A Hidden Broad-Line Region in the Weak Seyfert 2 Galaxy NGC 788

We have detected a broad H alpha emission line in the polarized flux spectrum of the Seyfert 2 galaxy NGC 788, indicating that it contains an obscured Seyfert 1 nucleus. While such features have been observed in ~15 other Seyfert 2s, this example is unusual because it has a higher fraction of galaxy starlight in its spectrum, a lower average measured polarization, and a significantly lower radio luminosity than other hidden Seyfert 1s discovered to date. This demonstrates that polarized broad-line regions can be detected in relatively weak classical Seyfert 2s, and illustrates why well-defined, reasonably complete spectropolarimetric surveys at H alpha are necessary in order to assess whether or not all Seyfert 2s are obscured Seyfert 1s.Comment: 10 pages using (AASTEX) aaspp4.sty and 4 postscript figures. Publications of the Astronomical Society of the Pacific, Research Notes, in pres

INCOME TAX EFFECTS ON BEEF COW REPLACEMENT STRATEGY

Livestock Production/Industries,

Cultivating Biblical Imagination Through Preaching

Explores the ways preaching can help increase familiarity and comfort with scripture so people are able to interpret their daily experiences and lifetime milestones with God’s story revealed in the Bible. The importance of narrative is explored, especially in relationship with competing narratives in today’s world. A variety of forms of interactive preaching are explored to evaluate the ability of the sermon to increase biblical imagination: biblical storytelling, people talking to one another, and writing down reflections to act on in the future. Sermons were preached in multiple ELCA congregation in a variety of contexts

Education for the sustainable global citizen:what can we learn from Stoic philosophy and Freirean environmental pedagogies?

In support of sustainable development, the United Nations launched its Global Education First Initiative with the aims of accelerating progress towards universal access to education and good quality learning whilst fostering global citizenship. This paper explores how and to what extent Stoic virtue ethics and critical Freirean ecopedagogies can advance the UN’s vision for progressive educational systems with transformative societal effects. We propose an integrated solution that provides ecopedagogical concepts a more robust philosophical foundation whilst also offering Stoicism additional tools to tackle those 21st century problems, such as climate change and environmental degradation, that ancient Stoics could not have envisioned nor scientifically understood. The result of the paper is the preliminary theoretical underpinnings of an educational framework that facilitates progress towards both individual and collective wellbeing whilst also encompassing planetary level concerns so as to holistically promote and plan for a fuller expression of the terms “sustainable development” and “global citizen”

Efficacy and safety of biosimilar CT-P17 versus reference adalimumab in subjects with rheumatoid arthritis: 24-week results from a randomized study

BACKGROUND: To demonstrate equivalent efficacy of the proposed high-concentration (100 mg/ml), citrate-free adalimumab biosimilar CT-P17 to European Union-approved adalimumab (EU-adalimumab) in subjects with active rheumatoid arthritis (RA). METHODS: This randomized, double-blind phase III study ( ClinicalTrials.gov , NCT03789292) randomized (1:1) subjects with active RA at 52 centers to receive CT-P17 or EU-adalimumab 40 mg subcutaneously every 2 weeks until week 52. Results to week 24 are reported here. The primary endpoint was 20% improvement by American College of Rheumatology criteria (ACR20) response rate at week 24. Equivalence was concluded if the corresponding confidence intervals (CIs) for the estimate of treatment difference were within predefined equivalence margins: - 15 to 15% (95% CI; European Medicines Agency assumption); - 12 to 15% (90% CI; Food and Drug Administration assumption). Additional efficacy, pharmacokinetic, usability, safety, and immunogenicity endpoints were evaluated. RESULTS: 648 subjects were randomized (324 CT-P17; 324 EU-adalimumab). The ACR20 response rate at week 24 was 82.7% (n = 268/324) in both groups (intention-to-treat population). The 95% CI (- 5.94 to 5.94) and 90% CI (- 4.98 to 4.98) were within predefined equivalence margins for both assumptions and equivalent efficacy was concluded. Additional endpoints and overall safety were comparable between groups. Mean trough serum concentrations of CT-P17 were slightly higher than those of EU-adalimumab. Immunogenicity was slightly lower numerically for the CT-P17 group than for the EU-adalimumab group. CONCLUSIONS: CT-P17 and EU-adalimumab have equivalent efficacy and comparable safety and immunogenicity in subjects with active RA. Overall safety of CT-P17 is consistent with the known safety profile of reference adalimumab. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03789292 . Registered 28 December 2018-retrospectively registered

Securing a Healthy Future: The Commonwealth Fund State Scorecard on Child Health System Performance, 2011

Ranks states on twenty indicators of healthcare access, affordability, prevention and treatment, potential for healthy lives, and health system equity for children. Examines the need for targeted initiatives and policy implications for better performance

Body Mass Index, Smoking, and Alcohol and Risks of Barrett’s Esophagus and Esophageal Adenocarcinoma: A UK Prospective Cohort Study

BACKGROUND: The timing of the risk factors cigarette smoking, alcohol and obesity in the development of Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) is unclear. AIMS: To investigate these exposures in the aetiology of BE and EAC in the same population. METHODS: The cohort included 24,068 men and women, aged 39–79 years, recruited between 1993 and 1997 into the prospective EPIC-Norfolk Study who provided information on anthropometry, smoking and alcohol intake. The cohort was monitored until December 2008 and incident cases identified. RESULTS: One hundred and four participants were diagnosed with BE and 66 with EAC. A body mass index (BMI) above 23 kg/m(2) was associated with a greater risk of BE [BMI ≥23 vs. 18.5 to <23, hazard ratio (HR) 3.73, 95 % CI 1.37–10.16], and within a normal BMI, the risk was greater in the higher category (HR 3.76, 95 % CI 1.30–10.85, BMI 23–25 vs. 18.5 to >23 kg/m(2)). Neither smoking nor alcohol intake were associated with risk for BE. For EAC, all BMI categories were associated with risk, although statistically significant for only the highest (BMI >35 vs. BMI 18.5 to <23, HR 4.95, 95 % CI 1.11–22.17). The risk was greater in the higher category of a normal BMI (HR 2.73, 95 % CI 0.93–8.00, p = 0.07, BMI 23–25 vs. 18.5 to >23 kg/m(2)). There was an inverse association with ≥7 units alcohol/week (HR 0.51, 95 % CI 0.29–0.88) and with wine (HR 0.49, 95 % CI 0.23–1.04, p = 0.06, drinkers vs. non-drinkers). CONCLUSIONS: Obesity may be involved early in carcinogenesis and the association with EAC and wine should be explored. The data have implications for aetiological investigations and prevention strategies

Teaching Machines to Read and Comprehend

Teaching machines to read natural language documents remains an elusive challenge. Machine reading systems can be tested on their ability to answer questions posed on the contents of documents that they have seen, but until now large scale training and test datasets have been missing for this type of evaluation. In this work we define a new methodology that resolves this bottleneck and provides large scale supervised reading comprehension data. This allows us to develop a class of attention based deep neural networks that learn to read real documents and answer complex questions with minimal prior knowledge of language structure.Comment: Appears in: Advances in Neural Information Processing Systems 28 (NIPS 2015). 14 pages, 13 figure

Validation of the NASA Dryden X-31 simulation and evaluation of mechanization techniques

This paper shall discuss the evaluation of the original Dryden X-31 aerodynamic math model, processes involved in the justification and creation of the modified data base, and comparison time history results of the model response with flight test