INVESTMENT MARKETING: TECHNIQUES AND METHODS OF IMPLEMENTATION IN THE FINANCIAL POLICY OF THE ORGANIZATIONS

The possibility of applying marketing technologies in the conditions of realization of investment projects when the financial-economic policy of Russian enterprises at the present stage are discussed. The analysis of existing methods of investment marketing in the Russian Federation taking into account the potential development of the main methods used by Russian investors is considered. The means of evaluating the effectiveness of investments in marketing in order to monitor ongoing marketing activities for timely adjustments to the selected strategy and financial policy of the company are dedicated and systemated. The main directions of the development and assessment of marketing potential investments for the creation of new spheres of production and spheres of maintenance, reconstruction and upgrading of existing industries are defined

The Use of Social Networks to Train the Intercultural Dimension of Foreign Languages at Higher Educational Institutions

The paper aims to identify how social networks contribute to training the intercultural dimension of foreign languages at higher educational institutions. We attempted to answer the questions of what effect the use of social networks has on foreign language training, fostering intercultural and occupational skills, and how both students and teachers perceive the intervention. To achieve research goals, we used quantitative tools, such as (1) checklists, (2) assessment records on English for Specific Purposes, (3) the cultural intelligence scale, (4) the multidimensional emotional empathy scale, and (5) the questionnaire for reflective thinking. Qualitative data were drawn from the observations and interviews. The research findings confirmed that the use of social networks provided students with a true-to-life (authentic) environment and context to gain cultural experience and train a foreign language. This strategy boosts English for Specific Purposes learning and teaching experiences using a distance-learning component. A longitudinal research design enhances transformations in students in terms of emotional empathy and reflective thinking

Effects of titanium dioxide nanoparticles on the Hprt gene mutations in V79 hamster cells

The genotoxicity of anatase/rutile TiO nanoparticles (TiO NPs, NM105 at 3, 15 and 75 µg/cm 2) was assessed with the mammalian in-vitro Hypoxanthine guanine phosphoribosyl transferase (Hprt) gene mutation test in Chinese hamster lung (V79) fibroblasts after 24 h exposure. Two dispersion procedures giving different size distribution and dispersion stability were used to investigate whether the effects of TiO NPs depend on the state of agglomeration. TiO NPs were fully characterised in the previous European FP7 projects NanoTEST and NanoREG2. Uptake of TiO NPs was measured by transmission electron microscopy (TEM). TiO NPs were found in cytoplasmic vesicles, as well as close to the nucleus. The internalisation of TiO NPs did not depend on the state of agglomeration and dispersion used. The cytotoxicity of TiO NPs was measured by determining both the relative growth activity (RGA) and the plating efficiency (PE). There were no substantial effects of exposure time (24, 48 and 72 h), although a tendency to lower RGA at longer exposure was observed. No significant difference in PE values and no increases in the Hprt gene mutant frequency were found in exposed relative to unexposed cultures in spite of evidence of uptake of NPs by cells

Arsenophonus nasoniae and Rickettsiae Infection of Ixodes ricinus Due to Parasitic Wasp Ixodiphagus hookeri

Abstract Arsenophonus nasoniae, a male-killing endosymbiont of chalcid wasps, was recently detected in several hard tick species. Following the hypothesis that its presence in ticks may not be linked to the direct occurrence of bacteria in tick's organs, we identified A. nasoniae in wasps emerging from parasitised nymphs. We confirmed that 28.1% of Ixodiphagus hookeri wasps parasitizing Ixodes ricinus ticks were infected by A. nasoniae. Moreover, in examined I. ricinus nymphs, A. nasoniae was detected only in those, which were parasitized by the wasp. However, in part of the adult wasps as well as in some ticks that contained wasp's DNA, we did not confirm A. nasoniae. We also found, that in spite of reported malekilling, some newly emerged adult wasp males were also infected by A. nasoniae. Additionally, we amplified the DNA of Rickettsia helvetica and Rickettsia monacensis (known to be Ixodes ricinus-associated bacteria) in adult parasitoid wasps. This may be related either with the digested bacterial DNA in wasp body lumen or with a role of wasps in circulation of rickettsiae among tick vectors

