Fatal necrotizing pneumonia due to a Panton-Valentine leukocidin positive community-associated methicillin-sensitive Staphylococcus aureus and Influenza co-infection: a case report

Recent studies have described a number of fatalities due to methicillin-resistant Staphylococcus aureus (MRSA) and influenza virus co-infection. MRSA isolates provide a challenge to caregivers due to inherent wide range antibiotic resistance. Many facilities have instituted screening methods, based on the presence of antibiotic resistance genes, to identify MRSA positive patients upon admission. However, the resistance profile of the pathogen does not necessarily determine the severity of disease caused by that organism

William H. Simon: Thinking like a Lawyer - About Ethics

This is the edited text of a panel discussion held as part of the legal ethics curriculum at Duquesne University Law School on October 24, 1999. The speakers have had the opportunity to update and correct this text; therefore, this printed version may deviate slightly from what was presented

Multisensor navigation systems: a remedy for GNSS vulnerabilities?

Space-based positioning, navigation, and timing (PNT) technologies, such as the global navigation satellite systems (GNSS) provide position, velocity, and timing information to an unlimited number of users around the world. In recent years, PNT information has become increasingly critical to the security, safety, and prosperity of the World's population, and is now widely recognized as an essential element of the global information infrastructure. Due to its vulnerabilities and line-of-sight requirements, GNSS alone is unable to provide PNT with the required levels of integrity, accuracy, continuity, and reliability. A multisensor navigation approach offers an effective augmentation in GNSS-challenged environments that holds a promise of delivering robust and resilient PNT. Traditionally, sensors such as inertial measurement units (IMUs), barometers, magnetometers, odometers, and digital compasses, have been used. However, recent trends have largely focused on image-based, terrain-based and collaborative navigation to recover the user location. This paper offers a review of the technological advances that have taken place in PNT over the last two decades, and discusses various hybridizations of multisensory systems, building upon the fundamental GNSS/IMU integration. The most important conclusion of this study is that in order to meet the challenging goals of delivering continuous, accurate and robust PNT to the ever-growing numbers of users, the hybridization of a suite of different PNT solutions is required

A new method for improving Wi-Fi based indoor positioning accuracy

Wi-Fi and smartphone based positioning technologies are play-ing a more and more important role in Location Based Service (LBS) indus-tries due to the rapid development of the smartphone market. However, the low positioning accuracy of these technologies is still an issue for indoor positioning. To address this problem, a new method for improving the in-door positioning accuracy was developed. The new method initially used the Nearest Neighbor (NN) algorithm of the fingerprinting method to iden-tify the initial position estimate of the smartphone user. Then two distance correction values in two roughly perpendicular directions were calculated by the pass loss model based on the two signal strength indicator (RSSI) values observed. The errors from the path loss model were eliminated through differencing two model-derived distances from the same access point. The new method was tested and the results were compared and as-sessed against that of the commercial Ekahau RTLS system and the NN algorithm. The preliminary results showed that the positioning accuracy has been improved consistently after the new method was applied and the root mean square accuracy was improved to 3.4 m from 3.8 m of the NN algorithm

Mitogenomes reveal two major influxes of Papuan ancestry across Wallacea following the last glacial maximum and Austronesian contact

The tropical archipelago of Wallacea contains thousands of individual islands interspersed between mainland Asia and Near Oceania, and marks the location of a series of ancient oceanic voyages leading to the peopling of Sahul—i.e., the former continent that joined Australia and New Guinea at a time of lowered sea level—by 50,000 years ago. Despite the apparent deep antiquity of human presence in Wallacea, prior population history research in this region has been hampered by patchy archaeological and genetic records and is largely concentrated upon more recent history that follows the arrival of Austronesian seafarers ~3000–4000 years ago (3–4 ka). To shed light on the deeper history of Wallacea and its connections with New Guinea and Australia, we performed phylogeographic analyses on 656 whole mitogenomes from these three regions, including 186 new samples from eight Wallacean islands and three West Papuan populations. Our results point to a surprisingly dynamic population history in Wallacea, marked by two periods of extensive demographic change concentrated around the Last Glacial Maximum ~15 ka and post-Austronesian contact ~3 ka. These changes appear to have greatly diminished genetic signals informative about the original peopling of Sahul, and have important implications for our current understanding of the population history of the region.1. Introduction 2. Materials and Methods 2.1. Sample Collection and Ethics 2.2. Mitochondrial Sequence Generation 2.3. Combined Wallacea–Sahul Dataset 2.4. Phylogenetic Parameter Estimation 2.5. Using Ancestral Node Dates from Geographically Exclusive Clades to Infer Demographic History 2.6. Migration Model Inference and Testing 2.7. Simulating and Estimating the Timing of Migration Events 3. Results 3.1. Summary of New Mitochondrial Haplogroups from Wallacea and West Papua 3.2. Phylogeographic Analyses 4. Discussion 4.1. Post-LGM Population Expansions and Movements 4.2. Redistribution of Papuan mtDNA Lineages Following Austronesian Contact 4.3. Comparison with Wallacean Archaeological and Linguistic Records 5. Conclusion

A new approach for GNSS tomography from a few GNSS stations

The determination of the distribution of water vapor in the atmosphere plays an important role in the atmospheric monitoring. Global Navigation Satellite Systems (GNSS) tomography can be used to construct 3-D distribution of water vapor over the field covered by a GNSS network with high temporal and spatial resolutions. In current tomographic approaches, a pre-set fixed rectangular field that roughly covers the area of the distribution of the GNSS signals on the top plane of the tomographic field is commonly used for all tomographic epochs. Due to too many unknown parameters needing to be estimated, the accuracy of the tomographic solution degrades. Another issue of these approaches is their unsuitability for GNSS networks with a low number of stations, as the shape of the field covered by the GNSS signals is, in fact, roughly that of an upside-down cone rather than the rectangular cube as the pre-set. In this study, a new approach for determination of tomographic fields fitting the real distribution of GNSS signals on different tomographic planes at different tomographic epochs and also for discretization of the tomographic fields based on the perimeter of the tomographic boundary on the plane and meshing techniques is proposed. The new approach was tested using three stations from the Hong Kong GNSS network and validated by comparing the tomographic results against radiosonde data from King's Park Meteorological Station (HKKP) during the one month period of May 2015. Results indicated that the new approach is feasible for a three-station GNSS network tomography. This is significant due to the fact that the conventional approaches cannot even solve a network tomography from a few stations

Relationships between CYP2D6 phenotype, breast cancer and hot flushes in women at high risk of breast cancer receiving prophylactic tamoxifen: results from the IBIS-I trial

Licensed under a Creative Commons Attribution Non-Commercial Share Alike Licens

Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells

While the intrinsic apoptosis pathway is thought to play a central role in shaping the B cell lineage, its precise role in mature B cell homeostasis remains elusive. Using mice in which mature B cells are unable to undergo apoptotic cell death, we show that apoptosis constrains follicular B (FoB) cell lifespan but plays no role in marginal zone B (MZB) cell homeostasis. In these mice, FoB cells accumulate abnormally. This intensifies intercellular competition for BAFF, resulting in a contraction of the MZB cell compartment, and reducing the growth, trafficking, and fitness of FoB cells. Diminished BAFF signaling dampens the non-canonical NF-κB pathway, undermining FoB cell growth despite the concurrent triggering of a protective p53 response. Thus, MZB and FoB cells exhibit a differential requirement for the intrinsic apoptosis pathway. Homeostatic apoptosis constrains the size of the FoB cell compartment, thereby preventing competition-induced FoB cell atrophy.Stéphane Chappaz, Kate McArthur, Liam Kealy, Charity W. Law, Maximilien Tailler, Rachael M. Lane ... et al

Tamoxifen for prevention of breast cancer: extended long-term follow-up of the IBIS-I breast cancer prevention trial

© Cuzick et al. Open Access article distributed under the terms of CC BY.http://dx.doi.org/10.1016/S1470-2045(14)71171-