VLF-LF Hiss Emissions Associated with Aurora

It is shown that auroral hiss emissions observed in high latitudes can be categorized into two types on the basis of the power spectrum and its temporal variation. They are called the narrow-band continuous hiss and the wide-band impulsive hiss. The continuous hiss has a narrow frequency range with a center frequency of about 10 kHz and a band width of a few kHz and is characterized by a long time duration (longer than a few tens of minutes). The impulsive hiss, on the other hand, has a wide frequency range with a spectral peak frequency of about 10 kHz and a band width of a few tens of kHz and is of a short time duration (usually shorter than 10 minutes). On the basis of observations at the two Stations, Syowa and Mizuho and the ISIS 2 satellite, the continuous hiss emissions are found usually to occur associated with the steady auroral arc located near the poleward horizon of Syowa Station, and the impulsive hiss emissions, on the other hand, are found to occur accompanying the initial brightening of active aurora (corona, rayed-band, west-ward traveling surge) that appeared near the zenith. These relationships between two types of hiss and the global auroral activity are confirmed by the comparison between the global auroral data observed on the DMSP satellite and the ground data of hiss. A systematic local time variation of the arrival direction of the continuous hiss emissions is also found. It is shown that the arrival direction in early evening (18h-19h) is the east and it changes from east to west around 20h-21h. This local time variation of the arrival direction will be discussed in relation to the statistical distribution of the source region of the continuous hiss emissions. The arrival direction of the waves was next examined and it shows that the continuous hiss arrives from several hundreds of km equatorward of the related aurora, while the impulsive hiss sometimes arrives from the region nearer the auroral location. It also becomes clear that the distance between the exit (the arrival direction) of hiss and the auroral location depend on the magnetic dip angle of the station by comparing the results obtained at Churchill and Syowa Station. Namely the arrival direction nearly tends to coincide with the auroral active region at Church-2 VLF-LF Hiss Emissions Associated with Aurora ill with a large dip angle (Dip～83°) and the wave exit is likely located hundreds of km equatorward of the aurora at Syowa Station with a small dip angle (Dip～65°). Simultaneous observations of VLF emissions observed on ISIS 2 and on the ground support the conclusion that the continuous hiss does not propagate along the magnetic field line from the satellite altitude (h～1400 km) to the ground but along a non-ducted path. The ray path of the VLF waves was calculated in comparison with the observational results mentioned above. It was found that the distance between the region where the wave normal angles lie within the transmission cone at the ionospheric level (h～200 km) and the foot point of the field line along which the duct terminates at 3000 km in altitude, is about 300-400 km at Syowa Station. These results explain the fact that the arrival direction of continuous hiss is several hundreds of km equatorward of the related aurora, and further that the duct of auroral hiss terminates at about 3000 km in altitude. By contrast, the arrival direction of the impulsive hiss is found sometimes much nearer to the auroral activity. Likewise, the impulsive hiss seems to propagate along the field line lower than 3000 km in altitude on account of the strong field-aligned irregularities or the large-scale horizontal gradient of ionization. Assuming that particles and waves are coupled in the Cerenkov condition and waves are generated with an electron beam with energy of a few keV or less, and further assuming that the enhancement factor along the field line is smaller than 0.5, the generation region of auroral hiss observed on the ground i

Simultaneous quasi-periodic optical and HF radar signatures observed in the postnoon sector

Zhongshan Station in Antarctica is located close to the polar cusp/cleft latitude. The field of view of the Syowa East HF radar also covers Zhongshan Station. Simultaneous quasi-periodic phenomena of optical aurora, HF radar backscatter power and Doppler velocity, and ground based magnetograms were observed in the magnetic postnoon sector (～330 MLT to 1510 MLT) on 3 August 1997. The characteristics of the quasi-periodic event are summarized in the following; 1) East-west aligned band/arc type discrete aurora showed quasi-periodic luminosity variations with period of -6-10 min, 2) Quasi-periodic variations of the optical aurora had one to one correspondence with the variations of HF radar backscatter powers and magnetic pulsations, 3) The HF backscatter region was located at the lower latitude of the quasi-periodic optical aurora, 4) Quasi-periodic variations of line-of-site Doppler velocity detected by HF radar showed very close relation to the magnetic pulsations observed at Zhongshan in Antarctica and the IMAGE magnetometer array in the northern hemisphere, 5) The IMAGE data revealed that the region of quasi-periodic HF radar backscatter (irregularities) corresponds to the region of intensity maximum of magnetic pulsations

Wheat‐ghretropins: novel ghrelin‐releasing peptides derived from wheat protein

Ghrelin is an endogenous orexigenic hormone mainly produced by stomach cells and is reported to influence appetite, gastrointestinal motility and growth hormone secretion. We observed that enzymatic digest of wheat gluten stimulated ghrelin secretion from mouse ghrelinoma 3-1, a ghrelin-releasing cell line. Further on, we characterized the ghrelin-releasing peptides present in the digest by comprehensive peptide analysis using liquid chromatography-mass spectrometry and structure-activity relationship. Among the candidate peptides, we found that SQQQQPVLPQQPSF, LSVTSPQQVSY and YPTSL stimulated ghrelin release. We then named them wheat-ghretropin A, B and C, respectively. In addition, we observed that wheat-ghretropin A increased plasma ghrelin concentration and food intake in mice after oral administration. Thus, we demonstrated that wheat-ghretropin stimulates ghrelin release both in vitro and in vivo. To the best of our knowledge, this is the first report of a wheat-derived exogenous bioactive peptide that stimulates ghrelin secretion