Structure functional status ofgastric mucous tunic and it microbiocenosis on chronical gastritis at children

The purpose of the research is to estimate morphofunctional condition mucus-producing apparatus of gaster according to its microbiocenosis at chronic gastritis. The objects of the research were gastric biopsy materials from 55 children at the age from 7 to 15 with diagnosis chronic gastritis (CG) which were divided into two groups: the 1st group — 35 patients with Helicobacter pylori (H.pylori)-fssociated CG; the 2nd — 20 patients with H.pylori-nonassociated CG. During the work there were used histologic, histochemical, lectinhistochemical, morphometric, bacteriologic and statistic methods.There was registered more evident recompartmentation of the lectin receptors on H.pylori-associated CG than on H.pylori-nonassociated CG, that was expressed by the elevation of the level of lectin connection by the cells having affinity to the Foucault mucins, and the reduction of the lectin receptors selectively reacting with the sialic acids (reduction of sialomucins's level) (p<0,05). It was found out that microbiocenosis disorders on H.pylori-associated CG and H.pylori-nonassociated CG have significant differences.Цель исследования — оценить морфофункциональное состояние компонентов слизьобразующего аппарата желудка в зависимости от его микробиоценоза при хроническом гастрите у детей. Объектами исследования стали гастробиоптаты от 55 детей в возрасте от 7 до 15 лет с диагнозом хронический гастрит (ХГ), которые сформировали две группы: 1-я — 35 пациентов с Helicobacter pylori (Н.ру1оп)-ассоциированным ХГ; 2-я группа — 20 больных с H.pylori-неассоциированным ХГ. В работе использованы гистологический, гистохимический, лектиногистохимический, морфометрический, бактериологический и статистический методы исследования. При H.pylori- ассоциированном ХГ зарегистрировано более выраженное перераспределение рецепторов к лектинам, чем при ХГ, не связанном с H.pylori, что выражалось в повышении уровня связывания клетками пектинов, имеющих сродство к фукомуцинам, и снижении содержания рецепторов к лектинам, селективно реагирующим с сиаловыми кислотами (падение уровня сиаломуцинов) (р<0,05). Показано, что нарушения микробиоценоза желудка при H.pylori-ассоциированном и при H.pylori-неассоциированном ХГ также имеют достоверные различия

Structure functional basis of remodeling of gastric mucous tunic on helicobacter pylori — associated gastritis at children

The purpose of the work is to estimate interaction between gelatinizes, tissular inhibitor of metalloproteinase-1 and growth factor in remodeling of gastric mucous tunic on Helicobacter pylori (H.pylori)-associated chronic gastritis (CG) at children. There were examined gastric biopsy materials from 35 children (25 boys and 10 girls) at the age from 7 to 15: 24 patients with H.pylori-associated CG (the 1st group) and 11 patients with functional dyspepsia (FD) (the 2nd group). There were used histologic, hietochemical, immunohistochemical. morphometric, bacteriologic and statistic methods. The results indicate reduction of production of the transforming growth factor-p receptors and elevation of production of the epidermal growth factor receptors, gelatinizes and tissular inhibitor of matrix metalloproteinase-1 on H.pylori-associated CG at children, that shows the formation of misbalance among growth factors, endoproteases and their inhibitors on this disease. There was proved the necessity of albation of the contagium at the earliest period of the disease beginning, and marked the ways for the target medical influence on some pathogenic points of the disease.Цель работы — оценить характер взаимодействий между желатиназами, тканевым ингибитором металлопротеиназ-1 и ростовыми факторами в ремоделировании слизистой оболочки желудка при Helicobacter pylori (H.pylori)-ассоциированном хроническом гастрите (ХГ) у детей. Изучены гастробиоптаты 35 детей (25 мальчиков и 10 девочек) в возрасте от 7 до 15 лет: 24 пациента с H.pylori-ассоциированным ХГ (1-я группа) и 11 больных с функциональной диспепсией (ФД) (2-я группа). Использовались гистологические, гистохимические, иммуногистохимические, морфометрические и статистические методы исследования. Полученные результаты свидетельствуют о снижении экспрессии рецепторов трансформирующего фактора роста-p и повышении уровня экспрессии рецепторов эпидермального фактора роста, желатиназ и тканевого ингибитора матриксных металлопротеиназ-1 при H.pylori-ассоциированном ХГ у детей, что свидетельствует о формировании при этом заболевании дисбаланса между факторами роста, эндопротеазами и их ингибиторами. Обоснована необходимость проведения эрадикации инфекта в наиболее ранние сроки от начала болезни, намечены подходы к таргетному медикаментозному воздействию на некоторые патогенетические звенья болезни

