411 research outputs found
Suzaku observations of the Hydra A cluster out to the virial radius
We report Suzaku observations of the northern half of the Hydra A cluster out
to ~1.4 Mpc, reaching the virial radius. This is the first Suzaku observations
of a medium-size (kT ~3 keV) cluster out to the virial radius. Two observations
were conducted, north-west and north-east offsets, which continue in a filament
direction and a void direction of the large-scale structure of the Universe,
respectively. The X-ray emission and distribution of galaxies elongate in the
filament direction. The temperature profiles in the two directions are mostly
consistent with each other within the error bars and drop to 1.5 keV at 1.5
r_500. As observed by Suzaku in hot clusters, the entropy profile becomes
flatter beyond r_500, in disagreement with the r^1.1 relationship that is
expected from accretion shock heating models. When scaled with the average
intracluster medium (ICM) temperature, the entropy profiles of clusters
observed with Suzaku are universal and do not depend on system mass. The
hydrostatic mass values in the void and filament directions are in good
agreement, and the Navarro, Frenk, and White universal mass profile represents
the hydrostatic mass distribution up to ~ 2 r_500. Beyond r_500, the ratio of
gas mass to hydrostatic mass exceeds the result of the Wilkinson microwave
anisotropy probe, and at r_100, these ratios in the filament and void
directions reach 0.4 and 0.3, respectively. We discuss possible deviations from
hydrostatic equilibrium at cluster outskirts. We derived radial profiles of the
gasmass- to-light ratio and iron-mass-to-light ratio out to the virial radius.
Within r_500, the iron-mass-to-light ratio of the Hydra A cluster was compared
with those in other clusters observed with Suzaku.Comment: 16 pages, 15 figures; Accepted for publication in PAS
A relativistic signature in large-scale structure
In General Relativity, the constraint equation relating metric and density perturbations is inherently nonlinear, leading to an effective non-Gaussianity in the dark matter density field on large scales-even if the primordial metric perturbation is Gaussian. Intrinsic non-Gaussianity in the large-scale dark matter overdensity in GR is real and physical. However, the variance smoothed on a local physical scale is not correlated with the large-scale curvature perturbation, so that there is no relativistic signature in the galaxy bias when using the simplest model of bias. It is an open question whether the observable mass proxies such as luminosity or weak lensing correspond directly to the physical mass in the simple halo bias model. If not, there may be observables that encode this relativistic signatur
Analysis of the anti-tumor mechanism of BRD4 inhibition in hepatocellular carcinoma
Bromodomain and extra terminal (BET) family proteins, which include BRD4, are readers of histone acetyl-lysines and key regulators of gene transcription. BRD4 inhibitors exert anti-tumor effects in various cancers, including hepatocellular carcinoma (HCC). We investigated the mechanism underlying the antitumor effects of BRD4 inhibition in HCC. We first tested the effects of the BRD4 inhibitor JQ1 in a series of 9 HCC cell lines and found that it strongly suppressed HCC cell proliferation by inducing cell cycle arrest and apoptosis. Gene expression microarray analysis revealed that JQ1 also induced marked changes in the gene expression profiles of HCC cells, and genes associated with cell cycle and apoptosis were significantly enriched among the affected genes. Notably, a number of cancer-related genes, including BCAT1, DDR1, GDF15, FANCD2, SENP1 and TYRO3, were strongly suppressed by JQ1 in HCC cells. We also confirmed BRD4 bound within the promoter regions of these genes, which suggests they are targets of BRD4 in HCC cells. JQ1 thus appears to exert its anti-tumor effects in HCC by suppressing multiple BRD4 target genes
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