Migration as a Climate Change Adaptation Strategy: What Role do Emotions Play?

Climate change intersecting with complex socio-economic and political processes has produced distinctive patterns of crisis migration. However there exists a significant gap in understanding and theorizing these forms of migration creating significant policy challenges. Using a case study of an interstate migrant settlement in Bengaluru, India this article unpacks migration as an adaptation strategy through the lens of emotions. The article offers significant insights into how emotions affect the choice of migration as an adaptation strategy and shapes the differential experiences of risks and vulnerability for different groups of people. Emphasizing such relational aspects of migration, the article calls for more research that develops a nuanced understanding of the emotional landscapes of migrants across migration pathways

Caring for energy, energy to care: Exploring the energy-care nexus through examples from Sweden and India

As the climate crisis continues to grow, there is an increasing focus both in research and policy spaces on the need and urgency of energy transitions. In this perspective, we urge scholars, policymakers and social movements to recognize the ways that care work and practices of care are intersecting with everyday experiences of energy use. Through case studies from India and Sweden, we depict how care activities and energy use intertwine in people\u27s daily lives in ways that are often deeply gendered. These two settings serve to illustrate our argument that energy and care are and must be deeply interlinked, in two main directions: energy as enabler or disabler of care work, and care work as shaping demands on energy access. To ensure a just energy transition where care is enabled and fairly shared, care must be an inherent part of energy transition analyses

Recognition in urban climate justice:marginality and exclusion of migrants in Indian cities

This paper explores the recognitional dimensions of urban climate change justice in a development context. Through the lens of migrants in the Indian cities of Bengaluru and Surat, we highlight how experiences of environmental marginality can be attributed to a lack of recognition of citizenship rights and informal livelihood strategies. Specifically, the drivers of non-recognition in this situation relate to broken social networks and a lack of political voice, as well as heightened exposure to emerging climate risks and economic precariousness. We find that migrants experience extreme forms of climate injustice as they are often invisible to the official state apparatus, or worse, are actively erased from cities through force or discriminatory development policies. Current theories must therefore engage more seriously with issues of recognition to enable more radical climate justice in cities

Barriers and enablers to climate adaptation : evidence from rural and urban India

This work was carried out under the Collaborative Adaptation Research Initiative in Africa and Asia (CARIAA), with financial support from the UK Government’s Department for International Development (DfID) and the International Development Research Centre (IDRC), Canada.Researchers from the Indian Institute for Human Settlements (IIHS) used focus group discussions, household surveys and life history interviews to collect information at settlement, household and intra-household levels in the rural districts of Kolar and Gulbarga and the urban district of Bangalore. While the current focus on watershed development with adaptation co-benefits is positive, it must be complemented by efforts to address the growing irrigation demand. Governance is a barrier to local adaptation. More than other factors, implementation of adaptation practices is slowed by the lack of staff especially at State and district levels

Barriers and enablers of local adaptive measures : a case study of Bengaluru’s informal settlement

This paper highlights the barriers and enablers to climate change-related adaptation experienced in some of Bengaluru’s informal settlements. The barriers described in the paper include economic, social, governance and information related issues that impede local actions and increase vulnerabilities. Enabling factors include improving social and human capital, gaining formal recognition and support from agencies (local government, civil societies, and community leaders). Hence, local level adaptation measures mainstreamed with local developmental agendas help address some of the structural causes of vulnerability. Contextual policies and interventions can facilitate successful local level adaptation measures.Great Britain. Dept for International Developmen

Dimensions of vulnerability in rural and urban areas : a case of migrants in Karnataka

This work was carried out under the Collaborative Adaptation Research Initiative in Africa and Asia (CARIAA), with financial support from the UK Government’s Department for International Development (DfID) and the International Development Research Centre (IDRC), Canada.The high growth regime in India during the last two decades has been widely critiqued for its apparently exclusionary development process that has rendered agrarian livelihoods untenable. When combined with climatic stressors – like changing rainfall and increasing temperature – this unviability of rural agrarian livelihoods has led to increased out-migration to the cities. However, the lack of opportunities in agriculture has not been compensated by increased quality job opportunities in urban areas. This structural imbalance has created a mass exodus of rural workers necessitated to engage in precarious city jobs

Improving the Transduction of Bone Marrow-Derived Cells with an Integrase-Defective Lentiviral Vector

In lentiviral vector (LV) applications where transient transgene expression is sufficient, integrase-defective lentiviral vectors (IDLVs) are beneficial for reducing the potential for off-target effects associated with insertional mutagenesis. It was previously demonstrated that human RPE65 mRNA expression from an integrating lentiviral vector (ILV) induces endogenous Rpe65 and Cralbp mRNA expression in murine bone marrow-derived cells (BMDCs), initiating programming of the cells to retinal pigment epithelium (RPE)-like cells. These cells regenerate RPE in retinal degeneration models when injected systemically. As transient expression of RPE65 is sufficient to activate endogenous RPE-associated genes for programming BMDCs, use of an ILV is an unnecessary risk. In this study, an IDLV expressing RPE65 (IDLV3-RPE65) was generated. Transduction with IDLV3-RPE65 is less efficient than the integrating vector (ILV3-RPE65). Therefore, IDLV3-RPE65 transduction was enhanced with a combination of preloading 20 × -concentrated viral supernatant on RetroNectin at a multiplicity of infection of 50 and transduction of BMDCs by low-speed centrifugation. RPE65 mRNA levels increased from ∼12-fold to ∼25-fold (p < 0.05) after modification of the IDLV3-RPE65 transduction protocol, achieving expression similar to the ∼27-fold (p < 0.05) increase observed with ILV3-RPE65. Additionally, the study shows that the same preparation of RetroNectin can be used to coat up to three wells with no reduction in transduction. Critically, IDLV3-RPE65 transduction initiates endogenous Rpe65 mRNA expression in murine BMDCs and Cralbp/CRALBP mRNA in both murine and human BMDCs, similar to expression observed in ILV3-RPE65-transduced cells. Systemic administration of ILV3-RPE65 or IDLV3-RPE65 programmed BMDCs in a mouse model of retinal degeneration is sufficient to retain visual function and reduce retinal degeneration compared to mice receiving no treatment or naïve BMDC. It is concluded that IDLV3-RPE65 is appropriate for programming BMDCs to RPE-like cells

