January 1958

My dear Brother: It does not require a great stretch of the imagination for me to hear you mutter: Didn\u27t I get one of these yellow sheets only a month ago? Why doesn\u27t he get back to work instead of cluttering up my mail? Well, thereby hangs a tale. A few weeks ago I spent an illuminating, and somewhat dismaying, evening with brother Theophilus in the Middle West. He has a good congregation of about five hundred members. It is an average parish, with the usual complement of saints and sinners, with the lines between them shifting back and forth. Theophilus has worked hard and the Lord of the Church has blessed his hands and his voice

Kırşehir yöresinde herpes zosterli 166 hastanın klinik ve demografik özelliklerinin değerlendirilmesi

Background and Design: Herpes zoster (HZ) occurs by reactivation of the latent varicella zoster virus at dorsal root ganglia. In the literature, there are studies on socio-demographic and clinical characteristics of patients with HZ in our country and in the world, however, there has been no study performed in our region. We aimed to evaluate demographic and clinical characteristics of patients with HZ and to investigate differences and similarities with other epidemiological studies in Turkey and in the world. Materials and Methods: One hundred sixty-six patients clinically diagnosed with HZ by dermatologists between January 2015 and December 2016 and were followed for 3 months in terms of possible complications were included this study. Demographic and clinical characteristics of the patients were recorded. Results: The mean age of the patients was 51.48±21.05 (1-90) years. Eighty-seven patients were female (52.4%), 79 were male (47.6%). Thirteen patients (7.8%) were in the pediatric age group (<18). The frequency of patient admission was highest in December and lowest in March. The most frequent locations of the lesions were thoracic (76 patients, 45.8%) and lumbar (40 patients, 24.1%) regions. The lesions were on the left side of the body in 96 (57.8%) and right side in 70 (42.2%) patients. The most frequent triggering factor was emotional stress. Post-herpetic neuralgia (27.7%) was the most frequently seen complication. The most common systemic comorbidity was hypertension. Malignancy was present in only 3 patients (1.8%). Conclusion: Our data were highly comparable with other studies. However, occurrence of HZ mostly during the winter and in the left side of the body was the difference from other studies. We conclude that further country-wide studies with larger number of patients are needed in order to clarify the epidemiological and clinical characteristics of HZ in our country.Amaç: Herpes zoster (HZ) dorsal kök ganglionlarında latent kalan varisella zoster virüsün reaktive olmasıyla ortaya çıkar. Literatürde ülkemizde ve dünyada HZ’nin sosyo-demografik ve klinik özelliklerini değerlendiren çalışmalar vardı ancak bölgemizde yapılan bir çalışma yoktu. Çalışmamızda HZ tanısı konulan hastaların klinik ve demografik özelliklerini incelemeyi ve Türkiye ve dünyadaki diğer epidemiyolojik çalışmalarla benzerlik ve farklılıklarını araştırmayı amaçladık. Gereç ve Yöntem: Ocak 2015-Aralık 2016 tarihleri arasında dermatologlar tarafından HZ tanısı konulan 166 hasta çalışmaya dahil edildi ve olası komplikasyonlar açısından 3 ay boyunca takip edildi. Hastaların demografik ve klinik özellikleri kaydedildi. Bulgular: Hastaların yaşları 1 ile 90 yaş arasında değişmekteydi (ortalama yaş: 51,48±21,05). Hastaların 81’i (%52,4) kadın, 79’u (%47,6) erkekti. Hastaların 13’ü (%7,8) pediatrik yaş grubunda (<18) idi. Hasta başvuruları aralık ayında en yüksek, mart ayında en düşük seviyedeydi. En sık etkilenen bölgeler torasik (76 hasta, %45,8) ve lumbar (40 hasta, %24,1) idi. Lezyonlar, 96 hastada (%57,8) vücudun sol tarafında, 70 hastada (%42,2) sağ tarafında gözlendi. En sık tetikleyici faktör emosyonel stresdi. En sık görülen komplikasyon postherpetik nevraljiydi (46 hasta, %27,7). En sık görülen sistemik hastalık hipertansiyondu. Sadece 3 hastada (%1,8) malignite mevcuttu. Sonuç: Çalışmamızın verileri diğer çalışmalar ile büyük oranda benzerdi. Ancak farklı olarak HZ en fazla kış mevsiminde saptandı ve vücudun sol tarafında tutulum daha sıktı. Türkiye’de HZ’nin klinik ve epidemiyolojik özelliklerini açıklığa kavuşturmak için daha fazla sayıda hastayla, ülke genelinde yapılacak çalışmalara ihtiyaç duyulduğunu düşünmekteyiz