Non-hemagglutinating flaviviruses: molecular mechanisms for the emergence of new strains via adaptation to European ticks

Tick-borne encephalitis virus (TBEV) causes human epidemics across Eurasia. Clinical manifestations range from inapparent infections and fevers to fatal encephalitis but the factors that determine disease severity are currently undefined. TBEV is characteristically a hemagglutinating (HA) virus; the ability to agglutinate erythrocytes tentatively reflects virion receptor/fusion activity. However, for the past few years many atypical HA-deficient strains have been isolated from patients and also from the natural European host tick, Ixodes persulcatus. By analysing the sequences of HA-deficient strains we have identified 3 unique amino acid substitutions (D67G, E122G or D277A) in the envelope protein, each of which increases the net charge and hydrophobicity of the virion surface. Therefore, we genetically engineered virus mutants each containing one of these 3 substitutions; they all exhibited HA-deficiency. Unexpectedly, each genetically modified non-HA virus demonstrated increased TBEV reproduction in feeding Ixodes ricinus, not the recognised tick host for these strains. Moreover, virus transmission efficiency between infected and uninfected ticks co-feeding on mice was also intensified by each substitution. Retrospectively, the mutation D67G was identified in viruses isolated from patients with encephalitis. We propose that the emergence of atypical Siberian HA-deficient TBEV strains in Europe is linked to their molecular adaptation to local ticks. This process appears to be driven by the selection of single mutations that change the virion surface thus enhancing receptor/fusion function essential for TBEV entry into the unfamiliar tick species. As the consequence of this adaptive mutagenesis, some of these mutations also appear to enhance the ability of TBEV to cross the human blood-brain barrier, a likely explanation for fatal encephalitis. Future research will reveal if these emerging Siberian TBEV strains continue to disperse westwards across Europe by adaptation to the indigenous tick species and if they are associated with severe forms of TBE

Parametric Assessment of Macrophytes Ecological Niches in Solving Problems of Sand Quarry Lakes Phytomelioration

Technogenic reservoirs, i.e., sand quarry lakes, appear when sand is extracted under the water column by dredgers or as a result of flooding of quarries. Studies of such reservoirs in the territory of Small Polissia (Ukraine) have shown that the devastated shoreline is like a neo-ecotope formed in the ecotone zone between the water environment of such reservoirs and natural areas upon completion of their operation. Changes in the ecotope within this zone lead to the formation of ecological niches with a set of new specific factors characteristic of aquatic and near-shore vegetation. It has been determined that the fundamental niche of macrophytes in the littoral area of sand quarry lakes in the conditions of Small Polissia is determined by the following parameters: illumination 2500-90000 lux; depth 0–5 m; and trophicity (humus content) – 0-5 %. The realized niches differ for plants of different ecological groups and make up about 50 % for helophytes, about 20 % for pleistophytes, and about 70 % for hydatophytes of the fundamental niche of aquatic vegetation. The volume of space in which the niches of all types of macrophytes in the technogenic lakes of Small Polissia overlay is 10%. The maximum overlay of niches is characteristic of areas covering a combination of factors in terms of illumination (in summer) 15000-90000 lux and depths of 1.3–2.8 m, which creates conditions for the formation of three-tiered phytocoenoses. The niche of submerged plants is the largest, which indicates their highly competitive potential, which is limited mainly by the illumination parameter. Under such conditions, the rapid development of submerged vegetation in the future may lead to the accumulation of its biomass and bogginess, which will limit the use of sand quarry lakes for recreational and other types of nature management. Phytomeliorative tree planting around sand quarry lakes is proposed to regulate illumination as a parameter of the ecological niche of submerged plants.   Doi: 10.28991/HEF-2022-03-04-02 Full Text: PD