Selection Criteria for Posterior Circulation Stroke and Functional Outcome Following Mechanical Thrombectomy

Objective: 20% of all acute ischemic strokes (AIS) are caused by posterior circulation strokes, which carry an intensified mortality touching 95%. Early recanalization improves outcome as shown by several reports; however, safety, patient selection, and prognostic factors remain lacking. An investigation of the safety and prognostic factors for posterior circulation mechanical thrombectomy (MT) was performed. Methods: A retrospective review of patients presenting with posterior circulation AIS, who underwent MT between 2010 and 2018. Results: Of 443 patients who underwent MT for AIS, 83 patients had posterior circulation strokes. 95% of procedures were conducted under general anesthesia. The median NIHSS upon admission was 19.1. Half of the patients underwent MT 8 hours from symptom onset, and half required a salvage contact thrombus aspiration after a stent retriever trial with an average of two passes for successful recanalization. The time to achieve revascularization was 61.6 minutes. Mortality rate was 28%, and modified Rankin Scale (mRS) \u3c 2 at three months was seen in 40.1% of surviving patients. A higher functional outcome trend (mRS\u3c2) was seen in patients who underwent MT within 8 hours of symptom onset. The overall complication rate was 28%. Regression analysis showed that stroke subtype, baseline NIHSS, and posterior circulation Alberta Stroke Program Early CT Score (pc-ASPECTS) before thrombectomy were independent predictive factors of positive clinical outcomes. Conclusions: MT is an effective intervention for posterior circulation strokes, and long-term functional independence relies upon proper patient selection. Baseline NIHSS and pc-ASPECTS are independent predictive factors

Inserting rights and justice into urban resilience : a focus on everyday risk

Resilience building has become a growing policy agenda, particularly for urban risk management. While much of the resilience agenda has been shaped by policies and discourses from the global North, its applicability for cities of the global south, particularly African cities, has not been sufficiently assessed. Focusing on rights of urban citizens as the object to be made resilient, rather than physical and ecological infrastructures, may help to address many of the root causes that characterize the unacceptable risks that urban residents face on a daily basis. Linked to this idea, we discuss four entry points for grounding a rights and justice orientation for urban resilience. First, notions of resilience must move away from narrow, financially-orientated risk analyses. Second, opportunities must be created for “negotiated resilience”, to allow for attention to processes that support these goals, as well as for the integration of diverse interests. Third, achieving resilience in ways that do justice to the local realities of diverse urban contexts necessitates taking into account endogenous, locally situated processes, knowledges and norms. And finally, urban resilience needs to be placed within the context of global systems, providing an opportunity for African contributions to help reimagine the role that cities might play in these global finance, politics and science processes

Mechanical Thrombectomy in Acute Ischemic Stroke Patients Greater than 90 years of age experience in 26 patients in a Large Tertiary Care Center: Outcome comparison with younger patients

Introduction: Several independent randomized control trials have shown the superior efficacy of mechanical thrombectomy for acute ischemic stroke (AIS). However, the elderly has been underrepresented or excluded in these trials. In this study, we investigated the feasibility and safety of mechanical thrombectomy in patients with AIS aged 90 years or greater. Methods: A retrospective review of patients age 90 years or older presenting with AIS who underwent mechanical thrombectomy between 2010 and 2018. Results: Of total 453 patients with AIS, 5.74 % (26) were aged 90 or older, and 69.32 % (314) ranged from 60-89 years of age. Of all baseline characteristics between both groups, there is a significant difference in age, gender, body mass index (BMI), smoking, hyperlipidemia (HLD), atrial fibrillation, and diabetes mellitus. The mean NIHSS upon admission was higher in the nonagenarians (17 vs. 15). Similar proportions of both groups received tPA (57.69%, 15 vs. 42.68%, 134, p=0.14). There was no difference in peri & post-procedural complications, good TICI score (88.46%, 23 vs. 87.58%, 275, p=1.00), “good” mRS scores (34.62%, 4 vs. 49.36%, 155, p=0.40), and mortality (11.54%, 3 vs. 13.06%, 41, p= 0.82). Discussion: Age is one of the factors that affect functional outcome following mechanical thrombectomy. Advancements in catheter techniques, technical experience, and great outcomes with mechanical thrombectomy allow for pushing the envelope to deal with age as one of the factors, rather, than an exclusion criterion. Our results show that mechanical thrombectomy is safe and feasible in nonagenarians