The genetic history of the Southern Arc: a bridge between West Asia and Europe

By sequencing 727 ancient individuals from the Southern Arc (Anatolia and its neighbors in Southeastern Europe and West Asia) over 10,000 years, we contextualize its Chalcolithic period and Bronze Age (about 5000 to 1000 BCE), when extensive gene flow entangled it with the Eurasian steppe. Two streams of migration transmitted Caucasus and Anatolian/Levantine ancestry northward, and the Yamnaya pastoralists, formed on the steppe, then spread southward into the Balkans and across the Caucasus into Armenia, where they left numerous patrilineal descendants. Anatolia was transformed by intra–West Asian gene flow, with negligible impact of the later Yamnaya migrations. This contrasts with all other regions where Indo-European languages were spoken, suggesting that the homeland of the Indo-Anatolian language family was in West Asia, with only secondary dispersals of non-Anatolian Indo-Europeans from the steppe

Clinical Effects of Topical Tacrolimus on Fox-Fordyce Disease

Fox-Fordyce Disease (FFD) is a rare, chronic, pruritic, inflammatory disorder of apocrine glands. It is characterized by dome-shaped, firm, discrete, skin-colored, and monomorphic perifollicular papules. The most common sites of involvement are axillae and anogenital and periareolar regions which are rich in apocrine sweat glands. Treatment is difficult. Topical, intralesional steroids, topical tretinoin, adapalene, clindamycin, benzoyl peroxide, oral contraceptives, isotretinoin, phototherapy, electrocauterisation, excision-liposuction and curettage, and fractional carbon dioxide laser are among the treatment options. In the literature, there are articles reporting beneficial effects of pimecrolimus in FFD. Nevertheless, there have not been any reports about the use of tacrolimus in FFD. We report two patients diagnosed with FFD by clinical and histopathologic examination and discussed therapeutic effects of topical tacrolimus on FFD in the light of literature

Assessment of Bone Mineral Density in Psoriasis Patients without Arthritis

: In this study, we aimed to investigate the bone mineral density (BMD) of psoriasis patients, compare withhealthy control group, and to evaluate whether topical corticosteroids and systemic treatments affect BMD inpsoriasis patients. Forty psoriasis patients admitted to dermatology outpatient clinic and 36 healthy subjects wereincluded in the study. Lumbar and femur BMD of patient and control groups were measured. No statisticallysignificant difference was found with regard to BMD in psoriasis and healthy control groups. When we compare theL1-L4 scores, femur BMD, L1-L4 BMD, femur Z, spine Z, and values of the psoriasis patients who receiving topicaland systemic treatments, we did not found statistically significant difference. Femur neck T score was significantlyhigher in the group receiving topical treatment than in the group receiving systemic treatment. There were notstatistically significant difference between disease duration and severity. The L1-L4 scores, L1-L4 BMD, spine Zvalues did not differ significantly between nail involvement and non-nail involvement groups. But the femur neck,femur total and femur Z scores were significantly lower in the group with nail involvement than group without nailinvolvement. This study shows that BMD of psoriasis patients is not different from healthy control group.</p

Evaluation of fibromyalgia syndrome in patients with rosacea

Objectives: This study aims to investigate the frequency of fibromyalgia syndrome (FMS) in rosacea patients and the relationship between disease disability score of FMS and quality of life score of rosacea

Methotrexate Treatment in Children with Febrile Ulceronecrotic Mucha-Habermann Disease: Case Report and Literature Review

Febrile Ulceronecrotic Mucha-Habermann disease is a rare and potentially fatal variant of pityriasis lichenoides et varioliformis acuta and is characterized by high fever, constitutional symptoms, and acute oncet of ulceronecrotic lesions. We present an 11-year-old male with Febrile Ulceronecrotic Mucha-Habermann disease who was cured with methotrexate and review the use of methotrexate for this disorder in the pediatric age group with the relevant literature

Morphea in Middle Anatolia, Turkey: a 5-year single-center experience

Introduction: Morphea, also referred to as localized scleroderma, is a rare fibrosing skin disorder of undetermined cause. Aim: We report our single-center experience with morphea. Material and methods: The study included 53 patients who were diagnosed with morphea by histopathology in our department between 2010 and 2015. Study data were collected retrospectively from the records of morphea patients. Results: The study included 53 patients (38 women, 15 men), and median age at onset was 39.0 (range: 8–85) years. Thirty (56.6%) patients had circumscribed morphea, 15 (28.3%) had generalized morphea, and 7 (13.2%) had linear morphea. One patient had mixed variant morphea (generalized, pansclerotic and linear morphea). ANA positivity was detected in 12 (22.6%) patients, but analysis for an association between the presence of ANA and morphea types, patients’ characteristics did not reveal any significant associations. We did not observe any extracutaneous manifestations in patients during follow-up period. There were 2 of 53 patients who had concomitant autoimmune disorder including vitiligo and spondyloarthritis. Thirty (56.6%) patients received only topical treatment. The patients with clinical improvement who were treated with systemic therapy received methotrexate (26.4%), colchicine (9.4%), mycophenolate mofetil (5.7%) and prednisolone (1.9%). Conclusions: Our results related to the demographic data of the patients and morphea types were consistent with the literature. On the other hand we observed that methotrexate was mostly used as an effective treatment option for generalized morphea