457 research outputs found
Gravitation and inertia; a rearrangement of vacuum in gravity
We address the gravitation and inertia in the framework of 'general gauge
principle', which accounts for 'gravitation gauge group' generated by hidden
local internal symmetry implemented on the flat space. We connect this group to
nonlinear realization of the Lie group of 'distortion' of local internal
properties of six-dimensional flat space, which is assumed as a toy model
underlying four-dimensional Minkowski space. The agreement between proposed
gravitational theory and available observational verifications is satisfactory.
We construct relativistic field theory of inertia and derive the relativistic
law of inertia. This theory furnishes justification for introduction of the
Principle of Equivalence. We address the rearrangement of vacuum state in
gravity resulting from these ideas.Comment: 17 pages, no figures, revtex4, Accepted for publication in Astrophys.
Space Sc
The combined use of imaging approaches to assess drug release from multicomponent solid dispersions
PURPOSE: Imaging methods were used as tools to provide an understanding of phenomena that occur during dissolution experiments, and ultimately to select the best ratio of two polymers in a matrix in terms of enhancement of the dissolution rate and prevention of crystallization during dissolution. METHODS: Magnetic resonance imaging, ATR-FTIR spectroscopic imaging and Raman mapping have been used to study the release mechanism of a poorly water soluble drug, aprepitant, from multicomponent amorphous solid dispersions. Solid dispersions were prepared based on the combination of two selected polymers - Soluplus, as a solubilizer, and PVP, as a dissolution enhancer. Formulations were prepared in a ratio of Soluplus:PVP 1:10, 1:5, 1:3, and 1:1, in order to obtain favorable properties of the polymer carrier. RESULTS: The crystallization of aprepitant during dissolution has occurred to a varying degree in the polymer ratios 1:10, 1:5, and 1:3, but the increasing presence of Soluplus in the formulation delayed the onset of crystallization. The Soluplus:PVP 1:1 solid dispersion proved to be the best matrix studied, combining the abilities of both polymers in a synergistic manner. CONCLUSIONS: Aprepitant dissolution rate has been significantly enhanced. This study highlights the benefits of combining imaging methods in order to understand the release process
High Resolution CO Imaging of the Molecular Disk around the jets in KjPN 8
We report high resolution (2.5 arcsec) CO J=1-0 line imaging which confirms
the presence of a molecular disk around the origin of the spectacular, 14
arcmin times 4 arcmin, episodic jets in the planetary nebula KjPn 8. The disk
is 30 arcsec in diameter with an expansion velocity of approximately 7 km/s.
The axis of the disk is aligned with the youngest and fastest (approximately
300 km/s) of the bipolar jets, and there is evidence for interaction between
the jets and the disk material. The inner 4 arcsec of the disk are
photo-ionized by the central star. The disk-jet system dominates the
environment of this young nebula, and should govern the morphology of KjPn 8 as
it evolves to become fully ionized.Comment: 15 pages, 4 figures, accepted for publication in Astrophysical
Journal Letter
Attenuated total reflection-FT-IR spectroscopic imaging of protein crystallization
Protein crystallization is of strategic and commercial relevance in the post-genomic era because of its pivotal role in structural proteomics projects. Although protein structures are crucial for understanding the function of proteins and to the success of rational drug design and other biotechnology applications, obtaining high quality crystals is a major bottleneck to progress. The major means of obtaining crystals is by massive-scale screening of a target protein solution with numerous crystallizing agents. However, when crystals appear in these screens, one cannot easily know if they are crystals of protein, salt, or any other molecule that happens to be present in the trials. We present here a method based on Attenuated Total Reflection (ATR)-FT-IR imaging that reliably identifies protein crystals through a combination of chemical specificity and the visualizing capability of this approach, thus solving a major hurdle in protein crystallization. ATR-FT-IR imaging was successfully applied to study the crystallization of thaumatin and lysozyme in a high-throughput manner, simultaneously from six different solutions. This approach is fast as it studies protein crystallization in situ and provides an opportunity to examine many different samples under a range of conditions
The Combined Use of Imaging Approaches to Assess Drug Release from Multicomponent Solid Dispersions
Models of Neutrino Masses and Baryogenesis
Majorana masses of the neutrino implies lepton number violation and is
intimately related to the lepton asymmetry of the universe, which gets related
to the baryon asymmetry of the universe in the presence of the sphalerons
during the electroweak phase transition. Assuming that the baryon asymmetry of
the universe is generated before the electroweak phase transition, it is
possible to dicriminate different classes of models of neutrino masses. While
see-saw mechanism and the triplet higgs mechanism are preferred, the Zee-type
radiative models and the R-parity breaking models requires additional inputs to
generate baryon asymmetry of the universe during the electroweak phase
transition.Comment: 27 pages including 5 figures; Review article for Pramana: the Indian
Journal of Physic
Energy Flow in the Hadronic Final State of Diffractive and Non-Diffractive Deep-Inelastic Scattering at HERA
An investigation of the hadronic final state in diffractive and
non--diffractive deep--inelastic electron--proton scattering at HERA is
presented, where diffractive data are selected experimentally by demanding a
large gap in pseudo --rapidity around the proton remnant direction. The
transverse energy flow in the hadronic final state is evaluated using a set of
estimators which quantify topological properties. Using available Monte Carlo
QCD calculations, it is demonstrated that the final state in diffractive DIS
exhibits the features expected if the interaction is interpreted as the
scattering of an electron off a current quark with associated effects of
perturbative QCD. A model in which deep--inelastic diffraction is taken to be
the exchange of a pomeron with partonic structure is found to reproduce the
measurements well. Models for deep--inelastic scattering, in which a
sizeable diffractive contribution is present because of non--perturbative
effects in the production of the hadronic final state, reproduce the general
tendencies of the data but in all give a worse description.Comment: 22 pages, latex, 6 Figures appended as uuencoded fil
The Second Byurakan Survey Galaxies. I. The Optical Database
A database for the entire catalog of the Second Byurakan Survey (SBS)
galaxies is presented. It contains new measurements of their optical parameters
and additional information taken from the literature and other databases. The
measurements were made using Ipg(near-infrared), Fpg(red) and Jpg(blue) band
images from photographic sky survey plates obtained by the Palomar Schmidt
telescope and extracted from the STScI Digital Sky Survey (DSS). The database
provides accurate coordinates, morphological type, spectral and activity
classes, apparent magnitudes and diameters, axial ratios, and position angles,
as well as number counts of neighboring objects in a circle of radius 50 kpc.
The total number of individual SBS objects in the database is now 1676. The 188
Markarian galaxies which were re-discovered by SBS are not included in this
database. We also include redshifts that are now available for 1576 SBS
objects, as well as 2MASS infrared magnitudes for 1117 SBS galaxies.Comment: 13 pages, 1 figure, 1 tabl
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