their emotional needs. This study assessed the secondary stress experiences of service providers (N = 43) within the National Consortium of Torture Treatment Programs in the United States and examined the supports offered by their organizations. The study found a significant correlation between rates of anxiety and depression among providers, r(34) = .49, p = .003. Although these participants reported that their work with survivors of torture was stressful, 91% indicated that their organizations offered a variety of stress-reduction activities. Overall, participants reported that their own personal activities were the most-effective stress reducers. The results are discussed in light of challenges that professionals who work with this population face and the effectiveness of support systems available to support their work

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

“911” among West African immigrants in New York City: A qualitative study of parents’ disciplinary practices and their perceptions of child welfare authorities

Immigrant parents’ perceptions of child protective services may have important implications for their engagement in public institutions that are central to their children’s well being. The current study examined West African immigrants’ perceptions of child welfare authorities and the role of disciplining and monitoring in these communities’ meaning making. A multiethnic group of 59 West African immigrants (32 parents and 27 adolescent children) living in the United States were interviewed in 18 focus groups and eight individual interviews between December 2009 and July 2010. Data were analyzed using a grounded theory approach; strategies for rigor included triangulation (multiple interview formats, varied composition of groups, multiple coders for each transcript), verification (follow-up interviewing, feedback to community-based organizations), and auditability. Primary among parents’ concerns were “911” (used to refer to the police and child protective authorities), the loss of collective child monitoring networks, and threats to their children posed by “American” values and neighborhood violence. Children were concerned with parents’ close monitoring that resulted in boredom and a sense that parents did not recognize them for adhering to their families’ values. Feedback from CBOs suggested that parents got their information about child protective policies from children but that although misinformed they were accurate in their negative assessment of contact. Not unlike in other urban populations, West African immigrants’ disciplinary tactics are instrumental, oriented toward protecting their children from the multiple dangers perceived in their surroundings, but may also put them at risk for contact with child protective services. Results suggest that “911” results from a “loss spiral” (Hobfoll,1989) that begins as West Africans resettle without collective child monitoring networks, leading to increased concern for their children’s safety, and interacting with a school-home disciplinary mismatch that may increase the likelihood of contact with child protection

Longitudinal Trajectories of Post-Concussive Symptoms Following Mild Traumatic Brain Injury.

BACKGROUND: Individuals recovering from mild traumatic brain injury (TBI) represent a heterogenous population that requires distinct treatment approaches. Identification of recovery trajectories improves our ability to understand the natural history of mild TBI recovery and develop targeted interventions. OBJECTIVE: To utilize group-based trajectory modeling (GBTM) to identify distinct patterns of symptom recovery following mild TBI in the first 6 months after mild TBI. METHODS: This study is comprised of 253 adults who presented to the emergency department with mild TBI and completed assessments for six-months post-injury. Patients were recruited for the prospective observational cohort study, HeadSMART. The primary outcome measure was the Rivermead Postconcussion Symptom Questionnaire. GBTM was used to identify longitudinal trajectories of recovery following mild TBI using Rivermead scores at baseline, one, three, and six months following diagnosis. RESULTS: Findings identified four distinct trajectories of symptom recovery follwing mild TBI including 9% of participants who were categorized with minimal acute symptoms that decreased over time, 45% with mild acute symptoms that decreased over time, 33% with relatively higher acute symptoms that decreased over time, and 13% with relatively higher acute symptoms that increased over time. CONCLUSIONS: GBTM identified four distinct trajectories of recovery following mild TBI and GBTM may be useful for research interventions that can alter recovery trajectories

The feasibility of remotely monitoring physical, cognitive, and psychosocial function in individuals with stroke or chronic obstructive pulmonary disease

Objective Clinical implementation of remote monitoring of human function requires an understanding of its feasibility. We evaluated adherence and the resources required to monitor physical, cognitive, and psychosocial function in individuals with either chronic obstructive pulmonary disease or stroke during a three-month period. Methods Seventy-three individuals agreed to wear a Fitbit to monitor physical function and to complete monthly online assessments of cognitive and psychosocial function. During a three-month period, we measured adherence to monitoring (1) physical function using average daily wear time, and (2) cognition and psychosocial function using the percentage of assessments completed. We measured the resources needed to promote adherence as (1) the number of participants requiring at least one reminder to synchronize their Fitbit, and (2) the number of reminders needed for each completed cognitive and psychosocial assessment. Results After accounting for withdrawals, the average daily wear time was 77.5 ± 19.9% of the day and did not differ significantly between months 1, 2, and 3 ( p  = 0.30). To achieve this level of adherence, 64.9% of participants required at least one reminder to synchronize their device. Participants completed 61.0% of the cognitive and psychosocial assessments; the portion of assessments completed each month didnot significantly differ ( p  = 0.44). Participants required 1.13 ± 0.57 reminders for each completed assessment. Results did not differ by disease diagnosis. Conclusions Remote monitoring of human function in individuals with either chronic obstructive pulmonary disease or stroke is feasible as demonstrated by high adherence. However, the number of reminders required indicates that careful consideration must be given to the resources available to obtain high adherence