19 research outputs found
Antitumor Effect of Sclerostin against Osteosarcoma
Various risk factors and causative genes of osteosarcoma have been reported in the literature; however, its etiology remains largely unknown. Bone formation is a shared phenomenon in all types of osteosarcomas, and sclerostin is an extracellular soluble factor secreted by osteocytes that prevents bone formation by inhibiting the Wnt signaling pathway. We aimed to investigate the antitumor effect of sclerostin against osteosarcoma. Osteosarcoma model mice were prepared by transplantation into the dorsal region of C3H/He and BALB/c-nu/nu mice using osteosarcoma cell lines LM8 (murine) and 143B (human), respectively. Cell proliferations were evaluated by using alamarBlue and scratch assays. The migratory ability of the cells was evaluated using a migration assay. Sclerostin was injected intraperitoneally for 7 days to examine the suppression of tumor size and extension of survival. The administration of sclerostin to osteosarcoma cells significantly inhibited the growth and migratory ability of osteosarcoma cells. Kaplan–Meier curves and survival data demonstrated that sclerostin significantly inhibited tumor growth and improved survival. Sclerostin suppressed the proliferative capacity and migratory ability of osteosarcoma cells. Osteosarcoma model mice inhibited tumor growth and prolonged survival periods by the administration of sclerostin. The effect of existing anticancer drugs such as doxorubicin should be investigated for future clinical applications.ArticleCancers 13(23) : 6015(2021)journal articl
First light demonstration of the integrated superconducting spectrometer
Ultra-wideband 3D imaging spectrometry in the millimeter-submillimeter
(mm-submm) band is an essential tool for uncovering the dust-enshrouded portion
of the cosmic history of star formation and galaxy evolution. However, it is
challenging to scale up conventional coherent heterodyne receivers or
free-space diffraction techniques to sufficient bandwidths (1 octave) and
numbers of spatial pixels (>). Here we present the design and first
astronomical spectra of an intrinsically scalable, integrated superconducting
spectrometer, which covers 332-377 GHz with a spectral resolution of . It combines the multiplexing advantage of microwave kinetic
inductance detectors (MKIDs) with planar superconducting filters for dispersing
the signal in a single, small superconducting integrated circuit. We
demonstrate the two key applications for an instrument of this type: as an
efficient redshift machine, and as a fast multi-line spectral mapper of
extended areas. The line detection sensitivity is in excellent agreement with
the instrument design and laboratory performance, reaching the atmospheric
foreground photon noise limit on sky. The design can be scaled to bandwidths in
excess of an octave, spectral resolution up to a few thousand and frequencies
up to 1.1 THz. The miniature chip footprint of a few
allows for compact multi-pixel spectral imagers, which would enable
spectroscopic direct imaging and large volume spectroscopic surveys that are
several orders of magnitude faster than what is currently possible.Comment: Published in Nature Astronomy. SharedIt Link to the full published
paper: https://rdcu.be/bM2F
Current concept and diagnosis of IgG4-related disease in the hepato-bilio-pancreatic system
Effect of Food Thickener on Dissolution and Laxative Activity of Magnesium Oxide Tablets in Mice
MOESM1 of Artificial neural networks to predict future bone mineral density and bone loss rate in Japanese postmenopausal women
Additional file 1: Table S1. Patient profiles. Data for age, height, body weight, BMI, age at menarche, age at menopause, duration after menopause, percent body fat, lean body mass, fat mass, lumbar BMD in 1993, annual lumbar bone loss rate, femoral BMD in 1993, annual femoral bone loss rate were shown