DNA damage profiles induced by sunlight at different latitudes

Despite growing knowledge on the biological effects of ultraviolet (UV) radiation on human health and ecosystems, it is still difficult to predict the negative impacts of the increasing incidence of solar UV radiation in a scenario of global warming and climate changes. Hence, the development and application of DNA-based biological sensors to monitor the solar UV radiation under different environmental conditions is of increasing importance. With a mind to rendering a molecular view-point of the genotoxic impact of sunlight, field experiments were undertaken with a DNA-dosimeter system in parallel with physical photometry of solar UVB/UVA radiation, at various latitudes in South America. Onapplying biochemical and immunological approaches based on specific DNA-repair enzymes and antibodies, for evaluating sunlight-induced DNA damage profiles, it became clear that the genotoxic potential of sunlight does indeed vary according to latitude. Notwithstanding, while induction of oxidized DNA bases is directly dependent on an increase in latitude, the generation of 6-4PPs is inversely so, whereby the latter can be regarded as a biomolecular marker of UVB incidence. This molecular DNA lesion-pattern largely reflects the relative incidence of UVA and UVB energy at any specific latitude. Hereby is demonstrated the applicability of this DNA-based biosensor for additional, continuous field experiments, as a means of registering variations in the genotoxic impact of solar UV radiation. Environ. Mol. Mutagen. 2012. (c) 2012 Wiley Periodicals, Inc.FAPESP (Sao Paulo, Brazil)FAPESP (Sao Paulo, Brazil)CNPq (Brasilia, Brazil)CNPq (Brasilia, Brazil)Ministry of Education, Culture, Sports, Science, and Technology (Japan)Ministry of Education, Culture, Sports, Science, and Technology of JapanLaboratory of Science and Engineering, Takushoku University, JapanLaboratory of Science and Engineering, Takushoku University, Japa

Upper atmosphere phenomena in Brazilian Geomagnetic Anomaly Region and their relationship to polar region disturbances

第2回極域科学シンポジウム/第35回極域宙空圏シンポジウム 11月16日（水） 統計数理研究所 3階リフレッシュフロ

Biological Sensors for Solar Ultraviolet Radiation

Solar ultraviolet (UV) radiation is widely known as a genotoxic environmental agent that affects Earth ecosystems and the human population. As a primary consequence of the stratospheric ozone layer depletion observed over the last decades, the increasing UV incidence levels have heightened the concern regarding deleterious consequences affecting both the biosphere and humans, thereby leading to an increase in scientific efforts to understand the role of sunlight in the induction of DNA damage, mutagenesis, and cell death. In fact, the various UV-wavelengths evoke characteristic biological impacts that greatly depend on light absorption of biomolecules, especially DNA, in living organisms, thereby justifying the increasing importance of developing biological sensors for monitoring the harmful impact of solar UV radiation under various environmental conditions. In this review, several types of biosensors proposed for laboratory and field application, that measure the biological effects of the UV component of sunlight, are described. Basically, the applicability of sensors based on DNA, bacteria or even mammalian cells are presented and compared. Data are also presented showing that on using DNA-based sensors, the various types of damage produced differ when this molecule is exposed in either an aqueous buffer or a dry solution. Apart from the data thus generated, the development of novel biosensors could help in evaluating the biological effects of sunlight on the environment. They also emerge as alternative tools for using live animals in the search for protective sunscreen products

Relationship between peripheral airway function and patient-reported outcomes in COPD: a cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Health status, dyspnea and psychological status are important clinical outcomes in chronic obstructive pulmonary disease (COPD). However, forced expiratory volume in one second (FEV₁) measured by spirometry, the standard measurement of airflow limitation, has only a weak relationship with these outcomes in COPD. Recently, in addition to spirometry, impulse oscillometry (IOS) measuring lung resistance (R) and reactance (X) is increasingly being used to assess pulmonary functional impairment.</p> <p>Methods</p> <p>We aimed to identify relationships between IOS measurements and patient-reported outcomes in 65 outpatients with stable COPD. We performed pulmonary function testing, IOS, high-resolution computed tomography (CT), and assessment of health status using the St. George's Respiratory Questionnaire (SGRQ), dyspnea using the Medical Research Council (MRC) scale and psychological status using the Hospital Anxiety and Depression Scale (HADS). We then investigated the relationships between these parameters. For the IOS measurements, we used lung resistance at 5 and 20 Hz (R5 and R20, respectively) and reactance at 5 Hz (X5). Because R5 and R20 are regarded as reflecting total and proximal airway resistance, respectively, the fall in resistance from R5 to R20 (R5-R20) was used as a surrogate for the resistance of peripheral airways. X5 was also considered to represent peripheral airway abnormalities.</p> <p>Results</p> <p>R5-R20 and X5 were significantly correlated with the SGRQ and the MRC. These correlation coefficients were greater than when using other objective measurements of pulmonary function, R20 on the IOS and CT instead of R5-R20 and X5. Multiple regression analyses showed that R5-R20 or X5 most significantly accounted for the SGRQ and MRC scores.</p> <p>Conclusions</p> <p>IOS measurements, especially indices of peripheral airway function, are significantly correlated with health status and dyspnea in patients with COPD. Therefore, in addition to its simplicity and non-invasiveness, IOS may be a useful clinical tool not only for detecting pulmonary functional impairment, but also to some extent at least estimating the patient's quality of daily life and well-being.</p

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie